Clinical trials: Neurosciences, open to volunteers
Pain, Disability
Additional Effects of Pain Neuroscience Education With Standard Pre-operative Physiotherapy on Post-laminectomy Pain and Disability.
This randomized controlled trial investigates whether adding Pain Neuroscience Education (PNE) to standard pre-operative physiotherapy improves outcomes after lumbar laminectomy.
- Conditions
- Pain, Disability, Laminectomy, Physical Therapy
- Trial name
- NCT07801586
- Testing
- Experimental Group - Pain Neuroscience Education + Standard Pre-operative Protocol, Control Group - Standard Pre-Operative Care
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Foundation University Islamabad
Depression Mild, Depression
fMRI Neurofeedback With Matter Neuroscience App
Study will utilize an app, Matter Neuroscience, designed to help users with depression understand positive emotions and the neurotransmitters that create them.
- Conditions
- Depression Mild, Depression, Depression Moderate
- Trial name
- NCT06735885
- Testing
- Matter Neuroscience App, Stock Photos, No Home Training
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Stanford University
Neuroscience, Neuromodulation
Study of the Dynamics of Verbal and Non-verbal Interaction in Healthy Subjects, Through the Recording of Body Movements and Non-invasive Neurophysiological Techniques
Based on study literature, the investigators can say that our study aims to give an explanation not only from a behavioral point of view but also with respect to what are the neuronal mechanisms underlying our ability to perceive…
- Trial name
- OMNIBUS2023 (NCT06251479)
- Testing
- behavioral 1, behavioral 2, neuromodulation 1
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Chronic Pain (Back / Neck)
Effectiveness of a Pain Neuroscience Education and Therapeutic Exercise Program Delivered by Primary Care Physiotherapists to Patients With Chronic Nociplastic Spinal Pain
The main objective of the project is to evaluate the effectiveness, in terms of quality of life, of a therapy based on an Active Coping Protocol for Non-Cancer Chronic Pain in the Primary Care setting.
- Trial name
- AP-AADC (NCT07133607)
- Testing
- education about pain and physical excersice, education about pain and physical excersice with somatosensorial treatment, Classic physiotherapy treatment with physical exercise, analgesic electrotherapy and thermotherapy
- Volunteers
- 135 people
- Sponsor
- Distrito de Atención Primaria Sevilla
Lumbar Radiculopathy
Effects of a Prehabilitation Program in Patients Undergoing Lumbar Radiculopathy Surgery
The purpose of the following study is to analyze the effects of a prehabilitation program based on therapeutic exercise, back care education and pain neuroscience education through the visualization of videos, compared to…
- Trial name
- NCT06145620
- Testing
- Physiotherapy
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Cardenal Herrera University
Pain, Normal Physiology
Neural and Psychological Mechanisms of Pain Perception
Background: Painful stimuli cause changes in a network of brain regions called the "Pain Matrix." But most of these regions respond to many other stimuli, not just pain.
- Conditions
- Pain, Normal Physiology, Healthy Volunteers
- Trial name
- NCT02446262
- Testing
- Instructions, Attention, Thermal Pain
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Delirium, Sedation
Neurosteer Bedside Monitoring System
The purpose of this study is to evaluate the clinical utility of Neurosteer's brain monitoring platform for monitoring delirium, sedation, and agitation in intubated and sedated ICU patients.
- Conditions
- Delirium, Sedation, Agitation
- Trial name
- NCT06718764
- Testing
- Neurosteer's single-channel EEG monitoring device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Low Back Pain
Pain Neuroscience Education Combined With Lumbar Stabilization Exercises on Disability and Kinesiophobia Among Patients With Chronic Low Back Pain
This study will investigate the effect of adding Pain Neuroscience Education (PNE) to a standard lumbar stabilization exercise program on disability and kinesiophobia among patients with chronic low back pain in the Gaza Strip.
- Trial name
- NCT07307859
- Testing
- Experimental Group - Lumbar Stabilization Exercises + PNE, Control Group - Lumbar Stabilization Exercises Only
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Neurological Disorders, Neuroscience
Advanced Space-time Resolved Techniques for Functional Neuroimaging at 7 Tesla MRI
In recent years, the in vivo study of the central nervous system has undergone significant advancement through the implementation of magnetic resonance imaging (MRI)-based neuroimaging techniques.
- Conditions
- Neurological Disorders, Neuroscience, Epilepsy, Brain Injuries, Focal
- Trial name
- AURORA (NCT07865546)
- Testing
- Functional neuroimaging
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Imago 7 Fondazione di Ricerca onlus
Non Specific Low Back Pain
Effects of Pain Neuroscience Education on Pain, Kinesiophobia in Patients With Non Specific Low Back Pain
Chronic non-specific low back pain (NSLBP) is a highly prevalent musculoskeletal condition and a leading cause of disability worldwide.
- Trial name
- NCT07460011
- Testing
- Core stabilization exercises, Pain neuroscience education + core stabilization
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Chronic Musculoskeletal Pain
Multimodal Intervention for Persistent Musculoskeletal Pain in Primary Care
This multicenter randomized controlled trial aims to evaluate the effectiveness of a multimodal intervention for the active management of persistent musculoskeletal pain in primary care.
- Trial name
- DolorAP (NCT07461298)
- Testing
- Multimodal Pain Management Program, Usual Primary Care
- Where
- 5 sites in Spain
- Volunteers
- 146 people
- Sponsor
- Universitat Jaume I
Diabetic Neuropathic Pain
Effectiveness of Pain Neuroscience Education Along With Neural Mobilization Versus Neural Mobilization Alone on Pain, Functional Disability And Quality of Life In Patients With Diabetic Neuropathic Pain
This is a randomized controlled trial aims to evaluate the comparative effect of Pain Neuroscience Education combined with neural mobilization versus neural mobilization alone in patients with diabetic neuropathic pain.
- Trial name
- NCT07695181
- Testing
- Pain Neurosciences Education + Neural Mobilization
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Ibadat International University, Islamabad
Healthy Aging, Healthy
The Effect of Different Focus of Attention Instructions on Resistance Training and Its Transfer to Gait Parameters in Older Adults
The goal of this clinical trial is to investigate the effects of strength training with different focus of attention strategies on plantar flexor force and how this affects gait in apparently healthy older adults.
- Trial name
- NCT06538766
- Testing
- Strength training with an internal focus of attention, Strength training with a proprioceptive external focus of attention, Strength training with a visual external focus of attention
- Where
- Portugal
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Psychotic Disorders, ADHD
Cognitive Remediation in Forensic Mental Health Care
Forensic patients often display cognitive deficits, particularly in the domain of executive functions, that represent a challenge to forensic rehabilitation.
- Conditions
- Psychotic Disorders, ADHD, TBI (Traumatic Brain Injury), Aggression
- Trial name
- CRFMHC (NCT04610697)
- Testing
- Cognitive Remediation, Active Control
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Anhedonia, Major Depressive Disorder (MDD)
Efficacy of kTMP, a Novel Non-invasive Brain Stimulation Method, for the Treatment of Anhedonia
The goal of this proposal is to provide a first assessment of the efficacy of our innovative non-invasive brain stimulation system, kTMP, in the treatment of anhedonia in MDD.
- Trial name
- kTMP Anhedonia (NCT07032428)
- Testing
- A new non-invasive brain stimulation tool
- Volunteers
- 104 people
- Sponsor
- Magnetic Tides
Neurosciences
Brain Networks Involved in Inner World Control
Inner speech (the "little voice" in our heads) plays a central role in our ability to perform complex cognitive tasks such as problem solving, reading, writing, thinking, and self awareness.
- Trial name
- INNERWORLD (NCT07469631)
- Testing
- Neuropsychological evaluation, questionnaires, and training on the tasks that will be performed in the MRI., MRI visits
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Fibromyalgia (FM), Chronic Low Back Pain (CLBP)
Pain Neuroscience Education for Chronic Pain
Chronic pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, with a high prevalence in Spain (25.9%) and an average duration of 6.83 years, highlighting its significant health…
- Conditions
- Fibromyalgia (FM), Chronic Low Back Pain (CLBP), Chronic Pain
- Trial name
- PNE (NCT07693998)
- Testing
- Therapeutic Exercise and Education in Pain Neuroscience
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- University of Valencia
Stroke
Amplitude Modulation Frequency Comparison in Kilohertz Transcranial Magnetic Perturbation (kTMP) for Chronic Stroke
Stroke is a leading cause of disability with many patients suffering chronic motor function impairments that affect their day-to-day activities.
- Trial name
- NCT07681102
- Testing
- kTMP
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Magnetic Tides
Low Back Pain
Neuroscience Education and Spinal Manipulation on Health Locus of Control in Low Back Pain
The purpose of this study is to evaluate the effects of combining Pain Neuroscience Education (PNE) with spinal manipulation for individuals suffering from chronic low back pain.
- Trial name
- LHC-LBP (NCT07639216)
- Testing
- Pain Neuroscience Education (PNE), Spinal Manipulation (SM)
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- Centro Universitário Augusto Motta
Irritable Bowel Syndrome
Effects of Aerobic Exercise and Pain Neuroscience Education in Irritable Bowel Syndrome
Irritable Bowel Syndrome (IBS) is a chronic disorder of gut-brain interaction characterized by abdominal pain and changes in bowel habits.
- Trial name
- NCT07397533
- Testing
- Exercise, Pain Neuroscience Education
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Istinye University