Clinical trials: Nerve Transfers
Brachial Plexus Injury
Exercise Training for Brachial Plexus Injury Following Nerve Transfer
Although peripheral nerve is capable of regrowth following injury, at only 1 mm/day, the slow rate represents a major barrier. Apart from rapid deterioration of the environment supportive of growth, denervated muscles become…
- Trial name
- NCT05859178
- Testing
- Exercise group
- Where
- Canada
- Sponsor
- University of Alberta
Tetraplegia, Plegia
Nerve Transfer Reconstruction in the Tetraplegic Upper Extremity
The cervical spine is most commonly injured, accounting for 53.4% of spinal injuries. More than 40% of all spinal injuries occur at either C4, C5 or C6 levels leading to variable loss of function in the upper extremities.
- Conditions
- Tetraplegia, Plegia, Paresis, Cervical Spinal Cord Injury
- Trial name
- NCT01579604
- Testing
- Nerve reconstruction
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of British Columbia
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8
Neurotization of the Nipple Areolar Complex to Restore Sensation for Patients With Breast Cancer Undergoing Nipple Sparing Mastectomy and Reconstruction
This phase II trial tests the willingness of patients undergoing nipple sparing mastectomy (NSM) to enroll in a randomized study of NSM with or without neurotization of the nipple areolar complex (NAC).
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8
- Trial name
- NCT06153836
- Testing
- Neurotization Procedure, Questionnaire Administration, Subcutaneous Mastectomy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mayo Clinic
Cervical Spinal Cord Injury, Cervical Spinal Cord Paralysis
Nerve Transfers Plus Electrical Stimulation to Improve Hand Function in Cervical Spinal Cord Injury
The goal of this prospective observational study is to determine whether brief intraoperative electrical stimulation and temporary postoperative electrical stimulation improve motor and/or pain outcomes for patients with cervical…
- Conditions
- Cervical Spinal Cord Injury, Cervical Spinal Cord Paralysis, Tetraplegia, Tetraplegia/Tetraparesis
- Trial name
- NCT06541041
- Testing
- Brief intraoperative electrical stimulation, Temporary Postoperative Peripheral Nerve Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Breast Reconstruction After Mastectomy, Neurotization
Longitudinal Evaluation of Direct Neurotization Technique in Breast Reconstruction With Fully Autologous Components
This clinical trial aims to evaluate whether direct neurotization using fully autologous components during autologous breast reconstruction improves postoperative breast sensation and sensory-related quality of life in women…
- Conditions
- Breast Reconstruction After Mastectomy, Neurotization, Mastectomy and Breast Reconstruction, Peripheral Nerve Regeneration
- Trial name
- NCT07308275
- Testing
- Autologous Breast Reconstruction With Direct Neurotization, Autologous Breast Reconstruction without Neurotization
- Where
- Indonesia
- Volunteers
- 28 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Spinal Cord Injury, Spinal Cord Injury at C5-C7 Level
Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury
The goal of this prospective, open-label cohort study is to assess functional outcomes in individuals with cervical spinal cord injury who have undergone nerve transfer surgery to restore upper limb function.
- Conditions
- Spinal Cord Injury, Spinal Cord Injury at C5-C7 Level, SCI - Spinal Cord Injury, Upper Extremity Paralysis
- Trial name
- NCT05638191
- Testing
- Nerve transfer surgery
- Where
- 4 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Facial Paresis
Reinnervation of Facial Muscles After Lengthening Temporalis Myoplasty
The purpose of this study is to determine the physiology of nerve healing and the neurotization of the facial muscles after lengthening temporalis myoplasty.
- Trial name
- FacialReinn (NCT01833221)
- Testing
- injection of 1% lidocaine, 2mL for facial nerve block
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Caen
Neurotrophic Keratitis
Corneal Neurotization vs. Cenergermin for Neurotrophic Keratitis: A Pilot Study
This pilot study evaluates the feasibility and outcomes of two treatment approaches for corneal sensory dysfunction due to neurotrophic keratitis (NK): corneal neurotization surgery and topical Cenergermin (Oxervate).
- Trial name
- NCT07073729
- Testing
- Corneal Neurotization, Cenergermin
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Peripheral Nerve Injuries
Registry of Avance® Nerve Graft's Utilization and Recovery Outcomes Post Peripheral Nerve Reconstruction
This study is a registry of general use of Avance Nerve Graft and is intended to evaluate the uses, response rates, and safety of Avance Nerve Graft in the real-life clinical setting.
