Clinical trials: Musculoskeletal Pain Disorder
Rheumatoid Arthritis
Safety, Tolerability, and Pharmacokinetics of a Single Oral Dose of SKI-O-703 in Healthy Volunteers
This double-blind, placebo-controlled, single ascending dose study is designed to demonstrate safety, tolerability and pharmacokinetics of SKI-O-703 in healthy volunteers.
- Trial name
- NCT02717988
- Testing
- SKI-O-703 capsule
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Oscotec Inc.
Rheumatoid Arthritis
Open-Label Study Comparing Etanercept to Conventional Disease Modifying Antirheumatic Drug (DMARD) Therapy
The purpose of this 2 phased, open-label study is to compare the safety and efficacy of etanercept with conventional Disease Modifying Antirheumatic Drug (DMARD) therapy in Latin American subjects with moderate to severe…
- Trial name
- NCT00848354
- Testing
- Phase 1: Etanercept, Phase 1: Methotrexate, Phase 2: Optional ETN, SSZ, HCQ, MTX
- Where
- 33 sites in Argentina, Chile and 3 more
- Volunteers
- 429 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
A Study in Patients With Rheumatoid Arthritis
The primary purpose of the study is to help answer the following research questions, and not to provide treatment for Rheumatoid Arthritis (RA): The safety of LY2439821 and any side effects that might be associated with it.
- Trial name
- NCT00966875
- Testing
- LY2439821
- Where
- 75 sites in United States, Argentina and 9 more
- Volunteers
- 448 people
- Sponsor
- Eli Lilly and Company
Rheumatoid Arthritis
An Observational Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis Treated With Glucocorticoids
This prospective, observational, multicenter study will assess the efficacy and safety of RoActemra/Actemra (tocilizumab) on the use of glucocorticoids in patients with moderate to severe rheumatoid arthritis and an inadequate…
- Trial name
- NCT01564901
- Where
- 13 sites in Spain
- Volunteers
- 23 people
- Sponsor
- Hoffmann-La Roche
Juvenile Idiopathic Arthritis
A Study to Evaluate Pharmacokinetics and Safety of Tocilizumab (RoActemra/Actemra) in Participants Less Than 2 Years Old With Active Systemic Juvenile Idiopathic Arthritis (sJIA)
This is a multi-center, open-label single-arm study to investigate the pharmacokinetics and safety of tocilizumab (RoActemra/Actemra) in participants less than 2 years old with active sJIA.
- Trial name
- NCT01455701
- Testing
- Tocilizumab
- Where
- 20 sites in United States, Argentina and 6 more
- Volunteers
- 11 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Clinical Study of Single Dose IL-6R mAb Injection in RA Patients
This is a single-dose,multi-center, randomized, double-blind, positive-controlled and parallel group clinical study that aims to evaluate the safety,tolerability,PK/PD characteristics and Preliminary Efficacy of Recombinant…
- Trial name
- NCT05232396
- Testing
- IL-6R Monoclonal Antibody Injection 4mg/kg, IL-6R Monoclonal Antibody Injection 6mg/kg, IL-6R Monoclonal Antibody Injection 8mg/kg
- Where
- 5 sites in China
- Volunteers
- 40 people
- Sponsor
- Beijing VDJBio Co., LTD.
Rheumatoid Arthritis
Safety and Effectiveness of Infliximab in Slovakia When Used for Rheumatoid Arthritis (Study P04741)(COMPLETED)
This study will gather information on the safety and efficacy of patients with rheumatoid arthritis (RA) who are starting treatment with infliximab for the first time.
- Trial name
- NCT00724243
- Testing
- Infliximab
- Volunteers
- 33 people
- Sponsor
- Merck Sharp & Dohme LLC
Osteoarthritis, Hip
Celecoxib Versus Diclofenac In The Treatment Of Osteoarthritis Of The Hip
To determine if celecoxib 200 mg once daily is as effective as diclofenac 50 mg three times daily in the treatment of pain symptoms associated with osteoarthritis of the hip
- Trial name
- NCT00174317
- Testing
- Celecoxib, Diclofenac
- Where
- 44 sites in United Kingdom
- Volunteers
- 250 people
- Sponsor
- Pfizer
Degenerative Joint Disease of Hip, Osteoarthritis, Hip
Maxera Large Cups - Canada
This study is monocentric, retrospective and prospective, non-controlled, consecutive series Post-Market Clinical Follow-up Study to Provide Safety, Performance and Clinical Benefits Data of the Largest Zimmer® Maxera™ Cup…
- Conditions
- Degenerative Joint Disease of Hip, Osteoarthritis, Hip, Avascular Necrosis of Hip, Post-Traumatic Osteoarthritis of Hip
- Trial name
- Maxera Canada (NCT04348968)
- Testing
- Total hip arthroplasty
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Zimmer Biomet
Keloid Scar
A Retrospective Evaluation of Superficial Radiation Therapy (SRT) and Keloid Scars.
