Clinical trials: Neoplasm, Uterine
HIV Infections, Cervix, Dysplasia
A Phase III Randomized Trial of Topical Vaginal Fluorouracil (5-Fluorouracil, 5-FU) Maintenance Therapy Versus Observation After Standard Treatment for High-Grade Cervical Dysplasia in HIV-Infected Women
To determine the efficacy and safety of intravaginal fluorouracil administered as prophylaxis in HIV-infected women who have received standard ablative therapy (surgery) for high-grade cervical dysplasia (pre-cancer of the…
- Trial name
- NCT00000758
- Testing
- Fluorouracil
- Where
- 21 sites in United States, Puerto Rico
- Volunteers
- 158 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Endometrial Neoplasms, Ovarian Neoplasms
Serum Biomarkers in Diagnosis and Predicting Prognosis of Ovarian Cancers
This study evaluates the usefulness of serum levels of trefoil factor 3 (TFF3), secreted frizzled related protein 4 (sFRP-4), reactive oxygen species modulator 1 (Romo1) and nuclear factor (NF)-κB as potential diagnostic and…
- Trial name
- NCT03112733
- Testing
- TFF3, SFRP4, Romo1, NFKB
- Where
- Turkey (Türkiye)
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Ilker Kahramanoglu
Cancer of Cervix
Para-Aortic Lymph Nodal Staging & Evaluation of Treatment Outcome by 18F FDG-PET in Advanced Cancer Cervix
18F-fluorodeoxyglucose Positron Emission Tomography (FDG-PET) Imaging has been extensively used in the evaluation of various malignancies and is rapidly being recognized as a mandatory investigations.
- Trial name
- NCT00193752
- Testing
- PET IMAGING
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Tata Memorial Hospital
Ovarian Cancer, Endometrial Cancer
Docetaxel and PTK787 in Metastatic Breast Cancer Patients and Gynecological Cancer Patients
The main purpose of this study is to see if the study drug, PTK787, is safe and to find the highest dose that can be given safely without causing serious side effects.
- Conditions
- Ovarian Cancer, Endometrial Cancer, Cervical Cancer, Fallopian Tube Cancer
- Trial name
- NCT00268918
- Testing
- Docetaxel, PTK787
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Dana-Farber Cancer Institute
Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma
Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer
This phase I trial is studying the side effects and best dose of cetuximab when given together with cisplatin and radiation therapy in treating patients with stage IB, stage II, stage III, or stage IVA cervical cancer.
- Conditions
- Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Small Cell Carcinoma, Cervical Squamous Cell Carcinoma
- Trial name
- NCT00104910
- Testing
- Internal Radiation Therapy, 3-Dimensional Conformal Radiation Therapy, Cetuximab
- Where
- 15 sites in United States
- Volunteers
- 64 people
- Sponsor
- Gynecologic Oncology Group
Cervical Cancer, Postoperative Pain
Laparoscopic vs Abdominal Radical Hysterectomy In Patients With Early Cervical Cancer
The purpose of this study is to determine whether laparoscopic radical hysterectomy for early cervical cancer will has decreased postoperative pain intensity compared to abdominal radical hysterectomy with similar postoperative…
- Trial name
- NCT01258413
- Testing
- Laparoscopic Radical Hysterectomy + pelvic lymphadenectomy, Abdominal radical hysterectomy
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Breast Cancer, Endometrial Cancer
S9630, Medroxyprogesterone in Treating Women With Breast Cancer
RATIONALE: It is not yet known whether medroxyprogesterone is effective in preventing endometrial disorder in patients with breast cancer who are taking tamoxifen.
- Trial name
- NCT00002920
- Testing
- medroxyprogesterone, tamoxifen citrate, adjuvant therapy
- Where
- 122 sites in United States
- Volunteers
- 313 people
- Sponsor
- SWOG Cancer Research Network
Cervical Cancer
Primary Care Providers' Views and Understanding of Current Recommended Guidelines for Cervical Cancer Screening
Significant developments have led to a dramatic change in recommendations for cervical cancer screening. The understanding that the Human Papilloma Virus (HPV) is the cause of nearly 100% of cervical cancer cases and the…
- Trial name
- NCT02265120
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms
Study of LY3537982 in Cancer Patients With a Specific Genetic Mutation (KRAS G12C)
The purpose of this study is to find out whether the study drug, LY3537982, is safe and effective in cancer patients who have a specific genetic mutation (KRAS G12C).
- Conditions
- Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms, Endometrial Neoplasms, Ovarian Neoplasms
- Trial name
- NCT04956640
- Testing
- LY3537982, Pembrolizumab, Cetuximab
- Where
- 49 sites in United States, Australia and 4 more
- Volunteers
- 540 people
- Sponsor
- Eli Lilly and Company
Contraception, Sexually Transmitted Infections
Connecting Healthy Women: Examining the Effect of an Intervention From the Effect of Being Reachable
The investigators propose to test a community-developed and targeted intervention that employs community health workers (CHWs) as aides to newly Medicaid-insured women.
- Conditions
- Contraception, Sexually Transmitted Infections, Cervical Cancer
- Trial name
- NCT02157168
- Testing
- Community health worker
- Where
- United States
- Volunteers
- 2,267 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Endometrial Cancer
A Prospective Study Comparing Three Injection Sites to Detect Sentinel Lymph Nodes in Endometrial Cancer
Uterine cancer is the most common gynecologic malignancy in developed countries. Adenocarcinoma of the endometrium is the most common histologic type of uterine cancer.
- Trial name
- SENNAN (NCT04577950)
- Testing
- Lymphatic drainage of endometrial cancer
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Corpus Uteri, Lung Cancer
Aerosolized Liposomal Camptothecin in Patients With Metastatic or Recurrent Cancer of the Endometrium or the Lung
To determine the concentration of 9-nitrocamptothecin (9NC) in the alveolar fluid over time. 1.2. To determine the arterial concentration of 9NC administered by inhalation in comparison to venous and urine concentrations. 1.3.
- Trial name
- NCT00277082
- Testing
- 9-NC in aerosol reservoir
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of New Mexico
Endometrial Cancer, Papillary Serous
Vaginal Cuff Brachytherapy Followed by Chemotherapy in Endometrial Cancer
The purpose of this study is to determine the feasibility of treatment in patients with high risk endometrial cancer treated by vaginal cuff brachytherapy followed by 3 cycles of dose dense paclitaxel and carboplatin chemotherapy.
- Conditions
- Endometrial Cancer, Papillary Serous, Clear Cell Endometrial Cancer
- Trial name
- NCT03189446
- Testing
- Vaginal Cuff Brachytherapy, Carboplatin, Paclitaxel
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Oklahoma
Endometrial Cancer, Cervical Cancer (Early Detection)
Remote Robotic Surgery for Gynecologic Cancer: A Safety and Effectiveness Study
This investigator-initiated, multicenter, single-blind, randomized controlled clinical study is designed to evaluate the safety and effectiveness of the MP2000 thoracoabdominal endoscopic surgical system (Shenzhen Jingfeng…
- Trial name
- RRS-GYN-RCT (NCT07896720)
- Testing
- MP2000 Thoracoabdominal Endoscopic Surgical System
- Volunteers
- 92 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Cervical Cancer Stage IIIB, Treatment Outcome
Feasibility Study Of A Telephonic Questionnaire For Follow-Up Of Locally Advanced Cervical Cancer Patients
Cross-sectional Feasibility study on all consecutive patients of locally advanced cancer of the cervix or vault treated entirely at Tata Memorial Centre with curative intent radiation or chemoradiation.
- Conditions
- Cervical Cancer Stage IIIB, Treatment Outcome, Follow up, QUESTIONNAIRE
- Trial name
- NCT03477240
- Volunteers
- 300 people
- Sponsor
- Tata Memorial Hospital
Human Papilloma Virus Related Carcinoma, Head and Neck Neoplasm
HARE-40: HPV Anti-CD40 RNA vaccinE
HARE-40 is a phase I/II vaccine dose escalation study with two different arms: Arm 1A will perform intrapatient dose escalation in patients with previously treated HPV16+ Head \& Neck Cancer using two dose cohorts to establish a…
- Conditions
- Human Papilloma Virus Related Carcinoma, Head and Neck Neoplasm, Cervical Neoplasm, Penile Neoplasms Malignant
- Trial name
- HARE-40 (NCT03418480)
- Testing
- BNT113
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Southampton
Cervical Cancer
Pembrolizumab Registry for Outcomes and Treatment Evaluation in Cervical Cancer
This is a nationwide, multicenter, registry-based prospective cohort study to assess real-world effectiveness of treatment with a pembrolizumab containing regimen in persistent, recurrent, or metastatic cervical cancer.
- Trial name
- PROTECx (NCT07645625)
- Testing
- Early discontinuation of Pembrolizumab with or without Bevacizumab
- Where
- 11 sites in Netherlands
- Volunteers
- 261 people
- Sponsor
- University Medical Center Groningen
Cervical Cancer
Effect of Compound Kushen Injection Combined With Pabolizumab in the Treatment of Cervical Adenocarcinoma
In the past few decades, the incidence of endocervical adenocarcinomas (ECAs) has been on the rise both in absolute numbers and overall proportion in cervical cancers.
- Trial name
- NCT05259540
- Testing
- compound kushen injection combined with pabolizumab
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Uterine Cervical Neoplasms, Endometrial Neoplasms
[F-18] Fluorothymidine PET/CT Imaging for Pelvic Cancers
[F-18] Fluorothymidine PET imaging will be used to create a radiation therapy treatment plan to avoid active bone marrow in the pelvis. This will be done to evaluate if sparing bone marrow will help maintain blood counts.
- Conditions
- Uterine Cervical Neoplasms, Endometrial Neoplasms, Anus Neoplasms, Rectal Neoplasms
- Trial name
- NCT01717391
- Testing
- fluorothymidine F 18
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- John M. Buatti
Cervical Cancer
Safety and Immunogenicity Study of Human Papilloma Virus Vaccine in Women Aged 9 to 30 and Men Aged 9 to 17
This study evaluates the safety of Tetravalent recombinant human papilloma virus vaccine (6,11,16,18 type) (Hansenula polymorpha) in women of 9 to 30 years old and men of 9 to 17 years old and preliminarily explore the…
- Trial name
- NCT02888418
- Testing
- Tetravalent recombinant human papilloma virus vaccine (6,11,16,18 type) (Hansenula polymorpha)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Beijing Chaoyang District Centre for Disease Control and Prevention
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