Clinical trials: Nocebo Effects
Pain, Nocebo Effect
Muscle Synergies in Pain and Pain Anticipation
This study investigates how the anticipation of pain affects muscle synergies. One group will be recruited who will first experience actual pain from capsaicin cream and are then presented with a harmless cream deceptively…
- Conditions
- Pain, Nocebo Effect, Pain Anticipation
- Trial name
- NCT07251387
- Testing
- Pain expectation conditioning, Gait assesment
- Where
- 2 sites in Canada, France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universite de Picardie Jules Verne
Pain, Itch
Topographical Distribution of Itch and Pain Receptors
The experiment consists of three experimental sessions conducted on three consecutive days. In all experimental sessions, the participant will fill in a series of questionnaires about how you perceive itch and pain, and about…
- Trial name
- NCT07122973
- Testing
- Histamine, Cowhage, Capsaicin 8% Patch
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Anesthesia
Poke and a Placebo
To discover if a positive description of the procedure for an epidural can reduce the overall pain score associated with the procedure.
- Trial name
- NCT04497220
- Testing
- Negative Connotation Langauge, Positive Connotation Language
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pain, Hyperalgesia
Reducing Nocebo Effects on Pressure Pain
Nocebo effects are known to adversely affect the experience of various physical symptoms, such as pain and itch. Nocebo effects can be induced by associative learning mechanisms of classical conditioning.
- Trial name
- NCT05284383
- Testing
- Closed-label nocebo conditioning, Closed-label counterconditioning, Open-label counterconditioning
- Where
- Netherlands
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Leiden University
Chronic Pain Syndrome, Chronic Pain, Psychogenic
Electrophysiological Correlates of Nocebo Effects on Pain
Pain is a nociceptive somatosensory process that can arise as a debilitating and chronic symptom in various diseases or following an injury.
- Conditions
- Chronic Pain Syndrome, Chronic Pain, Psychogenic, Chronic Pain, Hyperalgesia
- Trial name
- NCT04199858
- Testing
- Baseline pain stimulations, Conditioning, Evocation
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Attention Deficit Disorder With Hyperactivity, Placebo Effect
Attention and Pain in Children With and Without Attention Deficit and/or Hyperactivity Disorder
In Quebec, there has been an important increase of Attention Deficit Hyperactivity Disorder (ADHD) diagnosis since 2015. ADHD symptoms, related to behavioural and/or concentration difficulties, are very similar to other disorders…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Placebo Effect, Nocebo Effect, Pain
- Trial name
- ADE (NCT04766580)
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
ITCH
Mechanisms Underlying the Nocibo Effect of Contagious Itch. in Both Histaminergic and Nonhistaminergic Itch
The study consists of one experimental session of approximately 1½ hours. The participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as…
- Trial name
- NCT07255092
- Testing
- Histamine, Cowhage (Mucuna Pruriens)
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
ITCH
Mechanisms Underlying the Placebo Effect in Both Histaminergic and Non-histaminergic Itch
The study consists of one experimental session of approximately 1½ hours. The participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as…
- Trial name
- NCT07247695
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Low Back Pain, Musculoskeletal Injury
Does Self-efficacy Predict Outcomes Among U.S. Military Academy Cadets During Initial Entry Training?
Background: Lower back injuries are a common occurrence in athletes, sports programs, and in the military (Bengtsson, 2018; Lovalekar, 2021).
- Trial name
- NCT05453110
- Testing
- Deadlift Form Education
- Where
- United States
- Volunteers
- 903 people, healthy volunteers welcome
- Sponsor
- Keller Army Community Hospital
Pain
Neuromodulation of Lidocaine and Capsaicin Cream Effects on Pain Experience
The aim of this study is to use a brain stimulation tool called transcranial direct current stimulation (tDCS) to investigate the analgesic (reducing sensitivity to pain) effects of lidocaine cream and the hyperalgesic…
- Trial name
- NCT03102710
- Testing
- transcranial direct current stimulation (tDCS), Lidocaine cream, Capsaicin cream
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Communication Skills, Dental Care
Importance of the Type of Communication Used During Paraapical Anesthesia in Dentistry
Can we improve our communication to provide better care for our patients? In the healthcare field, the patient's experience is closely linked to pain management.
- Conditions
- Communication Skills, Dental Care, Hypnosis
- Trial name
- CADA (NCT06892184)
- Testing
- hypnotic communication, conventional communication
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Lower Back Pain, Healthy Control Subjects
Psychobiological Mechanisms of Placebo and Nocebo Effects in the Treatment of Chronic Back Pain
Placebo and nocebo responses have mainly been studied in healthy humans for pharmacological rather than psychological interventions.
- Trial name
- NCT02157389
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Healthy Participants
The Influence of Doctor-patient Communication on Treatment Expectation, Placebo and Nocebo Response
The purpose of this study is to determine whether a patient-centered compared to doctor-centered communication style of a physician influences the treatment expectation and the placebo and nocebo response in healthy individuals.
- Trial name
- SENSE (NCT03949816)
- Testing
- medical consultation: different doctor-patient-centered style of communication, information letter / no medical consultation
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Communication
Physiotherapists' Placebo or Nocebo Communication Regarding VR
Rationale: Chronic musculoskeletal pain (CMP) is a common and disabling condition. Physiotherapy is the most frequently administered nonpharmacological treatment option for patients with CMP and recently virtual reality (VR) was…
- Trial name
- NCT06307912
- Testing
- Video nocebo communication
- Where
- Netherlands
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- HAN University of Applied Sciences
Nocebo Effect, Kinesiophobia
Effect of Anticipated Pain on Corticospinal Excitability
The purpose of this study is to investigate how the anticipation of pain, in the absence of real pain, affects the excitability of the corticospinal pathway.
- Trial name
- PACE (NCT07407595)
- Testing
- Pain Expectation Manipulation
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universite du Littoral Cote d'Opale
Placebo Effect, Nocebo Effect
Neurophysiological Mechanisms of Placebo and Nocebo Effects in Sports - a Protocol Paper
This clinical trial aims to investigate the neurophysiological mechanisms of placebo and nocebo effects on sports performance, using Electroencephalography (EEG) and isometric strength testing of the lower extremities.
- Trial name
- NCT06835777
- Testing
- Positive Expectation, Negative Expectation, Control
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Canterbury Christ Church University
ADHD
Nocebo Education to Reduce the Potential Unintended Harms of Mental Health Awareness
This project has two aims. First, the research team will confirm whether providing a mental health awareness workshop poses unintended harms by raising the rate of self-diagnosis (as opposed to a neutral workshop) and causing…
- Trial name
- NCT06638411
- Testing
- ADHD information workshop, ADHD information workshop with nocebo education, Sleep workshop
- Where
- Canada
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Hyperalgesia, Chronic Pain Syndrome
Pain-related Fear as a Facilitator of Nocebo Hyperalgesia
Nocebo hyperalgesia is characterized by adverse pain outcomes, induced by patients' expectations. In the lab, nocebo effects are commonly studied via classical conditioning, a method that employs pairings of neutral…
- Conditions
- Hyperalgesia, Chronic Pain Syndrome, Chronic Pain, Psychogenic, Fear of Pain
- Trial name
- LFS (NCT04197154)
- Testing
- Threat manipulation (control, no threat), Threat manipulation, Conditioning of moderate pain
- Where
- Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Nocebo Effect, Pain Anticipation
Muscular Synergies and Behavioral Adaptations of Gait in Pain Anticipation (SYAMAPP)
The purpose of this study is to determine whether the anticipation of pain influences gait control and psychophysiological responses in healthy individuals.
- Trial name
- SYAMAPP (NCT06929559)
- Testing
- Pain expectation conditioning, Comparator (Control Group), Intervention: Gait
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universite de Picardie Jules Verne
Nocebo Effects, Hyperalgesia
The Role of Learning in Nocebo Hyperalgesia
Nocebo effects are adverse effects induced by patients' expectations. Nocebo effects on pain may underlie several clinical conditions, such as chronic pain. These effects can be learned via classical conditioning mechanisms.
- Conditions
- Nocebo Effects, Hyperalgesia, Chronic Pain, Pain Syndrome
- Trial name
- NCT03793790
- Testing
- Conditioning with partial reinforcement, Conditioning with continuous reinforcement, Counterconditioning
- Where
- Netherlands
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center