Clinical trials: Noninvasive
Pulmonary Disease, Chronic Obstructive (COPD), Chronic Respiratory Failure With Hypercapnia
RESET-COPD Cohort: Real-Time Monitoring and Early Warning in COPD Patients Receiving Home NPPV
This is a multicenter prospective cohort study designed to develop and validate a multisensor-based real-time monitoring and intelligent early warning model for acute exacerbations in patients with chronic obstructive pulmonary…
- Conditions
- Pulmonary Disease, Chronic Obstructive (COPD), Chronic Respiratory Failure With Hypercapnia, Noninvasive Ventilation
- Trial name
- RESET-COPD (NCT07701096)
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Beijing Chao Yang Hospital
Noninvasive Ventilation
The Effects of Nocturnal Non-invasive Ventilation in Stable COPD
Rationale: Application of long-term non-invasive ventilation (NIV) in chronic obstructive pulmonary disease (COPD) patients with chronic hypercapnic respiratory failure (CHRF) has recently been shown to improve outcomes.
- Trial name
- RECAPTURE (NCT03053973)
- Testing
- nocturnal noninvasive ventilation, Standard Care
- Where
- Netherlands
- Volunteers
- 116 people
- Sponsor
- University Medical Center Groningen
Delivery of Health Care, Genetic Testing
Supporting Just-In-Time Consent for Prenatal Screening: The INFORM Study
This clinical trial is about prenatal genetic screening. It will test an intervention to help people make decisions about screening. The intervention is a short set of information cards about screening.
- Conditions
- Delivery of Health Care, Genetic Testing, Humans, Pregnancy
- Trial name
- NCT07557303
- Testing
- Mobile-based Educational Intervention
- Where
- 3 sites in United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Lumbar Stabilization Surgery, Noninvasive Hemoglobin Monitoring
Effect of Prone Position on Continuous Noninvasive Hemoglobin Measurement
This prospective observational study aims to evaluate whether the prone position affects the agreement between noninvasive hemoglobin (SpHb) measurements and laboratory hemoglobin values in patients undergoing lumbar…
- Trial name
- NCT07823569
- Testing
- Prone Positioning
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Noninvasive Ventilation, Child, Only
Custom Non-invasive Ventilation Masks in Children
One significant challenge to non-invasive ventilation (NIV) use in children is finding masks to fit a wide range of growing shapes and sizes.
- Conditions
- Noninvasive Ventilation, Child, Only, Adherence, Patient
- Trial name
- NCT05336136
- Testing
- Custom mask, Current commercial mask
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Alberta
Patient Transport, Respiratory Failure
HERMES: International Survey and Portable External Power Evaluation During Respiratory Support Transport
The HERMES Phase I-II study was a two-phase observational investigation designed to characterize contemporary practices and safety-related challenges associated with the transport of patients requiring advanced respiratory…
- Conditions
- Patient Transport, Respiratory Failure, Noninvasive Ventilation, High-Flow Nasal Oxygen
- Trial name
- HERMES (NCT07807189)
- Testing
- Portable External Power Supply
- Where
- 20 sites in United States, Chile and 12 more
- Volunteers
- 246 people
- Sponsor
- Medipol University
Acute Respiratory Failure, Respiratory Insufficiency
HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport
The HERMES Phase III study is an international, multicenter, prospective observational investigation designed to characterize the quality and safety of patient transport during advanced respiratory support.
- Conditions
- Acute Respiratory Failure, Respiratory Insufficiency, Respiratory Distress, Critical Illness
- Trial name
- HERMES (NCT07805603)
- Testing
- Advanced Respiratory Support During Patient Transport
- Where
- 4 sites in Colombia, Egypt and 2 more
- Volunteers
- 565 people
- Sponsor
- Medipol University
Noninvasive Ventilation, COPD
Effect of Web-Based Adaptation and Insomnia Severity in Individuals Using Noninvasive Ventilators at Home
Home use of the NIV device, which is used to manage respiratory failure, one of the most disturbing symptoms due to COPD, will continue to increase.
- Trial name
- NCT06343324
- Testing
- Web-based education
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- KTO Karatay University
Renal Disease, Chronic, Renal Disease, End-Stage
Non-invasive Testing for End-Stage Chronic Kidney Disease
This study evaluates the clinical performance of a non-invasive digital diagnostic test (KF4+, developed and manufactured by Gisens Biotech) for the measurement of urea and potassium in capillary blood in patients with end-stage…
- Conditions
- Renal Disease, Chronic, Renal Disease, End-Stage, Dialysis Patients, Urea in Blood; High
- Trial name
- NiTED (NCT07777523)
- Testing
- KF4+ Noninvasive Test
- Where
- Argentina
- Volunteers
- 55 people
- Sponsor
- Gisens Biotech
Aging, Noninvasive Brain Stimulation
Memory Enhancement in Aging With Closed-Loop tACS
This project optimizes high-resolution tACS to improve memory in healthy older adults, advancing drug-free approaches for ADRD. We test stimulation schedules and develop an adaptive, brain-guided tACS system to strengthen…
- Conditions
- Aging, Noninvasive Brain Stimulation, Memory
- Trial name
- NCT07722598
- Testing
- Peak Frequency, Phase Lag, Peak Frequency + Phase Lag
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Aging, Noninvasive Brain Stimulation
Memory Enhancement in Aging With Optimal Dosing
This project optimizes high-resolution transcranial Alternating Current Stimulation (tACS) to improve memory in healthy older adults, advancing drug-free approaches for Alzheimer's disease and related dementia (ADRD).
- Conditions
- Aging, Noninvasive Brain Stimulation, Memory
- Trial name
- NCT07461584
- Testing
- 1-day patterned tACS, 3-day patterned tACS, 5-day patterned tACS
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Aging, Visual Perception
Restructuring the Alpha-Gamma Code in Aging Vision
Tests whether age-related visual deficits arise from disrupted alpha-gamma coupling in visual cortex (V1) and MT. Uses fMRI, source-resolved HD-EEG, and personalized complex-waveform HD-tACS to (1) quantify aging effects on…
- Conditions
- Aging, Visual Perception, Noninvasive Brain Stimulation
- Trial name
- NCT07208318
- Testing
- High definition transcranial electrical current stimulation
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Cerebral Aneurysms, Intracranial Aneurysms
NOn-inVAsive Blood Pressure Monitoring in Intracranial Aneurysm Embolization
The goal of this clinical trial is to evaluate whether non-invasive continuous blood pressure monitoring (NVBP) using the ClearSight system can safely serve as an alternative to radial arterial catheterization for invasive…
- Conditions
- Cerebral Aneurysms, Intracranial Aneurysms, Coil Embolization, Hemodynamic Instability
- Trial name
- NOVA (NCT07246148)
- Testing
- Non-invasive continuous blood pressure monitoring, Invasive arterial blood pressure monitoring
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Korea University Anam Hospital
Noninvasive Biomarkers, Ulcerative Colitis (UC)
Fecal Noninvasive Biomarkers Oriented Control Versus Usual Care Strategy in Ulcerative Colitis
Design: Multicenter, Open-Label, Randomized, Parallel Controlled Allocation: 1:1 Randomization Masking: Open-label (outcome assessors blinded for endoscopy) Primary Purpose: Treatment Strategy Evaluation Phase: Phase IV…
- Trial name
- FOCUS-UC (NCT07402135)
- Testing
- Preemptive therapy escalation based on preset thresholds (FC >250 μg/g or FIT >100 ng/mL) using the FOCUS-UC Ladder:, Therapy adjustment only upon clinical relapse (pMS increase ≥2 + rectal bleeding score ≥1).
- Volunteers
- 240 people
- Sponsor
- Qilu Hospital of Shandong University
Noninvasive Ventilation, Pneumonia
High PEEP in Noninvasive Ventilation Patients With Pneumonia or ARDS
Noninvasive ventilation is commonly employed in patients with pneumonia or acute respiratory distress syndrome (ARDS) and has been shown to reduce the need for intubation and invasive mechanical ventilation.
- Conditions
- Noninvasive Ventilation, Pneumonia, ARDS
- Trial name
- NCT07298889
- Testing
- The level of PEEP during noninvasive ventilation
- Where
- China
- Volunteers
- 706 people
- Sponsor
- Chongqing Medical University
Ventilator Associated Events, Asynchrony, Patient-Ventilator
Synchrony-Optimized Non-Invasive Ventilation Education Program and ICU Patients
The aim of this clinical trial is to find out whether a synchrony-optimized education program for non-invasive ventilation (NIV) can help ICU patients use their ventilator more effectively and improve their comfort, symptoms, and…
- Conditions
- Ventilator Associated Events, Asynchrony, Patient-Ventilator, Intensive Care (ICU), Noninvasive Ventilation
- Trial name
- NCT07291622
- Testing
- SYNC-NIV
- Volunteers
- 92 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Airway Management, Mask Ventilation
Prospective Development and Validation of an Objective Classification for Difficult Facemask Ventilation: the MASCAN Score
Difficult facemask ventilation remains poorly classified. Existing definitions rely on expert opinion and subjective rating of surrogates.
- Conditions
- Airway Management, Mask Ventilation, Noninvasive Ventilation
- Trial name
- NCT07275502
- Where
- Germany
- Volunteers
- 423 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Infant, Preterm, Respiratory Distress Syndrome (Neonatal)
Pulmonary Volume Changes During Synchonized Noninvasive Positive Pressure Ventilation
Current evidence suggests that noninvasive positive pressure ventilation (NIPPV) is more effective than continuous positive airway pressure (CPAP) in preventing respiratory failure in preterm infants with respiratory distress…
- Conditions
- Infant, Preterm, Respiratory Distress Syndrome (Neonatal), Chronic Lung Disease of Newborn, Respiratory Support
- Trial name
- INSPIRE (NCT07237139)
- Testing
- Electrical Impedance Tomography (EIT)
- Where
- Switzerland
- Volunteers
- 27 people
- Sponsor
- University of Zurich
Hypercapnic Respiratory Failure, Noninvasive Ventilation
Information-Motivation-Behavioral Skills Model-based Intervention to Domiciliary Non-invasive Ventilation of Patients
Domiciliary non-invasive ventilation (NIV) is a standard care for improving survival rates of selected patients with chronic hypercapnic respiratory failure (CHRF) and to improve the patients' hypercapnia, sleep quality…
- Trial name
- NCT05008211
- Testing
- Information-Motivation-Behavioral skills (IMB) model-based intervention, Control - usual care
- Where
- Hong Kong
- Volunteers
- 124 people
- Sponsor
- The University of Hong Kong
Accuracy and Precision of Noninvasive Measurement
Evaluation of Impression Accuracy: Digital Scanner Versus Analog Technique
The goal of this study is to evaluate the accuracy of intraoral impressions obtained using the Trios 3Shape® and Carestream CS 3600™ scanners, as well as traditional analog impressions using polyvinyl siloxane (PVS), in…
- Trial name
- NCT07252869
- Testing
- impression, Digital impression
- Where
- Italy
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Milan