- Trial name
- RANGER® (NCT01526681)
- Testing
- Processed Human Nerve Graft, Standard Treatment, Autogenous Nerve Graft, Direct Suture, etc., Autogenous Nerve Graft
- Where
- 49 sites in United States, Austria and 2 more
- Volunteers
- 3,126 people
- Sponsor
- Axogen Corporation
Sensory Restoration of the Reconstructed Finger Pulps, Cold Intolerance of the Reconstructed Finger
Nerve Transfer for Finger Sensory Reconstruction With Dorsal Branch of the Digital Nerve
A proper digital nerve (PDN) defect causes partial or complete sensory loss of the finger pulp, which results in functional disability.The dorsal branch of the PDN can be transferred for reconstruction of such nerve defects.In…
- Conditions
- Sensory Restoration of the Reconstructed Finger Pulps, Cold Intolerance of the Reconstructed Finger, Pain of the Reconstructed Finger
- Trial name
- NCT01559337
- Testing
- Nerve transfer
- Where
- China
- Volunteers
- 17 people
- Sponsor
- The Second Hospital of Tangshan
Median Nerve Injury
Effects of Robotic Glove Hand Training in Patients After Median Nerve Transfer
Selective nerve transfers provide an opportunity for restoring the motor function after nerve injuries. Upper-limb robot-assisted therapy has been established as a safe and feasible treatment to complement rehabilitation after…
- Trial name
- NCT06459908
- Testing
- Robot Glove Hand Training, Conventional Hand Rehabilitation Exercises
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Riphah International University
Cervical Spinal Cord Injury, Tetraplegia
Nerve Transfer to Improve Function in High Level Tetraplegia
The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury.
- Trial name
- NCT06288763
- Where
- 10 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Nerve Injury, Surgery
AIN Transfer for Cubital Tunnel Syndrome
Ulnar nerve compressive injury due to cubital tunnel syndrome is very common. Because of the long distance to the target muscles in the hand, functional outcome in severe cases even with decompression surgery is often poor.
- Trial name
- NCT05242302
- Testing
- nerve transfer
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- University of Alberta
Tetraplegia, Spinal Cord Injuries
Nerve Transfer After Spinal Cord Injury- Multi-center
Current treatment strategies of acute cervical spinal cord injuries remain limited. Treatment options that provide meaningful improvements in patient quality of like and long-term functional independence will provide a…
- Conditions
- Tetraplegia, Spinal Cord Injuries, Quadriplegia Flaccid
- Trial name
- NCT04023591
- Testing
- Surgery/Occupational Therapy
- Where
- 9 sites in United States, Canada
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Cervical Spinal Cord Injury, Spinal Cord Injuries
Restoring Hand Function Utilizing Nerve Transfers in Persons With Cervical Spinal Cord Injuries
The primary objective of this study is to evaluate the safety and efficacy of nerve transfer surgery for restoring hand function as a therapy for patients with cervical spinal cord injury.
- Conditions
- Cervical Spinal Cord Injury, Spinal Cord Injuries, Traumatic Spinal Cord Compression
- Trial name
- NCT03451474
- Testing
- Upper extremity nerve transfer surgery
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The University of Texas Health Science Center, Houston
Injury of Mental Nerve of One Side
Evaluation Of Cross Mental Nerve Transfer In Restoration Of Chin &Lip Sensation Post Inferior Alveolar Nerve Injury
Evaluation Of Cross Mental Nerve Transfer In Restoration Of Chin \&Lip Sensation Post Inferior Alveolar Nerve Injury
- Trial name
- NCT04218474
- Testing
- Evaluation Of Cross Mental Nerve Transfer In Restoration Of Chin &Lip Sensation Post Inferior Alveolar Nerve Injury
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ahmed Mohamed Basem
Mastectomy, Breast Reconstruction
Sensation After Nipple Sparing Mastectomy and Breast Reconstruction With or Without Neurotized Free Tissue Transfer
Tissue Expander/Implant Reconstruction: The purpose of this study is to determine how and when nerve sensation to the breast skin returns after mastectomy.
- Trial name
- NCT03135392
- Testing
- Breast Reconstruction with Artificial Implant, Autologous Breast Reconstruction, Neurotization
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Cubital Tunnel Syndrome, Ulnar Nerve Compression
Randomized Trial of Supercharged End-to-Side Anterior Interosseous Nerve Transfer for Severe Cubital Tunnel Syndrome
Functional motor recovery distal to a peripheral nerve lesion is predicated upon time to reinnervation of the motor end plate and the number of regenerate axons that reach the target.
- Conditions
- Cubital Tunnel Syndrome, Ulnar Nerve Compression, Ulnar Nerve Palsy, Ulnar Nerve Entrapment
- Trial name
- NCT04647058
- Testing
- Cubital tunnel release, Supercharged end-to-side (SETS) nerve transfer
- Where
- 2 sites in United States
- Sponsor
- Brigham and Women's Hospital
Neurotrophic Keratitis
Miniinvasive Corneal Neurotization. A Pilot Study.
Neurotrophic keratitis (NK) is a degenerative disease of the cornea due to the impairment of the nasociliary branch of the ophthalmic nerve.
- Trial name
- MICORNE (NCT03037450)
- Testing
- Miniinvasive corneal neurotization
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Strasbourg, France
Breast Cancer, Breast Reconstruction
Sensory Restoration After DIEP Flap Neurotization
Common goals of breast reconstruction include obtaining satisfactory breast symmetry, softness, and appropriate size and shape. Advances in surgical techniques have prompted a new goal: achieving breast sensation after…
- Conditions
- Breast Cancer, Breast Reconstruction, Sensory Restoration
- Trial name
- NCT04533373
- Testing
- DIEP Flap Neurotization
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Johns Hopkins University