Clinical trials: Noncardiac Surgery
Multidisciplinary Communication, Preoperative Care
Practice Variation in Preoperative MDT Meetings
The goal of this observational survey study is to evaluate the current practice variations of preoperative multidisciplinary team meetings (MDT meetings) for high risk noncardiac surgical patients.
- Conditions
- Multidisciplinary Communication, Preoperative Care, Patient Care Team
- Trial name
- NCT05797116
- Testing
- Survey
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- Rijnstate Hospital
Elective Surgical Procedure
Perioperative Management & Outcome Following Preoperative Transthoracic Echocardiography in Noncardiac Surgery Patients
In August 2022 the European Society of Cardiology published updated guidelines including recommendations on preoperative transthoracic echocardiography.
- Trial name
- NCT06409234
- Testing
- Transthoracic Echocardiography Recieved
- Where
- Germany
- Volunteers
- 8,250 people
- Sponsor
- European Society of Anaesthesiology
Delirium, Cognitive Disorders
Anesthetic Depth and Postoperative Delirium Trial - 2
Recent limited evidence suggests that anesthetic depth may influence postoperative cognitive outcomes, however, the mechanism between this association is unclear.
- Trial name
- ADAPT2 (NCT01983384)
- Testing
- Processed EEG-guided anesthetic depth
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Myocardial Injury
Prospective Trial: Acute Myocardial Injury After Radical Prostatectomy
This prospective observational study investigates the incidence of acute myocardial injury after radical prostatectomy for prostate cancer.
- Trial name
- NCT06273735
- Testing
- Pre- and postoperative determination of troponin as part of the study and 24-month FU survey
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Martini-Klinik am UKE GmbH
Cardiovascular
Comparison of Effects of Oxycodone and Sufentanil on Cardiovascular Stress Induced by Tracheal Intubation in the Patients With Coronary Heart Disease Undergoing Major Noncardiac Surgery
To evaluate the effect of oxycodone and sufentanil in preventing cardiovascular responses to tracheal intubation in the patients with coronary heart disease (CHD).
- Trial name
- NCT04121416
- Testing
- Oxycodone 10mg, Sufentanil
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shengjing Hospital
Myocardial Injury After Noncardiac Surgery (MINS)
Myocardial Injury After Transurethral Resection
This prospective observational study aims to determine the incidence of myocardial injury after noncardiac surgery (MINS) in adult patients undergoing elective transurethral resection of the prostate (TURP) or transurethral…
- Trial name
- TUR-MINS (NCT07900035)
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people
- Sponsor
- Haseki Training and Research Hospital
Postoperative Delirium, Major Noncardiac Surgery
The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium
Patients over the age of 65 years are at increased risk for developing delirium after noncardiac surgeries, resulting in increased morbidity and mortality.
- Conditions
- Postoperative Delirium, Major Noncardiac Surgery, Postoperative Cognitive Dysfunction
- Trial name
- RAPID-II (NCT05990790)
- Testing
- Desflurane, Sevoflurane, Propofol
- Where
- 2 sites in Austria
- Volunteers
- 1,332 people
- Sponsor
- Medical University of Vienna
Major Noncardiac Surgery, Geriatric Anesthesia
Risk Prediction Model for Older Adults Undergoing Noncardiac Surgery
This prospective observational study aims to develop and evaluate predictive models for postoperative complications in patients aged 65 years or older scheduled for elective major surgery.
- Conditions
- Major Noncardiac Surgery, Geriatric Anesthesia, Postoperative Complications
- Trial name
- NCT07409467
- Testing
- Preoperative assessment
- Where
- South Korea
- Volunteers
- 520 people
- Sponsor
- Seoul National University Hospital
Intraoperative Cerebral Autoregulation Monitoring
AUTOREGULATE- NONCARDIAC-COTRENDING
This study is to prospectively assess the feasibility and clinical implications of intraoperative real-time cAR monitoring using the Medtronic Cotrending algorithm.
- Trial name
- NCT07630129
- Testing
- Data collection
- Where
- Switzerland
- Volunteers
- 256 people
- Sponsor
- University Hospital, Basel, Switzerland
Anesthesia, Covert Stroke
A Prospective Cohort Study of Perioperative Covert Stroke and Postoperative Cognitive Dysfunction
With the development of population aging, the incidence of covert stroke gradually increased. Currently, there is still lack of prospective cohort study with large sample size on the relationship between perioperative covert…
- Trial name
- PRECISION (NCT03081429)
- Where
- 2 sites in China
- Volunteers
- 934 people
- Sponsor
- Beijing Tiantan Hospital
Acute Kidney Injury, Postoperative Complications
Evaluation of Postoperative Organ Injury, Risk Factors, and Short-Term Clinical Outcomes in Patients Admitted to Intensive Care After Noncardiac Surgery
This retrospective observational study examines whether troponin levels measured before surgery are associated with acute kidney injury during the first 48 hours after surgery in patients admitted to intensive care after…
- Trial name
- TROP-AKI (NCT07907887)
- Where
- Turkey (Türkiye)
- Volunteers
- 224 people
- Sponsor
- Ankara Training and Research Hospital
Cardiovascular Disease
Coronary CT Angiography to Predict Vascular Events In Noncardiac Surgery patIents cOhort evaluatioN (CTA -VISION) Study
Worldwide 200 million adults annually undergo major noncardiac surgery and 5 million of these patients will suffer a major vascular complication.
- Trial name
- CTA-VISION (NCT01635309)
- Testing
- Coronary CT Angiogram
- Where
- Canada
- Volunteers
- 987 people
- Sponsor
- Canadian Institutes of Health Research (CIHR)
Coronary Artery Disease
STOPping Versus Continuing Antiplatelet Therapy During Noncardiac Surgery and Procedures After Next Generation Drug-eluting Stent Implantation
Most previous trials support the absolute increase in bleeding risk with perioperative administration of antiplatelet. Furthermore, recent studies demonstrated that perioperative major bleeding may be related to increase…
- Trial name
- NCT03184805
- Testing
- Continuing aspirin, Stopping aspirin
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- Yonsei University
Acute Postoperative Pain, Trajectory
Pain Trajectories and Predictors After Noncardiac Surgery in Elderly Patients
This study will use group-based trajectory modeling to identify the different postoperative pain trajectory groups that exist in a mixed surgical population (non-cardiac surgery) of elderly patients during the first seven days…
- Trial name
- NCT05865366
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Feng Gao
Perioperative/Postoperative Complications, Morbidity, Multiple
Machine Learning Modeling of Intraoperative Hemodynamic Predictors of Postoperative Outcomes
With population aging and limited resources, strategies to improve outcomes after surgery are ever more important. There is a limited understanding of what ranges of hemodynamic variables under anesthesia are associated with…
- Conditions
- Perioperative/Postoperative Complications, Morbidity, Multiple, Surgery, Anesthesia
- Trial name
- NCT04014010
- Testing
- Blood pressure, Heart rate, Use of hemodynamic medications (i.e. special medications for blood pressure)
- Volunteers
- 35,000 people
- Sponsor
- Janny Xue Chen Ke
Cardiovascular Disease
PeriOperative ISchemic Evaluation-2 Trial
Major surgeries not involving the heart are common, and major heart problems during or after such surgeries represent a large population health problem.
- Trial name
- POISE-2 (NCT01082874)
- Testing
- Active Clonidine, Active ASA
- Where
- 23 sites in United States, Argentina and 21 more
- Volunteers
- 10,010 people
- Sponsor
- Hamilton Health Sciences Corporation
Perioperative Bleeding, Venous Thrombosis
PeriOperative ISchemic Evaluation-3 Trial
This study is a multicentre, international, randomized controlled trial of tranexamic acid (TXA) versus placebo and, using a partial factorial design, of a perioperative hypotension-avoidance versus hypertension-avoidance…
- Conditions
- Perioperative Bleeding, Venous Thrombosis, Arterial Thrombosis
- Trial name
- POISE-3 (NCT03505723)
- Testing
- Tranexamic Acid, Perioperative hypotension-avoidance strategy, Perioperative hypertension-avoidance strategy
- Where
- 114 sites in United States, Australia and 21 more
- Volunteers
- 9,535 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute