Clinical trials: Neuropathy
Type 2 Diabetes, Neuropathy, Painful
Methylglyoxal Evaluation in Humans
The investigators will test the hypothesis that patients with low back pain associated with lumbar disc aberrancy will have elevated MGO-protein levels circulating in the blood that are comparable to patients with painful…
- Conditions
- Type 2 Diabetes, Neuropathy, Painful, Chronic Low-back Pain, Lumbar Disc Herniation
- Trial name
- MEH (NCT05350553)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Painful Diabetic Neuropathy
Safety, Tolerability & Pharmacokinetics Study of CNTX-6016 in Healthy Subjects and Subjects With PDN
A Phase 1b study to evaluate the safety, tolerability and pharmacokinetics of multiple ascending doses of CNTX-6016 in healthy subjects and a single cohort to evaluate painful diabetic neuropathy.
- Trial name
- NCT04857957
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Centrexion Therapeutics
Carpal Tunnel Syndrome
Acute Effect of Topical Menthol on Carpal Tunnel Syndrome
Topical menthol gels are classified 'topical analgesics' and are used to relieve pain of the musculoskeletal system. However, double-blind randomized controlled trials are lacking.
- Trial name
- IRMA (NCT01716767)
- Testing
- Menthol
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Research Centre for the Working Environment, Denmark
Carpal Tunnel Syndrome
Cost Information on Carpal Tunnel Syndrome Treatment Decisions
The purpose of this study was to determine whether the provision of societal cost information affects patients' decisions whether or not to undergo surgical management in carpal tunnel syndrome, using a hypothetical scenario.
- Trial name
- NCT03880812
- Testing
- Societal cost
- Where
- 6 sites in United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Diabetic Polyneuropathy, Magnetic Resonance Imaging
Diffusion Tensor Imaging of Median Nerve in Diabetic Peripheral Neuropathy
This study is a diagnostic accuracy study that aims to evaluate the role of DTI in evaluation of DPN in comparison to clinical scores and nerve conduction studies (NCS).
- Trial name
- NCT03934970
- Testing
- Diffusion tensor imaging of peripheral nerves
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Diabetes Mellitus, Neuropathy, Diabetic
Assessments and Interventions for Hand Neuropathy in DM
This study is to investigate the effects of task-based biofeedback training compared with home-based programs on sensorimotor function and quality of life for diabetic patients with neuropathic hands.
- Trial name
- NCT03847129
- Testing
- Biofeedback training, Home-based tendon gliding and resistance training
- Where
- Taiwan
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Peripheral Neuropathy
Multimodal Ultrasound in Peripheral Neuropathy
This study will enforce the role of ultrasound in early diagnosis and screening on peripheral neuropathy in comparison with other modalities.
- Trial name
- NCT06711133
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Carpal Tunnel Syndrome (CTS), Biomarkers / Blood
Hematological and Metabolic Markers in Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy, but the severity of symptoms experienced by patients does not always correspond to abnormalities detected by nerve conduction studies.
- Trial name
- NCT06952647
- Where
- Turkey (Türkiye)
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Ankara Training and Research Hospital
Diabetic Foot
Validation of Ipswich Touch Test for Diabetic Peripheral Neuropathy Screening in Primary Care
The goal of this observational study is to assess the accuracy of screening for diabetic peripheral neuropathy by comparing the Ipswich touch test with the 10-g monofilament test in patients diagnosed with type 2 diabetes.
- Trial name
- NCT06288555
- Testing
- Ipswich touch test
- Where
- Thailand
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Ponlawat Hanchana, MD
Old Age; Debility, Peripheral Neuropathy
Protective Arm Balance Responses
The overall objective of this study is to investigate the effect of attention control training on reach-grasp stabilizing responses during fall-induced perturbations.
- Trial name
- PAT (NCT06388434)
- Testing
- Protective Arm Balance Response Training
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Diabetic Peripheral Neuropathy
The Effect of Related Blood Markers on Diabetic Peripheral Neuropathy
The goal of this observational study is to explore the relationship between related blood indicators and diabetic peripheral neuropathy.
- Trial name
- NCT06041399
- Testing
- hypoglycemic Agents(metformin), lipid-lowering drug(Statin)
- Where
- China
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Liver Cirrhoses, Peripheral Neuropathy
Electrophysiological Evaluation of Motor Dysfunction in Liver Cirrhotic Patients
cross sectional observational study, aimed to assess the electrophysiological function of the motor units in liver cirrhotic patients.
- Trial name
- NCT04340999
- Testing
- Nerve conduction studies and Quantitative EMG ( MUNE and IPA)
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
HIV, Non-HIV
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
The study team's prior research has shown that dysfunction of a specific nerve, called the vagus nerve, is associated with small intestinal bacterial overgrowth (SIBO), and that SIBO is associated with signs of inflammation in…
- Conditions
- HIV, Non-HIV, Vagus Nerve Dysfunction
- Trial name
- EVA (NCT04353778)
- Testing
- Pyridostigmine, non-invasive vagal nerve stimulation
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Diabetic Polyneuropathy, Diabetic Gastroparesis
Pilot Study to Evaluate Magnetic Marker Imaging on Diabetic Polyneuropathy and Gastroparesis
The purpose of this study is to determine whether Magnetic Marker Monitoring is an appropriate opportunity to diagnose and to quantify a suspicious gastroparesis in subjects with diabetic polyneuropathy.
- Conditions
- Diabetic Polyneuropathy, Diabetic Gastroparesis, Diabetes Mellitus
- Trial name
- NCT01607684
- Testing
- Magnetic Marker Imaging (MMI) with Magma 3D system
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Spinal Fusion, Spondylolisthesis
Spine Registration Using 3D Scanning - Arise
The primary objective is to assess the capability of the device as measured by its consistency, its accuracy, and feedback from surgical staff over the study period.
- Conditions
- Spinal Fusion, Spondylolisthesis, Scoliosis, Sciatica
- Trial name
- NCT05195593
- Testing
- Optical 3D Scanner
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Advanced Scanners Inc.
Neuropathy, Diabetic, Pain, Neuropathic
Balance and Gait in Diabetic Neuropathy
The aim of the study is to evaluate the effects of neuropathic pain due to type 2 diabetes on balance and gait. The study is a prospective controlled study.
- Conditions
- Neuropathy, Diabetic, Pain, Neuropathic, Gait Disorder, Sensorimotor
- Trial name
- NCT05127538
- Testing
- Gait analysis, Balance Assessment
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Baskent University
Diabetic Foot, Diabetic Foot Ulcer
This Research Hypothesizes That the Use of a Rigid Rocker Sole Reduces the Recurrence Rate of Diabetic Foot Ulcers in Patients With Peripheral Neuropathy.
This research presents a randomized clinical trial which analyzes the efficacy of a rigid rocker sole in the reduction of the recurrence rate of plantar ulcers in diabetic foot patients.
- Trial name
- NCT02995863
- Testing
- Rigid Rocker Sole Footwear, Therapeutic Footwear
- Where
- Spain
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Stroke, Peripheral Neuropathy
Arm Motor Control on Bi and Uni ADLs
This study is being performed to assess how certain chronic disabilities - stroke, upper extremity (UE) amputation, spinal cord injuries (SCI), cerebral palsy (CP) - differ from healthy subjects in their ability to perform ADLs.
- Conditions
- Stroke, Peripheral Neuropathy, Spinal Cord Injuries, Cerebral Palsy
- Trial name
- BiAs (NCT02778529)
- Testing
- Bilateral assessment robots (BiAS)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Carpal Tunnel Syndrome
Radiofrequency, Perineural Injection, Idiopathic Carpal Tunnel Syndrome
Aim of the study The aim of the study is to evaluate the role of pulsed radiofrequency versus platelet rich plasma injection in treatment of idiopathic mild to moderate carpal tunnel syndrome Patients will be classified into…
- Trial name
- NCT05053477
- Testing
- mehylprednisolone injection, pulsed radiofrequency (PRF), platelet-rich plasma
- Where
- 2 sites in Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Metabolic Syndrome
Multi-faceted Evaluations Following Weight Reduction in Subjects With Metabolic Syndrome
Central obesity, core of metabolic syndrome, has been recognized as one of the rooting factors for development of diabetes and cardiovascular disease.
- Trial name
- NCT01065753
- Testing
- Lifestyle Counseling
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital