Clinical trials: Neurological Disorders
Gait Analysis in Neurological Disorders
Investigation of Gait Parameters in Health and Neurological Disease Under Varying Locomotor Conditions
In the cross-sectional component of this study, our overall objective is to gather a large pool of data from which we can generate gait "profiles".
- Trial name
- NCT02165787
- Where
- Switzerland
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Covid19, Neurological Injury
Radiofrequency Intervention in Neurological Pathologies Post COVID-19
The sequelae that occur in post-COVID-19 patients are multiple and, at a therapeutic level, these represent a new challenge within the general context of the pandemic that the world is suffering.
- Conditions
- Covid19, Neurological Injury, Olfactory Disorder, Gustatory Agnosia
- Trial name
- NCT04920890
- Testing
- Radiofrequency therapy with manual therapy
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Clinica Gema Leon
Siderosis, Neurological Disorder
Audiovestibular Function in Infratentorial Superficial Siderosis
One in six people in the United Kingdom and over 400 million people worldwide have disabling hearing loss. This figure will double by 2050 as predicted by the World Health Organisation.
- Conditions
- Siderosis, Neurological Disorder, Rare Diseases, Age Related Hearing Loss
- Trial name
- AViSS (NCT04200664)
- Testing
- Hearing assessment, Vestibular/balance assessment, Quality of life assessment
- Where
- 2 sites in United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University College, London
Mental Health, Neurological Health
Brain Cooling Biomarkers
This research is being done to examine the effects of brain cooling on cognition, electrophysiological brain activity via EEG scans, inflammation of the brain, and mood in healthy subjects.
- Trial name
- NCT06542419
- Testing
- Brain Cooling
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Penn State University
Functional Neurological Disorder
The Role of Oxytocin and Interoception in Functional Neurological Disorder
The main goal of this project is to better understand the role of oxytocin and Interoception in FND. More specifically oxytocin's association with precision weighing, prediction errors and priors in the interoceptive domains will…
- Trial name
- NCT06084325
- Testing
- Respiration resistance sensitivity task (RRST), Heartbeat Tracking (HBT), Heartbeat evoked potential (HEP)
- Where
- 2 sites in Switzerland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Stroke, Spasticity
Efficacy of Shock Wave Therapy in Post-Stroke Muscle Spasticity Management
The goal of this clinical trial is to evaluate the efficacy and safety of shock wave therapy (SWT) in reducing muscle spasticity in patients who have suffered a stroke.
- Conditions
- Stroke, Spasticity, Post-stroke, Muscle Hypertonia
- Trial name
- SWT-PI (NCT06815328)
- Testing
- Shock Wave Therapy (SWT), Active Comparator - Conventional Therapy
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oviedo
Functional Neurological Symptom Disorder, Neurological Diseases or Conditions
Modulation of Sense of Agency With Non-invasive Brain Stimulation and Mindfulness-based Stress Reduction Therapy
A conversion disorder is a dysfunction of the nervous system in which no structural damage can be demonstrated. However, it must be distinguished from other psychiatric disorders such as psychosis or depression.
- Trial name
- NCT05086380
- Testing
- Mindfulness-based stress reduction therapy, Inhibitory TMS, Psychoeducation
- Where
- Switzerland
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Deglutition Disorders, Neurological Disorder
Automatic Voice Analysis for Dysphagia Screening in Neurological Patients
The proposed study suggests using automatic voice analysis and machine learning algorithms to develop a dysphagia screening tool for neurological patients.
- Trial name
- VOICED (NCT06219200)
- Where
- 2 sites in Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Cerebral Palsy, Brain Injury
Validation of a 3D Instrumented Serious Game to Evaluate Upper Limb Impairments in Children With Neuromotor Disorders
The goal of this clinical trial is to validate an instrumented 3D serious game to assess upper limb impairments in children with neuromotor disorders.
- Conditions
- Cerebral Palsy, Brain Injury, Neurological; Disorder, Nervous System
- Trial name
- Play2BEAPI (NCT06774456)
- Testing
- instrumented 3D serious game (BE API 3.0)
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Pain, Traumatic Brain Injury
The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study
Several rehabilitation datasets are presently in use for specific patient groups in England. The 'National Clinical Audit of Specialist Rehabilitation for patients with complex needs following major injury' (NCASRI) evaluated…
- Conditions
- Pain, Traumatic Brain Injury, Major Trauma, Multiple Sclerosis
- Trial name
- NCT06726135
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ThomasCorbett
Functional Neurological Symptom Disorder, Paralysis
Exploring Functional Paralysis with Advanced Magnetic Resonance Modalities
In functional neurological disorder (FND), neurological symptoms are present, such as paralysis, weakness and disturbed sensation of limbs, although clinically no abnormalities can be found.
- Conditions
- Functional Neurological Symptom Disorder, Paralysis, Conversion Disorder with Weakness/Paralysis
- Trial name
- NCT05139732
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- Switzerland
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Brain Cancer, Neurological Disorder
Wearable Devices and Biomarkers Project (Healthiomics)
The purpose of this study is to collect clinical data, biological specimens (e.g., blood, tumor, cerebrospinal fluid, urine sample, etc.), and digital health data from patients with tumors, cancer and/or neurological disorders in…
- Conditions
- Brain Cancer, Neurological Disorder, Neurological Cancer
- Trial name
- NCT05106725
- Where
- United States
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- CureScience
Neurological Injury, Motor Disorders
Transcutaneous Auricular Vagus Nerve Stimulation to Enhance Motor Learning
Vagus nerve stimulation (VNS) activates neural pathways leading to the release of chemicals that promote plasticity and learning.
- Conditions
- Neurological Injury, Motor Disorders, Paresis
- Trial name
- NCT05316519
- Testing
- Transcutaneous Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- VA Pittsburgh Healthcare System
Geriatric Patients, Neurological Disorder
Personalized Motor Learning in Primary Care Physiotherapy (TREAT)
Over the last decade many scientific articles have been published on motor learning in neurological and geriatric rehabilitation.
- Trial name
- NCT06390800
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Zuyd University of Applied Sciences
Functional Neurological Disorder
Integrated Treatment in FND (Functional Neurological Disorders)
The project will investigate the effectiveness of patient-centered integrated treatment. The correlations between physiotherapy indices, non-invasive brain stimulation, connectivity and psychological support will be analyzed.
- Trial name
- FND (NCT04310670)
- Testing
- Psychotherapy, Physiotherapy, Non-Invasive Brain Stimulation (NIBS)
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Neurological Disease, Motor Disorders
Technological Devices and Home Automation System in Neurological Rehabilitation
The use of home automation system may be useful in rehabilitation to collect data about the environment and the amount of therapy.
- Trial name
- SMART (NCT06270420)
- Testing
- Technological Motor Rehabilitation
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Neurological Movement Disorders
Probing Neural Circuitry for the Control of Movement
The investigators are interested in examining 1) the basic organization of spinal and cortical circuitry for the control of movement and 2) the influence of injury of these circuits.
- Trial name
- NCT02150642
- Where
- Switzerland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Neurological Disorder, Healthy Control
Protective Genetic Factors Against Neurological Diseases
NIH Precision Medicine Initiative, started in May 2018, will enroll one million people through an online portal. It hopes to identify genetic variants affecting a variety of human phenotypic outcomes.
- Trial name
- NCT03914599
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Surgery, Surgery--Complications
Patterns and Outcomes of Neurosurgery in England Over a Five-year Period
Neurosurgical practice has seen many important changes over several decades with advances in treatments and the types of patients treated.
- Conditions
- Surgery, Surgery--Complications, Neurological Morbidity, Neurological Diseases or Conditions
- Trial name
- NCT05097066
- Testing
- Neurosurgical procedure
- Volunteers
- 371,418 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Neurological Disorders
Muscle Delay Characterization
Functional electrical stimulation (FES) induced cycling is a common rehabilitative therapy. Closed-loop FES control holds the promise to improve rehabilitation procedures.
- Trial name
- NCT04094571
- Testing
- Functional Electrical Stimulation (FES) Control Protocol, Functional Electrical Stimulation (FES) Angle Protocol
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Florida