Clinical trials: Neglected Diseases
Trypanosomiasis, Trypanosomiasis, African
Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the SCYX-7158
This study is aimed at assessing the tolerability and pharmacokinetic parameters of SCYX-7158 in healthy volunteers. In animal models of both acute and chronic experimental Trypanosomiasis infections, SCYX-7158 shows highly…
- Conditions
- Trypanosomiasis, Trypanosomiasis, African, Protozoan Infections, Parasitic Diseases
- Trial name
- NCT01533961
- Testing
- SCYX-7158
- Where
- 2 sites in France
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Drugs for Neglected Diseases
HIV, Sexually Transmitted Diseases
Zambia One Love Aim 3 Trial
The aim of this study is to determine whether a Strengthening our Vows (SOV) intervention will reduce HIV exposures from concurrent partnership (CP) when compared to the control Good Health Package Plus (GHPP), in addition to…
- Conditions
- HIV, Sexually Transmitted Diseases, Neglected Diseases, Non-communicable Diseases
- Trial name
- NCT02744586
- Testing
- Strengthening Our Vows (SOV), Good Health Package Plus (GHPP)
- Where
- 2 sites in Zambia
- Volunteers
- 3,450 people, healthy volunteers welcome
- Sponsor
- Emory University
Myocardial Infarction
Venous Function in Cardiovascular Disease Patients
The primary aim is to determine the acute effect of two different training interventions on venous plasticity in patients with myocardial infarction (MI), revascularization or coronary artery graft surgery compared to age-matched…
- Trial name
- NCT01474408
- Testing
- interval training day 1, Moderate exercise day 2, Control day 3
- Where
- Norway
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Foreign Body; Inhalation
Presentation And Management Of Neglected Inhaled Foreign Body At Sohag University Hospital
Delayed presentation is not uncommon in children and may have been treated as asthma due to associated with low-grade cough and noisy breathing.
- Trial name
- NCT04988113
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Stroke, Hemispatial Neglect
Transcranial Direct Current Stimulation (tDCS) and Task-Specific Practice for Post-stroke Neglect
The purpose of this study is to test the effects of three different rehabilitation training sessions that combine non-invasive brain stimulation (transcranial direct current stimulation, tDCS) with arm rehabilitation training…
- Trial name
- NCT02892097
- Testing
- tDCS, Repetitive task-specific practice (RTP)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Medical University of South Carolina
Self-Neglect, Cognitive Ability, General
Multidimensional Assessment and Intervention for Elder Self-Neglect
This study is designed to assess the best method for caring for elders reported to Adult Protective Services (APS) for self-neglect.
- Conditions
- Self-Neglect, Cognitive Ability, General, Geriatric Disorder
- Trial name
- NCT00901706
- Testing
- Comprehensive Geriatric Assessment and APS Usual Care, APS usual care
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Unilateral Spatial Neglect (USN)
Rehabilitation Methods for Unilateral Spatial Neglect in Stroke Patients
Stroke remains one of the leading causes of mortality and disability worldwide. Between 30% and 40% of patients who have had an acute cerebral hemorrhage, develop unilateral spatial neglect syndrome (USN).
- Trial name
- NCT06802159
- Testing
- Conventional therapy, Eye tracking based therapy, Cognitive therapy
- Where
- 2 sites in Russia
- Volunteers
- 30 people
- Sponsor
- Federal Center of Cerebrovascular Pathology and Stroke, Russian Federation Ministry of Health
Leprosy, Leprosy, Multibacillary
Efficacy and Tolerability of Adjunct Metformin for Multibacillary Leprosy
This trial aims to evaluate the efficacy, tolerability and safety of adjunct metformin added to standard-of-care multi-drug therapy (MDT) in patients with multibacillary leprosy, and explore its effects on immunological…
- Conditions
- Leprosy, Leprosy, Multibacillary, Neglected Tropical Diseases
- Trial name
- MetLep (NCT05243654)
- Testing
- Metformin
- Where
- 6 sites in Indonesia
- Volunteers
- 166 people
- Sponsor
- Oxford University Clinical Research Unit Indonesia
Sustained Behavior Change, Mental Well-being
The Impact of Enhanced, Demand-side Sanitation and Hygiene Promotion on Sustained Behavior Change and Health in Ethiopia
This study is a two-year evaluation investigating the impacts of an enhanced, demand-side sanitation and hygiene intervention on sustainable adoption of improved water, sanitation, and hygiene (WASH) practices and mental…
- Trial name
- NCT03075436
- Testing
- Enhanced demand-side sanitation, hygiene, Standard of care
- Where
- Ethiopia
- Volunteers
- 10,375 people, healthy volunteers welcome
- Sponsor
- Emory University
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity of the Na-APR-1 Hookworm Vaccine in Healthy Adults
Hookworms digest hemoglobin from erythrocytes for use as an energy source via a proteolytic cascade that begins with the aspartic protease, APR-1.
