Clinical trials: Neuromuscular Function
Duchenne Muscular Dystrophy
PDE Inhibitors in DMD Study (Acute Dosing Study)
PDE5A inhibition, which boosts NO-cGMP signaling, will relieve functional muscle ischemia and restore normal blood flow regulation (i.e., functional sympatholysis) during exercise in boys with DMD.
- Trial name
- NCT01580501
- Testing
- Tadalafil and Sildenafil
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Duchenne Muscular Dystrophy
Tadalafil and Sildenafil for Duchenne Muscular Dystrophy
This study, supported by Parent Project Muscular Dystrophy, will determine if tadalafil or sildenafil can improve muscle blood flow during exercise in boys with Duchenne muscular dystrophy.
- Trial name
- NCT01359670
- Testing
- Tadalafil, Sildenafil
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Cedars-Sinai Medical Center
Amyotrophic Lateral Sclerosis
A Prospective Study to Evaluate the Correlation Between Oculometric Measurements and Clinical Endpoints in ALS Patients
This is a prospective study in a cohort of about 45 patients with ALS participating in the Neurosense PrimeC drug study (NCT05357950).
- Trial name
- NCT05407428
- Testing
- NeuraLight software-based platform
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- NeuraLight
Prevention and Control
Effects of a Neuromuscular Training Ankle Preventive Program in Soccer Player
Objetive:To determine the effects of a functional ankle instability prevention neuromuscular training (PENMT) program compared to the conventional FIFA 11+ program on the occurrence of ankle sprains, flexibility, balance and…
- Trial name
- PENT (NCT05688930)
- Testing
- PENMT (Experimental Group), FIFA 11+ (Control Group)
- Where
- Colombia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Autónoma de Manizales, Colombia
Muscle Damage, Inflammation
Protein and Recovery From Exercise-induced Muscle Damage
Intense, eccentric resistance exercise causes muscle damage, soreness, inflammation, and a loss of muscle function. Protein-amino acid supplementation before, during, and following damaging resistance exercise may reduce muscle…
- Trial name
- NCT02034721
- Testing
- Protein supplement
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Cancer, Aging
Effects of a Multicomponent Exercise Program in Older Adults Undergoing Cancer Treatment: A Randomized Controlled Trial
This study aims to understand how a home-based exercise program can help improve strength, mobility, and quality of life in older adults receiving cancer treatment.
- Trial name
- NCT07565519
- Testing
- Multicomponent exercise
- Where
- 2 sites in Brazil
- Volunteers
- 180 people
- Sponsor
- Federal University of Rio Grande do Sul
Muscle Weakness
The Effect of Exercise on Muscle, Function and Cost in VA Nursing Home Residents
Veterans are admitted to Veterans Health Administration (VA) Nursing Homes (NH) because impairment in their ability to perform activities of daily living (ADL) overwhelms their support system (family/friends) in the community.
- Trial name
- NCT00105807
- Testing
- participation in low intensity exercise, participation in art and music activities
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- US Department of Veterans Affairs
Heart Failure With Reduced Ejection Fraction
Neuromuscular Fatigability in Individuals With Heart Failure
Brief summary The aims of this project are to 1) characterise muscle fatigue in individuals with chronic heart failure during exercise involving a smaller and larger muscle mass (Part I), 2) to determine the effect of nitrate…
- Trial name
- NCT06551012
- Testing
- Nitrate-rich beetroot juice, Beetroot juice with nitrate extracted
- Volunteers
- 28 people
- Sponsor
- Newcastle University
Urinary Incontinence, Pelvic Floor Muscle Weakness
The Effects of Pelvic Floor Muscle Training Combined With Otago Exercises in Elderly People With Incontinence
Pelvic floor muscle weakness is one of the most important causes of incontinence. There are many studies supporting that pelvic floor muscle training prevents incontinence and reduces symptom severity, and with A level of…
- Conditions
- Urinary Incontinence, Pelvic Floor Muscle Weakness, Muscle Weakness
- Trial name
- NCT06331039
- Testing
- PFMT, PFMT+Otago
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Cervical Radiculopathy
Transcutaneous Electrical Nerve Stimulation Versus Repetitive Transcranial Magnetic Stimulation on Pain and Functional Outcome in Cervical Radiculopathy
this study will be conducted to compare between transcutaneous electrical nerve stimulation versus repetitive transcranial magnetic stimulation on pain and functional outcome in cervical radiculopathy
- Trial name
- CR (NCT07557511)
- Testing
- Transcutaneous Electrical Nerve Stimulation, repetitive Transcranial Magnetic Stimulation
- Volunteers
- 50 people
- Sponsor
- Cairo University
Peripheral Nerve Injury
Mirror Therapy Combined With Contralaterally Controlled Functional Electrical Stimulation for Peripheral Nerve Injury
The goal of this trial is to evaluate the effects of mirror therapy combined with contralaterally controlled functional electrical stimulation on motor recovery and neuroplasticity in patients with peripheral nerve injury.
