Clinical trials: Nitrate Supplementation
Small Vessel Cerebrovascular Disease, Diabete Mellitus
Targeting Neurovascular Coupling in Cognitive Decline Via Nitrate-Based Supplementation
Diet is established among the most relevant adjustable variables of human health in modern societies. The recognition by the World Health Organization of cognitive impairment and dementia associated with aging as one of the major…
- Trial name
- DietNOBrain (NCT07329647)
- Testing
- Beetroot Juice - Active
- Where
- 2 sites in Portugal
- Volunteers
- 25 people
- Sponsor
- University of Coimbra
Respiratory Failure
Strength Testing After Nitrate Delivery (STAND) in ICU Patients
It is well documented that intensive care unit (ICU) patients have lower levels of skeletal muscle strength compared to non-ICU patients upon hospital discharge, and this weakness affects the patient's ability to perform basic…
- Trial name
- NCT02293616
- Testing
- Nitrate Rich Beetroot Juice
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Wake Forest University Health Sciences
Citrulline, Nitrate
Long-Term Effect of Combined Citrulline and Nitrate-Rich Beetroot Extract Supplementation
Citrulline (CIT) and nitrate-rich beetroot extract (BEET) are widely studied ergogenic aids. However, both supplements have been studied in sort-term and isolated.
- Conditions
- Citrulline, Nitrate, Athletes
- Trial name
- NCT05143879
- Testing
- Citrulline, Nitrate, Nitrate plus Citrulline
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Burgos Nutrition
Healthy Adults, Mechanical Ventilation Dependence
Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude
This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions.
- Conditions
- Healthy Adults, Mechanical Ventilation Dependence, Hypoxia, Exercise Training
- Trial name
- NCT07216755
- Testing
- Respiratory Muscle Training (RMT), Dietary Supplement: Beetroot Juice Concentrate
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Embry-Riddle Aeronautical University
Chronic Obstructive Pulmonary Disease
Nitrate Supplementation in Chronic Obstructive Pulmonary Disease (COPD)
Each subject will consume (in a randomized fashion) both the intervention beverage (nitrate solution) and the placebo, separated by a 1 wk washout period.
- Trial name
- NCT02084758
- Testing
- Nitrate supplementation
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Maastricht University Medical Center
Oral Health, Dietary Nitrate
Evaluating the Impact of Various Dietary Nitrate Supplements on Oral Health
This study aims to investigate the effects of different dietary nitrate supplements, versus placebo, on microbiological and immunological markers associated with oral health in people aged 18-65 years.
- Trial name
- NCT06956612
- Testing
- Juice (Active comparator), Crystals (Experimental)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shatha Alhulaefi
Obese Individuals, Central Adiposity
Post-exercise Blood Pressure With Inorganic Nitrate
This study is examining whether acute inorganic nitrate supplementation in the form of beetroot juice, paired with an acute bout of exercise, affects blood pressure and what is the magnitude of the difference compared to exercise…
- Trial name
- BEET-DOWN (NCT07869472)
- Testing
- Beetroot Juice - Active + Exercise, Beetroot Juice - Active + No exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Hypertension
Bariatric Surgery and Cardiovascular Responses to Sodium Nitrate
Inorganic nitrite and nitrate can be reduced to NO and NO-related species such as S-nitrosothiols via the nitrate-nitrite-NO pathway.
- Trial name
- NCT06303830
- Testing
- Sodium nitrate
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Peripheral Arterial Disease, Peripheral Artery Disease
Dietary Nitrate Supplementation and Thermoregulation
This is a double-blinded, randomized, crossover design study to assess the effects of dietary nitrate supplementation (beetroot juice) on peripheral artery disease (PAD) patients (ages 50-85) diagnosed with Fontaine stage I or II…
- Trial name
- NCT03506646
- Testing
- Beet root juice
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Nebraska
Dietary Nitrate Supplementation
Evaluating the Metabolic Effects of Dietary Nitrate Supplementation
Dietary nitrate is found to enhance muscle fatty acid oxidation/glucose uptake and increase mitochondrial biogenesis, which in turn, aid in the prevention and management of metabolic diseases.
- Trial name
- NIMMI (NCT05579262)
- Testing
- Beetroot juice
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Arterial Hypertension, Resistant Hypertension
Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients
Arterial hypertension (AH) has been identified as an important public health problem and considered a new epidemic with high mortality and morbidity.
- Conditions
- Arterial Hypertension, Resistant Hypertension, Microvascular Function, Nitrate Supplementation
- Trial name
- NCT06169241
- Testing
- Beetroot extract
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Type 2 Diabetes
Effect of Nitrate on Red Blood Cell Function in Type 2 Diabetes
To investigate the effect of nitrate supplementation on red blood cell function in patients with type 2 diabetes.
- Trial name
- NCT04917471
- Testing
- Beet root juice
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Exercise Physiology, Sports Nutrition
Effects of Acute Beetroot Juice on Aerobic Performance and Muscle Oxygenation in Amateur Female Soccer Players
Effects of Acute Beetroot Juice on Aerobic Performance and Muscle Oxygenation in Amateur Female Soccer Players
- Conditions
- Exercise Physiology, Sports Nutrition, Cardiorespiratory Fitness
- Trial name
- NCT07840014
- Testing
- Nitrate-rich beetroot juice
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Sakarya Applied Sciences University
Exercise Performance, Supplementation
The Effect of Acute Beetroot Juice Supplementation on Anaerobic Performance in Football Players
The aim of this clinical trial is to examine the effects of two different natural fruit-vegetable blend beverages on short-duration, high-intensity exercise performance and muscle oxygenation in young male football players.
- Trial name
- NCT07048912
- Testing
- Beetroot Juice (BJ)
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Melike Nur Eroğlu
Menopause
Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females
Menopause greatly increases cardiovascular disease risk (CVD). Current exercise guidelines are inadequate to ameliorate this risk and higher intensity exercise may be necessary for cardiovascular benefits in postmenopausal…
- Trial name
- NCT06480695
- Testing
- Nitrate-Rich Beetroot Juice, High Intensity Exercise, Moderate Intensity Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Blood Pressure, Cognitive Change
Dietary Nitrate and Healthy Older Adults
This study investigates the influence of dietary nitrate supplementation on cardiovascular health and physical and cognitive performance in older adults.
- Conditions
- Blood Pressure, Cognitive Change, Functional Capacity, Brain Metabolism
- Trial name
- NCT03473678
- Testing
- Nitrate-rich beetroot juice, Nitrate-depleted beetroot juice
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Males, Females
Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes
This study is examining whether short-term supplementation with inorganic nitrate, in the form of beetroot juice, can enhance blood vessel health, insulin sensitivity, and exercise capacity in individuals with prediabetes.
- Conditions
- Males, Females, Sedentary, Metformin
- Trial name
- NO3-PreDM (NCT07131384)
- Testing
- Dietary Supplement: Inorganic Nitrate (Beetroot juice)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Autosomal Dominant Polycystic Kidney, Hypertension
Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease
People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is reduced in ADPKD, and may…
- Conditions
- Autosomal Dominant Polycystic Kidney, Hypertension, Endothelial Dysfunction
- Trial name
- BEET-PKD (NCT05401409)
- Testing
- Beetroot juice, Nitrate-depleted beetroot juice
- Where
- 2 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Western Sydney Local Health District
Ramadan Fasting
Impact of Dietary Nitrate Supplementation on VO2max During Ramadan Fasting in Healthy Adults
The goal of this clinical trial is to determine if beetroot juice supplementation changes exercise performance following one week of Ramadan fasting in young, healthy adults.
- Trial name
- NCT06767176
- Testing
- Beetroot Juice (Beet-It Stamina Shot) & Supervised Exercise Training
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University of Guelph
Healthy
Acute Effect of Nitrate From Natural Dietary Sources on Arterial Stiffness and Blood Pressures in Healthy Individuals
The purpose of this study is to evaluate the acute effect of a meal high in dietary nitrates on aortic augmentation index, brachial and aortic blood pressures, and subendocardial viability ration (SEVR).
- Trial name
- DNAB (NCT01604993)
- Testing
- Spinach soup, Asparagus soup
- Where
- Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto