Clinical trials: Nitrate Supplementation
Citrulline, Nitrate
Long-Term Effect of Combined Citrulline and Nitrate-Rich Beetroot Extract Supplementation
Citrulline (CIT) and nitrate-rich beetroot extract (BEET) are widely studied ergogenic aids. However, both supplements have been studied in sort-term and isolated.
- Conditions
- Citrulline, Nitrate, Athletes
- Trial name
- NCT05143879
- Testing
- Citrulline, Nitrate, Nitrate plus Citrulline
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Burgos Nutrition
Healthy Adults, Mechanical Ventilation Dependence
Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude
This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions.
- Conditions
- Healthy Adults, Mechanical Ventilation Dependence, Hypoxia, Exercise Training
- Trial name
- NCT07216755
- Testing
- Respiratory Muscle Training (RMT), Dietary Supplement: Beetroot Juice Concentrate
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Embry-Riddle Aeronautical University
Oral Health, Dietary Nitrate
Evaluating the Impact of Various Dietary Nitrate Supplements on Oral Health
This study aims to investigate the effects of different dietary nitrate supplements, versus placebo, on microbiological and immunological markers associated with oral health in people aged 18-65 years.
- Trial name
- NCT06956612
- Testing
- Juice (Active comparator), Crystals (Experimental)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shatha Alhulaefi
Obese Individuals, Central Adiposity
Post-exercise Blood Pressure With Inorganic Nitrate
This study is examining whether acute inorganic nitrate supplementation in the form of beetroot juice, paired with an acute bout of exercise, affects blood pressure and what is the magnitude of the difference compared to exercise…
- Trial name
- BEET-DOWN (NCT07869472)
- Testing
- Beetroot Juice - Active + Exercise, Beetroot Juice - Active + No exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Hypertension
Bariatric Surgery and Cardiovascular Responses to Sodium Nitrate
Inorganic nitrite and nitrate can be reduced to NO and NO-related species such as S-nitrosothiols via the nitrate-nitrite-NO pathway.
- Trial name
- NCT06303830
- Testing
- Sodium nitrate
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Dietary Nitrate Supplementation
Evaluating the Metabolic Effects of Dietary Nitrate Supplementation
Dietary nitrate is found to enhance muscle fatty acid oxidation/glucose uptake and increase mitochondrial biogenesis, which in turn, aid in the prevention and management of metabolic diseases.
- Trial name
- NIMMI (NCT05579262)
- Testing
- Beetroot juice
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Exercise Physiology, Sports Nutrition
Effects of Acute Beetroot Juice on Aerobic Performance and Muscle Oxygenation in Amateur Female Soccer Players
Effects of Acute Beetroot Juice on Aerobic Performance and Muscle Oxygenation in Amateur Female Soccer Players
- Conditions
- Exercise Physiology, Sports Nutrition, Cardiorespiratory Fitness
- Trial name
- NCT07840014
- Testing
- Nitrate-rich beetroot juice
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Sakarya Applied Sciences University
Exercise Performance, Supplementation
The Effect of Acute Beetroot Juice Supplementation on Anaerobic Performance in Football Players
The aim of this clinical trial is to examine the effects of two different natural fruit-vegetable blend beverages on short-duration, high-intensity exercise performance and muscle oxygenation in young male football players.
- Trial name
- NCT07048912
- Testing
- Beetroot Juice (BJ)
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Melike Nur Eroğlu
Menopause
Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females
Menopause greatly increases cardiovascular disease risk (CVD). Current exercise guidelines are inadequate to ameliorate this risk and higher intensity exercise may be necessary for cardiovascular benefits in postmenopausal…
- Trial name
- NCT06480695
- Testing
- Nitrate-Rich Beetroot Juice, High Intensity Exercise, Moderate Intensity Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Blood Pressure, Cognitive Change
Dietary Nitrate and Healthy Older Adults
This study investigates the influence of dietary nitrate supplementation on cardiovascular health and physical and cognitive performance in older adults.
- Conditions
- Blood Pressure, Cognitive Change, Functional Capacity, Brain Metabolism
- Trial name
- NCT03473678
- Testing
- Nitrate-rich beetroot juice, Nitrate-depleted beetroot juice
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Healthy
Acute Effect of Nitrate From Natural Dietary Sources on Arterial Stiffness and Blood Pressures in Healthy Individuals
The purpose of this study is to evaluate the acute effect of a meal high in dietary nitrates on aortic augmentation index, brachial and aortic blood pressures, and subendocardial viability ration (SEVR).
- Trial name
- DNAB (NCT01604993)
- Testing
- Spinach soup, Asparagus soup
- Where
- Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Health Adult Subjects
Dose-response Effects of Dietary Nitrate on Running Time-to-exhaustion and Neuromuscular Fatigue: a Randomized Crossover Exploratory Pilot Study
Background: Dietary nitrate is a natural compound found in vegetables such as beetroot and leafy greens. Previous research suggests that consuming nitrate before exercise may improve endurance and physical performance.
- Trial name
- Nitrate TTE (NCT07735455)
- Testing
- Dietary Nitrate
- Where
- Spain
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Madrid
Healthy Individuals With no Periodontal Disease
The Effect of Nitrate Supplementation on Tongue Microbiome
The objective of this study is to investigate how the host environment influences microbiome structure. Specifically, the spatial organization of nitrate-metabolizing bacteria that will flourish in high and low salivary nitrate…
- Trial name
- NCT07865481
- Testing
- Nitrate-Supplemented Beet Juice, Nitrate-Depleted Beet Juice
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The Forsyth Institute
Air Pollution
The Effect of Juice Types on the Responses to Air Pollution
The study hypothesis is that drinking different juices will affect the body's responses to air pollution. Subjects will be exposed to air pollution during a 2-hour car ride on the NJ (New Jersey) Turnpike.
- Trial name
- NCT02027415
- Testing
- Beet juice, Orange juice
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Exercise Performance
The Effect of Dietary Nitrate Supplementation on Linear Running Sprint Performance, Agility and Vertical Jump Performance in a Rested and Fatigued State
Dietary nitrate (NO3-) supplementation has been shown to improve skeletal muscle contractility and fatigue resistance, particularly in fast-twitch (type II) muscle fibers.
- Trial name
- NCT03565523
- Testing
- Beetroot
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Healthy
Beetroot Juice and Sleep
The purpose of this study is to investigate the effects of acute inorganic nitrate supplementation (with beetroot) on the regulation of sleep and neurovascular physiology.
- Trial name
- NCT05864521
- Testing
- Active Beetroot Juice Supplement (aBRJ)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Erectile Dysfunction
The Effects of a Nitrate Supplementation on Erectile Function
Twenty (20) individuals to be recruited from Ballantyne Medical Associates in Charlotte, NC, without any significant chronic medical history. These patients are general patients for primary care that meet inclusion criteria.
- Trial name
- NCT06213077
- Testing
- Nitric Oxide, Tadalafil
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- RHA Investments Ltd
Endothelial Dysfunction
Effects of Dietary Nitrate on Age-related Vascular Function
Purpose of the study is to characterize the chronic effect of dietary nitrate on vascular function in healthy volunteers with particular emphasis on age-related alterations.
- Trial name
- NCT01729234
- Testing
- Nitrate
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Blood Pressure
Effects of Dietary Nitrate and Vitamin C Co-supplementation on Blood Pressure and Endothelial Function in Overweight Individuals
The investigators have shown in two short-term studies in healthy, young participants that the combined supplementation of inorganic nitrate with vitamin C has beneficial effects on blood pressure and blood vessel wall stiffness.
- Trial name
- NCT07242066
- Testing
- Beetroot juice plus vitamin C tablet
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Hypoxia
The Effect of Chronic Nitrate Supplementation on Acute Mountain Sickness and Exercise Performance in Hypoxia
The study will aim to describe and evaluate the effect of chronic beetroot juice supplementation on acute mountain sickness symptoms and exercise in a hypoxic environment.
- Trial name
- NCT03101904
- Testing
- Beetroot Juice
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Bangor University