Clinical trials: Nonfluent Aphasia
Logopenic Variant Primary Progressive Aphasia, Non-Fluent Primary Progressive Aphasia
rTMS as a Treatment for PPA
Primary progressive aphasia (PPA) includes three variants. Two such variants, the non-fluent/agrammatic variant (nfvPPA) and the logopenic variant (lvPPA), are characterized by progressive word-finding difficulties and effortful…
- Trial name
- NCT03406429
- Testing
- Active rTMS
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Non-fluent Aphasia
Combined Intervention Program for Non-fluent Aphasia Based on Neuroplasticity
Sequentially applying Melodic Intonation Therapy (MIT) during the subacute phase, followed by Constraint-Induced Aphasia Therapy (CIAT) during the chronic phase
- Trial name
- CIPAN (NCT07759375)
- Testing
- CIPAN = MIT + CIAT, MIT + MIT, CIAT + CIAT
- Volunteers
- 48 people
- Sponsor
- Universidad de Granada
Aphasia Non Fluent, Stroke
Effectiveness of TDCS Over Broca's Area in Verb Naming: a Randomized, Double-Blind, Crossover Study
This clinical trial investigated whether transcranial direct current stimulation (tDCS) over Broca's area (F5) could improve verb naming abilities in adults with aphasia.
- Trial name
- NCT06776978
- Testing
- Active treatment
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Aphasia Non Fluent, Stroke
Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia
SEMO is a multidisciplinary project (language sciences, cognitive psychology and neuropsychology, physical medicine and rehabilitation, neurology, speech-language pathology, functional neuroimaging and engineering sciences) that…
- Trial name
- SEMO (NCT04433351)
- Testing
- Enriched rehabilitation, Simple rehabilitation
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Grenoble
Aphasia
Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Aphasia
We hypothesize patients who have difficulty with word recall (naming pictures) due to a stroke will experience greater benefit in word recall after receiving a combination of transcranial direct current stimulation (tDCS) and…
- Trial name
- NCT02226796
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Minnesota
Aphasia, Stroke
Melodic-Intonation-Therapy and Speech-Repetition-Therapy for Patients With Non-fluent Aphasia
We are doing this clinical trial in order to evaluate two different treatments for non-fluent aphasia: Melodic Intonation Therapy (MIT) and Speech Repetition Therapy (SRT).
- Conditions
- Aphasia, Stroke, Cerebrovascular Accident, Apoplexy
- Trial name
- NCT00903266
- Testing
- Melodic Intonation Therapy, Speech-Repetition-Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Beth Israel Deaconess Medical Center
Primary Progressive Aphasia, Logopenic Progressive Aphasia
Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia
While many have strongly suggested that transcranial direct current stimulation (tDCS) may represent a beneficial intervention for patients with primary progressive aphasia (PPA), this promising technology has not yet been…
- Conditions
- Primary Progressive Aphasia, Logopenic Progressive Aphasia, Non-Fluent Primary Progressive Aphasia
- Trial name
- NCT05386394
- Testing
- Active tDCS + Language Therapy
- Where
- 3 sites in United States, Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alzheimer's Disease, Primary Progressive Non-fluent Aphasia
A Medium Chain Triglyceride Intervention for Patients With Alzheimer Disease
The purpose of this study is to determine safety, tolerability, and pharmacokinetics/dynamics of a ketogenic dietary supplement containing medium chain triglycerides (MCTs) in patients with Alzheimer disease (AD).
- Conditions
- Alzheimer's Disease, Primary Progressive Non-fluent Aphasia, Frontotemporal Dementia (FTD)
- Trial name
- MINT-01 (NCT02912936)
- Testing
- Ketogenic medium chain triglyceride drink (MCT drink)
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- University of British Columbia
Stroke, Ischemic, Aphasia Non Fluent
Effects of Neuronavigated Theta Burst Stimulation in Therapy of Post-stroke Aphasia
Aphasia is an impairment in the ability to express and/or understand language, commonly observed after stroke to the language dominant (left) hemisphere.
- Trial name
- NCT05303649
- Testing
- Noninvasive transcranial brain stimulation: excitatory iTBS, Noninvasive transcranial brain stimulation: inhibitory cTBS, Individual speech-language therapy (SLT)
- Where
- Poland
- Volunteers
- 45 people
- Sponsor
- Institute of Psychiatry and Neurology, Warsaw
Frontotemporal Lobar Degeneration (FTLD), Progressive Supranuclear Palsy (PSP)
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through 2019) as a single North American…
- Conditions
- Frontotemporal Lobar Degeneration (FTLD), Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD), Behavioral Variant Frontotemporal Dementia (bvFTD)
- Trial name
- NCT04363684
- Where
- 26 sites in United States, Canada
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Primary Progressive Nonfluent Aphasia
A 24-month Phase 1 Pilot Study of AADvac1 in Patients With Non Fluent Primary Progressive Aphasia
This study is a pilot trial evaluating the safety and immunogenicity of AADvac1 in patients with the non-fluent variant of Primary Progressive Aphasia.
