Clinical trials: OA Knee
Knee Osteoarthritis
Efficacy of Thread-Embedding Acupuncture Using the Longitudinal Oblique Technique From BL40 Toward BL57 on KOOS Scores and Joint Range of Motion in Knee Osteoarthritis
This study aims to evaluate the efficacy of thread embedding acupuncture using a longitudinal oblique technique from BL40 toward BL57 in patients with knee osteoarthritis.
- Trial name
- NCT07833462
- Testing
- Thread Embedding Acupuncture
- Where
- Indonesia
- Volunteers
- 44 people
- Sponsor
- Universitas Indonesia
Osteoarthritis, Knee, Patellofemoral Knee Arthroplasty
Study of Knee Replacements for Patellofemoral Osteoarthritis
This is a randomized comparison of PFA and TKR in treatment of isolated patellofemoral osteoarthritis.
- Trial name
- PFA/TKR (NCT01326156)
- Testing
- Knee arthroplasty
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Osteoarthritis, Knee, Prosthesis User
Characteristics of Marrow Fatty Cells in the Ageing of Bone and Joints, Osteoarthritis and Osteoporosis
Obesity and other associated complications promote the development and the progression of osteoarthritis. The subcutaneous and abdominal fat release several factors that alter bone and the cartilage.
- Trial name
- MEDADIPO (NCT03678831)
- Testing
- tissue
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Lille
Knee Osteoarthritis
Autologous Adipose Tissue Derived Mesenchymal Stem Cells Therapy for Patients With Knee Osteoarthritis
Two injections in total and 3 ml autologous adipose-tissue-derived stem cells(haMSCs) for each injection; time-points for intervention: 1) initial injection; 2) 3 weeks following initial injection.
- Trial name
- NCT01809769
- Testing
- Mesenchymal stem cells low-dose group, Mesenchymal stem cells mid-dose group, Mesenchymal stem cells high-dose group
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai AbelZeta Ltd.
Osteoarthritis
Efficacy and Safety of RTX-GRT7039 in Adult Subjects With Knee Osteoarthritis
A double-blind, randomized, placebo-controlled, parallel-group, multi-site, clinical trial to confirm the efficacy and safety of repeated injections of RTX-GRT7039 versus placebo in patients who have pain associated with…
- Trial name
- NCT05248386
- Testing
- RTX-GRT7039
- Where
- 103 sites in Canada, Czechia and 7 more
- Volunteers
- 469 people
- Sponsor
- Grünenthal GmbH
Osteoarthritis, Knee
Prospective Evaluation of PRP and BMC Treatment to Accelerate Healing After ACL Reconstruction
This is a prospective, randomized, placebo-controlled trial to evaluate potential beneficial effects of leukocyte-poor platelet rich plasma and bone marrow concentrate on the healing and health of critical joint tissues in the…
- Trial name
- NCT04205656
- Testing
- Leukocyte-Poor Platelet Rich Plasma (LP-PRP), Bone Marrow Concentrate (BMC)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Steadman Philippon Research Institute
Medial Compartment Knee Osteoarthritis
Study of How An Ankle Strap Changes Effects of Insole Treatment for Knee Osteoarthritis
The goal of this project is to assess the effects of an ankle strap on the effectiveness of a laterally-wedged insole with ankle strapping in reducing knee symptoms and improving static and dynamic lower limb biomechanics.
- Trial name
- NCT00331110
- Testing
- Laterally-Wedged Insole with Ankle Strapping, Laterally-Weged Insole
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Iowa
Knee Osteoarthritis
A Study to Evaluate the Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee
This study is being conducted to evaluate the efficacy and safety of ASA compared to placebo in the management of osteoarthritis (OA) symptoms of the knee.
- Trial name
- NCT06000410
- Testing
- Amniotic Suspension Allograft
- Where
- 41 sites in United States
- Volunteers
- 594 people
- Sponsor
- Organogenesis
Knee Osteoarthritis
Community Based Rehabilitation Model After Total Knee Replacement
To investigate the clinical efficacy of community-based early stage knee replacement rehabilitation program as compared with usual care in acute hospital outpatient clinic
- Trial name
- NCT06270446
- Testing
- Community based physiotherapy, Outpatient physiotherapy
- Where
- Singapore
- Volunteers
- 59 people
- Sponsor
- Tan Tock Seng Hospital
Osteoarthritis, Knee, Knee Arthritis
Total Fat Pad Excision Leads to Worse Isokinetic Performance in Total Knee Arthroplasty
There are concerns that total infrapatellar fat pad (IPFP) excision in total knee arthroplasty (TKA) results in patellar tendon shortening due to ischemic contracture.
- Trial name
- NCT04419142
- Testing
- Total infrapatellar fat pad excision, Partial infrapatellar fat pad excision
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Aksaray University Training and Research Hospital
Osteoarthritis, Knee
Vitamin D to Slow Progression of Knee Osteoarthritis
Knee osteoarthritis (OA) is a common and disabling health problem in older adults and for which there is no cure. The purpose of this study is to determine the effects of vitamin D on knee OA symptoms and physical function in…
- Trial name
- NCT00306774
- Testing
- Vitamin D (cholecalciferol)
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Tufts Medical Center
Osteoarthritis (OA) of the Knee
Knee Pain and Lumbar Proprioception in Knee Osteoarthritis Patients
Knee osteoarthritis (KOA), is a chronic degenerative joint pathology with a global prevalence of 22.9% in individuals aged 40 and over.
- Trial name
- NCT07436897
- Testing
- porprioception
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Cairo University
Total Knee Arthroplasty
Performance and Safety Evaluation of the FHK®-CK Knee Prosthesis
The life expectancy worldwide is increasing and leading to an increase of knee arthroplasty. Also, as millions of people around the world are currently living with a Total Knee Arthroplasty (TKA), the need for revision surgery…
- Trial name
- FHK-CK (NCT06124482)
- Testing
- Total Knee arthroplasty
- Where
- 7 sites in France
- Volunteers
- 92 people
- Sponsor
- FH ORTHO
Knee Osteoarthritis
Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty
The total knee arthroplasty (TKA) is a well established option for the treatment of osteoarthritis in this joint. Nevertheless, there are still some concerns related to the peri-operative management of elderly patients…
- Trial name
- NCT02152917
- Testing
- Tranexamic acid, Floseal®
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Knee Osteoarthritis
The Effect of Acupressure in Patients With Knee Osteoarthritis
Abstract Pain is the most common symptom of osteoarthritis and affects people's functional status with quality of life. This study was conducted to determine the effect of acupressure on pain, functional status, and quality of…
- Trial name
- NCT05238350
- Testing
- Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Knee Osteoarthritis
Cognitive Muscular Therapy for People Awaiting Knee Joint Replacement
The primary aim will seek to understand whether Cognitive Muscular Therapy (CMT) could provide pain relief for people on a waiting list for joint replacement.
- Trial name
- NCT05801510
- Testing
- Cognitive Muscular Therapy for knee pain
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Salford
Osteoarthritis, Knee
Kinesiotaping in Knee Osteoarthritis
Kinesiotape is one of the treatment choices for the patients with knee osteoarthritis. Unlike the brace, it seems to be an important advantage in kinesiotape application in that it permits the movement of the joint.
- Trial name
- NCT05351996
- Testing
- Kinesiotape, Home-based exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people
- Sponsor
- Bozyaka Training and Research Hospital
Osteoarthritis, Knee
Descriptive Study of Strength Training Exercises to Activate the Muscles of the Operated Leg After Total Knee Replacement
Background: In the early phase after a total knee replacement (TKA), patients experience multi-level weakness in the operated leg, which is caused primarily by reduced central (CNS) activation failure of the muscles - especially…
- Trial name
- NCT01708980
- Testing
- Six different strength training exercises
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Knee Osteoarthritis
Effectiveness of BREG Flex in 12-week Peri-operative Total Knee Arthroplasty
Patient outcomes following total knee replacement and standard physical therapy will be compared between subjects who use the Breg Flex study device vs those who do not.
- Trial name
- NCT03840096
- Testing
- Breg Flex
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- The Hawkins Foundation
Osteoarthritis, Knee
Monopolar Versus Biopolar Radiofrequency in OA Knee Pain
This is a prospective randomized controlled trial study will aim to evaluate the the efficacy and procedural pain of BRFA and to compare it with conventional technique (MRFA).
- Trial name
- NCT05591768
- Testing
- Monopolar radiofrequency, Bipolar radiofrequency
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University