- Trial name
- NCT06209632
- Testing
- mirror therapy, contralaterally controlled functional electrical stimulation, conventional physiotherapy
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- National Taiwan University Hospital
Smoking Dependence, Smoking Among Youth
Efficacy of Diaphragmatic Proprioceptive Neuromuscular Facilitation on Functional Capacity and Pulmonary Function in Heavy Twenties Smokers
Although research on the health risks of e-cigarettes is still limited, there is increasing evidence of debilitating lung disease and general immune dysfunction from e-cigarettes, leading to various infections.
- Trial name
- NCT07003893
- Testing
- Diaphragmatic Proprioceptive Neuromuscular Facilitation + Aerobic exercises
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Zaytoonah University of Jordan
Fibromyalgia
The Effectiveness Of BETY In Fibromyalgia
Fibromyalgia Syndrome (FMS) is a nonarticular, chronic rheumatic disorder of unknown etiology characterized by widespread musculoskeletal pain, impaired sleep quality, fatigue and the presence of identified tender points.
- Trial name
- NCT07034417
- Testing
- Exercise, Home exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Aysima Barlak
Post Menopausal, Resistance Exercise
Feasibility of Lower-Body EMS Resistance Training in Postmenopausal Women
This pilot randomized controlled trial evaluates whether combining lower-body electrical muscle stimulation (EMS) with resistance training is feasible and beneficial for physically inactive postmenopausal women, who experience…
- Conditions
- Post Menopausal, Resistance Exercise, Body Composition, Autonomic Function
- Trial name
- LB-EMS-Pilot (NCT07628790)
- Testing
- Lower-Body EMS combined with Resistance Training, Resistance Training
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Seoul National University
Alzheimer Disease, Sarcopenia
Silkworm Pupa Powder Improves Alzheimer's Disease
The goal of this clinical trial is to learn if silkworm pupa powder works to treat Alzheimer's disease in patients. It will also learn about the safety of silkworm pupa powder, and its effect on patients' nutritional and frailty…
- Conditions
- Alzheimer Disease, Sarcopenia, Asthenia, Frailty
- Trial name
- NCT07638449
- Testing
- Silkworm pupa powder
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhejiang Provincial Tongde Hospital
Osteopenia, Osteoporosis, Sarcopenia
Functional and Metabolic Effects of Fonte Fausta® Water on Bone and Muscle Health in Osteoporotic Patients
This clinical study investigates the effects of Fonte Fausta® water on bone and muscle metabolism, as well as quality of life, in patients with osteoporosis or osteopenia, with or without sarcopenia.
- Trial name
- FOCUS (NCT06851676)
- Testing
- water supplemented by calcium
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- ANTIMO
Healthy
Strength Training and Muscle Lipids
The purpose of this study is examine the effects of 8 weeks (3 days/week) of resistance exercise training in children 8 to 10 years of age on muscle strength and power, motor unit activation, and lipid profiles of the vastus…
- Trial name
- Strength-Lip (NCT06480747)
- Testing
- Resistance exercise training
- Where
- 4 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Healthy, Healthy Participants
Acute Effects of Structured Exercise and Static Stretching on Vascular Function, Neuromuscular Performance, and Metabolic Regulation in Adults
This experimental study investigates the acute cardiovascular and vascular responses to a single session of resistance training, with and without additional static stretching, compared with a resting control condition.
- Conditions
- Healthy, Healthy Participants, Healthy Subjects (HS), Resistance Training Adaptation
- Trial name
- NCT07364149
- Testing
- Resistance Training, Resistance training + Static Stretching
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Executive Dysfunction, Occupational Problems
Investigation of the Relationship Between Executive Functions and Occupational Performance of Children With Duchenne Muscular Dystrophy
The effects of Duchenne muscular dystrophy and its treatments on executive functions and occupational performance are under-mentioned in the literature.
- Conditions
- Executive Dysfunction, Occupational Problems, Duchenne Muscular Dystrophy
- Trial name
- NCT06868784
- Testing
- Evaluations
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Lokman Hekim University
Fibromyalgia
Development of Treatments Aiming at Improvement of Function in Patients With Chronic Widespread Pain
The study aims to evaluate the effects of adding supervised exercise in supplement to an educational self-management program, and to determine which subgroups would gain effects of the treatment.
- Trial name
- NCT00545649
- Testing
- Exercise and education, Education
- Where
- 3 sites in Sweden
- Volunteers
- 164 people
- Sponsor
- Göteborg University