Keloid formation in response to skin trauma inflicts about 18 million individuals. A key impediment in successful treatment of keloids is that the predominant treatments, particularly surgical excision and shaving, tend to…
- Trial name
- NCT03693924
- Testing
- SRT-100
- Volunteers
- 100 people
- Sponsor
- Sensus Healthcare
Osteoarthritis
A Study of Patients Treated With the Journey Deuce Bicompartmental Knee System
This is a prospective, multicenter, consecutive clinical study of the Journey Deuce Knee System and is intended to evaluate the safety and effectiveness of the new device.
- Trial name
- NCT01704326
- Where
- 4 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis of the Knee
Efficacy and Safety of 3 Different Dosage Regimens of Hyaluronic Acid in Patients With Knee Osteoarthritis (OA)
The main objective is the comparison of three different dosage regimens of hyaluronic acid in the treatment of osteoarthritis of the knee.
- Trial name
- NCT01290497
- Testing
- Hyaluronic acid 5 x 2.5 ml, Hyaluronic acid 1 x 5 ml, Hyaluronic acid 2 x 5 ml
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Tedec-Meiji Farma, S.A.
Rheumatoid Arthritis (RA)
The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of SHR-3045 in Healthy Subjects
The study is being conducted to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of a single-dose subcutaneous injection of SHR-3045 in healthy subjects.
- Trial name
- NCT07200596
- Testing
- SHR-3045 Injection
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Spinal Fractures
A Safety and Efficacy Study for Treatment of Painful Vertebral Compression Fractures Caused by Osteoporosis
Doctors are studying an investigational treatment to be used during the vertebroplasty procedure when treating vertebral compression fractures (spine fractures) that may help to reduce pain and restore mobility.
- Trial name
- NCT00290862
- Testing
- Percutaneous Vertebral Augmentation of compression fractures
- Where
- 18 sites in United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Orthovita d/b/a Stryker
Osteoarthritis
A 2 Week Blinded Study For Pain Due To Arthritis Of The Knee
The primary aim is to assess if PF-00592379 is able to reduce pain in patients with osteoarthritis of the knee.
- Trial name
- NCT00483977
- Testing
- Oxycodone, PF-000592379
- Where
- 21 sites in United States
- Volunteers
- 113 people
- Sponsor
- Pfizer
Rheumatoid Arthritis (RA)
A Phase IIa Study of JAB-8263 in Patients With Active Rheumatoid Arthritis
This study is an open-label, multi-center Phase IIa study. The study is divided into two phases. The first phase is a safety exploration phase.
- Trial name
- JAB-8263 (NCT07684157)
- Testing
- JAB-8263
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Jacobio Pharmaceuticals Co., Ltd.
Rheumatoid Arthritis
Exposure Study Comparing 3 Routes of Methotrexate (MTX) Administration
Pharmacokinetics (PK) study
- Trial name
- NCT01737944
- Testing
- Methotrexate (MTX)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Antares Pharma Inc.
Rheumatoid Arthritis
A Study to Evaluate the Efficacy and Safety of ASP1707 in Postmenopausal Female Patients With Rheumatoid Arthritis Taking Methotrexate
The objective of this study is to evaluate the efficacy, pharmacokinetics, pharmacodynamics and safety of ASP1707 in combination with MTX in postmenopausal female patients with RA.
- Trial name
- NCT02884635
- Testing
- ASP1707, Methotrexate
- Where
- 27 sites in Japan
- Volunteers
- 72 people
- Sponsor
- Astellas Pharma Inc
Medial Malleolus Fracture, Lisfranc Injury
Performance and Safety Evaluation of Inion CompressOn Screw in Foot and Ankle Surgeries. PMCF Investigation
The study in question is a post market clinical follow up (PMCF) study to evaluate the safety and performance of bioabsorbable headless compression screw Inion CompressOn in selected fracture, osteotomy and arthrodeses operations…
- Conditions
- Medial Malleolus Fracture, Lisfranc Injury, Lisfranc Fracture, Talus Fracture
- Trial name
- NCT05555459
- Testing
- Operation
- Where
- Finland
- Volunteers
- 125 people
- Sponsor
- Inion Oy
Rheumatoid Arthritis (RA)
Safety and Efficacy of TollB-001 Tablets in Moderate to Severe Rheumatoid Arthritis
The goal of this study is to evaluate the safety, pharmacokinetic (PK) characteristics, and preliminary efficacy of a new oral chemical drug in : adults aged 18-70 years (male or female) with moderate to severe active rheumatoid…
- Trial name
- NCT07408024
- Testing
- TollB-001
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Toll Biotech Co. Ltd. (Beijing)