Clinical trials: Neuralgia Peripheral
Piriformis Syndrome
Comparative Effects of PIR and PFS on Pain, Hip ROM, and Disability in Piriformis Syndrome
This randomized clinical trial evaluates the effectiveness of Post-Isometric Relaxation (PIR) and Post-Facilitation Stretching (PFS) for managing pain, improving hip abduction and internal rotation, and enhancing functional…
- Trial name
- PIR-PFS RCT (NCT07255053)
- Testing
- Post Isometric Relaxation (PIR), Post Facilitation Stretching (PFS)
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Faisalabad
Neuropathic Pain
Safety, Tolerability and Pharmacokinetics of Single Ascending Doses of REL-1017 (d-Methadone)
This study evaluated the safety, tolerance, and pharmacokinetics (PK) of d-methadone in a limited dose range, in single administrations in humans.
- Trial name
- NCT03637361
- Testing
- REL-1017
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Relmada Therapeutics, Inc.
Chronic Pain, Pain, Chronic
Investigating Biological Targets, Markers, and Intervention for Chronic Pain
This multi-modal methods study will investigate neurophysiological, endocrinological, cognitive, psycho-social-emotional markers of chronic pain, and therapeutic targets using integrative health treatments.
- Conditions
- Chronic Pain, Pain, Chronic, Pain Syndrome, Pain, Neuropathic
- Trial name
- NCT04625504
- Testing
- Mindfulness Based Intervention
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Neuropathy;Peripheral
Depolarising Electrical Skin Stimulation in Neuropathic and Postoperative Pain
The aim of the study is to evaluate voltage gated sodium channel (NaV1.7) dependent pain phenomena in neuropathic pain and chronic postoperative pain.
- Trial name
- NCT03037684
- Testing
- neurophysiology
- Where
- Switzerland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Neuropathic Pain
Focused Ultrasound for the Treatment of Neuropathic Pain
A possible treatment approach for neuropathic pain would employ a process designed to promote healthier function of the ventral posteromedial (VPM) and ventral posterolateral (VPL) thalamic nuclei.
- Trial name
- NCT04485208
- Testing
- Focused Ultrasound
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Neurological Associates of West Los Angeles
Therapy, Acupuncture, MRI, Functional
Acupuncture Treatment for Chronic Sciatica: the Neuroimaging Pain-network Study
Sciatica is a common pain disorder in the neurological clinic that typically present as low back or gluteal pain and may radiate to one leg with motor or sensory complaint.
- Trial name
- NCT03489681
- Testing
- acupuncture
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Healthy
Bioequivalence Study of Two Formulations of Pregabalin CR (Controlled-release) Table 150 mg
The purpose of this clinical trial is to (1) evaluate the bioequivalence(BE) of GLA5PR GLARS-NF3 tablet 150mg administered regular diet relative to GLA5PR GLARS-NF1 tablet 150mg administered regular diet and (2) determine the…
- Trial name
- NCT02955472
- Testing
- GLA5PR GLARS-NF3 tablet 150mg, GLA5PR GLARS-NF1 tablet 150mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GL Pharm Tech Corporation
Neuropathic Pain
Measuring the Effects of Complementary Therapies in Chronic Neuropathic Pain
The objective of the study is to a) assess the presence of a maladaptive stress response, a decreased pain modulation and any cognitive impairment in patients with chronic neuropathic pain in comparison to healthy controls.
- Trial name
- NCT03783624
- Testing
- Hypnosis
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Chantal Berna
Pain, Neuropathic, Pain, Inflammatory
Phase I Single Ascending Dose and Multiple Ascending Doses of Oral AFA-281 in Healthy Volunteers
Phase I Part 1 (single ascending dose): Double-blind dosing will occur in healthy volunteers in 4 cohorts of 8 subjects each. Six subjects in each cohort will be randomized to receive AFA-281 and 2 subjects will be randomized to…
- Trial name
- NCT05547503
- Testing
- AFA-281
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Afasci Inc
Postherpetic Neuralgia
Ultrasound-Guided Thoracic Paravertebral Block With Steroid and Local Anesthetic for Acute Herpes Zoster: Effects on Pain Control and Prevention of Postherpetic Neuralgia
Background: Acute herpes zoster causes severe neuropathic pain and may progress to postherpetic neuralgia (PHN). This study aims to evaluate ultrasound-guided thoracic paravertebral block with local anesthetic and steroid in…
- Trial name
- NCT07349680
- Testing
- Valacyclovir + Paracetamol (Acetaminophen) + Gabapentin (standard medical therapy), Ultrasound-guided thoracic paravertebral block (TPVB) with bupivacaine 0.25% + methylprednisolone 40 mg
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Small-Fiber Neuropathy
Evaluation of Pregabalin in Idiopathic Small Fiber Neuropathy
Idiopathic Small Fiber Neuropathy (called SFN for short), is a condition where nerves that sense pain have become damaged, and often painful.
- Trial name
- NCT00787462
- Testing
- Pregabalin
- Where
- Canada
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Pain Management, Peripheral Neuropathic Pain
Wearable Focused Ultrasound Stimulation for Peripheral Nerve Pain Management
This study will evaluate the feasibility of a novel wearable focused ultrasound (FUS) device for peripheral nerve stimulation in healthy volunteers.
- Trial name
- PERNEUS (NCT07160049)
- Testing
- Cold Pressor Task - Upper Limb, Algometry Pain Tests in the Upper Limb, Algometry Pain Tests in the Lower Limb
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Evan (Huiliang) Wang
Neuropathic Pain
Comparison of Pain-Related Changes in Cerebral Blood Volume in Burn Patients With Neuropathic Pain
The investigators will observe increased or decreased CBV in patients with thermal injury compared with the CBV in healthy controls.
- Trial name
- NCT04125576
- Testing
- magnetic resonance imaging(MRI)
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hangang Sacred Heart Hospital
Neuropathic Pain
Pgp Transporter and CNS Biodistribution of Ondansetron in Healthy Volunteers
To determine the time-course of plasma and CSF concentrations of intravenous (IV) ondansetron in healthy subjects, with and without selective inhibition of Pgp efflux transporter.
- Trial name
- NCT03809234
- Testing
- Ondansetron 8mg with Saline & Tariquidar, Ondansetron 16mg with Saline & Tariquidar
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University
Migraines
A Study of LY2951742 in Healthy Volunteers
To evaluate the safety and tolerability of LY2951742 given as single or multiple subcutaneous injection in healthy male subjects
- Trial name
- NCT01337596
- Testing
- LY2951742
- Where
- Belgium
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Spinal Cord Injury, Neuropathic Pain
Virtual Walking for Neuropathic Pain in Spinal Cord Injury
Spinal cord injury neuropathic pain (SCI-NP) is a common problem, and when severe, is one of the most problematic of secondary conditions that is minimally to modestly responsive to currently available treatments.
- Trial name
- NCT01884662
- Testing
- Virtual walking, Wheeling tape
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy Volunteers, Patients Suffering of Peripheral Neuropathic Pain
Study of Integrity of Down Inhibitor Bundle at Patients Suffering of Neuropathic Pain
Several studies showed that activity of down inhibitor bundle is weakened in different painful pathologies as the fibromyalgy or the trigeminal nevralgy.
- Trial name
- PhyDoNe (NCT01053845)
- Testing
- Neuropathic pain
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Complex Regional Pain Syndromes, Healthy
Study of Proteins Associated With Complex Regional Pain Syndrome
This study will try to learn more about complex regional pain syndrome, or CRPS (previously known as reflex sympathetic dystrophy, spreading neuralgia, and sympathalgia), by examining the release of small proteins in the blood of…
- Trial name
- NCT00033969
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Sciatica
PET/MRI Imaging of Neuraxial Inflammation in Sciatica Patients
The purpose of this study is to see if the spine shows areas of inflammation using a specific type of imaging (pictures).
- Trial name
- NCT02130271
- Testing
- Radioactive dye, PET/MRI, Blood draw
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital