Clinical trials: Natural Orifice Endoscopic Surgery
Colorectal Neoplasms, Urologic Neoplasms
A Novel Robotic System for Single Port and Natural Orifice Transluminal Endoscopic Surgery
This is a prospective, single center, multispecialty study that aimed to evaluate the clinical feasibility and safety of single port surgery and NOTES (mainly transanal and transoral surgery) using a novel single port robotic…
- Conditions
- Colorectal Neoplasms, Urologic Neoplasms, Urologic Diseases, Nasopharyngeal Neoplasms
- Trial name
- NCT03010813
- Testing
- Robotic single port surgery and NOTES
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Chinese University of Hong Kong
Cholecystolithiasis, Surgery
The Effect of Transvaginal vs. Conventional Laparoscopic Cholecystectomy on the Postoperative Course
Uncomplicated laparoscopic cholecystectomy will in most patients result in moderate to severe pain until the first postoperative day. This will subside during the second and third postoperative day [1].
- Conditions
- Cholecystolithiasis, Surgery, Pain
- Trial name
- TRAVAKOL (NCT01552421)
- Testing
- TV NOTES cholecystectomy
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Laparoscopy-assisted Surgery, Total Laparoscopic Surgery With no Incision (Natural Orifice Transluminal Endoscopic Surgery, NOSES)
The Comparison Between Traditional Laparoscopy-assisted Surgery and NOSES in Radical Resection of Colorectal Cancer
This study is to compare the short-term and long-term outcomes of traditional laparoscopy-assisted surgery and total laparoscopic surgery with no incision (natural orifice transluminal endoscopic surgery, NOSES) for colorectal…
- Trial name
- NCT03470142
- Testing
- traditional laparoscopy-assisted surgery, total laparoscopic surgery with no incision (natural orifice transluminal endoscopic surgery, NOSES)
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Dong Yang
Hysterectomy, Vaginal
Hysterectomy by Transvaginal Natural Orifice Transluminal Endoscopic Surgery Versus or Laparoscopic Hysterectomy
In France, there are approximately 62,000 hysterectomies per year, 70% of which are benign. It is the most frequent surgical procedure in gynecology.
- Trial name
- vNOTESHC (NCT05884658)
- Testing
- vNOTES : natural vaginal orifice transluminal endoscopic system for hysterectomies, laparoscopic hysterectomy
- Where
- 6 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cholecystectomy, Laparoscopic, Endoscopy
NOTES-Assisted Laparoscopic Cholecystectomy Surgery
Refinements in laparoscopic surgery, coupled with advancements in therapeutic flexible endoscopy, have set the stage for surgery to move to even less invasive techniques to treat conditions in the GI tract and peritoneal cavity.
- Trial name
- TAS-NOTES (NCT00848146)
- Testing
- Endoscopically assisted Laparoscopic Cholecystectomy Surgery
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Northwestern University
Pelvic Organ Prolapse
Evaluation of the Results of Lateral Suspension Surgeries Performed With the V-NOTES (Vaginal-Natural Orifice Transluminal Endoscopic Surgery) Technique
It was aimed to evaluate the quality of life and sexual function of patients by Pre- and postoperative POP-Q (Pelvic Organ Prolapse Quantification) staging and PISQ-12 (Pelvic Organ Prolapse/Urinary Incontinence Sexual…
- Trial name
- NCT05066737
- Testing
- lateral suspension via V-NOTES surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Appendicitis, Cholelithiasis
Minimally Invasive Surgery: Using Natural Orfices
This is an observational study of pain and outcomes from females undergoing transvaginal NOTES removal of their appendix or gallbladder.
- Conditions
- Appendicitis, Cholelithiasis, Gallstones
- Trial name
- NOTES (NCT00530998)
- Testing
- Transvaginal Appendectomy, Transvaginal Cholecystectomy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Surgery, Gynecologic Disease
Study Evaluating the Success Rate of Outpatient Management of the Total Benign Hysterectomy by Transvaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) Compared to Each of the Two Laparoscopic Routes (Conventional and Robot-assisted).
Benign total hysterectomy is one of the most commonly performed gynecological surgery. Conventionally performed by a classical surgical approach, it is now provided routinely and for several years by laparoscopy and more recently…
- Trial name
- HYSTERAMBU (NCT06471049)
- Testing
- Benign Hysterectomy
- Where
- France
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Elsan
Obese, Surgery
Does BMI Influence Pain Follow vNOTE Surgery
Overweight and obesity are increasing dramatically worldwide and contribute substantially to the burden of morbidity and mortality.
- Conditions
- Obese, Surgery, Pain, Postoperative
- Trial name
- BMIVNOTES (NCT05230407)
- Testing
- Visual analog scale (VAS) assesment of pain
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Gastrointestinal Surgery, Natural Orifice Surgery
IMTN Study- International Prospective Multicenter Trial on Clinical NOTES
Objectives: Since 2007, natural orifice surgery evolved from theory and animal research to clinical applications, but is still limited in the literature to small casuistic reports.
- Trial name
- IMTN (NCT00995735)
- Testing
- Cholecystectomy, Appendectomy
- Where
- Brazil
- Volunteers
- 1,000 people
- Sponsor
- IMTN NOTES Research Group
Achalasia, Dysphagia
Efficacy & Safety of Submucosal Endoscopic Myotomy With Mucosal Flap (SEMF) in the Treatment of Patients With Achalasia
The purpose of this study is to learn about the safety and usefulness of a procedure called endoscopic submucosal myotomy, which is a new technique in the treatment of achalasia.
- Trial name
- NCT01438398
- Testing
- Submucosal endoscopic myotomy with mucosal flap technique, Submucosal Endoscopic Mucosal Flap (SEMF) technique
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Winthrop University Hospital
Myoma
Multi-center Prospective Study on E-NOTES for Myomectomy With Traction of Multidirectional Sutures
Primary objectives : To investigate technical feasibility and postoperative morbidity after E-NOTES for Myomectomy with Traction of Multidirectional Sutures Secondary objectives : To investigate postoperative pain after E-NOTES…
- Trial name
- E-NOTES (NCT01829022)
- Testing
- E-NOTES
- Where
- 2 sites in South Korea
- Volunteers
- 35 people
- Sponsor
- National Cancer Center, Korea
Ectopic Pregnancy
Comparison of Two Different Approaches in the Surgical Treatment of Tubal Ectopic Pregnancy
In this study we aim to compare conventional laparoscopy and natural orifice transluminal endoscopic surgery in the surgical treatment of ectopic pregnancy.
- Trial name
- NCT04315779
- Testing
- Salpingectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ege University
Cervical Cancer, Endometrial Cancer，Endometrial Lesion & Adnexal Lesion，Ectopic Pregnancy & Infertility，Pelvic Obstructive Disorder & Genital Tract Deformity
Clinical Application of Laparo-endoscopic Single-site Surgery and Natural Orifice Transluminal Endoscopic in Gynecology
The GLESS registry is a prospective multi-center observational registry. Data from the time of patient admission, operation, discharge, and follow-up will be collected for this registry.
- Trial name
- GLESS (NCT04096872)
- Where
- China
- Volunteers
- 9,000 people
- Sponsor
- Peking Union Medical College Hospital
Vaginal Prolapse
0050-19-RMB CTIL - VNOTES Compared to VH for Vaginal Apex Prolapse
VNOTES (Transvaginal natural orifice transluminal endoscopic surgery) is a relatively new surgery for Hysterectomy and Uterosacral ligament suspension to treat Vaginal prolapse.
- Trial name
- NCT04078802
- Testing
- VNOTES/VH
- Volunteers
- 60 people
- Sponsor
- Rambam Health Care Campus
Pelvic Organ Prolapse
Comparison of V-NOTES and Laparoscopic Mesh-Free Sacrocolpopexy Techniques
This study aims to compare the surgical outcomes, safety profiles, and patient satisfaction between two minimally invasive techniques for pelvic organ prolapse repair: Vaginal Natural Orifice Transluminal Endoscopic Surgery…
- Trial name
- vnotes (NCT07082023)
- Testing
- V-NOTES Mesh-Free Sacrocolpopexy, Laparoscopic Mesh-Free Sacrocolpopexy
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Havva Betül Bacak
Obesity
Transvaginal NOTES Sleeve Gastrectomy
This is a prospective chart review/data collection study of natural orifice translumenal endoscopic surgery (NOTES) for sleeve gastrectomy, that will include questionnaires administered throughout the study.
- Trial name
- NCT01402505
- Testing
- Transvaginal NOTES sleeve gastrectomy
- Where
- United States
- Sponsor
- University of California, San Diego
Surgery
vNOTES for Salpingo-oophorectomy
The aim of this study is to compare the common approach of laparoscopy for bilateral salpingo - oophorectomy to a new approach via transvaginal natural orifice transluminal endoscopic surgery (vNOTES).
- Trial name
- NCT04012710
- Testing
- Laparoscopy, vNOTES
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Calculus of Gallbladder With or Without Cholecystitis, Laparoscopic Cholecystectomy
Needlescopic Versus Transvaginal/Transumbilical Cholecystectomy
Laparoscopic surgery has become the golden standard for the removal of the gallbladder. Recently, developments have been made so that operations can be performed through a natural orifice instead of the abdominal wall, thus…
- Trial name
- NATCH (NCT01685775)
- Testing
- Transvaginal/transumbilical, Needlescopic with 3 trocars
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Witten/Herdecke
Endometrial Cancer, Lymphadenectomy
Comparison of Transvaginal Paracervical and Transperitoneal Approaches in Lymphadenectomy During v-NOTES Surgery for Patients Diagnosed With Endometrial Cancer
The aim of this study is to compare two types of lymphadenectomy (transperitoneal vs. paracervical) during the lymphadenectomy phase of endometrial cancer staging surgery performed using V-NOTES, a new and advanced technique.
- Conditions
- Endometrial Cancer, Lymphadenectomy, Sentinel Lymph Node Biopsy, Minimally Invasive Surgical Procedures
- Trial name
- ENDONOTE (NCT06870903)
- Testing
- Extraperitoneal(transvaginal paracervical sentinel lymphadenectomy) group lymphadenectomy, Transperitoneal lymphadenectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital