Clinical trials: Myopathies
Stroke, Brain Injuries
Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticity
The study seeks to compare the effectiveness of three preparations of BOTOX-A® in treating muscle tightness and spasms in the feet and ankles of people with stroke.
- Conditions
- Stroke, Brain Injuries, Spasticity
- Trial name
- NCT00178646
- Testing
- Botox
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- The University of Texas Health Science Center, Houston
Muscle Soreness
Effect of Acheta Domesticus Supplementation on Post-Exercise Muscle Recovery in Recreationally Active Male
The goal of this clinical trial is to test the effect of house cricket (Acheta domesticus) supplementation for strength recovery in recreationally active males.
- Trial name
- NCT06096389
- Testing
- 100 Drop Jumps, Whey supplementation, Carbohydrate supplementation
- Where
- Malaysia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Fibromyalgia
Fibromyalgia Activity Study With Transcutaneous Electrical Nerve Stimulation (FAST)
Pain associated with fibromyalgia interferes with daily function, work, and social activities resulting in a decreased quality of life. People with fibromyalgia also have a significant amount of fatigue and a fear of movement.
- Trial name
- FAST (NCT01888640)
- Testing
- TENS
- Where
- 2 sites in United States
- Volunteers
- 301 people
- Sponsor
- Kathleen Sluka
Epicondylitis, Lateral, Tendinopathy, Elbow
OVT for Epicondylosis (Tennis Elbow)
To assess the residual risk of OrthoVisc-T (OVT) for the treatment of chronic lateral epicondylosis (Tennis Elbow). This trial will provide clinical data on a subject population not previously researched which have failed prior…
- Trial name
- NCT04026191
- Testing
- OrthoVisc®-T (OVT)
- Where
- 3 sites in Czechia
- Volunteers
- 50 people
- Sponsor
- Anika Therapeutics, Inc.
Cystinosis, Native Kidney
Cystinosis and Mitochondrial Metabolism
Cystinosis is a monogenic autosomal recessive lysosomal storage disease with complete penetrance, caused by a biallelic mutation in the CTNS gene (17p13.2) encoding cystinosin, a ubiquitous membrane protein whose role is to clear…
- Trial name
- CYSTI-MITO (NCT07319091)
- Testing
- Mitochondrial metabolism
- Where
- 9 sites in France
- Volunteers
- 25 people
- Sponsor
- Hospices Civils de Lyon
Myofascial Trigger Points, Musculoskeletal Pain
Ischemic Compression and Home Exercise in Non-Specific Neck Pain
The purpose of this study is to investigate the effects of ischemic compression combined with home exercise on pain, cervical range of motion, neck disability level, and quality of life in individuals with non-specific neck pain.
- Conditions
- Myofascial Trigger Points, Musculoskeletal Pain, Non-specific Neck Pain, Neck Pain
- Trial name
- NSNP (NCT07685418)
- Testing
- Ischemic Compression, Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Istanbul Rumeli University
Fibromyalgia
A Comparison of the Effect of Two Types of Whole Body Vibration on Fibromyalgia. A Randomized Controlled Trial.
The objective of this study is to compare the effectiveness of two types of body vibration platform, one vertical and one rotational, through a 12-week training in patients with fibromyalgia.
- Trial name
- NCT04128813
- Testing
- Vertical whole body vibration
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of the Balearic Islands
Gulf War Syndrome, Gulf War Illness
Long Term Efficacy of Neuronavigation Guided rTMS in Alleviating Gulf War Illness Related Headaches and Pain Symptoms
This study aims to look at the long term efficacy of using repetitive transcranial magnetic stimulation (rTMS) in relieving Gulf War Illness related headaches and pain.
- Conditions
- Gulf War Syndrome, Gulf War Illness, Headache, Muscle Pain
- Trial name
- NCT04182659
- Testing
- Transcranial Magnetic Stimulation
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Veterans Medical Research Foundation
Spasticity, Multiple Sclerosis
A Study of Sativex® for Relief of Spasticity in Subjects With Multiple Sclerosis.
The purpose of this study is to evaluate the efficacy, safety and tolerability of Sativex® in subjects diagnosed with MS and spasticity.
- Trial name
- NCT00711646
- Testing
- Sativex®
- Where
- United Kingdom
- Volunteers
- 189 people
- Sponsor
- Jazz Pharmaceuticals
Intra-abdominal Hypertension, Acute Respiratory Distress Syndrome (ARDS)
End-expiratory Transpulmonary Pressure-guided vs Electrical Impedance Tomography-guided PEEP Titration Methods in Patients With Intra-abdominal Hypertension Combined With Acute Respiratory Distress Syndrome: a Randomized Crossover Controlled Study
This study aims to adopt a randomized crossover design to compare the effects of end-expiratory transpulmonary pressure-guided PEEP titration and EIT-guided PEEP titration on local lung ventilation, shunt, dead space, and…
- Trial name
- NCT06697717
- Testing
- Transpulmonary Pressure-Guided PEEP Titration in IAH and ARDS Patients, EIT-Guided PEEP Titration in IAH and ARDS Patients
- Where
- China
- Volunteers
- 15 people
- Sponsor
- XiaoJing Zou,MD
Synovial Diseases, Pigmented Villonodular Synovitis
Clinical Study of Magnetic Resonance Imaging and Deep Learning of Joint Synovial Disease
Through the high-throughput feature extraction of magnetic resonance images, the deep learning prediction model of joint synovial lesions is constructed used for the diagnosis, differential diagnosis and curative effect…
- Conditions
- Synovial Diseases, Pigmented Villonodular Synovitis, Gout, Rheumatoid Arthritis
- Trial name
- NCT04952896
- Testing
- Synovitis diagnosis
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Peking University Third Hospital
Spasticity, Movement Disorders
Leg Stretching Using an Exoskeleton on Demand for People With Spasticity
The purpose of this research study is to develop a protocol using a fully wearable, portable lower-limb exoskeleton for improving leg and walking function in people with movement disorders.
- Conditions
- Spasticity, Movement Disorders, Spinal Cord Injury
- Trial name
- NCT05926596
- Testing
- Wearable Robotic Exoskeleton
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Becker Muscular Dystrophy
Open-Label Extension of EDG-5506 in Participants With Becker Muscular Dystrophy
EDG-5506-203 MESA is an open-label extension study to assess the long-term effect of sevasemten (EDG-5506) on safety, biomarkers, and functional measures in adults and adolescents with Becker muscular dystrophy
- Trial name
- MESA (NCT06066580)
- Testing
- Sevasemten
- Where
- 48 sites in United States, Australia and 10 more
- Volunteers
- 260 people
- Sponsor
- Edgewise Therapeutics, Inc.
Upper and/or Lower Limb Focal Spasticity
A Study to Review Treatment Outcomes From Treatment With Dysport® Injections in Adults for Upper and/or Lower Limb Focal Spasticity
The aim of this retrospective study is to describe the real-world outcomes with the treatment of adult patients with Dysport® injections for focal upper limb spasticity (ULS) and/or focal lower limb spasticity (LLS) in NHS…
- Trial name
- DYSCOVER (NCT04604379)
- Where
- 3 sites in United Kingdom
- Volunteers
- 123 people
- Sponsor
- Ipsen
Stroke
Early Treatment of Post-stroke Spasticity With Botulinum Toxin
This was a multicentric observational study with the aim to evaluate the effect of early treatment with botulinum toxin type A (BoNT-A) on post-stroke spasticity in adult patients.
- Trial name
- BTX_ST-ITA14 (NCT04404868)
- Testing
- Normal clinical practice
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- Universita di Verona
Long COVID
Effect of Metformin in Reducing Fatigue in Long COVID in Adolescents
Long Covid is a multisystem condition comprising often severe symptoms that follow a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
- Trial name
- REVIVE (NCT06147050)
- Testing
- Metformin
- Where
- Pakistan
- Volunteers
- 16 people
- Sponsor
- Purpose Life Sciences
Muscular Dystrophies
Exercise Therapy for Patients with Muscle Dystrophies
Muscular Dystrophies (MD) are a heterogeneous group of diseases characterised by muscle wasting that lead to progressive loss of function.
- Trial name
- NCT05081791
- Testing
- Exercise Training
- Where
- Spain
- Volunteers
- 38 people
- Sponsor
- Universitat Pompeu Fabra
Sleep Apnea, Spinal Cord Injuries
Untreated Sleep Apnea as an Aggravating Factor for Other Secondary Medical Conditions After Spinal Cord Injury
This cross-sectional prospective study will assess the potential association of more severe sleep apnea after spinal cord injury with more intense neuropathic pain, more severe spasticity, and more significant cardiovascular…
- Conditions
- Sleep Apnea, Spinal Cord Injuries, Spasticity, Muscle, Neuropathic Pain
- Trial name
- NCT05687097
- Testing
- Home-based sleep screening test or hospital-unattended sleep screening test, Cardiovascular beat-to-beat monitoring, ECG monitoring
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Polymyalgia Rheumatica
Timed Release Tablet Prednisone in Polymyalgia Rheumatica
Polymyalgia Rheumatica (PMR) is a disease that usually affects older people. Patients complain of stiffness and pain around the shoulders and hips. The stiffness is more severe in the morning.
- Trial name
- NCT00836810
- Testing
- Timed Release Tablet Prednisone, Prednisolone
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
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