Clinical trials: NERVES
Shoulder Surgery, Nerve Block
The Effects of Dexamethasone on Low Dose Interscalene Brachial Plexus Block
A standard interscalene nerve block is performed with long acting local anesthetic (bupivacaine or ropivacaine in concentrations varying from 0.25% to 0.75%).
- Trial name
- ISB-Dex (NCT02322242)
- Testing
- Systemic Dexamethasone, Perineural dexamethasone
- Where
- Canada
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Dr. Stephen Choi
Neurofibromatosis 2, Meningioma
AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas
The goal of this clinical research study is to learn if the study drug AZD2014 can shrink growing or symptomatic meningiomas.
- Trial name
- NCT02831257
- Testing
- AZD2014
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Shoulder Arthroplasty
Interscalene Block With Liposomal Bupivacaine vs. Interscalene Block With Bupivacaine and Adjuvants
The purpose of this study is to determine whether the use of plain bupivacaine with common adjuvants for interscalene block (ISB) provides non-inferior analgesic results compared to the use of liposomal bupivacaine for ISB, in…
- Trial name
- NCT03845894
- Testing
- Liposomal bupivacaine, Bupivacaine with adjuvants
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Strabismus
Mobile Medical Application for Cost-effective Strabismus Screening
Develop and evaluate a new smartphone based app to screen for and measure eye misalignment (strabismus). The investigators will validate the app against simulated strabismus of known magnitude and common clinical tests.
- Trial name
- NCT03450980
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Normal Tension Glaucoma
Systemic Glutathione Level in Normal Tension Glaucoma
The purpose of this study is to evaluate whether systemic glutathione level is decreased in patients with normal tension glaucoma.
- Trial name
- NCT00570362
- Where
- South Korea
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Anesthesia, Pain
Neural Correlates of Lidocaine Analgesia
The purpose of this study is to characterize the effects of intravenous lidocaine on pain processing and cognitive function. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena.
- Trial name
- NeuCLA (NCT05501600)
- Testing
- Peripheral Nerve Stimulation, Lidocaine IV
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Keith M Vogt
Saphenous Nerve Block
Saphenous Nerve Block for Foot and Ankle Surgery
Patients undergoing foot and ankle surgery have the option of having a nerve block administered by their Anesthesiologist. The nerve block numbs the foot and results in less post-operative nausea and vomiting, and better pain…
- Trial name
- NCT02382744
- Testing
- Ultrasound Guidance, Ultrasound guidance + nerve stimulation
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Progressive Supranuclear Palsy, Corticobasal Degeneration
Tau Imaging in Subjects With Progressive Supranuclear Palsy, Corticobasal Degeneration and Healthy Volunteers
This study will evaluate flortaucipir for brain imaging of tau in subjects with progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and healthy volunteers.
- Trial name
- NCT02167594
- Testing
- Flortaucipir F18, Brain PET scan
- Where
- 5 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Carpal Tunnel Syndrome, Susceptibility to
Non-surgical Intervention for Carpal Tunnel Syndrome
This randomized controlled trial graduate student research study will explore the effect of non-surgical intervention of the dorsal application of Kinesio Tape for carpal tunnel syndrome, and forearm wrist hand pain.
- Trial name
- NCT03360344
- Testing
- Kinesio 12 inch Tape, Kinesio 4 inch Tape, Cock up Splint and Lumbrical exercises
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Pain, Postoperative
A Randomized Control Trial Comparing Analgesic Benefits of Ultrasound-guided Single vs Continuous Quadratus Lumborum Blocks (QLB)vs Intrathecal Morphine(ITM) for Post Cesarean Section Pain
the purpose of this study is to compare opioid consumption in morphine equivalents between the groups that received postoperative analgesia with intrathecal morphine versus US guided QL blocks versus US guided QL catheters
- Trial name
- NCT04368364
- Testing
- Intrathecal morphine sulfate (ITM), Bupivacaine hydrochloride, ropivacaine hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Endometrial Diseases, Pain, Postoperative
Transcutaneous Electrical Nerve Stimulation During Outpatient Endometrial Biopsy
The purpose of this study is to see whether transcutaneous electrical nerve stimulation (or TENS) reduces pain during an endometrial biopsy.
- Trial name
- NCT05472740
- Testing
- TENS 7000
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Duke University
Relatively Healthy Volunteers
Optimizing Local Anesthetic Concentration for Continuous Popliteal-Sciatic Nerve Blocks
A continuous peripheral nerve block-also termed "perineural local anesthetic infusion"-involves the insertion of a tiny tube (a "catheter") through the skin and adjacent to a peripheral nerve, followed by local anesthetic…
- Trial name
- NCT01898689
- Testing
- Ropivacaine 0.1%, Ropivacaine 0.4%
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Adiposity
Characterization of Transient Alterations of Cutaneous Sensory Nerve Function by Cryolipolysis
Cryolipolysis with Zeltiq CoolSculpting device is a novel method of non-invasive fat removal. The technique works by application of cold plates to the skin surface for a single cooling cycle lasting 60 minutes, after which a…
- Trial name
- NCT01673113
- Testing
- Zeltiq CoolSculpting device
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Orthopedic Disorders, Injury of Anterior Cruciate Ligament
Injection Pressure & Adductor Canal Block
This is a prospective, randomized, single-blinded human clinical trial that will examine how injection pressure influences the spread of a given volume of injectate in the adductor canal, during adductor canal nerve block.
- Trial name
- NCT02563990
- Testing
- High Pressure Injection, Low Pressure Injection
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Miami
Skin Cancer
An Appearance-Based Intervention to Reduce Teen Skin Cancer Risk
The purpose of this study is to determine whether a skin cancer prevention website is effective at reduce female teenagers' desire to use indoor tanning and ultimately their use of indoor tanning over an 18 month period.
- Trial name
- iSTART (NCT01508013)
- Testing
- Appearance-Focused Website Intervention, Control Website
- Where
- United States
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- East Tennessee State University
Glioblastoma Multiforme, Anaplastic Astrocytoma
Oral Tarceva Study for Recurrent/Residual Glioblastoma Multiforme and Anaplastic Astrocytoma
This study will offer a safe treatment for patients with relapsing recurring glioblastoma (GBM) or anaplastic astrocytoma (AA). The trial will test the hypothesis that Erlotinib (Tarceva, OSI-774) can be safely used up to a dose…
- Trial name
- NCT00301418
- Testing
- Erlotinib
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Local Anaesthetic Drug Adverse Reaction
Computer - Controlled Intraligamentary Local Anaesthesia In Extraction of Primary Molars
Background: Exodontia poses a psychological threat for children, increasing the need for profound local anesthesia to assure painless extraction and maintain child cooperation on the dental chair.
- Trial name
- NCT04739735
- Testing
- Dental Local Anaesthesia
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Total Knee Arthroplasty
Bupivacaine Liposome Suspension Versus a Concentrated Multi Drug Periarticular Injection
Despite a robust multimodal pain management regimen, patients undergoing total knee arthroplasty (TKA) continue to report low satisfaction with postoperative pain management.
- Trial name
- NCT02299349
- Testing
- bupivacaine liposome suspension, concentrated multi drug Ketorlac, Morphine PF, Epinephrine, Ropivicaine, 0.9% NaCL
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Non-arteritic Ischemic Optic Neuropathy
Citicoline in Non-Arteritic Ischemic Optic Neuropathy
The investigators tested the hypothesis whether the treatment with Citicoline in oral solution (OS-Citicoline) would increase or stabilize visual acuity, retinal ganglion cells (RGCs) function and neural conduction along the…
- Trial name
- NCT03758118
- Testing
- Citicoline
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione G.B. Bietti, IRCCS
Needle Guidance; Nerve Blocks
Needle-Guided vs Free-Hand Technique in Performing Brachial Plexus Blockade
This is an openly randomized controlled parallel group study evaluating the effectiveness of using a guided approach and free-hand approach in performing upper extremity regional blocks.
- Trial name
- NCT02380183
- Testing
- Civco Needle Guidance Device
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center