Clinical trials: Neglected Diseases
Stroke, Recovery of Function
Virtual Prism Adaptation Therapy on Hemispatial Neglect
The purpose of this study is to investigate the effect of virtual prism adaptation therapy on hemispatial neglect in chronic stroke patients. This study is the randomized, double-blind, sham-controlled, cross-over design.
- Conditions
- Stroke, Recovery of Function, Rehabilitation, Perceptual Disorders
- Trial name
- NCT03771872
- Testing
- Virtual Prism Adaptation Therapy
- Where
- 2 sites in South Korea
- Volunteers
- 2 people
- Sponsor
- Seoul National University Hospital
Neglect, Sensory, Neglect, Hemispatial
Mixed-Reality Visual Attention Task for Neglect Diagnosis and Rehabilitation
Neglect, a common and disabling neurological deficit post-CNS injury, profoundly hinders recovery and escalates healthcare costs.
- Conditions
- Neglect, Sensory, Neglect, Hemispatial, Neglect, Hemisensory
- Trial name
- Neglex01 (NCT07227844)
- Testing
- VR Neglect Training
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Markey Olson
Sustained Behavior Change, Mental Well-being
The Impact of Enhanced, Demand-side Sanitation and Hygiene Promotion on Sustained Behavior Change and Health in Ethiopia
This study is a two-year evaluation investigating the impacts of an enhanced, demand-side sanitation and hygiene intervention on sustainable adoption of improved water, sanitation, and hygiene (WASH) practices and mental…
- Trial name
- NCT03075436
- Testing
- Enhanced demand-side sanitation, hygiene, Standard of care
- Where
- Ethiopia
- Volunteers
- 10,375 people, healthy volunteers welcome
- Sponsor
- Emory University
Child Abuse, Child Neglect
Fostering Healthy Futures for Teens: An RCT
This study will implement and evaluate a mentoring program designed to promote positive youth development and reduce adverse outcomes among maltreated adolescents with open child welfare cases.
- Conditions
- Child Abuse, Child Neglect, Risk Behavior, Delinquency
- Trial name
- FHF-T (NCT03707366)
- Testing
- FHF-T
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- University of Denver
Hemispatial Neglect, Visual Neglect
Cerebellum and Neglect
The goal of this clinical trial is to learn if a non-invasive brain stimulation method called continuous theta burst stimulation (cTBS) can improve attention in adults who have hemispatial neglect after stroke.
- Conditions
- Hemispatial Neglect, Visual Neglect, Stroke
- Trial name
- NCT07580066
- Testing
- Continuous theta burst stimulation
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Luzerner Kantonsspital
Trachoma, Lymphatic Filariasis
Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis
Trachoma and lymphatic filariasis (LF) are two 'Neglected Tropical Diseases' (NTDs), infectious diseases that affect millions of poor people in countries in the developing world.
- Trial name
- AZIVAL2 (NCT01903057)
- Testing
- azithromycin, ivermectin, albendazole
- Where
- Mozambique
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Onchocerciasis, Loiasis
Evaluation of the Diagnosis Performances of DEC LTS-2 Skin Patch for Onchocerciasis in Central Africa
This study aims at evaluating the diagnosis performances of the LTS-2 DEC patch for onchocerciasis compared to the gold standard which are the skin snips.
- Conditions
- Onchocerciasis, Loiasis, Diagnoses Disease, Neglected Diseases
- Trial name
- EOLoa (NCT04035174)
- Testing
- LTS-2 DEC patch, Skin snips
- Where
- Cameroon
- Volunteers
- healthy volunteers welcome
- Sponsor
- Center for Research on Filariasis and Other Tropical Diseases, Cameroon
Mild Leptospirosis
Comparing Two Antibiotic Therapy Periods (3 Versus 7 Days) in Patients With Mild Leptospirosis and Seen at the Hospital in 5 French Overseas Departments (Martinique, Guadeloupe, French Guiana, Reunion, Mayotte)
Leptospirosis is a globally distributed neglected tropical disease affecting subtropical and tropical areas, such as the Caribbean and the Indian Ocean, with favorable climatic conditions for disease transmission.
- Trial name
- LEPTO3 (NCT04211649)
- Testing
- 3 days of antibiotherapy
- Where
- 5 sites in French Guiana, Guadeloupe and 3 more
- Volunteers
- 220 people
- Sponsor
- University Hospital Center of Martinique
Chagas Disease
Population Pharmacokinetics of Benznidazole in Children With Chagas Disease
Background: Chagas disease is a parasitic infection caused by the Trypanosome cruzi. The initial phase of the infection happens mainly in children. Up to 10% of infected children die.
- Trial name
- NCT00699387
- Testing
- Benznidazole
- Where
- Argentina
- Volunteers
- 37 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Trypanosomiasis, Trypanosomiasis, African
Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the SCYX-7158
This study is aimed at assessing the tolerability and pharmacokinetic parameters of SCYX-7158 in healthy volunteers. In animal models of both acute and chronic experimental Trypanosomiasis infections, SCYX-7158 shows highly…
- Conditions
- Trypanosomiasis, Trypanosomiasis, African, Protozoan Infections, Parasitic Diseases
- Trial name
- NCT01533961
- Testing
- SCYX-7158
- Where
- 2 sites in France
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Drugs for Neglected Diseases
Cerebrovascular Accident, Perceptual Disorders
Effectiveness of Rehabilitation on the Recovery of Patients Post Right Stroke With Unilateral Spatial Neglect
Unilateral spatial neglect (USN) is believed to be a disorder of attention, characterized by impairment in the ability to perceive or respond to stimuli presented to the contralesional space, and which is not attributable to…
- Trial name
- NCT00305513
- Testing
- The phasic alerting treatment
- Where
- Israel
- Volunteers
- 6 people
- Sponsor
- Hadassah Medical Organization
Chronic Inflammatory Bowel Disease
Methotrexate-associated Anti-TNF Combination Therapy, the Neglected One !
The results of the SONIC trial represented a significant advance in the management of patients with chronic inflammatory bowel disease by demonstrating the superiority of the combination of an alpha TNF anti-TNF with…
- Trial name
- MTX (NCT04196920)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Substance Abuse, Child Abuse
Family-Based Treatment for Parental Substance Abuse and Child Maltreatment
Parental substance abuse is a leading determinant of child maltreatment and, consequently, is often linked with negative clinical outcomes for children, exorbitant financial costs for the child welfare system, and serious social…
- Conditions
- Substance Abuse, Child Abuse, Child Neglect
- Trial name
- NCT01656837
- Testing
- Comprehensive Community Treatment, MST-BSF
- Where
- United States
- Volunteers
- 191 people
- Sponsor
- Medical University of South Carolina
Unilateral Spatial Neglect
Use of Vibration to Improve Visual/Spatial Neglect in Patients Affected by Stroke
This study will measure if five minutes of vibration to the upper back neck muscles, prior to standard of care treatment, will improve symptoms of spatial neglect and/or activities of daily living function for patients who have…
- Trial name
- NEGLECT (NCT03141996)
- Testing
- Vibration to upper posterior neck muscles, Standard of Care
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Intermountain Health Care, Inc.
Substance Use
Brief Intervention in At-Risk First-time Mothers
Preliminary controlled trial of a brief intervention designed to reduce child maltreatment risk among low-income pregnant mothers.
- Trial name
- NCT00230009
- Testing
- Brief motivational intervention
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Stroke, Ischemic Stroke
Robotic rEhabilitation sCenario fOr patieNts With NeglECT
The goal of this pilot clinical trial is to develop an integrated motor and cognitive rehabilitation program and evaluate the usability and acceptability of a new virtual reality scenario designed for the MOTORE device.
- Conditions
- Stroke, Ischemic Stroke, Haemorrhagic Stroke, Neglect, Hemispatial
- Trial name
- RECONNECT (NCT06890481)
- Testing
- Upper-limb planar robotic intervention
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Stroke
Clinical Assessment of Spatial Neglect Following Stroke
Spatial neglect (SN) is a common heterogeneous cognitive affliction that predicts poor recovery after a stroke. It is important to identify SN so alliviating actions can be initated.
- Trial name
- NCT04072614
- Where
- Iceland
- Volunteers
- 1,000 people
- Sponsor
- Landspitali University Hospital
Stroke
An Augmented Reality Based System for Neglect Detection, Assessment, and Rehabilitation
The aim of this phase is to examine the feasibility and acceptability of the Augmented Reality (AR)-based and electroencephalography (EEG)-based neglect detection and rehabilitation tool.
- Trial name
- NCT04187131
- Testing
- augmented reality
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Pittsburgh
Alcohol Abuse, Alcohol Drinking
TREAT Child Alcohol Use Disorder (C-AUD) in Eastern Uganda
The investigators will investigate the existence of alcohol drinking among children living under adult supervision and care, living within the communities.
- Conditions
- Alcohol Abuse, Alcohol Drinking, Alcoholism, Alcohol Use Disorder
- Trial name
- TREAT C-AUD (NCT04743024)
- Where
- Uganda
- Volunteers
- 7,188 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Stroke
NonInvasive Brain Stimulation in Stroke Patients
After a stroke affecting the right side of the brain, many patients are affected by "spatial neglect": the damage to the brain causes them to ignore the left side of their surroundings.
- Trial name
- RTNIBS (NCT02401724)
- Testing
- Transcranial direct current stimulation, Action Training
- Volunteers
- 60 people
- Sponsor
- NHS Greater Glasgow and Clyde