Clinical trials: Nervous System Disorders
Acid Sphingomyelinase Deficiency, Ceroid Lipofuscinosis, Neuronal, 2
ScreenPlus: A Comprehensive, Flexible, Multi-disorder Newborn Screening Program
ScreenPlus is a consented, multi-disorder pilot newborn screening program implemented in conjunction with the New York State Newborn Screening Program that provides families the option to have their newborn(s) screened for a…
- Conditions
- Acid Sphingomyelinase Deficiency, Ceroid Lipofuscinosis, Neuronal, 2, Cerebrotendinous Xanthomatosis, Fabry Disease
- Trial name
- ScreenPlus (NCT05368038)
- Testing
- Confirmatory Testing
- Where
- 9 sites in United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Aspiration, Respiratory, Pain
Determining The Effects Of Nasopharyngeal Suction
Objective: The aim of the study is to determine the effects of nasopharyngeal suction with negative and positive pressure on the pain level, respiratory parameters, and mucosal irritation in infants.
- Conditions
- Aspiration, Respiratory, Pain, Mucosal Irritation, Infant
- Trial name
- NCT06020638
- Testing
- Experimental group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fenerbahce University
Acute Ischemic Stroke
PROMISE: PRedictors Of Good outcoMes in Thrombectomy for Large Infarct Core Stroke Evaluation
Identify the factors associated with a favorable clinical outcome in participants with acute ischemic stroke and large core infarcts within 24 hours of onset who are treated with endovascular intervention.
- Trial name
- NCT06016348
- Testing
- Endovascular treatment
- Where
- 4 sites in Vietnam
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- 115 People's Hospital
Age-related Hearing Loss, Cognitive Decline
Auditory-Cognitive Dual-Task Intervention for Older Adults With Hearing Loss
Background: Age-related hearing loss (ARHL) is a common and irreversible condition that has been recently associated with cognitive decline and dementia. Hence, if ARHL is treated earlier, the risk of dementia might decrease.
- Conditions
- Age-related Hearing Loss, Cognitive Decline, Loneliness, Social Isolation
- Trial name
- NCT06486285
- Testing
- Auditory-cognitive dual-task training (ACDT)
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Parkinson Disease, Freezing of Gait
Motor Adaptation to Split-Belt Treadmill in Parkinson's Disease
Freezing of Gait (FOG) is a disabling symptom common in advanced Parkinson's Disease. FOG is an independent contributor to fall risk and is only partially relieved by medication.
- Trial name
- NCT03725215
- Testing
- Split-Belt Treadmill Training
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Insomnia
Eszopiclone Co-Administered With Escitalopram for Insomnia in Elderly Adults With Major Depressive Disorder
Research has established the incidence of insomnia increases with age and the possible causes contributing to sleep problems in the elderly are still being explored and debated.
- Trial name
- NCT00813735
- Testing
- Eszopiclone, Escitalopram
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lehigh Center for Clinical Research
Meningococcal Infections
Immunogenicity and Safety of a Booster Dose of a Quadrivalent Meningococcal Conjugate Vaccine in Children
This was an open-label, multi-center study to describe the immune persistence of the priming dose and describe the immunogenicity and safety of a booster dose of Meningococcal Polysaccharide (Serogroups A, C, Y, and W) Tetanus…
- Trial name
- NCT03476135
- Testing
- MenACYW conjugate vaccine
- Where
- 8 sites in Finland
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Japanese Encephalitis
This is a Study to Assess the Safety and Immunogenicity of Ixiaro® (IC51) in an Elderly Population
This is an open-label, uncontrolled phase 4 study to assess the safety and immunogenicity of the Japanese encephalitis (JE) vaccine Ixiaro® (IC51) in an elderly population.
- Trial name
- NCT01158599
- Testing
- IXIARO®
- Where
- 5 sites in Austria, Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Valneva Austria GmbH
Dementia, Caregiver
Artificial Intelligence + Care Coach Intervention
The purpose of this research study is to develop and test an artificial intelligence intervention for emergency department (ED) discharge care transitions experienced by caregivers of older adults with cognitive impairment.
- Conditions
- Dementia, Caregiver, Emergency Department, Artificial Intelligence
- Trial name
- NCT05352399
- Testing
- NeuViCare application
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
Epilepsy, Anxiety
Phenotypic Exploration During Sensory Stimulation in an Acoustic Chamber
An observational behavioural and neurophysiological study of the effects of controlled sensory stimulation (such as music, for example) on brain function
- Conditions
- Epilepsy, Anxiety, Depression Anxiety Disorder
- Trial name
- EMO-INTRA (NCT07544563)
- Where
- France
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Aged 60 Years or Older, Volunteering to Participate in the Study
The Effect of Health Belief Model-Based Education on Knowledge and Behavioral Changes Regarding Dementia in Older Adults
While age is one of the strongest known risk factors for the onset of dementia, dementia is not an inevitable consequence of aging.
- Conditions
- Aged 60 Years or Older, Volunteering to Participate in the Study, Dementia Education, Prevention Intervention
- Trial name
- NCT07505693
- Testing
- 1. Introduction Session: Increasing Perceived Sensitivity, Session 2: Increasing the Perception of Seriousness/Importance, Session 3: Increasing the Perception of Benefit
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
MCI, Dementia
Validation of the Montreal Cognitive Assessment (MoCA) Version 8.x and MoCA-MIS in Greece.
Objective: The purpose of this study is to assess the psychometric qualities of the Montreal Cognitive Assessment (MoCA) version 8.x in Greek, including the MoCA-MIS.
- Conditions
- MCI, Dementia, Mild Cognitive Impairment (MCI)
- Trial name
- NCT07297121
- Where
- Greece
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Problem Behavior, Developmental Delay
Problem Behavior Assessment and Intervention in IDEA Part C Services
The purpose of this study is to evaluate the effect of function-based assessment and intervention to reduce problem behavior in children with developmental disability or delay in the context of IDEA Part C services.
- Conditions
- Problem Behavior, Developmental Delay, Developmental Disability
- Trial name
- NCT06771284
- Testing
- Function-based assessment and intervention
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Voice Disorders, Muscle Tension Dysphonia
A Study to Evaluate Effects of Gargle Phonation in Voice
The purpose of this study is to assess subjects with muscle tension dysphonia for perceived effort and acoustic effects of gargle phonation compared to baseline and a sham water swallow.
- Conditions
- Voice Disorders, Muscle Tension Dysphonia, Speech Therapy
- Trial name
- NCT04766658
- Testing
- Gargle Phonation, Water swallow
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Postpartum
Effect of Different Foot Baths on Postpartum Insomnia and Fatigue
The goal of this clinical trial is to assess if different footbaths works to decrease postpartum fatigue and insomnia. The main questions are: Does peppermint oil footbaths decrease fatigue and insomnia in postpartum period? Does…
- Trial name
- NCT07060755
- Testing
- Peppermint oil footbath, Warm Water Footbath
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Cerebral Palsy, Growth
Predictive Models of Weight and Height for the Evaluation of the Growth of Children and Adolescents With Cerebral Palsy
Cerebral palsy (CP) is the most frequent disability in children. The vast majority of these patients are malnourished. In this population, there are practical difficulties to perform a nutritional and growth assessment which…
- Conditions
- Cerebral Palsy, Growth, Child
- Trial name
- NCT03303755
- Where
- Argentina
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
REM Sleep Behavior Disorder
Gut Microbiota Across Early Stages of Synucleinopathy: From High-risk Relatives, REM Sleep Behavior Disorder to Early Parkinson's Disease
With the global ageing population, neurodegenerative disorders including synucleinopathy are major burdens to patients, carers and society.
- Trial name
- NCT03645226
- Testing
- Colonoscopy
- Where
- 2 sites in Hong Kong
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Sleep Apnea, Obstructive
Effect of Adenotonsillectomy on Quality of Life in Children With Mild Obstructive Sleep Apnea
In children, enlarged adenoids and/or tonsils are the most common cause of obstructive sleep apnea (OSA), which is temporary blockage of breathing during sleep.
- Trial name
- NCT01539278
- Testing
- Adenotonsillectomy, Observation alone / no intervention
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
Obstructive Sleep Apnea
Evaluation of Prefabricated Adjustable Thermoplastic Mandibular Advancement Devices for Obstructive Sleep Apnoea
Use of mandibular advancement devices(MADs) in the treatment of Obstructive Sleep Apnea is established, however this is hampered by high costs, long wait times and non-assured success in the local Asian setting.
- Trial name
- NCT04124978
- Testing
- mandibular advancement device
- Where
- Singapore
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Back Pain
Cytology Study of Cells From Patients With Low Back Pain
The investigators are doing this study to learn more about the cause of back pain with or without pain shooting down one or both legs.
- Trial name
- NCT01089478
- Volunteers
- 605 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
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