Clinical trials: Neurobiological
Suicidal Ideation, Suicide Attempt
Neural Correlates of Suicidal Behavior in Youth
This study, titled "Neural Correlates of Suicidal Behavior in Youth: a Pre and Post CAMS Therapy Neuroimaging Study," aims to better understand the brain mechanisms underlying suicidal thoughts and behaviors in adolescents and…
- Conditions
- Suicidal Ideation, Suicide Attempt, Suicidal Behavior, Depression / Major Depressive Disorder
- Trial name
- NCT07568054
- Testing
- CAMS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Depression, Anxiety Disorders
SKY Breath Intervention
Depression is highly debilitating and prevalent among adolescents. Adolescent-onset depression is associated with long, severe, and recurrent episodes that are often not responsive to treatment.
- Trial name
- NCT05388110
- Testing
- SKY Breath Intervention
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cannabis Use Disorder
Resistance Exercise and Cannabis Use
Cannabis is the most widely used illicit drug and rates of hazardous use, and cannabis use disorders (CUDs), have continued to rise in recent years.
- Trial name
- NCT03867786
- Testing
- Exercise, Video Control
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Penn State University
Analgesia
The Analgesic Effect of Auditory Inputs and Its Relation to Psychological and Neurobiological Mechanisms
The study investigates the analgesic effect of different auditory inputs. Employing a within-subject design, the study includes healthy participants that are exposed to thermal stimuli while listening to three different auditory…
- Trial name
- NCT03410563
- Testing
- Auditory inputs
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Long COVID
Neurobiological Underpinnings of Neuropsychological Consequences in Long COVID
Objectives: To describe the standardized evaluation of the psychological and cognitive function of long COVID patients and their evolution, to compare immunological and HPA-axis related biomarkers between long COVID patients and…
- Trial name
- Cov-N-Psy (NCT06279936)
- Testing
- Neuropsychological battery, Surveys and symptom severity questionnaires, Blood withdrawal
- Where
- Belgium
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Sexual Behavior, Hypoxia, Brain
Uncovering the Acute Neurobiological Significance of Emerging Sexual Behaviors
The purpose of this study is to examine the acute effect of being choked during partnered sex on neurological measures. The study is designed to identify the effects being choked during partnered sex on the brain through the use…
- Trial name
- NCT06602362
- Testing
- Partnered sex involving choking, Partnered sex not involving choking
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alcohol Abuse
Sex Differences in Risk for Alcohol Abuse
This study will determine the neural and hormonal mechanisms underlying sex differences in sensitivity to the disinhibiting effects of alcohol in heavy drinkers.
- Trial name
- NCT04543942
- Testing
- Alcohol, Saline
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mark Fillmore
Major Depressive Disorder (MDD), Rumination
Neurobiological Mechanisms of Pathological Rumination and Effects of Aripiprazole
This randomized, single-blind (assessor-blind) controlled trial aims to investigate the efficacy of aripiprazole as an augmentation strategy for treating pathological rumination in patients with major depressive disorder (MDD).
- Trial name
- NCT06937476
- Testing
- Escitalopram, Aripiprazole 5mg
- Where
- China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Central South University
Emotional Intelligence
Neurobiological Basis of Emotional Intelligence
Emotional Intelligence (EI) is defined as the ability to accurately perceive and identify emotions in oneself and others, understand and use emotions to enhance cognitive processes, and effectively manage one's own emotions as…
- Trial name
- EQ (NCT01721356)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Major Depressive Disorder, Healthy Participants
A Study of the Neurobiology of Depression
Previous research studies have shown that depression is associated with changes in structure and activity in different parts of the brain and that antidepressant medication can affect brain activity in different parts of the…
- Trial name
- NCT01051466
- Testing
- Duloxetine
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Schizophrenia
Neurobiological Effects of Oxytocin in Schizophrenia
22 male patients with schizophrenia and 22 male healthy volunteers will be included in the study. Subjects who meet the inclusion and exclusion criteria for the study will be recruited.
- Trial name
- NCT04177719
- Testing
- Oxytocin
- Where
- India
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
Basic Science
The Neurobiological Effect of 5-HT2AR Modulation
The investigators wish to investigate neurobiological effects of serotonin 2A receptor modulation in healthy volunteers, contrasting effects of an agonist (psilocybin) and an antagonist (ketanserin).
- Trial name
- NeuroPharm2 (NCT03289949)
- Testing
- Psilocybine, Ketanserin
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Gitte Moos Knudsen
Major Depressive Disorder
Stress Dynamics and Familial Risk for Depression in Female Adolescents
Stress and a parental history of major depressive disorder (MDD) are among the strongest risk factors for future development of MDD.
- Trial name
- NCT06816329
- Testing
- Computer Task Manipulation
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Aging, Anxiety
Neurobiological Mechanisms of Aging and Stress on Prospective Navigation
Two hallmarks of both healthy aging and age-related disease are 1) memory and navigational deficits, particularly in orienting towards goal locations and planning how to navigate to them, and 2) increased susceptibility to stress…
- Conditions
- Aging, Anxiety, Memory Impairment
- Trial name
- NCT03896529
- Testing
- Anticipatory psychological stress
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Post-Traumatic Stress Disorder
Neurobiological Correlates of Post Traumatic Stress Disorder (PTSD) During Rapid Eye Movement (REM) Sleep
The overarching aim of this Exploratory/Developmental Research Grant Award (R21) is to explore the neurobiological correlates of PTSD during REM sleep by using state-of-the science positron emission tomography (PET) sleep…
- Trial name
- REM-P (NCT00871650)
- Testing
- Sleep data recording, PET scan - waking, PET scan - REM Sleep
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Schizophrenia
Oxytocin and Social Decision Making in Schizophrenia
schizophrenia patients and healthy volunteers will be included. Subjects who meet the inclusion and exclusion criteria for the study will be recruited.
- Trial name
- NCT04176835
- Testing
- Oxytocin nasal spray
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
ADD, ADHD
Neurocognitive and Neurobiological Improvement in ADHD Children With High Protein Diet
Multicenter, Prospective, randomized, comparative and controlled study about the beneficial effects in behavior and brain connectivity of different dietary patterns in 100 children with ADHD between 7 and 12 years, followed up…
- Trial name
- BrainProtein (NCT02614599)
- Testing
- BP22042013, Low carbohydrate diet
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Spanish Foundation for Neurometrics Development
Drug Use
Neurobiological Substrate of Social Context on Cognitive Control in Drug Users
The aim of the present project is to reveal, using Functional Magnetic Resonance Imaging (fMRI) in drug users, a specific modulation of brain structures and circuits involved in cognitive control (and especially those of…
- Trial name
- STNdrugaddict (NCT03508362)
- Testing
- Functional Magnetic Resonance Imaging (fRMI)
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Adolescent With Early Life Stress, Resilience
Mindfulness for Resilience in Early Life
Early life stress (ELS) is associated with a number of psychiatric and medical conditions later in life, thought to be caused by subsequent disruptions in biological processes involved in regulation of stress responses.
- Trial name
- MindREaL (NCT03633903)
- Testing
- Mindfulness
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Chronic Widespread Pain, Stress, Psychological
Neurobiological Mechanisms of Stress in Youth With Chronic Widespread Pain
Chronic widespread pain (CWP) is a common chronic pain condition in youth and often associated with significant pain-related and psychosocial impairment.
- Conditions
- Chronic Widespread Pain, Stress, Psychological, Stress, Physiological
- Trial name
- NCT04488757
- Testing
- functional Magnetic Resonance Imaging (fMRI), Allostatic Load Composite
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital