Clinical trials: Nerve Condition
Adult Patients With Stage IIB, IIC, and Stage III Melanoma Following Complete Resection (Adjuvant Settings)
Pharmacokinetics, Safety, and Immunogenicity of Bmab1800 and Keytruda® as Adjuvant Monotherapy in Patients With Melanoma
The purpose of the study is to evaluate the pharmacokinetic (PK) equivalence of Bmab1800 as compared with reference product Keytruda® in a randomized, double-blind, two-arm, parallel comparative, multi-center study in patients…
- Trial name
- NCT07581509
- Testing
- Bmab1800, US-Licensed Keytruda
- Where
- Brazil
- Volunteers
- 138 people
- Sponsor
- Biocon Biologics UK PLC
HIV Infections, Peripheral Nervous System Diseases
Acetyl-L-Carnitine for the Treatment of NRTI-Associated Peripheral Neuropathy
The purpose of this study is to determine if acetyl-L-carnitine (ALC) reduces pain, numbness, and tingling in the feet and legs of patients with nucleoside reverse transcriptase inhibitor (NRTI)-associated peripheral neuropathy.
- Trial name
- NCT00050271
- Testing
- Acetyl-L-carnitine
- Where
- 11 sites in United States, Puerto Rico
- Volunteers
- 27 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Melanoma (Skin), Metastatic Cancer
S9903: Whole Brain Radiotherapy Followed By Stereotactic Radiosurgery for Limited Malignant Melanoma Brain Metastases
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Stereotactic radiosurgery may kill more tumor cells.
- Trial name
- NCT00003911
- Testing
- stereotactic radiosurgery
- Where
- 86 sites in United States
- Volunteers
- 2 people
- Sponsor
- SWOG Cancer Research Network
Postoperative Pain, Postoperative Nausea and Vomiting (PONV)
Transauricular Vagus Nerve Stimulation Frequencies for Postoperative Pain
The goal of this clinical trial is to learn whether different frequencies of transauricular vagus nerve stimulation (tVNS) can reduce postoperative pain and opioid consumption in adults undergoing abdominal or urologic surgery.
- Conditions
- Postoperative Pain, Postoperative Nausea and Vomiting (PONV), Opioid Consumption, Postoperative
- Trial name
- TVNS-PAIN (NCT07633444)
- Testing
- Transauricular Vagus Nerve Stimulation (tVNS)
- Where
- Brazil
- Volunteers
- 174 people
- Sponsor
- Federal University of Bahia
Malignant Melanoma
UV1 Vaccination Plus Nivolumab and Ipilimumab in Treatment of Melanoma
This is a randomized, open label study to investigate efficacy and safety of UV1 vaccination in combination with nivolumab and ipilimumab as first line treatment of adult patients with histologically confirmed unresectable…
- Trial name
- NCT04382664
- Testing
- UV1, Sargramostim, Ipilimumab
- Where
- 37 sites in United States, Belgium and 2 more
- Volunteers
- 156 people
- Sponsor
- Ultimovacs ASA
Recurrent Central Nervous System Neoplasm
Vaccine Therapy in Treating Patients Undergoing Surgery for Recurrent Glioblastoma Multiforme
RATIONALE: Vaccines made from a person's tumor cells and dendritic cells may help the body build an effective immune response to kill tumor cells.
- Trial name
- NCT00890032
- Testing
- BTSC mRNA-loaded DCs
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- John Sampson
Gonarthrosis; Primary
Efficacy of Ultrasound-Guided Genicular Nerve Block in Patients With Gonarthrosis: A Randomized, Placebo-Controlled, Double-Blind Study
This study planned to enroll a minimum of 30 patients aged 50 years and older, with a diagnosis of gonarthrosis classified as stage 2 or higher according to the Kellgren-Lawrence grading system, and who report complaints of knee…
- Trial name
- NCT07326098
- Testing
- genicular nerve block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ege University
Post Operative Pain, Chronic
Pericapsular Nerve Group Block Versus Lumber Erector Spinae Plane Block for Pain Management After Total Hip Arthroplasty
Pain is a major problem that has to be dealt with in case of hip fracture, as it presents an obstacle for examination, positioning for receiving neuroaxial anesthesia and postoperative mobility and physiotherapy.
- Trial name
- NCT05050487
- Testing
- PENG block, lumbar erector spinae plane block
- Volunteers
- 60 people
- Sponsor
- Assiut University
Tennis Elbow Syndrome, Golfer's Elbow
Effects of Peripheral Repetitive Peripheral Magnetic Stimulation on Individuals With Elbow or Wrist Chronic Pain
This pilot, randomized, sham-controlled, single-blind study will evaluate the effectiveness of repetitive peripheral magnetic stimulation (rPMS) in reducing pain in adults with tennis/golfer's elbow or carpal tunnel syndrome.
- Conditions
- Tennis Elbow Syndrome, Golfer's Elbow, Carpal Tunnel Syndrome (CTS)
- Trial name
- rPMS (NCT07544914)
- Testing
- Two days Active rPMS
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Glioblastoma Multiforme
NanoTherm In Adjuvant Therapy of Glioblastoma Multiforme
Glioblastoma multiforme (GBM), the most common and malignant primary brain tumor in adults is classified as a World Health Organisation (WHO) grade 4. Surgical removal of the tumor is the primary method of treatment.
- Trial name
- ANCHIALE (NCT06271421)
- Testing
- NanoTherm therapy, Glioma Resection, radiotherapy according to Stupp protocol
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Poznan University of Medical Sciences
Neurofibromatosis 1, Neurofibroma, Plexiform
Medication Adherence in Children, Adolescents and Adults With Neurofibromatosis Type 1(NF1) on Clinical Treatment Trials
Background: Neurofibromatosis type 1 (NF1) is a genetic disorder. It has a broad variety of effects on the body. Up to half of people with NF1 get plexiform neurofibromas (PNs). These are benign tumors.
- Trial name
- NCT03531814
- Testing
- Medication Event Monitoring System (MEMS^TM), Questionnaires
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Melanoma
Post-Approval Study of MelaFind
The purpose of this study is to collect data to describe the real-world use and safety and effectiveness of MelaFind® in a post-approval clinical setting.
- Trial name
- NCT01700114
- Testing
- MelaFind
- Where
- 6 sites in United States
- Volunteers
- 487 people, healthy volunteers welcome
- Sponsor
- MELA Sciences, Inc.
Melanoma
A Phase I Trial of Vemurafenib and Hydroxychloroquine in Patients With Advanced BRAF Mutant Melanoma
This is a Phase I study combining vemurafenib and hydroxychloroquine in the treatment of BRAF V600E+ metastatic melanoma.
- Trial name
- NCT01897116
- Testing
- Hydroxychloroquine (HCQ), Vemurafenib (VEM)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Melanoma
MySmartSkin Online Skin Self-exam Intervention for Melanoma Survivors
This project, mySmartSkin (MSS), includes an innovative Type 1 hybrid effectiveness-implementation trial designed to enhance the effects of MSS and simultaneously assess key implementation outcomes (e.g., cost, adoption) as well…
- Trial name
- NCT05373823
- Testing
- MySmartSkin enhancement, Educational webpage on Skin Self-Examination, Assess implementation outcomes
- Where
- United States
- Volunteers
- 385 people
- Sponsor
- Rutgers, The State University of New Jersey
Nausea, Emesis
Post- Surgery Recovery: Nerve Blocks w/ Sedation vs. Nerve Block w/ Either Sedation/Gen. Anesthesia
Nausea after surgery may negatively influence patient satisfaction, may delay discharge, and cause unexpected hospital admissions.
- Trial name
- NCT02602080
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Hospital for Special Surgery, New York
Multiple Sclerosis, Radiologically Isolated Syndrome
Clinical Impact Through AI-assisted MS Care - A Prospective Multi-center Study
The goal of the PROCLAIM study is to assess the effectiveness of quantitative brain MRI, as measured by icobrain mr, on the detection of disease activity in multiple sclerosis, including the identification of smouldering disease…
- Conditions
- Multiple Sclerosis, Radiologically Isolated Syndrome, Clinically Isolated Syndrome
- Trial name
- PROCLAIM (NCT07032246)
- Testing
- quantitative brain MRI (icobrain mr), Standard of Care (SOC)
- Where
- 6 sites in Czechia, Germany and 1 more
- Volunteers
- 750 people
- Sponsor
- icometrix
Carpal Tunnel Syndrome
The Effect of Perineural Injection Therapy in Patients With Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy with involving compression of the median nerve in the carpal tunnel.
- Trial name
- NCT02809261
- Testing
- Ultrasound-guided perineural injection with 5% dextrose, Ultrasound-guided perineural injection with normal saline, Normal Saline
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Pain
Parasternal Nerve Block Using Bupivacaine for Postoperative Analgesia in Children Undergoing Cardiac Surgery
All pediatric patients who undergo cardiac surgery require analgesic medications for postoperative pain control and many require sedation to facilitate comfort with cares.
- Trial name
- NCT02512861
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Melanoma, Metastatic Melanoma
Trial of Vemurafenib/Cobimetinib With or Without Bevacizumab in Patients With Stage IV BRAFV600 Mutant Melanoma
This phase 2 clinical trial randomizes patients with BRAF mutant melanoma to either (1) standard of care (SOC) - BRAF inhibitor vemurafenib in combination with MEK inhibitor cobimetinib; or, (2) SOC plus bevacizumab, an anti-VEGF…
- Trial name
- NCT01495988
- Testing
- Vemurafenib, Bevacizumab, Cobimetinib
- Where
- 14 sites in United States
- Volunteers
- 10 people
- Sponsor
- Melanoma Research Foundation Breakthrough Consortium
Peripheral Artery Disease
Effect of Transcutaneous Electrical Nerve Stimulation in Peripheral Artery Disease TENS-PAD Study / TENS-AOMI
Purpose: The investigators team recently carried out a proof of concept study testing the efficacy of one single 45-minute session of 10 Hz TENS prior to walking, versus placebo.
- Trial name
- TENS-PAD (NCT02678403)
- Testing
- Transcutaneous electrical nerve stimulation (TENS)
- Where
- 4 sites in France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Toulouse
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