Clinical trials: Neuromuscular Disease in Post-Intensive Care Syndrome
COVID-19 Pandemic, ICU
Chronic Pain in COVID-19 Patients Discharged From Intensive Care Unit
More than six million French were affected by SARS-COV2 epidemic. About 20% of infected peoples were hospitalized, and about 5% were admitted to the intensive care units (ICU) for severe SARS-COV2 acute respiratory distress…
- Conditions
- COVID-19 Pandemic, ICU, Pain, Chronic, Post Intensive Care Unit Syndrome
- Trial name
- NCT04940208
- Testing
- Pain and neuropsychological questionnaires, Quantitative Sensory testing
- Where
- 3 sites in France
- Volunteers
- 143 people
- Sponsor
- Mikhail Dziadzko, MD, PhD
Acute Respiratory Distress Syndrome
Monitoring in Intensive Care Unit of Neuromuscular Blocking Agents Used for Acute Respiratory Distress Syndrome After Cardiothoracic Surgery
Mortality in Acute Respiratory Distress Syndrome (ARDS) is high (40 to 60 %). Protective mechanical ventilation is the cornerstone of the ARDS therapeutic strategies.
- Trial name
- CURAREA (NCT02546947)
- Testing
- Train of four monitoring
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Amyotrophia, Weakness, Muscle
Diagnosis of Muscular Weakness Syndrome After a Stay in Intensive Care : Measurement by Ultrasound
The objective is to diagnose earlier and more precisely the occurrence of a weakness neuromuscular syndrome at the end of intensive care, or within 28 days if the stay is longer than 28 days.
- Trial name
- FIBER (NCT03735693)
- Testing
- Ulstrasound
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Association Pro-arte
Surgery, Critical Illness
Sedation Optimisation Strategy (S.O.S.) Ventilation
Use of sedatives and analgesics is common in mechanically ventilated patients hospitalized in Intensive Care Unit (ICU). That is called " sedation " and aimed to reduce both pain and anxiety and also to allow an effective and…
- Conditions
- Surgery, Critical Illness, Mechanical Ventilation Complication, Organ Dysfunction Syndrome
- Trial name
- NCT01486121
- Testing
- Therapy strategy
- Where
- 3 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Montpellier
Post Intensive Care Unit Syndrome, Critical Illness
Improving Recovery After Critical Illness
Rationale: Survival rates of patients with critical illness have increased due to improved facilities and treatment methods in the intensive care unit (ICU).
- Conditions
- Post Intensive Care Unit Syndrome, Critical Illness, Malnutrition, Muscle Weakness
- Trial name
- IMPROVE (NCT05182086)
- Testing
- Group physical therapy and dietary improvements
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Frisius Medisch Centrum
COVID-19 Pneumonia
Neuromuscular Electrical Stimulation in Patients With COVID19 Associated Pneumonia
Neuromuscular electrical stimulation (NMES) has been considered as a promising approach for the early rehabilitation of patients in and/or after the intensive care unit (ICU).
- Trial name
- NCT04382729
- Testing
- Neuromuscular Electrical Stimulation, Physical Therapy Exercise
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Turin, Italy
Critical Illness, Post Intensive Care Syndrome (PICS)
Effectiveness of a Structured Multidimensional Tele-rehabilitation Intervention in Cardiac Patients With Post-Intensive Care Syndrome (CARDIO-PICS)
This two-arm, parallel-group randomized clinical trial investigates the effectiveness of an additional telerehabilitation program compared with standard care in patients with Post-Intensive Care Syndrome (PICS).
- Conditions
- Critical Illness, Post Intensive Care Syndrome (PICS), Cardiopathy
- Trial name
- CARDIO-PICS (NCT07599306)
- Testing
- Tele-rehabilitation, Standard of Care
- Where
- Italy
- Volunteers
- 326 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Critically Ill, Post Intensive Care Syndrome
Testing of a New Therapeutic Vibration Device to Reduce Neuromuscular Weakness in Hospitalized Patients
Objective: Test the ability of vibration to produce physiologic, biochemical, and anatomic changes consistent with exercise that would help prevent the development of muscle weakness that occurs when patients are immobile for…
- Trial name
- NCT03479008
- Testing
- Therapeutic Vibration Device
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Muscle Weakness, Critical Illness
Assessing The Effects of Exercise, Protein, and Electric Stimulation On Intensive Care Unit Patients Outcomes
Elderly patients who experience a prolonged ICU stay are at high risk for developing post intensive care unit syndrome (PICS), a serious medical condition manifested by loss of muscle mass, weakness, malnutrition and…
- Conditions
- Muscle Weakness, Critical Illness, Sarcopenia
- Trial name
- ExPrEs (NCT02509520)
- Testing
- MPR and High Protein Supplement (HPRO) and Neuromuscular Electric Stimulation (NMES)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Myasthenia Gravis, Guillain-Barre Syndrome
Ventilator Weaning Practices in Patients Intubated for Guillain-Barré Syndrome or Myasthenia Gravis
Guillain-Barré syndrome and myasthenia gravis are two neuromuscular diseases that are commonly managed in ICUs that may require different weaning protocols.
- Trial name
- GUIMAUVE (NCT07022028)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Poitiers University Hospital
Neuromuscular Disease in Post-Intensive Care Syndrome
Feasibility Study on the Use of a Walking Exoskeleton in the Intensive Care Unit
The purpose of this study is to evaluate the feasibility of using a lower-limb exoskeleton in the intensive care unit for early mobilization of participants with intensive care neuromyopathy.
- Trial name
- ExoRea (NCT07907237)
- Testing
- rehabilitation session assisted by an exoskeleton
- Volunteers
- 30 people
- Sponsor
- CHU de Reims
Critical Illness, Intensive Care (ICU) Myopathy
Muscle Dysfunction in Critical Illness
Patients surviving critical illness suffered significant skeletal muscle dysfunction and weakness that impacts their functionality and independence.
- Conditions
- Critical Illness, Intensive Care (ICU) Myopathy, PICS, Muscle Weakness
- Trial name
- NCT03717831
- Testing
- Observational study of standard of care
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Kentucky