Clinical trials: Neuropathic
Corneal Pain, Chronic Pain
Effects of Transcranial Direct Current Stimulation (tDCS) in Chronic Corneal Pain
In this study the investigators aim to examine the effects of Transcranial Direct Current Stimulation (tDCS) on pain levels as well as the changes in cognitive (thought) processing in individuals with chronic pain of the cornea…
- Conditions
- Corneal Pain, Chronic Pain, Neuropathic Pain
- Trial name
- NCT01575002
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Pain, Neuropathic, Pain, Acute
Ice Immersion Using Virtual Reality & Augmented Reality
The purpose of this study is to evaluate the effectiveness of different technologies, Virtual Reality and Augmented Reality with modifications as passive content, active content, cognitive load modulation, and positive…
- Trial name
- NCT04196686
- Testing
- VR/AR, Ice Bath
- Where
- United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pain, Neuropathic Pain
Radicle Relief 2: A Study of Health and Wellness Products on Pain and Health Outcomes
A randomized, blinded, placebo-controlled study assessing the impact of health and wellness products on pain and other health outcomes
- Conditions
- Pain, Neuropathic Pain, Nociceptive Pain
- Trial name
- NCT05837923
- Testing
- Relief Active Study Product 1.1 Usage, Relief Active Study Product 1.2 Usage, Relief Active Study Product 2.1 Usage
- Where
- United States
- Volunteers
- 2,016 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Chronic Pain
Use of PET/MR Imaging in Chronic Pain
The investigators are studying the ability of PET/MR imaging (using the PET tracer [18F]FDG) to objectively identify and characterize pain generators in patients suffering from chronic pain.
- Trial name
- NCT03195270
- Testing
- [18F]FDG, PET/MRI
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Stanford University
Neuropathic Pain
The Effect of Neuropathic Pain in Patients With Combat-related Extremity Injury
It has been suggested that veterans with chronic pain might be at increased risk for the development of depression, anxiety and post-traumatic stress disorder.
- Trial name
- NCT04674631
- Testing
- The effect of neuropathic pain on quality of life, depression and sleep quality
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
HIV Infection
Pharmacokinetic Study on Raltegravir and Lamotrigine
The purpose of this study is to determine whether interactions between raltegravir and lamotrigine take place and to study the safety of the combination raltegravir/lamotrigine before used in HIV patients.
- Trial name
- GRANOLA (NCT00618241)
- Testing
- lamotrigine, Raltegravir
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Neuropathic Pain
Safety, Tolerability and Pharmacokinetics of Single Ascending Doses of REL-1017 (d-Methadone)
This study evaluated the safety, tolerance, and pharmacokinetics (PK) of d-methadone in a limited dose range, in single administrations in humans.
- Trial name
- NCT03637361
- Testing
- REL-1017
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Relmada Therapeutics, Inc.
Chronic Pain, Pain, Chronic
Investigating Biological Targets, Markers, and Intervention for Chronic Pain
This multi-modal methods study will investigate neurophysiological, endocrinological, cognitive, psycho-social-emotional markers of chronic pain, and therapeutic targets using integrative health treatments.
- Conditions
- Chronic Pain, Pain, Chronic, Pain Syndrome, Pain, Neuropathic
- Trial name
- NCT04625504
- Testing
- Mindfulness Based Intervention
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Neuropathy;Peripheral
Depolarising Electrical Skin Stimulation in Neuropathic and Postoperative Pain
The aim of the study is to evaluate voltage gated sodium channel (NaV1.7) dependent pain phenomena in neuropathic pain and chronic postoperative pain.
- Trial name
- NCT03037684
- Testing
- neurophysiology
- Where
- Switzerland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Neuropathic Pain
Focused Ultrasound for the Treatment of Neuropathic Pain
A possible treatment approach for neuropathic pain would employ a process designed to promote healthier function of the ventral posteromedial (VPM) and ventral posterolateral (VPL) thalamic nuclei.
- Trial name
- NCT04485208
- Testing
- Focused Ultrasound
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Neurological Associates of West Los Angeles
Healthy
Bioequivalence Study of Two Formulations of Pregabalin CR (Controlled-release) Table 150 mg
The purpose of this clinical trial is to (1) evaluate the bioequivalence(BE) of GLA5PR GLARS-NF3 tablet 150mg administered regular diet relative to GLA5PR GLARS-NF1 tablet 150mg administered regular diet and (2) determine the…
- Trial name
- NCT02955472
- Testing
- GLA5PR GLARS-NF3 tablet 150mg, GLA5PR GLARS-NF1 tablet 150mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GL Pharm Tech Corporation
Autoimmune Diseases, Dry Eye
Use of Acthar Gel Single-Dose Pre-Filled SelfJectTM Injector in Patients With Moderate-Severe Keratitis and Autoimmune Disease
Single-site, open label pilot study of 20 autoimmune patients diagnosed with dry eye demonstrating via the proparacaine challenge some peripheral corneal pain component.
- Conditions
- Autoimmune Diseases, Dry Eye, Neurotrophic Keratitis
- Trial name
- MNK (NCT06964269)
- Testing
- Acthar Gel 80 UNT/ML Injectable Solution
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Toyos Clinic
Neuropathic Pain
Measuring the Effects of Complementary Therapies in Chronic Neuropathic Pain
The objective of the study is to a) assess the presence of a maladaptive stress response, a decreased pain modulation and any cognitive impairment in patients with chronic neuropathic pain in comparison to healthy controls.
- Trial name
- NCT03783624
- Testing
- Hypnosis
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Chantal Berna
Pain, Neuropathic, Pain, Inflammatory
Phase I Single Ascending Dose and Multiple Ascending Doses of Oral AFA-281 in Healthy Volunteers
Phase I Part 1 (single ascending dose): Double-blind dosing will occur in healthy volunteers in 4 cohorts of 8 subjects each. Six subjects in each cohort will be randomized to receive AFA-281 and 2 subjects will be randomized to…
- Trial name
- NCT05547503
- Testing
- AFA-281
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Afasci Inc
Small-Fiber Neuropathy
Evaluation of Pregabalin in Idiopathic Small Fiber Neuropathy
Idiopathic Small Fiber Neuropathy (called SFN for short), is a condition where nerves that sense pain have become damaged, and often painful.
- Trial name
- NCT00787462
- Testing
- Pregabalin
- Where
- Canada
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Pain Management, Peripheral Neuropathic Pain
Wearable Focused Ultrasound Stimulation for Peripheral Nerve Pain Management
This study will evaluate the feasibility of a novel wearable focused ultrasound (FUS) device for peripheral nerve stimulation in healthy volunteers.
- Trial name
- PERNEUS (NCT07160049)
- Testing
- Cold Pressor Task - Upper Limb, Algometry Pain Tests in the Upper Limb, Algometry Pain Tests in the Lower Limb
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Evan (Huiliang) Wang
Neuropathic Pain
Comparison of Pain-Related Changes in Cerebral Blood Volume in Burn Patients With Neuropathic Pain
The investigators will observe increased or decreased CBV in patients with thermal injury compared with the CBV in healthy controls.
- Trial name
- NCT04125576
- Testing
- magnetic resonance imaging(MRI)
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hangang Sacred Heart Hospital
Neuropathic Pain
Pgp Transporter and CNS Biodistribution of Ondansetron in Healthy Volunteers
To determine the time-course of plasma and CSF concentrations of intravenous (IV) ondansetron in healthy subjects, with and without selective inhibition of Pgp efflux transporter.
- Trial name
- NCT03809234
- Testing
- Ondansetron 8mg with Saline & Tariquidar, Ondansetron 16mg with Saline & Tariquidar
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University
Migraines
A Study of LY2951742 in Healthy Volunteers
To evaluate the safety and tolerability of LY2951742 given as single or multiple subcutaneous injection in healthy male subjects
- Trial name
- NCT01337596
- Testing
- LY2951742
- Where
- Belgium
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company