Clinical trials: Neurological Condition
Frailty, Cognitive Impairment
Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic
This multicenter, prospective, non-interventional observational study (ORTOPODCZ) investigates the association between preoperative cognitive impairment and postoperative delirium (POD) in older adults undergoing elective total…
- Conditions
- Frailty, Cognitive Impairment, Older Adults, Hip Arthroplasty
- Trial name
- ORTOPODCZ (NCT07432009)
- Where
- 7 sites in Czechia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tomas Bata Hospital, Czech Republic
Fibromyalgia Syndrome, Fibromyalgia
Can a Relaxometer Improve Cognitive Impairment of Fibromyalgia Patients
The aim of the study is to evaluate the differences in cognitive performance and quality of life, after a cycle of treatment with the relaxometer, between a group of patients affected by fibromyalgia and a control group.
- Conditions
- Fibromyalgia Syndrome, Fibromyalgia, Pain, Chronic, Impairment
- Trial name
- Fibrorilax (NCT04170387)
- Testing
- Relaxometer
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
PRF
The Efficacy of A-PRF+ on Postoperative Outcomes Following Surgical Removal of Impacted Mandibular Third Molars (A-PRF+: Advanced Platelet Rich Fibrin)
Objectives: This study aims to evaluate the effects of A-PRF+ on postoperative pain, swelling, and trismus after surgical removal of impacted mandibular third molars.
- Trial name
- A-PRF+ (NCT05824793)
- Testing
- A-PRF+
- Where
- Vietnam
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Thermal Injury, Skin Burn
Gellan Contact Study
The primary objective of this study will be to establish the safety of the two different Gellan formulations (sheet and fluid gel) following its application to the epidermis of healthy volunteers.
- Trial name
- GCS (NCT04044014)
- Testing
- Gellan sheet, Gellan fluid gel, Mepitel One
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Color Blindness, Color Vision Defects
Impact of Color Correcting Lenses on Color Vision Deficiency
To demonstrate improved color vision in subjects with color vision deficiencies while wearing color-correcting lenses and after color-correcting lense use.
- Conditions
- Color Blindness, Color Vision Defects, Color Blindness, Green, Color Blindness, Red
- Trial name
- NCT05463016
- Testing
- Experimental Group 1: Color Correcting Lenses, Color Correcting Lenses in Subjects with Normal Color Vision
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of the Incarnate Word
Laryngeal Mask, Throat Pain
The Effect of Preoperative Chewing Gum on Anxiety and Sore Throat in Patients With Laryngeal Mask Airway
This study was planned to investigate the effect of chewing gum in the preoperative period on patients' sore throat and anxiety levels.
- Conditions
- Laryngeal Mask, Throat Pain, Anxiety
- Trial name
- NCT06168981
- Testing
- Chewing Gum
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University
Alzheimer Disease, Dementia, Mixed
Targeting Brain Physiology to Treat Neuropsychiatric Symptoms of Dementia Using TMS-EEG and tDCS
Agitation and aggression impose a tremendous burden on the individuals living with dementia, their families, caregivers, and healthcare systems.
- Conditions
- Alzheimer Disease, Dementia, Mixed, Dementia, Behavior Problem
- Trial name
- tTED (NCT03846492)
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Back Pain, Low
Pilates in Women With Chronic Low Back Pain
The purpose of this study is to evaluate the effect of a Pilates exercise program (PEP) on the flexo-relaxation ratio (FRR) of the erector spinae (ES) muscle during standing maximal trunk flexion/extension in women with chronic…
- Trial name
- NCT05264311
- Testing
- Pilates exercise program
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Postoperative Pain
Total Knee Replacement TIVA With Robotic Arm Assisted
Total knee replacement (TKR) is a commonly performed surgical procedure, and is associated with moderate to severe acute postoperative pain.
- Trial name
- NCT04002271
- Testing
- Propofol, Sevoflurane, Spinal anaesthesia
- Where
- 2 sites in Hong Kong
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Developmental Delay
Development and Effectiveness of Home-based Programs for Preschool Children With Developmental Delay
Early intervention refers to the provision of early detection, early diagnosis, and early intervention for infants and young children with special needs.
- Trial name
- NCT02115334
- Testing
- professional therapists delivering the PHPA, parents executing the PHPA, health education
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Pain Management, Fibromyalgia
Effects of Adding Motor Imagery Training to Exercise on Pain, Fibromyalgia Impact, and Kinesiophobia in Women With Fibromyalgia: a Randomized Controlled Trial
Aim: To evaluate the effects of adding motor imagery training to exercise on pain, fibromyalgia impact, and kinesiophobia in women with fibromyalgia, and compare imagery ability and kinesiophobia with healthy volunteers.
- Conditions
- Pain Management, Fibromyalgia, Imagery, Psychotherapy
- Trial name
- NCT07883434
- Testing
- Motor imagery
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ufuk University
Neuropathic Pain
Cortical Plasticity After Motor Cortex Stimulation in Healthy Subject and Chronic Pain Patients
The primary aim of this study is to evaluate the induction of sensory-motor cortex plasticity after motor cortex stimulation in healthy subjects, using laser-evoked nociceptive cortical potentials, and in chronic neuropathic pain…
- Trial name
- NCT02849834
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Aging
Effectiveness and Safety of STYLAGE® M LIDOCAINE Versus STYLAGE® M in Filling Nasolabial Folds
This clinical investigation is designed to compare the STYLAGE® M Lidocaïne to STYLAGE® M in terms of correction of nasolabial folds severity and pain felt by the subject, and to assess and compare the safety and effectiveness of…
- Trial name
- MLIDOM (NCT05087732)
- Testing
- STYLAGE® M Lidocaïne, STYLAGE® M
- Where
- France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Laboratoires Vivacy
Emergence Delirium, Anxiety Preoperative
Comparative Study Between Nebulised Dexmedetomidine and Nebulised Midazolam in Children Undergoing Lower Abdominal Surgeries
Comparative study between nebulised dexmedetomidine and nebulized midazolam in reducing preoperative anxiety and emergence delirium in children undergoing lower abdominal surgeries
- Trial name
- NCT05872087
- Testing
- Nebulised Dexmeditomidine, Nebulised Midazolam
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Muscle Protein Synthesis, Sarcopenia
The Impact of a Whole-food Animal-based Versus Plant-based Protein Rich Meal on Muscle Protein Synthesis
Rationale: Food intake stimulates muscle protein synthesis rates. The magnitude of the anabolic response to feeding forms a key factor in regulating muscle mass maintenance.
- Trial name
- MeaL (NCT05151887)
- Testing
- Muscle protein synthesis
- Where
- Netherlands
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Chronic Pain, Central Sensitisation
Childhood Adversity, Inflammatory Reactivity and Persistent Pain
The goal of this observational study is to investigate how adverse experiences during childhood are linked to people experiencing persistent pain and fatigue in adulthood. The questions the investigators aim to answer are: 1.
- Conditions
- Chronic Pain, Central Sensitisation, Immune Response, Adverse Childhood Experiences
- Trial name
- CAIR (NCT06127693)
- Testing
- Tetravalent Influenza Vaccine, High-frequency electrical stimulation
- Where
- South Africa
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Pain, Postoperative
Management of Pain Post Hepatectomy : Infiltration of Local Anesthetics Versus Continuous Spinal Analgesia .
Analgesia in liver surgery is a challenge, postoperative coagulopathy risk raises fears an epidural haematoma formation following the epidural analgesia, "gold standard" in major abdominal surgery.
- Trial name
- CATHEPAT (NCT03238430)
- Testing
- intrathecal morphine, Morphine PCA, Ropivacaine infiltration
- Where
- France
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Vision Impairment, Eye Diseases
The Proactive Ophthalmic Examination Cohort
The Proactive Ophthalmic Examination Cohort of Older Adults is a prospective cohort study recruiting community-dwelling older adults aged 65 years or older.
- Trial name
- POEC (NCT05851287)
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Postoperative Pain
Effect of Resin, Calcium Silicate and Silicone Based Root Canal Sealers on Postoperative Pain
After endodontic procedures, depending on the individual and many variables, postoperative pain can be occur within hours and continue for days following the treatment.
- Trial name
- NCT05033093
- Testing
- Root Canal Sealants
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Postoperative Pain, Cesarean Section
Liposomal Bupivacaine + Bupivacaine vs. Bupivacaine Alone on Opioid Use After Elective c/Section
The purpose of this study is to compare the effectiveness of local wound infiltration of EXPAREL® (liposomal bupivacaine) with bupivacaine HCl compared to active control with bupivacaine HCl alone following elective primary or…
- Trial name
- NCT04232306
- Testing
- Liposomal bupivacaine, Bupivacaine HCl
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
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