Clinical trials: Nitrate
Becker Muscular Dystrophy
Sodium Nitrate to Improve Blood Flow
Investigators recently showed that tadalafil restores functional sympatholysis in patients with Becker muscular dystrophy (BMD).
- Trial name
- NCT02847975
- Testing
- Sodium nitrate
- Where
- 2 sites in United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Dietary Nitrate Supplementation
Evaluating the Metabolic Effects of Dietary Nitrate Supplementation
Dietary nitrate is found to enhance muscle fatty acid oxidation/glucose uptake and increase mitochondrial biogenesis, which in turn, aid in the prevention and management of metabolic diseases.
- Trial name
- NIMMI (NCT05579262)
- Testing
- Beetroot juice
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Dietary Supplement, Placebo
Neuromuscular Responses to Acute Beetroot Ingestion in Women Older Adults
Beetroot juice supplementation has shown the capacity for provoking different physiological effects (e.g. vasodilation and muscle contraction increments).
- Trial name
- BEET_ELDERLY (NCT05337527)
- Testing
- beetroot juice
- Where
- Spain
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Cardiovascular Diseases, Inflammation
Influence of Dietary Nitrate on Skin Inflammation
This study evaluates the potential anti-inflammatory effects of inorganic dietary nitrate in a model of acute inflammation relevant to cardiovascular disease (CVD).
- Conditions
- Cardiovascular Diseases, Inflammation, Inflammation; Skin, Inflammatory Response
- Trial name
- NCT03183830
- Testing
- Nitrate-rich Beetroot Juice, Nitrate-deplete Beetroot Juice
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Blood Pressure
Dietary Nitrate Intake in Vegetarians and Omnivores
Vegetarian diets are commonly associated with lower blood pressure levels. This has been related to greater consumption of inorganic nitrate, since vegetables are the main source of this anion.
- Trial name
- NO3 (NCT03871777)
- Testing
- Chlorhexidine mouthwash
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Health Risk Behaviors
Nitrate INFORMER Nitrosamine Study
Nitrate is a controversial component of vegetables, meat, and drinking water. The now well-established benefits of nitrate, through the enterosalivary nitrate-nitrite-nitric oxide (NO) pathway, on cardiovascular risk factors and…
- Trial name
- NCT05045807
- Testing
- Meat with added nitrate, Meat with added nitrate plus vegetables
- Where
- Australia
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Edith Cowan University
Dietary Supplements: Beetroot Juice Acute Supplementation, Dietary Supplement: Placebo Acute Supplementation
Acute Effects of Beetroot Juice Ingestion on Cognitive Function and Neuromuscular Performance in Elite Female Taekwondo Athletes
Beetroot juice is a good source of nitrate (NO3-), which is a precursor of nitric oxide (NO) through the NO3- to nitrite (NO2-) to NO pathway (Lundberg et al., 2008).
- Trial name
- BEET_TAEKWONDO (NCT06675305)
- Testing
- Beetroot juice (James White, UK)
- Where
- Spain
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Universidad Pontificia Comillas
Medicaments Substances in Therapeutic Use
Potassium Oxalate and Potassium Nitrate and Post-bleaching Sensitivity
Objectives: This study will determine the effectiveness of the use of desensitivity gels prior in office bleaching on risk and intensity of tooth sensitivity caused by in-office bleaching using 35% hydrogen peroxide.
- Trial name
- NCT02941653
- Testing
- Potassium nitrate 2% gel, Potassium oxalate 5% gel
- Where
- Brazil
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sergipe
Vertigo
Evaluation of Aminobutyric Acid, Glutamic Acid, Calcium, Thiamine, Pyridoxine and Cyanocobalamin as Therapy for Vertigo
The goal of this clinical trial is to assess the efficacy and safety of a combination of aminobutyric acid, glutamic acid, calcium, thiamine, pyridoxine and cyanocobalamin as adjuvant therapy for vertigo comparatively to ginger…
- Trial name
- NCT05221892
- Testing
- Gamma-aminobutyric acid tartarate, glutamic acid, dibasic calcium phosphate, thiamine nitrate, pyridoxine chloride and cyanocobalamin, Ginger
- Where
- Brazil
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Fundação Educacional Serra dos Órgãos
Fluorosis, Dental, Non-Fluoride Enamel Opacities
Treatment of Hypersensitivity Using Diode Laser and Desensitising Agent on Fluorosed and Non-fluorosed Teeth
The present study was designed as a randomised controlled clinical trial which was unicenter, double-blinded, parallel designed study, according to the Consolidated Standards of Reporting Trials (CONSORT) criteria, 2010.
- Conditions
- Fluorosis, Dental, Non-Fluoride Enamel Opacities, Dentin Sensitivity
- Trial name
- NCT03237793
- Testing
- Fluorosed Group, Non Flourosed Group
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
no Medications
Dietary Nitrate and Cardiovascular Health
An expanding number of studies suggest a therapeutic role for nitrate and nitrite, most notably in treatment and prevention of cardiovascular disease including ischemia-reperfusion (IR) injury and hypertension.
- Trial name
- NCT01262521
- Testing
- Dietary nitrate, Water
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Endothelial Dysfunction
Nitrate and Vitamin C on Vascular Health Oxidative Stress
The objective of this study is to examine whether the co-administration of dietary nitrate combined with vitamin C for 4 weeks in patients at risk for CVD would yield robust effects on endothelial function using blood measures…
- Trial name
- NCT04283630
- Testing
- Dietary nitrate in the form of beetroot juice for all participnats, Nature Made vitamin c 1000 mg
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- David Travis Thomas
Preeclampsia, Hypertension
Effects of Nitrate-rich Beetroot Juice in Pregnant Women With High Blood Pressure
BACKGROUND: Preeclampsia (PE) is a serious syndrome that affects 3-7% of all pregnant women. PE is characterized by hypertension and kidney problems after the 20th week of pregnancy and is associated with an increased risk of…
- Conditions
- Preeclampsia, Hypertension, Endothelial Dysfunction, Nitric Oxide
- Trial name
- NITBEETPE (NCT05241327)
- Testing
- Beetroot Juice
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Blood Pressure, Sports Physical Therapy
Oral Nitrite Synthesis and Post-exercise Hypotension
Exercise is probably the most effective approach to reduce blood pressure. In fact, a single bout of exercise induces a physiological response known as Post-Exercise Hypotension (PEH) where a prolonged decrease in resting blood…
- Trial name
- NCT03904394
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Supplementation
Effects of Nitrates and Citrulline Malate on Performance in Professional Professional Soccer
Randomized, single-center, parallel, team-stratified, stratified experimental study to evaluate the efficacy of a high sports supplement in improving high-intensity intermittent exercise performance in professional female soccer…
- Trial name
- NiCiFut (NCT05525871)
- Testing
- Nitrates and Citrulline Malate, Control product
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Healthy
Tolerability and Pharmacokinetic Study of Econazole Nitrate and Benzydamine HCl Intravaginal Cream
The primary objective of the study is to evaluate local tolerability of the new Econazole/Benzydamine product, in comparison with the Econazole and Benzydamine stand-alone products and placebo.
- Trial name
- NCT02713893
- Testing
- Econazole nitrate 1% plus Benzydamine HCl 0.12% intravaginal cream
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Aging
Exploring the Effect of Inorganic Nitrates on the Human Microvascular Physiology - a Pilot Study.
We conducted a randomised, placebo-controlled, double blind, cross-over, trial to examine the short-term effect of concentrated beetroot juice on vascular outcomes in a young (18-35 years) and older group (55-75 years).
- Trial name
- ENIH-MPS (NCT04276766)
- Testing
- Crossover intervention
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Healthy Adults
Effect of Acute Nitrate Supplementation on Vascular Function in Hispanic, Black and White Population
The purpose of the study is to assess vascular function in African Americans, Hispanic and Caucasian Americans to better understand racial differences in cardiovascular health.
- Trial name
- NCT05188079
- Testing
- Beetroot juice
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Obese Individuals, Central Adiposity
Post-exercise Blood Pressure With Inorganic Nitrate
This study is examining whether acute inorganic nitrate supplementation in the form of beetroot juice, paired with an acute bout of exercise, affects blood pressure and what is the magnitude of the difference compared to exercise…
- Trial name
- BEET-DOWN (NCT07869472)
- Testing
- Beetroot Juice - Active + Exercise, Beetroot Juice - Active + No exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Gestational Hypertension
Role of the Oral Microbiome in Blood Pressure Regulation in Pregnancy
High blood pressure in pregnancy is associated with poor outcomes for both mum and baby, increasing the risk of pregnancy complications including pre-eclampsia, fetal growth restriction and preterm birth.
- Trial name
- NCT03930693
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Manchester