Clinical trials: Muscle Breakdown
Sarcopenia
The Role of Muscle Protein Breakdown in the Regulation of Muscle Quality in Frail Elderly Individuals
The purpose of this study is to investigate mechanisms underlying the reduction in muscle quality (the ratio between muscle strength and muscle size) with aging, and to investigate how these factors are affected by strength…
- Trial name
- NCT03326648
- Testing
- Strength training, Protein supplementation
- Where
- Norway
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Truls Raastad
Inflammaging, Sarcopenia
Inflammaging and Muscle Protein Metabolism
The development of a low-grade, chronic, systemic inflammation observed in the elderly (inflammaing) has been associated with increased risk for skeletal muscle wasting, strength loss and functional impairments.
- Trial name
- NCT03308747
- Testing
- Instantized Whey Protein Isolate
- Where
- Greece
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Crohn Disease
ProteIn Nutrition in Crohn's Disease
Muscles are essential for good quality of life. The investigators have shown that when children with Crohn's disease eat protein, only very little of it enters the muscles, leading to poor muscle growth and fatigue.
- Trial name
- PINC (NCT05572008)
- Testing
- Protein nutrition in paediatric Crohn's disease
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Obesity
Effects of Short-term Energy Deficit on Muscle Protein Turnover
Weight loss through energy restriction results in the loss of both fat and muscle mass. Muscle mass is important for mobility, strength, glucose control and energy expenditure, and therefore the retention of muscle mass during…
- Trial name
- NCT02406040
- Testing
- Energy Restriction
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Protein Metabolism
Skeletal Muscle Protein Synthetic Response to Amino Acid and Peptides
Skeletal muscle quality is an important determinant of exercise performance and overall health. It is vital for not just movement, but also metabolizing nutrients.
- Trial name
- NCT03952884
- Testing
- Resistance Exercise, No Resistance Exercise, Leucine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Sarcopenia
Modulation of Muscle Protein Synthesis With Diet and Exercise in Old Aged Women
In this study will measure differences in how muscle responds to both exercise and protein supplements in healthy women aged 60-69.
- Trial name
- NCT02053441
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Exercise Recovery, Physical Performance Parameters
Effects of Pork Protein on Recovery Following Simulated Fireground Activity
The goal of this clinical trial is to learn whether consuming pork-based protein before and after physically demanding simulated firefighting activities can improve recovery, physical performance, and cognitive performance in…
- Conditions
- Exercise Recovery, Physical Performance Parameters, Muscle Damage, Cognition
- Trial name
- PORK-FIRE (NCT07819565)
- Testing
- Pork-Based Protein Ready-to-Eat Meals, Plant-Based Protein Ready-to-Eat Meals, Carbohydrate-Focused Lower-Protein Ready-to-Eat Meals
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sam Houston State University
Healthy
Effect of Nutrition on Muscle Protein Synthesis
The present proposal is designed to examine the effect of carbohydrate and protein co-ingestion on muscle protein synthesis during endurance type exercise activities.
- Trial name
- NCT00604929
- Testing
- carbohydrate and protein
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Physical Performance Parameters, Exercise Recovery
Effects of Beef-Forward Ready-to-Eat Meals on Recovery Following Simulated Fire Suppression Activities
This clinical trial aims to determine whether consuming beef-based protein before and after physically demanding simulated firefighting activities improves recovery, physical performance, and cognitive performance in healthy…
- Conditions
- Physical Performance Parameters, Exercise Recovery, Cognition, Muscle Damage
- Trial name
- FIRE-BEEF (NCT07822048)
- Testing
- Beef-Based Protein Ready-to-Eat Meals, Plant-Based Protein Ready-to-Eat Meals
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sam Houston State University
Muscle Atrophy, Insulin Sensitivity
Metabolic and Muscular Adaptations During Inactivity in 3 Days of Bed-rest
Space flight is associated with detrimental changes to the human body, including bone and muscle loss, fluid changes and deconditioning of muscles in the heart and blood vessels.
