Clinical trials: Myocardial Ischemia
Chest Pain, CAD
Comparing a Diagnostic and Treatment Strategy of Upfront CTCA With SOC in Patients With Chest Pain and Suspected CAD
Rationale: Patients with chest pain usually undergo multiple diagnostic examinations to demonstrate or rule out atherosclerotic coronary artery disease (CAD).
- Trial name
- CLEAR-CAD (NCT05344612)
- Testing
- CT Coronary Angiography
- Where
- Netherlands
- Volunteers
- 6,444 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Ischemic Heart Disease, Myocardial Infarction
Low-Dose Dobutamine Tc-99m-Mibi Gated SPECT to Predict Left Ventricular Remodelling in Patients Reperfused in the Acute Phase of MI
Left myocardial infarction (MI), has a negative impact of long term morbidity and mortality. Even in patients treated successfully by angioplasty in the acute phase of infarct, the remodelling is observed in approximately 30% of…
- Trial name
- NCT00487812
- Testing
- Low-dose dobutamine Tc-99-m-mibi gated SPECT imaging
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cardiac Arrest (CA), Cardiogenic Shock
Evaluation of Acid-base Disorders and Ventilation Settings in Cardiogenic Shock and Post-cardiac Arrest Patients: Comparison With VentilO Algorithm
This study aims to better understand how mechanical ventilation settings affect patients admitted to the coronary care unit after cardiac arrest or with cardiogenic shock.
- Conditions
- Cardiac Arrest (CA), Cardiogenic Shock, Mechanical Ventilation, Acid Base Disorder
- Trial name
- VentilO CU (NCT07484828)
- Testing
- Initiation of mechanical ventilation
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Laval University
Pain, Postoperative, Coronary Artery Disease
Pecto-Intercostal Fascial Block vs. Transversus Thoracic Muscle Plane Block in Cardiac Surgery
In patients undergoing open cardiac surgery, pain control is an essential part of the enhanced recovery process. The current study aimed to evaluate the analgesic efficacies of ultrasound-guided pecto-intercostal fascial block…
- Trial name
- NCT04791592
- Testing
- Single-injection, ultrasound-guided bilateral PIF block., Single-injection, ultrasound-guided bilateral TTMP block.
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ondokuz Mayıs University
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Influence of Prior Walking on Postprandial Metabolism in Centrally Obese Men
The present study will investigate the effect of prior walking on postprandial metabolism and endothelial function in centrally obese South Asian and White European men.
- Conditions
- Diabetes Mellitus, Type 2, Cardiovascular Diseases, Endothelial Dysfunction, Insulin Resistance
- Trial name
- NCT03952000
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Chronic Coronary Artery Disease
Contribution of the Pharmacological Profile of the A2A Receptor to Adenosine in the Diagnosis of Myocardial Ischemia
The chronic coronary artery disease could be detected by a drop in the expression of A2A receptors to adenosine, while high values of the KD / EC50 ratio are a sign of coronary ischemia.
- Trial name
- RIMACI (NCT04640844)
- Testing
- blood sample
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Ischemic Heart Disease
Myocardial Injury in Remifentanil-based Versus Sevoflurane-sufentanil Balanced Regimens in OPCAB Surgery
In patients undergoing off-pump coronary artery bypass (OPCAB) surgery with different anesthesia regimens: remifentanil (0.75 mcg/kg/min) and propofol (TCI effect-site concentration 0.8-1.5 mcg/ml) (Group -RP); remifentanil (0.75…
- Trial name
- NCT02499445
- Testing
- Remifentanil, sevoflurane 1, sevoflurane 2
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Konkuk University Medical Center
Coronary Artery Disease
The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions
The purpose of this study is to evaluate the safety and effectiveness of the PROMUS Element™ Everolimus-Eluting Coronary Stent System for the treatment of patients with up to 2 de novo atherosclerotic coronary artery lesions.
- Trial name
- PLATINUM (NCT00823212)
- Testing
- PROMUS Coronary Stent System, PROMUS Element Coronary Stent System, Aspirin
- Where
- 133 sites in United States, Australia and 15 more
- Volunteers
- 1,530 people
- Sponsor
- Boston Scientific Corporation
Acute Coronary Syndrome
EmploYEd Antithrombotic Therapies in Patients With Acute Coronary Syndromes HOspitalized in iTalian CCUs
This registry has the aim to assess the use of different antithrombotic therapies, including untested drug combinations, routinely used during the hospitalization phase, with their timing, route and dose of administration, in…
- Trial name
- EYESHOT-2 (NCT06316128)
- Where
- 189 sites in Italy
- Volunteers
- 2,806 people
- Sponsor
- Heart Care Foundation
Coronary Artery Disease
PREventive Invasive Strategy for Obstructive Coronary Artery Disease With Vulnerable Plaque Evaluated by CoroNary Computed Tomography Angiography-2
The PREVENT-2 trial is to determine whether an initial invasive strategy-consisting of early coronary angiography (CAG) with intent for preventive percutaneous coronary intervention (PCI) in addition to optimal medical therapy…
- Trial name
- PREVENT-2 (NCT07569692)
- Testing
- Initial Invasive Strategy, Initial Conservative Strategy
- Where
- South Korea
- Volunteers
- 2,500 people
- Sponsor
- Duk-Woo Park, MD
Angina, Stable
Effectiveness of Inspiratory Muscle Training in Patient With Stable Angina
Stable angina is a cardiac pathology that adversely affects the quality of life of the patient, which develops as a result of narrowing of the coronary vessels developing in atherosclerotic ground and / or impaired oxygen…
- Trial name
- NCT03923153
- Testing
- Inspiratory muscle training with PowerBreathe (IMT Technologies Ltd., Birmingham,England)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Mustafa Kemal University
Atherosclerosis, Coronary Artery Disease
XIENCE V® EXCEED: Evaluation of XIENCE V® Catheterization Lab Endpoints and Excellence in Delivery
This trial is to assess physician-determined XIENCE V® EECSS acute performance, deliverability and resource utilization in the catheterization lab during commercial use by various physicians with a range of coronary stenting…
- Trial name
- EXCEED (NCT00731237)
- Where
- 44 sites in United States
- Volunteers
- 2,517 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease
CABG Based on CT-FFR Versus Conventional Coronary Angiography
The aims of study are (1) to compare early and 1-year graft patency rates in patients who underwent coronary artery bypass grafting (CABG) based on conventional coronary angiography(CAG) versus cardiac computed…
- Trial name
- NCT06028165
- Testing
- Coronary artery bypass grafting based on conventional coronary angiography, Coronary artery bypass grafting based on cardiac computed tomography-derived fractional flow reserve.
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Myongji Hospital
Acute Coronary Syndrome, Chronic Coronary Artery Disease
The Correlation Between Genetic Polymorphism, Platelet Activity, Clopidogrel Responsiveness, and Serum Adipokine Concentration in Asian Acute Coronary Syndrome Patients
In this study, we evaluate the acute coronary syndrome patients to see if there is correlation between platelet activity, genetic polymorphism (CYP2C19 and ABCB1), serum adipokines level, and Clopidogrel responsiveness.
- Trial name
- NCT01255267
- Where
- Taiwan
- Volunteers
- healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Coronary Artery Disease
Myocardial Stress Perfusion Imaging With Dual Source CT
The investigators propose a novel technique using dual source multidetector computed tomography (DSCT) where information on both coronary anatomy and myocardial perfusion is obtained in a single scan.
- Trial name
- NCT00853671
- Testing
- Adenosine Stress Dual-source CTP
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Acute Coronary Syndrome, STEMI - ST Elevation Myocardial Infarction
SOLVE-ACS: Bioresorbable Magnesium-Stents Magmaris in ACS Lesions
The aim of the registry is to investigate the clinical performance of the Magmaris Magnesium Stent in STE-ACS and NSTE-ACS patients.
- Conditions
- Acute Coronary Syndrome, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- SOLVE-ACS (NCT03773081)
- Testing
- Implantation of the Magmaris scaffold
- Where
- 4 sites in Germany
- Volunteers
- 11 people
- Sponsor
- Charite University, Berlin, Germany
Coronary Artery Disease, Left Ventricular Dysfunction
Balloon Pump Assisted Coronary Intervention Study
This study will test the hypothesis that elective use of the Intra-Aortic Balloon Pump (IABP) in patients undergoing high-risk Percutaneous Coronary Intervention (PCI) will reduce the rate of in-hospital major adverse cardiac and…
- Trial name
- BCIS-1 (NCT00910481)
- Testing
- Intra-Aortic Balloon Pump
- Where
- United Kingdom
- Volunteers
- 301 people
- Sponsor
- British Cardiovascular Intervention Society
Coronary Stenosis, Acute Coronary Syndrome
Systemic, Pancoronary and Local Coronary Vulnerability
The aim of the VIP study is to investigate the impact of vulnerability markers (inflammatory serum biomarkers for systemic vulnerability, coronary shear stress and vulnerability mapping for pancoronary vulnerability, and…
- Conditions
- Coronary Stenosis, Acute Coronary Syndrome, Acute Myocardial Infarction, Atheromatous Plaques
- Trial name
- VIP (NCT03606330)
- Testing
- Cardiac imaging tests, Venous blood sample collection
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Angina, Stable, Chest Pain
Acupuncture for Individuals With Stable Angina
This RCT aims to determine if it is possible to perform acupuncture on men and women diagnosed with stable angina who have symptoms, chest pain, and/or chest discomfort.
- Conditions
- Angina, Stable, Chest Pain, Microvascular Angina, Heart Failure
- Trial name
- AIMS-A (NCT02914834)
- Testing
- Acupuncture, Non-pain related video health education
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Illinois Chicago
Acute Coronary Syndrome
Different Doses of Rosuvastatin Therapy on Regression of Critical Coronary Atherosclerosis in ACS Patients
The purpose of this study is to determine whether Rosuvastatin 10mg/d or 20mg/d for 36 weeks can regress critical coronary atherosclerosis as determined by IVUS imaging in Chinese Acute Coronary Syndrome (ACS) patients.
- Trial name
- NCT02420899
- Testing
- rosuvastatin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Friendship Hospital
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