Clinical trials: Neuronal Plasticity
Stroke
Robotic Pedaling Therapy for Targeted Neural Plasticity
The aim of this Pilot study is to determine whether robotically targeted lower-limb pedaling therapy can increase the extent of stroke recovery on behavioral measures and induce brain plasticity as measured by functional magnetic…
- Trial name
- NCT03300258
- Testing
- Robotic therapy, Aerobic therapy
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Amblyopia
An Active Approach to Treat Amblyopia: Video Game Play
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast.
- Trial name
- NCT01223716
- Testing
- Perceptual learning, Video Game, Crossover (Occlusion therapy + Video Game)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Aging, Music
Brain Imaging and Behavioural Changes Following Cued-movement Training of Finger Sequences in Healthy Older Adults
The goal of this study is to examine changes in the brain, behavior, and personal experience when music is used to guide learning of finger movement sequences (compared to visual stimuli alone) in healthy older adults.
- Conditions
- Aging, Music, Motor Activity, Magnetic Resonance Imaging
- Trial name
- NMSOA (NCT06174740)
- Testing
- Music-cued audiovisual motor training, Visually-cued motor training
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universiteit Leiden
Traumatic Brain Injury
PC-Based Cognitive Rehabilitation for Traumatic Brain Injury (TBI)
The investigators evaluated whether it was possible to improve the measurement of memory, attention, and executive function in patients who have suffered traumatic brain injury through the use of computer-based testing.
- Trial name
- NCT00927576
- Testing
- Digit span testing, Spatial span testing, Finger tapping
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Mild Cognitive Impairment
The Effects of Exercise on Synaptic Plasticity in Individuals With Mild Cognitive Impairment and in Healthy Aging.
The research is focused on ameliorating cognitive decline in aging and in individuals diagnosed with Mild Cognitive Impairment (MCI).
- Trial name
- NCT05663918
- Testing
- Self- determined Intensity Interval Training
- Where
- 6 sites in Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
Treatment-resistant Depression
The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant Depression
In this project, the investigators evaluate an accelerated schedule of repetitive transcranial magnetic stimulation for treatment-resistant depression.
- Trial name
- NCT05607654
- Testing
- active iTBS
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Multiple Sclerosis, Cognitive Decline
MS-NEUROPLAST: Neuroplasticity of Cortical Areas Induced by Cognitive Training in Patients With Multiple Sclerosis
This clinical study aims to identify MS related beneficial plasticity and by contrast maladaptive reorganization in combination with elements of daily functional status as a response to a cognitive training program
- Trial name
- MSNEUROPLAST (NCT04806568)
- Testing
- Cognitive Training, Monitoring of daily activity
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Fibromyalgia
An Exploration of the Neuroplasticity of Endogenous Analgesia in Health and Chronic Pain
Transcranial magnetic stimulation (TMS) is a neurophysiological tool for studying cortical functions, and in addition, has an analgesic therapeutic effect whose underlying mechanism is unknown.
- Trial name
- NCT02572726
- Testing
- active repeated transcranial magnetic stimulation
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Microgravity, Neuroplasticity
Neuroimage Genome Study of Neuroplasticity Associated With Microgravity
This clinical trial investigates the neuroplasticity and cognitive status changes of the human brain in microgravity. To explore the relationship between cognitive status changes and brain functional activities, gray matter and…
- Conditions
- Microgravity, Neuroplasticity, MRI, Repeatable Battery for the Assessment of Neuropsychological Status
- Trial name
- NCT06350422
- Testing
- Head-Down tilt Bed Rest test
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Cervical Spinal Cord Injury
Combined Therapeutic Air Mixture and Electrical Stimulation to Improve Breathing and Hand Function in Spinal Cord Injury
The goal of this clinical trial is to determine whether people with paralysis due to a spinal cord injury can benefit from breathing short intermittent bouts of air with low oxygen (O2) combined with slightly higher levels of…
- Trial name
- AIHH+tSCS (NCT06101199)
- Testing
- Acute Intermittent Hypercapnic Hypoxia, Transcutaneous spinal cord stimulation
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Healthy Young Adults
iTBS Effect on M1 Plasticity, Blood Glucose, and Cardiovascular Response
Transcranial magnetic stimulation is a medical device that can alter motor cortical (M1) excitability through the scalp via various protocols.
- Trial name
- NCT06043076
- Testing
- TMS
- Where
- Malaysia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Postural Balance, Neuronal Plasticity
Effect of Balance Training on White Matter Tracts in Healthy Elderly Population
Balance impairment increases the risk of falling and is associated with a fear of falling and immobility. Balance impairment can ultimately affect the morbidity of cardiovascular disease, cognitive impairment, and mortality…
- Conditions
- Postural Balance, Neuronal Plasticity, Elderly Population
- Trial name
- NCT05539690
- Testing
- Balance training
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Stroke With Hemiparesis
Strategies for Recovery of Dexterity Post Stroke
Motor learning can be affected by the sensory difficulties that may be experienced as a result of a stroke. This study will help us better understand what kinds of sensory information can help with the re-learning of grasping…
- Trial name
- NCT01977027
- Testing
- Alternate Hand Training or Affected Hand Training
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Migraine
Structural and Molecular Neuroplasticity in Migraine
The main purpose of this study is to integrate novel MRI techniques with positron emission tomography(PET) for the study of structural and molecular neuroplasticity in the brain of migraineurs, and its clinical association with…
- Trial name
- NCT03004313
- Testing
- Pet Scan, MRI scan, Quantitative Sensory Testing (QST)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Parkinson Disease
The Learning Effects of Attentional Strategy on Dual-task Walking in Patients With Parkinson's Disease: Behavioral Performance and Neural Plasticity
[year1] 1. To compare the effects of dual-task training with two different task priority instruction in people with Parkinson's disease and healthy controls on dual-task weight shifting performances. 2.
- Trial name
- NCT03895125
- Testing
- [year1] dual-task training with task priority strategy, [year2-3] dual-task training with internal and external focus
- Where
- Taiwan
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Anxiety, Depressive Symptoms
A Single-Session Intervention for Adolescents and Young Adults With Internalizing Problems
With the increasing number of adolescents and young adults (AYA) experiencing depression and anxiety, paired with the lack of time, access, and funding towards social services, AYA need a mental health intervention that is…
- Trial name
- NCT05826392
- Testing
- Adolescent/Young Adult Self-Administered Web-Based Single-Session Intervention
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Pain, Osteoarthritis
Optimizing Chronic Pain Treatment With Enhanced Neuroplastic Responsiveness
The purpose of the study is to identify non-invasive strategies that will optimize the neurobiological environment and improve learning and memory in the treatment of chronic pain.
- Trial name
- OPTIMIZE (NCT02681081)
- Testing
- Glucose Administration, Intermittent Fasting, Control
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Florida
Brain Health, Longevity
L-serine and Strength Training in the Elderly
This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older…
- Conditions
- Brain Health, Longevity, Cognitive Performance, Strength Training Effects
- Trial name
- AAAging (NCT07466290)
- Testing
- Strength training, L-serine supplementation, Control (cornstarch)
- Where
- Austria
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Anterior Cruciate Ligament Injuries
Neuromuscular Rehab for ACL Reconstruction: Knee Function & Brain Plasticity
This study focuses on patients with anterior cruciate ligament (ACL) rupture and reconstruction, aiming to systematically investigate the clinical efficacy and underlying mechanisms of neuromuscular training in restoring knee…
- Trial name
- NCT07243860
- Testing
- Neuromuscular Training, Conventional Rehabilitation
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Hypoxia, Altitude, Exercise Tolerance
Direct and Cross Effects of Adaptation to Systemic Hyperthermia: Impact on Quality of Life, Neurohormonal and Psychophysiological Human Status
Life expectancy and quality of human life are important indicator of the sustainable development of the society. At the same time, the physical, functional, emotional and psychological components of the of the quality of life…
- Conditions
- Hypoxia, Altitude, Exercise Tolerance, Metabolic Disturbance, Quality of Life
- Trial name
- NCT04089410
- Testing
- Hyperthermic Fitness Treatment (HFT), Physical Examination, Assessment of Cardiorespiratory Fitness
- Where
- Russia
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University