Clinical trials: Neonatal Screening
Developmental Dysplasia of the Hip
Selective Ultrasound Screening for DDH 1991-2006
Early treatment is considered essential for developmental dysplasia of the hip (DDH), but the choice of screening strategy is debated. The investigators evaluated the effect of a selective ultrasound (US) screening programme.
- Trial name
- NCT01866527
- Where
- Norway
- Volunteers
- 81,564 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Familial Hypercholesterolemia
Pilot Study for a National Screening for Familial Hypercholesterolemia
A pilot study to study the feasibility of the screening of familial hypercholesterolemia within the setting of the legal medical visits at primary school.
- Trial name
- EARLIE (NCT05271305)
- Where
- Luxembourg
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier du Luxembourg
Gout Initiating Urate-loweringUrate-lowering Therapy, Gout Arthritis
HLA-B*58:01-Guided Therapy for Gout: Effectiveness, Safety, and Cost-Effectiveness
Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS), are rare but life-threatening complications that…
- Conditions
- Gout Initiating Urate-loweringUrate-lowering Therapy, Gout Arthritis, Gout and Hyperuricemia
- Trial name
- HLA-SCREEN (NCT07369622)
- Testing
- HLA-B*58:01 Genotyping, Allopurinol Tablet, Febuxostat
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Haiphong University of Medicine and Pharmacy
Sickle Cell Trait
A Program to Increase Sickle Cell Trait Knowledge Among Parent of Young Children Identified in Newborn Screening
This is a study for parents of young children with Sickle Cell Trait (SCT) identified by newborn screening who are referred and present for in person SCT education at the Institution.
- Trial name
- SCTaware (NCT03984500)
- Testing
- Education
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Susan Creary
Neonatal Jaundice
NeoSCB App for Screening Jaundice in Newborns
About 60% of babies born after 36 weeks of pregnancy have jaundice during the first two weeks of life. Due to the accumulation of bilirubin in the bloodstream, jaundiced babies appear yellow, which allows healthcare professionals…
- Trial name
- neoSCB (NCT06963450)
- Testing
- Taking photos of a baby's eye
- Where
- United Kingdom
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- University College, London
Neonatal Jaundice, Hyperbilirubinemia
Transcutaneous Screening for Risk of Severe Hyperbilirubinemia in South African Newborns
In South Africa, healthy term newborns are usually discharged early (<72 hours after delivery). Many studies have shown that hospital readmission rates have increased with this practice, and jaundice or hyperbilirubinemia is the…
- Trial name
- NCT02613676
- Testing
- Transcutaneous bilirubin screening, Standard care (Visual inspection)
- Where
- South Africa
- Volunteers
- 1,858 people, healthy volunteers welcome
- Sponsor
- University of Stellenbosch
Hemoglobinopathies
Screening for Hemoglobinopathies in Pregnant Women
This prospective monocentric study project is to identify hemoglobinopathies in pregnant women in order to optimize antenatal care and to investigate the prevalence of hemoglobinopathies in pregnant women in Switzerland.
- Trial name
- NCT04029142
- Testing
- Review of routine lab data
- Where
- Switzerland
- Volunteers
- 1,785 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Congenital Cardiovascular Malformation
Newborn Screening for Critical Congenital Heart Disease
Previous studies have examined the usefulness of pulse oximetry or oxygen saturation to screen for left-sided cardiac lesions. These studies have shown that the occurrence of critical congenital cardiac malformations among…
- Trial name
- NCT01765205
- Testing
- Pulse Oximetry using the INVOS (In Vivo Optical Spectroscopy) Cerebral/Somatic Oximeter
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Florida
Retinopathy of Prematurity (ROP)
The Effect of Two Non-Pharmacological Methods on Pain During Retinopathy Examination
The goal of this randomized controlled trial is to determine the effect of reverse kangaroo care position and ROP (Retinopathy of Prematurity) position applied during ROP examination in premature infants on pain.
- Trial name
- NCT06694103
- Testing
- Reverse Kangaroo Care Position, ROP Position
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Sinem Basdemir
Metabolism, Inborn Errors, Hearing Loss
North Carolina Newborn Exome Sequencing for Universal Screening
The NC NEXUS research study is exploring the utility of next generation sequencing in newborn screening and parental decision making.
- Conditions
- Metabolism, Inborn Errors, Hearing Loss, Hereditary Disease
- Trial name
- NC_NEXUS (NCT02826694)
- Testing
- Well infant, whole exome sequencing, Diagnosed, whole exome sequencing
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Preeclampsia, Intrauterine Growth Restriction
sFlt1/PlGF and Planned Delivery to Prevent Preeclampsia at Term.
Preeclampsia (PE) affects ~5% of pregnancies. Although improved obstetrical care has significantly diminished associated maternal mortality, PE remains a leading cause of maternal morbidity and mortality in the world.
- Conditions
- Preeclampsia, Intrauterine Growth Restriction, Maternal Hypertension, Neonatal Outcome
- Trial name
- PE37 (NCT04766866)
- Testing
- sFlt1/PlGF screening in maternal blood at 35 to 36.6 weeks of gestation
- Where
- 21 sites in Belgium, Colombia and 7 more
- Volunteers
- 9,132 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Severe Combined Immunodeficiency, Atypical
Generalized Neonatal Screening of Severe Combined Immunodeficiencies
Severe combined Immunodeficiencies ( SCID ) are a group of inherited diseases of the immune system by characterised profound abnormalities of T cell development .
- Trial name
- DEPISTREC (NCT02244450)
- Testing
- SCID screening
- Where
- 51 sites in France
- Volunteers
- 190,539 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Lynch Syndrome, Endometrial Neoplasms
Universal Screening for Lynch Syndrome in Women With Endometrial and Non-Serous Ovarian Cancer
This study will maximize identification of women with Lynch Syndrome using an enhanced screening strategy to identify those at risk.
- Conditions
- Lynch Syndrome, Endometrial Neoplasms, Ovarian Neoplasms, Colorectal Neoplasms
- Trial name
- LS2 (NCT02494791)
- Testing
- Questionnaire, Educational Material
- Where
- Canada
- Volunteers
- 886 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Twin Pregnancy, Monochorionic, Pregnancy Followed
Ductus Venosus Doppler at 16 Weeks in Monochorial Pregnancy
Studies shows that the realization of the Ductus venosus Doppler may improve the screening of the twin-twin transfusion syndrome.
- Trial name
- DVSTT (NCT03579069)
- Testing
- Ductus venosus Doppler
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Lysosomal Storage Diseases
Screening of Lysosomal Storage Disorders Diseases in Minority Groups
Aim is to undertake a screening study that identifies undiagnosed patients with LSDs and determine the prevalence of these diseases with special focus on underrepresented minority groups.
- Trial name
- NCT03812042
- Testing
- Enzyme assay and molecular sequencing
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Lysosomal and Rare Disorders Research and Treatment Center, Inc.
Nursing Education
Kolb-Based AI-Powered Neonatal Simulation Training
This quasi-experimental study aims to evaluate the multidimensional effects of an artificial intelligence-supported newborn simulation training program based on Kolb's Experiential Learning Theory on nursing students'…
- Trial name
- NCT07872969
- Testing
- Kolb-Based Artificial Intelligence-Supported Neonatal Simulation Training
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Maltepe University
Aspiration of Blood in Newborn
Simulation-Based Training Program Effect on Pediatric Nurses Regarding Heel-Prick Screening Test
This study aimed to assess the impact of simulation-based training on pediatric nurses' knowledge and performance regarding the heel-prick technique used during newborn blood screening tests in select hospitals in Saudi Arabia…
- Trial name
- NCT06685471
- Testing
- Screeing test
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Abeer Abd Elwahed Almowafy
Jaundice, Neonatal
A mHealth Application as a Screening Tool for Neonatal Jaundice in Filipino Neonates
The purpose of the study is to test the reliability of the Picterus smartphone application in Filipino neonates. A descriptive cross-sectional study will be the method to understand the correlation of the modalities and to…
- Trial name
- NCT05616845
- Testing
- Picterus Jaundice Pro
- Where
- Philippines
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Picterus AS
Trisomy 21
Non-invasive Screening of Fetal Trisomy 21 by Digital PCR
In France, as in many countries of the world, trisomy 21 or Down syndrome (DS) is the subject of an antenatal screening based on a risk calculation (R) including the assay of biochemical markers in the maternal blood, and the…
- Trial name
- dPNI-T21 (NCT03687866)
- Testing
- non invasive prenatal testing
- Where
- France
- Volunteers
- 776 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Aneuploidy, Birth Defect
Use of Videos to Improve Patient Knowledge on Prenatal Genetics
This is a randomized controlled trial of a low income and low health literacy population of pregnant women from a diverse racial and ethnic background to assess the effectiveness of a pre-visit educational video on prenatal…
- Trial name
- VPE (NCT03816423)
- Testing
- video
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of South Florida