Clinical trials: Non-invasive Treatment
Urothelial Carcinoma of the Urinary Bladder
Intravesical Cabazitaxel, Gemcitabine, and Cisplatin (CGC) in the Treatment Urothelial Carcinoma of the Bladder
The investigators intend to evaluate the safety and toxicity profile of intravesically administered multidrug regimen of Cabazitaxel, Cisplatin and Gemcitabine in treatment refractory Transitional Cell Carcinoma.The investigators…
- Trial name
- CGC (NCT02202772)
- Testing
- Cabazitaxel, Gemcitabine, Cisplatin
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Guarionex J. Decastro
Sleep Disordered Breathing
Contribution of an Educational Game for Continuous Positive Pressure/Non-invasive Ventilation Therapeutic Education in Children
A growing number of children with obstructive sleep apnea syndrome (OSAS) or nocturnal alveolar hypoventilation syndrome are treated with continuous positive airway pressure (CPAP) or nocturnal non-invasive ventilation (NIV)…
- Trial name
- YAPOUNI (NCT04660994)
- Testing
- Educational game
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non-invasive CAR-T Cell Monitoring, BCMA-targeted PET Imaging
CAR-T Cell Efficacy With Molecular Imaging in Multiple Myeloma
⁶⁸Ga-NOTA-BCMA is a novel, targeted PET tracer under clinical investigation. It is designed to provide a non-invasive method for monitoring the biodistribution and persistence of BCMA CAR-T cells in patients.
- Conditions
- Non-invasive CAR-T Cell Monitoring, BCMA-targeted PET Imaging, CAR-T Cell Biodistribution and Persistence, GMP-compliant Radiopharmaceutical Preparation
- Trial name
- NCT07280793
- Testing
- BCMA-Targeting CAR-T Cell Therapy, PET/CT Imaging
- Volunteers
- 10 people
- Sponsor
- Xuzhou Medical University
Stress Urinary Incontinence
PelviSense, an Innovative, Non-invasive, Biofeedback Device for the Treatment of Stress Urinary Incontinence in Women
Background and purpose: The research team developed the PelviSense, a non-invasive biofeedback device paired with wearable EMG sensors for use as a PFMT adjunct.
- Trial name
- NCT06126757
- Testing
- PelviSense-assisted pelvic floor muscle training, Active Comparator
- Where
- Hong Kong
- Volunteers
- 132 people
- Sponsor
- The Hong Kong Polytechnic University
Non-muscle Invasive Bladder Cancer
A Clinical Trial Aimed at Assessing the Efficacy and Safety of VT-101 for the Treatment of Non-muscle Invasive Bladder Cancer
This is an experimental study to evaluate the efficacy and safety of VT-101 for the treatment of non-muscle invasive bladder cancer
- Trial name
- NCT06632964
- Testing
- Recombinant oncolytic adenovirus injection solution of VT-101
- Where
- China
- Volunteers
- 16 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Raynaud Phenomenon, Primary Raynaud Phenomenon
Potential Benefit for Non Invasive Vagus Nerve Stimulation Using GammaCore in the Treatment of Raynaud's Phenomena.
Raynaud's phenomenon (RP) is a common vascular disorder that affects approximately 10% of the general population. RP is associated with significant morbidity that may include loss of the digits due to repeated episodes of…
- Conditions
- Raynaud Phenomenon, Primary Raynaud Phenomenon, Raynaud Disease, Raynaud Syndrome
- Trial name
- NCT03869008
- Testing
- gammaCore Sapphire
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Toledo Health Science Campus
Urinary Bladder Neoplasms
The Bladder Instillation Comparison Study
To compare the efficacy of Mitomycin C vs. Gemcitabine vs. no adjuvant treatment as a single intraoperative instillation in preventing recurrence of bladder cancer.
- Trial name
- BIC (NCT02695771)
- Testing
- Mitomycin C, Gemcitabine
- Where
- 3 sites in United States
- Volunteers
- 101 people
- Sponsor
- Corewell Health West
High - Risk NMIBC
Observational Clinical Study on High - Risk NMIBC Patients Choosing Trimodality Bladder - Sparing Therapy
The goal of this observational study is to assess the safety and efficacy of trimodality bladder - sparing therapy in high - risk NMIBC patients.
- Trial name
- NCT07053748
- Testing
- Trimodality Bladder-preserving Therapy
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Periodontitis
Minimally-invasive Non-surgical Treatment in Teeth With Unfavourable Prognosis
This is a pilot prospective cohort study to assess the efficacy of minimally-invasive non-surgical periodontal therapy (MINST) for the treatment of teeth with unfavourable periodontal prognosis.
- Trial name
- NCT04236648
- Testing
- Minimally-invasive non-surgical therapy (MINST)
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Total Rupture of the Anterior Cruciate Ligament in the Knee
Khalifa Effectiveness Study
The primary hypothesis is that Khalifa's therapy brings additional benefit compared to standard therapy (physiotherapy) for patients with a ruptured anterior cruciate ligament (ACL).
- Trial name
- NCT01762358
- Testing
- Khalifa's therapy, Physiotherapy
- Where
- 4 sites in Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Graz
Solid Tumor, Adult, Metastatic Nonsmall Cell Lung Cancer
Paclitaxel Therapeutic Drug Monitoring in Cancer Patients
The goals of this prospective, observational cohort study are to determine the feasibility of implementing paclitaxel therapeutic drug monitoring for cancer patients and explore the relationship between paclitaxel drug exposure…
- Conditions
- Solid Tumor, Adult, Metastatic Nonsmall Cell Lung Cancer, Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Cervical Carcinoma
- Trial name
- NCT03987555
- Testing
- Blood draws, QLQ-CIPN20 Survey, PR-CTCAE Survey
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Wake Forest University Health Sciences
Dentine Hypersensitivity
Three Different Topically Applied Materials as Non-invasive Treatment of Sensitivity in Permanent Teeth With Molar Incisor Hypomineralization
This clinical study main goal is to investigate the effectiveness of nano hydroxy apatite crystal varnish and potassium nitrate gel as a non invasive approach in managing Dentin Hypersensitivity in MIH-affected teeth.
- Trial name
- NCT07056855
- Testing
- nano hydroxy apatite varnish Intervention (1), Potassium Nitrate Gel, Varnishes, Fluorid
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acute Respiratory Failure, High Flow Nasal Cannula
Tracheal Positive Pressure During High Flow Nasal Oxygen Administration in Critically Ill Patients: a Physiologic Study.
High flow nasal cannula administration in critically ill patients is frequently used to improve acute respiratory failure or to prevent respiratory failure after extubation.
- Conditions
- Acute Respiratory Failure, High Flow Nasal Cannula, Critically Ill, Airway Disease
- Trial name
- HPEEP (NCT05467332)
- Testing
- HIGH FLOW NASAL OXYGEN
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Injectable Platelet-Rich Fibrin, Minimally Invasive
Injectable Platelet-Rich Fibrin With Minimally Invasive Non-Surgical Technique in Treatment of Grade II Furcation Defects
This study aims to compare the clinical and radiographic effectiveness of injectable platelet-rich fibrin (i-PRF) combined with minimally invasive non-surgical therapy (MINST) versus MINST alone in the management of class II…
- Conditions
- Injectable Platelet-Rich Fibrin, Minimally Invasive, Non-Surgical Technique, Grade II Furcation Defects
- Trial name
- NCT07787949
- Testing
- Minimally invasive non-surgical technique (MINST), Minimally invasive non-surgical technique (MINST) + injectable platelet-rich fibrin (i-PRF) injection
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- October 6 University
Aphasia, Stroke
Brain Correlates of Multimodal Rehabilitation in Chronic Post-stroke Aphasia
Post-stroke aphasia (PSA), the partial or total loss of the ability to produce and/or understand language associated with stroke, is a highly prevalent and disabling disorder that negatively impacts the personal, social and…
- Trial name
- NCT04134416
- Testing
- Donepezil, Intensive-Language Action Therapy, Transcranial direct current stimulation
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- University of Malaga
Tinnitus
Evaluation of a Non-invasive Tinnitus Device for the Management of Tinnitus Symptoms in Military Veterans
The prevalence of tinnitus in military veterans is notably higher than the non-veteran population and can significantly disrupt the lives of veterans.
- Trial name
- NCT06905158
- Testing
- White noise device
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Combat Stress
Irritable Bowel Syndrome (IBS), Sucrase Isomaltase Deficiency
Genetic Carbohydrate Maldigestion as a Model to Study Food Hypersensitivity
Irritable bowel syndrome (IBS) affects one in seven people with gastrointestinal (GI) symptoms. IBS strongly impacts quality of life, is a leading cause of work absenteeism, and consumes 0.5% of the healthcare annual budget.
- Trial name
- GenMalCarb (NCT05795049)
- Testing
- Stool and saliva sample collection, Questionnaire completion
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Bladder Cancer
Celecoxib and Rosiglitazone in Treating Patients Who Are Undergoing Cystoscopic Surveillance for Early-Stage Noninvasive Carcinoma of the Bladder or Radical Cystectomy for Muscle-Invasive Carcinoma of the Bladder
RATIONALE: Celecoxib may stop the growth of tumor cells by blocking the enzymes necessary for their growth and by stopping blood flow to the tumor. Rosiglitazone may help tumor cells develop into normal bladder cells.
- Trial name
- NCT00084578
- Testing
- celecoxib, rosiglitazone maleate, conventional surgery
- Sponsor
- Fox Chase Cancer Center
Invasive Aspergillosis
Olorofim Aspergillus Infection Study
The purpose of this study is to compare treatment with olorofim versus treatment with AmBisome® followed by standard of care (SOC) in patients with IFD caused by proven IA or probable lower respiratory tract disease Aspergillus…
- Trial name
- OASIS (NCT05101187)
- Testing
- Olorofim, AmBisome®
- Where
- 143 sites in United States, Australia and 19 more
- Volunteers
- 225 people
- Sponsor
- F2G Ltd
Atrial Fibrillation
The Use of Flecainide for Treatment of Atrial Fibrillation
This prospective observational study will include patients with atrial fibrillation that has indication for treatement with flecainide. Included patients are followed during a 12 month period.
- Trial name
- NCT05084495
- Testing
- Global peak atrial longitudinal strain and ECG
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Lund University