- Trial name
- NCT01717950
- Testing
- Na-APR-1 (M74)/Alhydrogel®, Gluco-Pyranosylphospho-Lipid A Aqueous Formulation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Brain Tumours
Investigating Visual Verticality Disorder and Lateropulsion in a Neurosurgical Cohort of Patients With Brain Tumours
The overall objective of this research is to investigate the clinical characteristics pre- and post-brain tumour resection with a focus on visual verticality disorder, and lateropulsion, including neuroimaging analysis, of a…
- Trial name
- NCT06951659
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- The University of Western Australia
Spatial Neglect After Stroke
Early Versus Delayed Treatment of Unilateral Neglect After Stroke
'Unilateral neglect' is a disorder that occurs regularly after stroke. It is caused by right- as well as left-sided brain lesions, but more often by right-sided lesions.
- Trial name
- NCT01341574
- Testing
- Prism adaptation with optical shift of 10 degrees., Prism adaptation optical shift of 0 degrees.
- Where
- 3 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- University Ghent
Stroke
Effect of Optokinetic Stimulation on Spatial Neglect and Postural Stability in Patients With Stroke
The purpose of this study is to investigate the efficacy of optokinetic stimulation in stroke patients by examining its effects on spatial neglect, static balance, dynamic balance, and weight-bearing symmetry.
- Trial name
- NCT07424105
- Testing
- Optokinetic stimulation, Traditional therapy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Lassa Fever
ARN-75039 Lassa Fever Treatment in West Africa
This multicenter, randomized, open-label Phase 2 clinical trial evaluates the safety, tolerability, and virologic efficacy of ARN-75039, a novel oral antiviral, for treating Lassa fever in hospitalized adults in West Africa.
- Trial name
- NCT07419373
- Testing
- ARN-75039 high, Intravenous ribavirin, ARN-75039 low
- Where
- 4 sites in United States, Nigeria
- Volunteers
- 135 people
- Sponsor
- Arisan Therapeutics, Inc.
Leishmaniasis, Visceral
Predicting Visceral Leishmaniasis in HIV Infected Patients
In this cohort study, the investigators will study the asymptomatic period preceding the onset of active Visceral Leishmaniasis (VL) in HIV-infected individuals from VL endemic regions in Ethiopia as an avenue to develop an…
- Trial name
- PreLeisH (NCT03013673)
- Testing
- No intervention
- Where
- Ethiopia
- Volunteers
- 566 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Lymphatic Filariasis, Yaws
PK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs )
This is a Pharmacokinetic and Pharmacodynamic study evaluating the safety of co-administering Azithromycin alongside the new IDA (Ivermectin, Diethylcarbamazine, Albendazole) combination treatment for LF.
- Conditions
- Lymphatic Filariasis, Yaws, Trauma
- Trial name
- NCT03664063
- Testing
- Azithromycin, Albendazole, Ivermectin
- Where
- Papua New Guinea
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Lihir Medical Centre
Stroke, Anosognosia
Improving Awareness for Spatial Neglect With tDCS
Brain-damaged patients can show severe neurological and cognitive deficits, and yet often remain strikingly unaware of these symptoms: this condition is called anosognosia.
- Conditions
- Stroke, Anosognosia, Neglect, Hemispatial
- Trial name
- ANOSO (NCT04845529)
- Testing
- transcranial direct current stimulation (tDCS)
- Volunteers
- 12 people
- Sponsor
- University of Geneva, Switzerland
Unilateral Spatial Neglect
Use of Vibration to Improve Visual/Spatial Neglect in Patients Affected by Stroke
This study will measure if five minutes of vibration to the upper back neck muscles, prior to standard of care treatment, will improve symptoms of spatial neglect and/or activities of daily living function for patients who have…
- Trial name
- NEGLECT (NCT03141996)
- Testing
- Vibration to upper posterior neck muscles, Standard of Care
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Intermountain Health Care, Inc.
Neglect, Hemispatial
Assessment of LF-rTMS in Patients With Visual Neglect
Visual neglect is a common disorder following stroke and an indicator of poor recovery compared to stroke survivors without visual neglect.
- Trial name
- NCT06050408
- Testing
- 1hz repetitive transcranial magnetic stimulation
- Volunteers
- 30 people
- Sponsor
- Landspitali University Hospital