Clinical trials: Neuropathy (Disorder)
Carpal Tunnel Syndrome
Efficacy of Hyalase Hydro-dissection in Treatment of Carpal Tunnel: Randomized Double Blind Controlled Clinical Trial
Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy, this study aims to investigate if, and to what extent hydro-dissection hyalase and saline of the median nerve could offer symptoms and clinical improvement
- Trial name
- NCT03675295
- Testing
- Hyalase, Saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Cognitive Impairment, Hereditary Spastic Paraplegia
Studying Cognition in SPG4
Comparing the cognitive levels of patients with SPG4 mutations to healthy controls.
- Trial name
- NCT03104088
- Testing
- CANTAB, MOCA
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Coronary Artery Disease, Pain
Study of Ranexa in Patients With Coronary Artery Disease and Painful Polyneuropathy
This study was to determine whether ranolazine was effective in the treatment of neuropathic pain in patients with coronary artery disease.
- Conditions
- Coronary Artery Disease, Pain, Peripheral Nervous System Diseases, Polyneuropathy
- Trial name
- NCT00832572
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Gilead Sciences
Diabetic Neuropathic Pain
A Multicenter Study Comparing the Analgesic Effects and Safety of ABT-639 Compared to Placebo in Subjects With Diabetic Neuropathic Pain
People with diabetes can, over time develop nerve damage throughout the body with symptoms such as pain, tingling, or numbness (loss of feeling) in the hands, arms, feet and legs.
- Trial name
- NCT01345045
- Testing
- ABT-639, pregabalin
- Where
- 35 sites in United States, Czechia and 3 more
- Volunteers
- 193 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Type 1 Diabetes
The Effect of Omega-3 Supplementation on Nerve Structure and Function in Type 1 Diabetes
Nerves are made of different fats including omega-3s and omega-6s; however, dietary intakes of omega-6s are very high and omega-3 intakes are very low.
- Trial name
- NCT02034266
- Testing
- Omega-3 supplementation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Eduardo Ng
Diabetes Mellitus
Microvascular Response in Diabetes Mellitus
Vascular and neurological mechanisms are both likely to be involved in foot ulcer. We recently reported on the hand an original transient pressure-induced vasodilation (PIV) during a 5 mmHg/min increase of pressure strain using…
- Trial name
- NCT00160927
- Testing
- local heating, iontophoresis, actylcholine
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Carpal Tunnel Syndrome
Reliability And Validity Of Urdu Version Of Disabilities Of The Arm, Shoulder And Hand Questionnaire
The goal of study is to convert Disabilities Of The Arm, Shoulder And Hand Questionnaire into Urdu and test its reliability and validity among the Pakistani citizens.
- Trial name
- NCT05411068
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Riphah International University
Peripheral Neuropathy
Evaluation of an Exercise Intervention for Vincristine Induced Peripheral Neuropathy in Pediatric Cancer Patients
The purpose of this study is to better understand whether or not children with ALL can complete an exercise program during treatment and whether or not that program may impact peripheral neuropathy.
- Trial name
- Exercise (NCT03430674)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Indiana University
Diabetic Foot Ulcers
Clinical Efficacy of Platelet Gel From Cord Blood for the Treatment of Diabetic Foot Ulcers
A novel method (PCT n. WO 2010/007502 A2, 2010) has been developed to obtain platelet gel from umbilical cord blood (CBPG). The main advantages so far identified in CBPG as compared to platelet gel derived from adult platelets…
- Trial name
- CBPG-DFU (NCT02389010)
- Testing
- Allogeneic cord blood platelet gel-CBPG, Standard Local Medications-SLM
- Where
- 9 sites in Italy, Spain
- Volunteers
- 50 people
- Sponsor
- Centro Nazionale Sangue
Cubital Tunnel Syndrome, Nerve Compression
Promoting Healing of Nerves Through Electrical Stimulation
This study is evaluating a new therapeutic use of electrical stimulation to promote nerve healing and improve functional recovery following surgical intervention for nerve compression.
- Conditions
- Cubital Tunnel Syndrome, Nerve Compression, Nerve Injury, Ulnar Neuropathies
- Trial name
- PHONES (NCT04662320)
- Testing
- Checkpoint BEST System
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Checkpoint Surgical Inc.
Diabetes Mellitus, Type 2
Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus
An AGE-rich diet can induce after 2-6 weeks persistent increases in mediators linked to vascular dysfunction (e.g. TNFα, VCAM-1) in people with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT00446810
- Testing
- Benfotiamine
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Ruhr University of Bochum
Carpal Tunnel Syndrome
Clinical Validation of a Decompression Prototype Splint for Patients With Carpal Tunel Syndrome
A multicentric randomized controlled trial has been designed to study the effects of a decompression prototype splint on symptoms, functional capacity and nerve conduction studies in patients with carpal tunnel syndrome.
- Trial name
- NCT04043780
- Testing
- Decompression prototype splint for carpal tunnel syndrome, Standard splint for carpal tunnel syndrome
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Zaragoza
Carpal Tunnel Syndrome
Comparison of Difference Hydrodissection for CTS
Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy with involving compression of the median nerve in the carpal tunnel.
- Trial name
- NCT03031041
- Testing
- Ultrasound-guided short-axis hydrodissection with 5cc normal saline, Ultrasound-guided long-axis hydrodissection with 3cc normal saline
- Where
- Taiwan
- Volunteers
- 47 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Diabetic Foot Ulcer
Efficacy and Safety of Garamycin® Sponge in Diabetic Patients With a Moderate or Severe Foot Ulcer Infection
The purpose of this study is to determine whether Garamycin Sponge (Gentamicin-Collagen sponge) in combination with antibiotics is safe and effective in treating moderate and severe diabetic foot infections.
- Trial name
- NCT01951768
- Testing
- Garamycin Sponge (Gentamicin-Collagen sponge), Systemic Antibiotic
- Where
- Switzerland
- Volunteers
- 88 people
- Sponsor
- University Hospital, Geneva
Postherpetic Neuralgia, Chronic Pain
Efficacy of Transcutaneous Pulsed Radiofrequency in Postherpetic Neuralgia
Postherpetic neuralgia (PHN) is a chronic pain syndrome that may be resistant to treatment and can lead to physical and social disability as well as psychological disturbances, persisting for years in some patients.
- Conditions
- Postherpetic Neuralgia, Chronic Pain, Neuropathy
- Trial name
- NCT07390279
- Testing
- Transcutaneous Pulsed Radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Diabetic Foot Ulcer
Bioactive Smart Dressings for Diabetic Foot Ulcers: Randomized Controlled Trial
We propose a randomized controlled study to assess the efficacy of: 1. Platelet-lysate loaded sustained release thermo-gelling formulation (Platelets-SR) 2.
- Trial name
- NCT05671250
- Testing
- PRP gel and SOC-treatment, EPO/ISDN/UFH cryogel dressing, Standard of Care
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Painful Diabetic Neuropathy, Diabetic Neuropathy, Painful
Extension of Phase 3 Gene Therapy for Painful Diabetic Neuropathy
The purpose of this study is to explore the overall safety profile and durability of efficacy of Engensis (VM202) in painful diabetic peripheral neuropathy.
- Trial name
- NCT04055090
- Testing
- Long-Term Follow-Up of Patients who Received Engensis (VM202)
- Where
- 14 sites in United States
- Volunteers
- 101 people
- Sponsor
- Helixmith Co., Ltd.
Chronic Pain, Complex Regional Pain Syndromes
The Success of Lumbar Sympathetic Ganglion Block Using Lower Extremity Perfusion Index
The patient, who is experiencing chronic pain in the lower extremities persisting for more than three months, is scheduled to undergo lumbar sympathetic ganglion block.
- Conditions
- Chronic Pain, Complex Regional Pain Syndromes, Peripheral Neuropathy, Post Herpetic Neuralgia
- Trial name
- NCT06241820
- Testing
- Lumbar Sympathetic Ganglion Block
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Jeongsoo Kim
Carpal Tunnel Syndrome
Lidocaine With Epinephrine vs. Bupivacaine With Epinephrine as Local Anesthetic Agents in Wide-awake Hand Surgery
This study is focused on comparing patients' pain scores on a visual analogue scale (VAS) and the difference in analgesics use post-operatively (with the same prescription defining only the maximum frequency) between lidocaine…
- Trial name
- NCT02315573
- Testing
- Wrist block anesthesia
- Where
- Canada
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- St. Mary's Research Center, Canada
Diabetic Foot Ulcers, Venous Ulcers
Registry Trial of the Effectiveness of Platelet Rich Plasma for Chronic Non-Healing Wounds
This study will examine differences in the process of wound-healing in patients treated with platelet rich plasma (a concentration of proteins derived from a patients own blood) applied to the wound as a gel; injected into the…
- Conditions
- Diabetic Foot Ulcers, Venous Ulcers, Pressure Ulcers
- Trial name
- CMS (NCT02071979)
- Testing
- Autologous PRP Gel, Autologous PRP Injections, Autologous PRP Gel plus PRP Injections
- Where
- 6 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Arteriocyte, Inc.
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