Clinical trials: Neglected Diseases
Hookworm Infection, Hookworm Disease
Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese Adults
Na-GST-1 is a protein expressed during the adult stage of the Necator americanus hookworm life cycle that is thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source.
- Trial name
- NCT03373214
- Testing
- Na-GST-1, CPG 10104
- Where
- Gabon
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Dementia, Abuse Client
Partnership in Safeguarding People With Dementia From Primary and Social Care Perspectives
"Adult safeguarding is everyone's responsibility". The Care Act 2014 makes safeguarding a legal duty. It provides local authorities and other agencies in England with a responsibility to protect adults with care and support needs…
- Conditions
- Dementia, Abuse Client, Neglect; Care, Malnutrition
- Trial name
- NCT05883527
- Testing
- Not applicable as not an intervention - PLwD and family/carers, Not applicable as not an intervention - HCP's
- Where
- 5 sites in United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Spatial Neglect, Stroke
Virtual Reality for Neglect Diagnostics
Compared to the classical "paper and pencil"-tests, testing patients in our virtual reality setup might have a higher sensitivity and specificity.
- Trial name
- KMS-Neglect (NCT01399073)
- Testing
- virtual reality setup, paper and pencil tests, c-mri
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Onchocerciasis, Ascaris Lumbricoides Infection
Moxidectin Versus Ivermectin as Mass Drug Administration for the Control of Onchocerciasis and Other Neglected Tropical Diseases
This clinical trial compares two treatments - ivermectin and moxidectin - to learn which is better at reducing the proportion of people with onchocerciasis (river blindness) when given through mass drug administration (MDA) in…
- Conditions
- Onchocerciasis, Ascaris Lumbricoides Infection, Trichuris Trichiura; Infection, Hookworm Infections
- Trial name
- EKAIO (NCT07145736)
- Testing
- Moxidectin, Ivermectin
- Where
- Angola
- Volunteers
- 52,000 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
Behavior, Child, Caries,Dental
Are Dental Neglect and the Siblings Risk Factors in Children
Neglect insidiously affects a child's overall health in all aspects. The aim of this study was to determine whether the presence of siblings caused dental neglect, and whether there was a relationship between dental neglect and…
- Conditions
- Behavior, Child, Caries,Dental, Neglect, Child, Anxiety
- Trial name
- NCT04122508
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Human African Trypanosomiasis
Assessment of Recombinant HAT-RDT Specificity
Human African trypanosomiasis HAT, or sleeping sickness, is a tropical disease caused mainly by the parasite Trypanosoma brucei gambiense (gHAT).
- Trial name
- NCT05637632
- Where
- Democratic Republic of the Congo
- Volunteers
- 1,504 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Opioid-Related Disorders, Stimulant-Related Disorder
Preventing Parental Opioid and/or Methamphetamine Addiction Within DHS-Involved Families: PRE-FAIR
Young parents aged 16 to 30, involved in the DHS system for child welfare or self-sufficiency needs are at risk for opioid use disorder and/or methamphetamine use disorder (OUD; MUD).
- Conditions
- Opioid-Related Disorders, Stimulant-Related Disorder, Child Neglect, Mental Health Impairment
- Trial name
- PRE-FAIR (NCT05380440)
- Testing
- Prevention Adaptation of Families Actively Improving Relationships (PRE-FAIR), Standard Case Management and Referral
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Type 2 Diabetes (T2DM), Geriatric Syndromes
Using Virtual Reality to Improve Medical Training
As the U.S. population ages, future physicians must be prepared to care for older adults with multiple health conditions and complex needs.
- Conditions
- Type 2 Diabetes (T2DM), Geriatric Syndromes, Disability Hearing, Disability Physical
- Trial name
- NCT07542834
- Testing
- Cinematic Virtual Reality Training, Traditional Didactic Lecture
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ohio University
Hemispatial Neglect, Stroke
Vestibular Stimulation to Treat Hemispatial Neglect
The purpose of the current proposal is to pilot a new and potentially improved treatment for neglect. The procedure involves the delivery of transcutaneous small-amplitude current to the vestibular nerves that lie directly below…
- Trial name
- NCT00271388
- Testing
- Transcutaneous current to the vestibular nerve
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Healthy
Safety, Tolerability and PK of Single and Multiple Doses of Oxantel Pamoate Tablets
The goal of this clinical trial is to evaluate the safety, tolerability and pharmacokinetics of oxantel pamoate tablet after administration of a single and multiple dose in healthy male and female adult volunteers.
- Trial name
- HELP-OXA (NCT06606860)
- Testing
- Oxantel Pamoate
- Where
- Tanzania
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Overweight, Obesity
Relationship of Adverse Childhood Experiences to Overweight and Obesity
The purpose of this study is to determine if there is an association between a variety of adverse childhood experiences and overweight and obesity.