- Trial name
- NCT03495128
- Testing
- Bed Rest, Reconditioning
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Myotonic Dystrophy 1
Myotonic Dystrophy Type 1 and Resistance Exercise
The purpose of this study is to investigate the response after one bout of moderate-heavy resistance exercise in patients suffering from Myotonic Dystrophy type 1.
- Trial name
- STYRK DM1 (NCT05036447)
- Testing
- Moderate-Heavy Resistance Exercise
- Where
- Norway
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Exercise Training
Impact of Muscle Temperature on Muscle Growth and Breakdown: Cooling During Resistance Training
The purpose of this study is to examine the effect of human skeletal muscle temperature during resistance exercise on myogenic and proteolytic signaling.
- Trial name
- NCT05302791
- Testing
- Muscle Cooling, Resistance Exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Muscle Synthesis
Protein Blends (Soy, Whey and Casein) for Muscle Synthesis
Soy protein is a high quality, plant-based protein that is comparable to milk, meat and eggs. Soy protein has a digestion rate (intermediate) compared to whey (fast) and casein (slow).
- Trial name
- NCT01358305
- Testing
- Protein Blend
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- DuPont Nutrition and Health
Muscle Damage, Healthy
Exploring Muscle Breakdown During Exercise Recovery
This study will allow researchers to explore how muscle responds to heavy exercise. The researchers will characterise rates of muscle protein breakdown and synthesis 24hours after heavy exercise with a post exercise protein…
- Trial name
- EMBER (NCT04841772)
- Testing
- Recover Vegan Protein Supplement
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Healthy
The Impact of Leg Immobilization on Postabsorptive and Postprandial Muscle Protein Breakdown in Healthy Young Males
The present study will seek the quantify the simultaneous muscle protein synthesis and breakdown response with and without amino acid provision in humans following 2 days of immobilisation.
- Trial name
- NCT03934632
- Testing
- Postabsorptive, Postprandial, Immobilisation
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Tissue Breakdown
Muscle Pressure in the Flank Position
Using healthy volunteers, participants will lay on an operating room table in various positions employed during kidney surgery. Using a pressure sensor mat, we hope to determine which areas of the body are subject to higher…
- Trial name
- NCT00395980
- Testing
- surgical table pressure mat
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Chronic Obstructive Pulmonary
Involvement of Plasmatic Factors in the Peripheral Muscle Dysfunction of COPD Patients - In Vitro Study
Chronic Obstructive Pulmonary Patients is a defined by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or…
- Trial name
- NCT03197909
- Testing
- Determination of pro-inflammatory plasma factors
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Sarcopenia
Dose Response of Whey and Soy Protein Ingestion With and Without Resistance Exercise in Elderly Men
When we age, we lose muscle. It is not exactly clear why this happens, but we do know that this muscle loss can increase health risks and lead to health problems. Lifting weights (i.e.
- Trial name
- NDC (NCT01062711)
- Testing
- Whey or soy protein
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Mass, Protein Intake
Distribution of Nutrient Derived Amino Acids
The project examines over several days how the distribution pattern of dietary protein stimulate and affect the protein turnover of important proteins in the aging perspective, such as skeletal muscle proteins.
- Conditions
- Muscle Mass, Protein Intake, Diet Modification, Protein Synthesis
- Trial name
- NCT03870425
- Testing
- Distribution pattern of dietary proteins (minced meat)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Ketosis, Resistance Exercise
Acute Effects of Ketone Monoester Co-Ingestion With Dietary Protein on Whole-Body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Older Males
The goal of this trial is to determine if ketone monoester supplementation in conjunction with protein supplementation in the post exercise period can augment whole-body protein metabolism following resistance exercise in older…
- Conditions
- Ketosis, Resistance Exercise, Dietary Protein, Aging
- Trial name
- KET-OLD-M (NCT07884513)
- Testing
- Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- McGill University