Clinical trials: Nebulization
Respiratory Failure, Critical Illness
Jet or Vibrating Mesh Nebulisation for Secretion Management in ICU
Critically unwell patients in Intensive Care have a decreased ability to effectively clear secretions. High secretion load is a major risk factor in the failure of tracheal extubation failure and the requirement for reintubation.
- Trial name
- NCT05635903
- Testing
- Continuous nebulisation 0.9% saline Aerogen Solo vibrating mesh Nebuliser, Intermittent nebulisation 0.9% saline Aerogen vibrating mesh Solo Nebuliser, Intermittent standard intermittent nebulisation of 0.9% saline Intersurgical Cirrus 2 self sealing Jet Nebuliser
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- NHS Greater Glasgow and Clyde
Ovarian Cysts
Intraperitoneal Ropivacaine Nebulization for Pain Control After Gynecologic Laparoscopic Surgery
The purpose of this study is to assess if intraperitoneal nebulization of Ropivacaine 150 mg may prevent the use of morphine during the first day after laparoscopic ovarian cyst surgery.
- Trial name
- NCT01142622
- Testing
- Ropivacaine nebulization, Ropivacaine instillation
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- San Gerardo Hospital
Bronchial Asthma
Efficacy and Safety of Nebulised Beclomethasone Dipropionate Plus as Needed Salbutamol vs as Needed Salbutamol or as Needed Salbutamol/Beclomethasone Fixed Combination in Young Children With Asthma Symptoms
To demonstrate a superior efficacy of BDP plus rescue salbutamol suspension for nebulisation, compared to placebo plus rescue salbutamol, in the relief of symptoms of asthma in young children with persistent symptoms of asthma.
- Trial name
- NCT00497523
- Testing
- Beclomethasone dipropionate, Beclomethasone dipropionate/Salbutamol combination, Salbutamol
- Where
- 19 sites in Poland, Ukraine
- Volunteers
- 283 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
NSCLC, Advanced Solid Tumor
YSCH-01 Via Nebulization in Pulmonary Metastasis of Advanced Solid Tumors and Non-small Cell Lung Cancer (NSCLC)
This is an open-label, dose-escalation and cohort expansion study to evaluate the safety and preliminary efficacy of YSCH-01 in subjects with pulmonary metastasis of advanced solid tumors and advanced non-small cell lung cancer…
- Trial name
- NCT07793500
- Testing
- YSCH-01
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Hemoptysis, NEBULIZATION
Tranexamic Acid : Nebulization vs IV Route for Hemoptysis
This study compares the effect of tranexamic acid on hemoptysis when given through the conventional IV route and Through nebulization.
- Conditions
- Hemoptysis, NEBULIZATION, Tranexamic Acid
- Trial name
- NCT07212452
- Testing
- Tranexamic Acid (TXA)
- Where
- Pakistan
- Volunteers
- 172 people
- Sponsor
- University of Health Sciences Lahore
Postoperative Pain
Peritoneal Nebulization of Ropivacaine for Pain Control After Laparoscopic Colectomy
The purpose of this study is to assess if intraperitoneal nebulization of Ropivacaine 150 mg produces better postoperative pain control than Saline nebulization after laparoscopic colectomy.
- Trial name
- NCT01432496
- Testing
- Ropivacaine 150 mg, saline 15 ml
- Where
- 3 sites in Italy
- Volunteers
- 130 people
- Sponsor
- San Gerardo Hospital
Postoperative Pain
Effect of Intraperitoneal Nebulisation of Magnesium Sulphate for Analgesia Following Laparoscopic Cholecystectomy
intraperitoneal nebulisation with magnesuim sulphate will reduce post operative pain and analgesic consumption in postoperative period following laparoscopic cholecystectomy.
- Trial name
- NCT01542697
- Testing
- intraperitoneal nebulisation of magnesium sulphate
- Where
- Nepal
- Volunteers
- 60 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Asthma
Single Dose Study to Evaluate the Safety, and Efficacy of S-1226 (8%) in Subjects With Mild Atopic Asthma
Evaluate the safety and tolerability of a single dose of S-1226 (8%) in subjects with mild atopic asthma.
- Trial name
- S-1226(8%) (NCT02334553)
- Testing
- S1226(8%)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- SolAeroMed Inc.
Ventilator Associated Pneumonia
Nebulised Colistimethate Sodium to Prevent Pediatric Ventilator-associated Pneumonia
The goal of this clinical trial is to learn if nebulized colistimethate sodium can prevent pneumonia in ventilated children. The main question it aims to answer is: Does nebulized colistimethate sodium lower the number of times…
- Trial name
- ColiPed (NCT06488794)
- Testing
- colistimethate sodium, 0.9% Saline
- Volunteers
- 400 people
- Sponsor
- University Hospital Fattouma Bourguiba
Acute Respiratory Insufficiency, Chronic Respiratory Insufficiency
Pharmacokinetics of Nebulized Amikacin in Non Invasive Ventilated Healthy Volunteers.
The purpose of the study is to compare the pharmacokinetics of nebulized amikacin administered with three vibrating mesh nebulizers coupled with a single limb circuit bilevel ventilator in healthy volunteers.
- Conditions
- Acute Respiratory Insufficiency, Chronic Respiratory Insufficiency, Bronchospasm and Obstruction
- Trial name
- NIV-NEBU (NCT01901497)
- Testing
- Nebulizer
- Where
- Belgium
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University Hospital St Luc, Brussels
Anesthesia, Endotracheal
Application of Electrically Driven Atomized Surface Anesthesia in ATI in Patients With Predictably Difficult Airway.
This is a parallel and randomized-controlled clinical study aimed to identify the optimized size of atomized particles of 2% lidocaine that can provide the best topical anesthesia during ATI.
- Trial name
- NCT06420947
- Testing
- atomizer
- Where
- China
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Cystic Fibrosis
Study to Evaluate the Safety & Tolerability of MRT5005 Administered by Nebulization in Adults With Cystic Fibrosis
This Phase 1/2, first-in-human study evaluated the safety and tolerability of single and multiple escalating doses of MRT5005 administered by nebulization to the respiratory tract of adult subjects with cystic fibrosis (CF).
- Trial name
- RESTORE-CF (NCT03375047)
- Testing
- MRT5005, Normal saline
- Where
- 16 sites in United States
- Volunteers
- 42 people
- Sponsor
- Sanofi
Bronchiectasis Adult, Pseudomonas Infections
Tobramycin in Bronchiectasis Colonized With Pseudmonas Aeruginosa
This is a phase 3 study. Patients will be enrolled from 14 medical centers in mainland China. Eligible patients will be randomly allocated to treatment group (tobramycin nebulization, 300mg bid) and control group (natural saline…
- Trial name
- TORNASOL (NCT03715322)
- Testing
- Tobramycin Inhalant Product, usual care, Natural saline inhalation
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Acute Bronchiolitis
Comparison of 3% Normal Saline Nebulization Versus Steroid Nebulization in the Treatment of Bronchiolitis
To compare the efficacy of 3% normal saline nebulization and steroid nebulization in the treatment of bronchiolitis in infants.
- Trial name
- NCT06139029
- Testing
- 3% normal saline, steroid(beclomethasone dipropionate 400 μg/day) and salbutamol with 0.9% normal saline
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Mardan Medical Complex
Postoperative Pain, NEBULIZATION
Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery
Postoperative sore throat is a common complication following tracheal intubation under general anesthesia for thyroidectomy. The special surgical position for thyroidectomy, as well as the physical and electrical stimulation from…
- Conditions
- Postoperative Pain, NEBULIZATION, Thyroid Surgery
- Trial name
- NCT07491991
- Testing
- Inhalation of budesonide combined with lidocaine, Inhalation of saline solution via nebulization
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Qianfoshan Hospital
Acute Asthma
Heliox and Posture in Patients With Asthma
The purpose of this study is to verify that nebulization with bronchodilators associated with heliox gas (helium + oxygen) and the posture of a leaning forward truck is effective in patients with an asthma attack.
- Trial name
- NCT00922350
- Testing
- HELIOX, OXYGEN, HELIOX+POSTURE
- Where
- Brazil
- Volunteers
- 59 people
- Sponsor
- Universidade Federal de Pernambuco
Transmission, Patient-Professional
Different Modalities in Reducing Airborne Particulate Concentrations During AGP for Health Volunteers
Several clinical procedures have been described as aerosol generating procedure (AGP), including nebulization, high-flow nasal cannula oxygen therapy, noninvasive ventilation, and bronchial hygiene treatment, etc.
- Trial name
- NCT04681599
- Testing
- Filter, Scavenger face tent
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Healthy Subjects
Effect of Drug Targeting Nebulization on Lung Deposition
To compare deposition between two modalities of nebulization
- Trial name
- NCT01877304
- Testing
- AKITA
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Bronchiolitis
Randomized Controlled Trial Comparing Standard Versus Positive Pressure Nebulization in Infants With Bronchiolitis to Reduce Hospital Admissions
Hypothesis: That administration of nebulized therapy for bronchiolitis when using positive airway pressure is superior to standard mask ventilation in reducing hospital admissions.
- Trial name
- BPAP (NCT01229384)
- Testing
- Positive Airway Pressure nebulization, Standard passive nebulization of respiratory medications
- Volunteers
- healthy volunteers welcome
- Sponsor
- Phoenix Children's Hospital
Asthma
Lung Function of Asthmatic Children by Nebulized MgSO4
Asthma is a common chronic respiratory illness which results in frequent wheezing, cough,reduced quality of life. Standard treatment for asthma attack includes oxygen therapy, β2-agonists (e.g.
- Trial name
- NCT01799109
- Testing
- Magnesium Sulfate & albuterol, albuterol, magnesium
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chongqing Medical University