Clinical trials: Nonalcoholic Steatohepatitis
NAFLD (Non-alcoholic Fatty Liver Disease)
A Trial to Evaluate the Efficacy, Safety, PK, and PD of HP515 in Non - Alcoholic Fatty Liver Disease ( NASH/MASH )
Primary Objective: To evaluate the efficacy of HP515 tablets in participants with non-alcoholic fatty liver disease. Secondary objectives: To evaluate the safety of HP515 tablets in participants with non-alcoholic fatty liver…
- Trial name
- NASH/MASH (NCT07308548)
- Testing
- HP515 10 mg Tablet, HP515 20 mg Tablet
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Hinova Pharmaceuticals Inc.
Nonalcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus
Adding Exenatide to Insulin Therapy for Patients With Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease
The primary aim of the study is to determine the impact on hepatic steatosis of replacing premeal rapid-acting insulin for exenatide (Byetta) while maintaining bedtime long-acting detemir (Levemir) insulin in well-controlled…
- Trial name
- NCT01006889
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
Nonalcoholic Fatty Liver
Weight, Energy, Lipids, and the Liver (WELL) Study
The research study is a parallel arm, randomized placebo-controlled clinical trial designed to assess changes in hepatic lipid accumulation, visceral adipose tissue and postprandial lipid, markers of inflammation and energy…
- Trial name
- NCT05199948
- Testing
- Soybean Oil Foods, Palm Oil Foods
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Ohio State University
Non-Alcoholic Fatty Liver Disease, Type2 Diabetes
Antidiabetic Effects on Intrahepatic Fat
This was a 24-week single-center, open-label, parallel controlled group comparing gliclazide, liraglutide, and metformin effects on diabetes with nonalcoholic fatty liver disease.
- Trial name
- NCT03068065
- Testing
- Liraglutide, Metformin, Gliclazide
- Where
- China
- Volunteers
- 87 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Liver Steatoses
Subclinical Cardiovascular Changes in NAFLD Patient (Predictive Value of Speckle Tracking Echocardiography )
the goal of this study (observational study ) is to learn about the subclinical cardiovascular changes in patients with nonalcoholic fatty liver . the main questions it aims to answer are 1.
- Trial name
- NCT05790057
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Metabolic Dysfunction Associated Fatty Liver Disease
Dietary Glycine Supplementation in Metabolic Dysfunction-associated Steatotic Liver Disease
This study aims to investigate abnormalities in glycine-dependent metabolic pathways in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and evaluate whether dietary glycine supplementation improves…
- Trial name
- NCT07285135
- Testing
- Glycine
- Where
- Singapore
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Non-alcoholic Fatty Liver, Metabolic Syndrome
Dairy Fat as a Mediator of Vitamin E Adequacy in Individuals With Metabolic Syndrome
This study is conducted to investigate if vitamin E status in healthy individuals and individuals with metabolic syndrome can be improved by dairy fat.
- Trial name
- NCT01787591
- Testing
- Fat-Free Milk, Low-Fat Milk, Full-Fat Milk
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Fatty Liver, Nonalcoholic
Efficacy and Safety of Fermented Ginseng Powder on Liver Function
This study was conducted to investigate the effects of daily supplementation of fermented ginseng powder on improvement of Liver function.
- Trial name
- NCT03260543
- Testing
- fermented ginseng powder
- Where
- South Korea
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis), Fatty Liver Disease, Nonalcoholic
Thermoacoustic Method for Estimating Liver Fat Fraction
The goal of this study is to use our Thermoacoustic Enhanced Ultrasound device to measure the fat levels in your liver and compare it to the the gold standard MRI PDFF measurements.
- Trial name
- NCT07321925
- Testing
- Thermoacoustic Enhanced Ultrasound
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Endra Lifesciences
Non Alcoholic Fatty Liver Disease
Serum Pentraxin-3 in Non-alcoholic Fatty Liver Disease With or Without Hepatitis C Virus
This study included 70 subjects divided into 3 groups. Group I included 25 patients with NAFLD. Group II included 25 patients with NAFLD and chronic HCV. Group III: included 20 controls.
- Trial name
- NCT03276039
- Testing
- plasma pentraxin-3
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Nonalcoholic Steatohepatitis (NASH)
A Study of BOS-580 in Obese Subjects at Risk for, or With Biopsy-confirmed, Nonalcoholic Steatohepatitis (NASH) With an Extension
This is a randomized, blinded, placebo-controlled study of Efimosfermin in obese participants at risk for, or with biopsy-confirmed, nonalcoholic steatohepatitis (NASH), with a single arm open-label extension.