- Trial name
- NCT00632346
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Soil-transmitted Helminthiasis, Schistosomiasis
Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders
NIDIAG is an international collaboration on integrated diagnosis-treatment platforms, funded by the European Commission (EC). NIDIAG aims to develop an improved, patient-centred system for delivering primary health care in…
- Conditions
- Soil-transmitted Helminthiasis, Schistosomiasis, Strongyloidiasis, Shigellosis
- Trial name
- NIDIAGDigest (NCT02105714)
- Testing
- Stool culturing for pathogenic bacteria, Kato-Katz technique, Baermann technique
- Where
- 7 sites in Côte d’Ivoire, Indonesia and 2 more
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Sustained Behavior Change, Mental Well-being
The Impact of Enhanced, Demand-side Sanitation and Hygiene Promotion on Sustained Behavior Change and Health in Ethiopia
This study is a two-year evaluation investigating the impacts of an enhanced, demand-side sanitation and hygiene intervention on sustainable adoption of improved water, sanitation, and hygiene (WASH) practices and mental…
- Trial name
- NCT03075436
- Testing
- Enhanced demand-side sanitation, hygiene, Standard of care
- Where
- Ethiopia
- Volunteers
- 10,375 people, healthy volunteers welcome
- Sponsor
- Emory University
Trachoma, Lymphatic Filariasis
Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis
Trachoma and lymphatic filariasis (LF) are two 'Neglected Tropical Diseases' (NTDs), infectious diseases that affect millions of poor people in countries in the developing world.
- Trial name
- AZIVAL2 (NCT01903057)
- Testing
- azithromycin, ivermectin, albendazole
- Where
- Mozambique
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Onchocerciasis, Loiasis
Evaluation of the Diagnosis Performances of DEC LTS-2 Skin Patch for Onchocerciasis in Central Africa
This study aims at evaluating the diagnosis performances of the LTS-2 DEC patch for onchocerciasis compared to the gold standard which are the skin snips.
- Conditions
- Onchocerciasis, Loiasis, Diagnoses Disease, Neglected Diseases
- Trial name
- EOLoa (NCT04035174)
- Testing
- LTS-2 DEC patch, Skin snips
- Where
- Cameroon
- Volunteers
- healthy volunteers welcome
- Sponsor
- Center for Research on Filariasis and Other Tropical Diseases, Cameroon
Trypanosomiasis, Trypanosomiasis, African
Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the SCYX-7158
This study is aimed at assessing the tolerability and pharmacokinetic parameters of SCYX-7158 in healthy volunteers. In animal models of both acute and chronic experimental Trypanosomiasis infections, SCYX-7158 shows highly…
- Conditions
- Trypanosomiasis, Trypanosomiasis, African, Protozoan Infections, Parasitic Diseases
- Trial name
- NCT01533961
- Testing
- SCYX-7158
- Where
- 2 sites in France
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Drugs for Neglected Diseases
Substance Use
Brief Intervention in At-Risk First-time Mothers
Preliminary controlled trial of a brief intervention designed to reduce child maltreatment risk among low-income pregnant mothers.
- Trial name
- NCT00230009
- Testing
- Brief motivational intervention
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Alcohol Abuse, Alcohol Drinking
TREAT Child Alcohol Use Disorder (C-AUD) in Eastern Uganda
The investigators will investigate the existence of alcohol drinking among children living under adult supervision and care, living within the communities.
- Conditions
- Alcohol Abuse, Alcohol Drinking, Alcoholism, Alcohol Use Disorder
- Trial name
- TREAT C-AUD (NCT04743024)
- Where
- Uganda
- Volunteers
- 7,188 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Stroke, Spatial Neglect
Validation of Web-Based Star Cancellation and Line Bisection Tests in Hemiplegic Stroke
The goal of this observational study is to evaluate the clinical usability and diagnostic performance of newly developed web-based Star Cancellation and Line Bisection tests in assessing visuospatial neglect in hemiplegic stroke…
- Conditions
- Stroke, Spatial Neglect, Spatial Neglect After Stroke
- Trial name
- NCT07538076
- Testing
- Web-Based Star Cancellation Test, Web-Based Line Bisection Test
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Segmental Exclusion Syndrome, Complex Regional Pain Syndrome (CRPS)
Peripersonal Space Representation in Upper Limb Segmental Exclusion
This study aims to evaluate the representation of action peripersonal space (PPS) in subjects suffering from unilateral segmental exclusion syndrome of the upper limb compared to healthy control subjects.
- Conditions
- Segmental Exclusion Syndrome, Complex Regional Pain Syndrome (CRPS), Upper Limb Neglect (Peripheral)
- Trial name
- NCT07349173
- Testing
- Reachability Judgment Task in VR.
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est