Clinical trials: Muscle Dysfunction
Lung Neoplasm, Survivorship
Assessment of Functional Capacity, Pain, Cognitive and Respiratory Functions in Lung Cancer Survivors
Serious side effects occurs with disease and treatments in survival after lung cancer. For this reason, functional capacity, cognitive status, pain perception and respiratory functions may be affected in lung cancer.
- Trial name
- NCT04431921
- Testing
- Functional capacity
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Diabetes, Obesity
PGC-1 & Muscle Mitochondrial Dysfunction in Diabetes
The goal of this study is to understand how and why insulin resistant individuals respond differently to exercise as compared with insulin sensitive individuals at the skeletal muscle and gene expression level.
- Trial name
- PGC-1 (NCT02282423)
- Testing
- Pre-study dietary and exercise instruction., Screening examination and oral glucose tolerance test, Euglycemic clamp
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Frailty Syndrome, Cognitive Impairment
Successful Aging and Frailty
Frailty is the term commonly utilized to describe the geriatric syndrome that exposes the elderly to increased risk of negative health-related events.
- Conditions
- Frailty Syndrome, Cognitive Impairment, Sarcopenia
- Trial name
- SAFe (NCT03963050)
- Testing
- Exercise Training, Exercise Training + Cognitive Training, Control
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Low Back Pain
Sequential Core Stability Corrective Exercise Approach in Lower Crossed Syndrome
The objective of the study will be to determine the effects of Sequential Core Stability Corrective Exercise Approach for Alignment and Muscle Function in Lower Crossed Syndrome.
- Trial name
- SCSCRLCS (NCT05505851)
- Testing
- Control, Sequential Core Stability Corrective Exercise Approach
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Motor Neuron Disease, Amyotrophic Lateral Sclerosis, Motor Neuron Disease Progressive Spinal Muscle Atrophy
Non-invasive Spinal, Cortical, and Sensorimotor Biomarkers in Motor Neurone Disease
Substantial variability exists in the onset, and rate of degeneration across individuals with Motor Neurone Disease (MND) or Amyotrophic Lateral Sclerosis (ALS).
- Conditions
- Motor Neuron Disease, Amyotrophic Lateral Sclerosis, Motor Neuron Disease Progressive Spinal Muscle Atrophy, Primary Lateral Sclerosis, Multiple Sclerosis
- Trial name
- NCT06320444
- Testing
- 232 Electrode Electrophysiology (EEG-ECG-EMG-EXG)
- Where
- Ireland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Pelvic Floor Dysfunction
The Evaluation of Pelvic Floor Muscle Function: A Reliability and Correlation Study
1. To explore the correlations among measures of PFM strength between using vaginal palpation quantified by modified Oxford Grading Scale and Levator ani testing and manometry in PHENIX instrument; 2.
- Trial name
- NCT03511911
- Testing
- evaluation of pelvic floor muscle function through the PHENIX instrument, vaginal palpation
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Pelvic Floor Muscle Weakness, Pelvic Floor Disorder
Does Hip Strength Impact Active Females Rate of Pelvic Floor Dysfunction? The Primary Goal of This Research is to Collect Data on Hip Strength for Active Females and Assess if There is a Relationship Between Hip Strength and Pelvic Floor Dysfunction (PFD).
The primary goal of this research is to collect data on hip strength for active females and assess if there is a relationship between hip strength and pelvic floor dysfunction (PFD).
- Conditions
- Pelvic Floor Muscle Weakness, Pelvic Floor Disorder, Pelvic Pain, Hip Strength
- Trial name
- NCT07119476
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- George Fox University
HIV Infections
Use of Muscle Spectroscopy to Evaluate Mitochondrial Dysfunction in HIV-Infected Patients
The purpose of this study is to see if magnetic resonance spectroscopy (MRS) can be used to detect damage to the mitochondria in HIV-infected patients taking nucleoside reverse transcriptase inhibitor (NRTI) drugs.
- Trial name
- NCT00036478
- Where
- 8 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy
Analysis of Heart Muscle Function Following Exercise in Patients With Heart Disease
This study is designed to examine the blood flow, the nutrition, and the beating function of the heart under different conditions. Patients with narrowed coronary arteries my have restricted blood flow to the heart.
- Trial name
- NCT00001528
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Myotonic Dystrophy Type 2, Myotonic Dystrophy Type 1
Brain Structure and Clinical Endpoints in Myotonic Dystrophy Type 2
Nearly two-third of patients with myotonic dystrophy type 2 (DM2) report that impaired cognition is among the most disabling symptoms and deeply affects their quality of life.
- Trial name
- BraCE-DM2 (NCT05854433)
- Testing
- Non-interventional study
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Muscle Dysfunction, Exertional Rhabdomyolysis
Nutritional Prevention of Exertional Muscle Dysfunction
The investigators want to find out whether a choline supplement can protect muscle health in young men with very common genetic vulnerabilities.
- Conditions
- Muscle Dysfunction, Exertional Rhabdomyolysis, Muscle Strength
- Trial name
- MUSREC (NCT01722448)
- Testing
- Choline
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Obesity
Nicotinamide Riboside and Mitochondrial Metabolism
Vitamin B3 has recently been found to be a potent modifier of energy metabolism, especially the function of mitochondria. Mitochondria power up all cells in our bodies, by generating fuel, ATP, for cellular functions.
- Trial name
- VitaPower (NCT03951285)
- Testing
- NR in BMI-discordant twins, NR in BMI-concordant twins
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Diabetes Type 2, Frail Elderly Syndrome
Involvement of Muscle Mitochondrial Dysfunction in Frailty in Older Adults. Role of Exercise
This study aims to investigate the role of skeletal muscle mitochondrial dysfunction in the development of frailty in older adults and to evaluate whether a short-term, supervised resistance training intervention can improve…
- Conditions
- Diabetes Type 2, Frail Elderly Syndrome, Mitochondrial Function, Bioenergetics, Functionality
- Trial name
- MITOSTRENGTH (NCT07828847)
- Testing
- Short-duration resistance training
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Heart Failure With Preserved Ejection Fraction, Hypertrophic Cardiomyopathy
Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition
Heart scarring, also known as fibrosis, plays a major role in a lot of heart muscle abnormalities. These abnormalities of the heart muscle can lead to major issues such as symptoms of heart failure, dangerous heart rhythm…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Hypertrophic Cardiomyopathy, Cardiac Sarcoidosis, Hypertensive Heart Disease
- Trial name
- CHIEFTain (NCT06409585)
- Testing
- 68Ga-FAPI or 18F-AlF-FAPI cardiac PET-MR, Echocardiogram, Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Aging, Vascular Endothelium
Vascular Dysfunction During Physical Inactivity
Prolonged periods of reduced activity are associated with decreased vascular function and muscle atrophy. Physical inactivity due to a sedentary lifestyle or acute hospitalization is also associated with impaired recovery…
- Conditions
- Aging, Vascular Endothelium, Skeletal Muscle
- Trial name
- NCT04872998
- Testing
- Step Count Reduction
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Utah
Heart Failure, Congestive
Skeletal Muscle Dysfunction in Heart Failure
Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart.
- Trial name
- NCT00156234
- Testing
- One-knee extension ergometer
- Where
- 2 sites in Norway
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital
Pelvic Floor Muscle Training, Transperineal Ultrasound
Transperineal Ultrasound as a Biofeedback Tool for Pelvic Floor Muscle Therapy in Postpartum Patients
Regular and effective pelvic floor muscle exercises after vaginal birth are crucial in reducing the risk of pelvic floor disorders in women.
- Conditions
- Pelvic Floor Muscle Training, Transperineal Ultrasound, Biofeedback Therapy, Postpartum
- Trial name
- NCT07065708
- Testing
- Visual biofeedback using transperineal ultrasound, Transperineal ultrasound without visual biofeedback
- Where
- Singapore
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Type 2 Diabetes Mellitus
Impact of Muscle and Tendon Dysfunction in People With Type 2 Diabetes Mellitus
Diabetes is a chronic-degenerative metabolic disorder that has reached pandemic proportions mainly because of the increasing incidence and prevalence of type 2 diabetes mellitus (T2D).
- Trial name
- T2D_MTU (NCT05585502)
- Testing
- Training (minute oscillation stretching)
- Where
- Italy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Post-Acute COVID-19 Vaccination Syndrome, Postviral Fatigue
Clinical Laboratory Evaluation, Assessment of Symptoms and Recovery in Patients With Post-COVID-19-Vaccination Syndrome
Some people report persistent health problems after receiving the COVID-19 vaccine. These symptoms persist well beyond typical short-term vaccine side effects and are not attributable to any other known medical conditions.
- Trial name
- CLEAR (NCT07400848)
- Testing
- Blood sampling and analysis, The continuous Reactive Hyperemia Index (InRHI) measured by EndoPAT
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Bern
Posterior Tibial Tendon Insufficiency
Low-Level Laser Therapy and Orthotic Insole in Tibialis Posterior Tendon Insufficiency
The purpose of this study is to compare low-level laser therapy and insole interventions on pain, function and muscle strength in subjects with posterior tendon insufficiency.
- Trial name
- NCT03363074
- Testing
- Orthotic Insole, Low-Level Laser
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University