- Trial name
- NCT04880031
- Testing
- Efimosfermin
- Where
- 48 sites in United States
- Volunteers
- 231 people
- Sponsor
- GlaxoSmithKline
Non-Alcoholic Fatty Liver Disease
Probiotics in NASH Patients - PROBILIVER TRIAL
Non-alcoholic Fatty Liver Disease (NAFLD) is characterized by excessive accumulation of lipids in hepatocytes, not associated with alcohol consumption and ranges from hepatic steatosis to steatohepatitis, a form that can progress…
- Trial name
- NASH (NCT03467282)
- Testing
- Probiotic
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
NAFLD
Prediction of Severity of Liver Disease Non Alcoholic Fatty Liver Disease in Patients With Suspected NAFLD by a 13C Octanoate Breath Test
The Exalenz clinical investigation is a multicenter, non-randomized, blinded, study of the ¹³C-Octanaote breath test (OBT). The OBT is a non-invasive test for evaluation of disease severity in patients with suspected non…
- Trial name
- NCT01281059
- Testing
- BreathID - Breath Test - 13C Octanoate
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Nonalcoholic Fatty Liver Disease
Effectiveness of Exercise Applications on Hepatic Steatosis and Physical Fitness in Patients With NAFLD
Purpose of the study will investigate the effects of two different training programs on hepatic steatosis and physical fitness parameters.
- Trial name
- NCT03461562
- Testing
- Aerobic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Okan University
Non-Alcoholic Fatty Liver Disease
Super HEROES: Searching How the Extract Rebaudioside Occludes Excess Steatosis
In order to determine whether rebaudioside consumption can be used as a treatment for adolescents with Non-alcoholic Fatty Liver Disease (NAFLD) by demonstrating a decrease in alanine aminotransferase (ALT) levels participants…
- Trial name
- NCT03985020
- Testing
- Stevia Intervention, Water Intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Los Angeles
Morbid Obesity, Type2diabetes
Comorbidities Resolution After MGB Surgery and Change in Body Composition
This observational study aims to learn about the correlation between the improving comorbidities associated with obesity after MGB (Mini-Gastric Bypass) surgery and changes in body composition in morbidly obese patients.
- Conditions
- Morbid Obesity, Type2diabetes, Sleep Apnea, Hypothyroidism
- Trial name
- MOGAMBO (NCT06015620)
- Testing
- Mini gastric bypass surgery
- Where
- India
- Volunteers
- 35 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Non-Alcoholic Fatty Liver Disease
The Effect of Bariatric Surgery on Hepatic Metabolism in Non-Alcoholic Fatty Liver Disease
The purpose of this study is to investigate the mechanisms underlying bariatric surgery-induced resolution of non-alcoholic fatty liver disease.
- Trial name
- BASIC (NCT05551559)
- Testing
- bariatric surgery
- Where
- Finland
- Volunteers
- 180 people
- Sponsor
- Helsinki University Central Hospital
Fatty Liver Disease
Effect of Thyroid Disorders in Liver Diseases
Aims of the Research 1. To detect correlation between hyperthyroidism and non alcoholic fatty liver disease (NAFLD). 2. To detect hepatic risk in subclinical and clinical hypothyroidism . 3.
- Trial name
- NCT06071923
- Testing
- Fibroscan
- Volunteers
- 140 people
- Sponsor
- Assiut University
Nonalcoholic Steatohepatitis, Osteoarthritis
FTIH Study of ECC0509 in Healthy Volunteers
A Phase 1, Single-Center, Randomized, Double-Blind, Placebo-Controlled, Single And Multiple Ascending Dose, First-Time-In-Human Study to Assess The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ECC0509 in…
- Trial name
- NCT05012423
- Testing
- ECC0509
- Where
- Australia
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Eccogene
Nonalcoholic Fatty Liver Disease
Effect of Mediterranean Diet in Obese Adolescents With Nonalcoholic Fatty Liver Disease
The aim of this study was to evaluate the effects of mediterranean and low-fat diet on hepatic fat, inflammation markers and oxidative stress in adolescents with nonalcoholic fatty liver disease.
- Trial name
- NCT04845373
- Testing
- Mediterranean diet, Control diet: Low fat diet
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Gazi University
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