- Trial name
- AIDA (NCT03174886)
- Testing
- AADvac1 40 µg, AADvac1 160 µg
- Where
- 3 sites in Germany
- Volunteers
- 33 people
- Sponsor
- Axon Neuroscience SE
Aphasia, Nonfluent Aphasia
Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies
The purpose of this research is to utilize functional magnetic resonance imaging (fMRI) to investigate brain reorganization for language behavior in stroke patients with aphasia.
- Conditions
- Aphasia, Nonfluent Aphasia, Stroke
- Trial name
- NCT00467103
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Stroke, Aphasia, Non-fluent
Repetitive Transcranial Magnetic Stimulation and Multi-modality Aphasia Therapy for Post-stroke Non-fluent Aphasia
Many stroke survivors experience aphasia, a loss or impairment of language affecting the production or understanding of speech. One common type of aphasia is known as non-fluent aphasia.
- Trial name
- REMAP (NCT04102228)
- Testing
- 1Hz inhibitory rTMS, Multi-Modality Aphasia Therapy (M-MAT)
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- University of Calgary
Stroke, Acute, Expressive Aphasia
Music After Stroke To Enhance Rehabilitation
Music that is familiar and preferred by patients has been shown to heighten neuroplasticity and can mitigate these disabilities.
- Conditions
- Stroke, Acute, Expressive Aphasia, Movement, Abnormal, Depressive Disorder
- Trial name
- MASTER (NCT04441515)
- Testing
- Ipod with music, ipod with books to listen, ipod only with usual care
- Volunteers
- 12 people
- Sponsor
- Pace University
Aphasia, Dysgraphia
Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Induced Recovery
The purpose of this study is to investigate the effects of treatment for specific language deficits in people with aphasia. In addition to language and cognitive measures, changes in brain function will also be gathered before…
- Conditions
- Aphasia, Dysgraphia, Anomia, Agrammatism
- Trial name
- NCT01927302
- Testing
- Treatment Focusing on Naming Objects, Treatment Focusing on Improving Spelling Abilities, Treatment Focusing on Improving Sentence Processing
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- Northwestern University
Aphasia, Acquired, Aphasia
Aphasia Physical EXercise Study: Randomized Trial
The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia.
- Conditions
- Aphasia, Acquired, Aphasia, Aphasia, Fluent, Aphasia, Non-fluent
- Trial name
- APEX (NCT07281313)
- Testing
- High-intensity physical exercise, Low-intensity physical exercise
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, Berkeley
Expressive Aphasia, Aphasia Following Cerebral Infarction
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Aphasia
The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with aphasia to generate text on a computer screen and audible…
- Conditions
- Expressive Aphasia, Aphasia Following Cerebral Infarction, Aphasia Following Nontraumatic Intracerebral Hemorrhage, Aphasia Non Fluent
- Trial name
- BG2-Aphasia (NCT07791459)
- Testing
- BrainGate Neural Interface System
- Volunteers
- 5 people
- Sponsor
- Leigh R. Hochberg, MD, PhD.
Stroke, Aphasia
Effects of rTMS Based on Brain Activation During Language Performance in Stroke Patients With Non-fluent Aphasia
The aim of this study is to assess the safety and clinical efficacy of high or low-frequency repetitive transcranial magnetic stimulation based on brain activation with functional near infrared spectroscopy in poststroke…
- Trial name
- NCT02556385
- Testing
- High frequency rTMS, Low frequency rTMS
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- Seoul National University Bundang Hospital
Primary Tauopathies, Corticobasal Degeneration Syndrome
BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES
A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Parallel Cohort Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of Intravenously Infused BIIB092 in Patients with Four Different…
- Conditions
- Primary Tauopathies, Corticobasal Degeneration Syndrome, Frontotemporal Lobar Degeneration With Tau Inclusions, MAPT Mutation Carriers, Symptomatic
- Trial name
- TauBasket (NCT03658135)
- Testing
- BIIB092
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, San Francisco
Aphasia, Broca
Effects of PACE Technique in Patients With Aphasia
Aphasia, a communication disorder often resulting from him brain injury such as stroke, impacts an individual's ability to understand or produce language.
- Trial name
- NCT07521098
- Testing
- experimental, control group conventional therapy
- Where
- Pakistan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Riphah International University