Clinical trials: Oesophageal Disease
Esophageal Achalasia, Gastroparesis
Respiratory and Hemodynamic Implications of Endoscopic Myotomy of the Esophagus and Stomach
The goal of this observational study is to learn about hemodynamic and respiratory repercussions during general anesthesia in patients with achalasia or gastroparesis who underwent an endoscopic treatment such as a peroral…
- Trial name
- NCT05602272
- Testing
- General anesthesia for per-oral endoscopic myotomy
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Dysphagia
Intermittent Oro-esophageal Tube on Feeding Hesitancy in Stroke Patients
The aim of this clinical trial is to compare Feeding Hesitancy of ischemic stroke patients who receive enteral nutrition support through either Intermittent Oro-esophageal Tube or Nasogastric Tube.
- Trial name
- NCT06312371
- Testing
- Intermittent Oro-esophageal Tube Feeding, Nasogastric Tube Feeding
- Volunteers
- 80 people
- Sponsor
- Muhammad
Barrett's Esophagus
Detection of Barrett s Esophagus in Patients Without GERD Symptoms
The purpose of this study is to develop a method to detect Barrett's esophagus (BE) in individuals with a new office-based diagnostic test.
- Trial name
- NCT04880044
- Testing
- EsoCheck/EsoGuard (EC/EG), Esophago-gastro-duodenoscopy (EGD)
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Case Comprehensive Cancer Center
Solid Tumor, Adult
FT538 in Combination With Monoclonal Antibodies in Advanced Solid Tumors
This is a Phase 1 dose-finding study of FT538 in combination with monoclonal antibodies.
- Trial name
- NCT05069935
- Testing
- FT538, Cyclophosphamide, Fludarabine
- Where
- 4 sites in United States
- Volunteers
- 16 people
- Sponsor
- Fate Therapeutics
Oropharyngeal Dysphagia, Geriatric Patients
Effect of Tongue-to-Palate Resistance Training in Geriatric Patients With Oropharyngeal Dysphagia
The goal of this randomized controlled trial is to learn if a home-based Tongue-to-Palate Resistance Training (TPRT) program can improve swallowing muscle activity and swallowing safety in geriatric patients (aged >60 years) with…
- Trial name
- NCT07203508
- Testing
- Tongue-to-Palate Resistance Training, Standard Dysphagia Therapy
- Where
- Indonesia
- Volunteers
- 17 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Gastro Esophageal Reflux
Effect of a Combination of Hyaluronic Acid, Chondroitin Sulphate and Magnesium Trisilicate on Subjects With GastroEsophageal Reflux Disease
The aim of this study is to investigate whether a 3-week treatment with an oral melt in mouth medical device, made up with hyaluronic acid, chondroitin sulphate and magnesium trisilicate, can lead to a reduction of…
- Trial name
- NCT03883074
- Testing
- hyaluronic acid with chondroitin + sulphate + magnesium trisilicate
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- SOFAR S.p.A.
Esophageal Squamous Cell Carcinoma
Adebrelimab With Famitinib and Chemotherapy as Neoadjuvant Therapy for ESCC
This is a prospective, single-arm, exploratory clinical study enrolling patients with resectable, locally advanced thoracic esophageal squamous cell carcinoma (ESCC) confirmed by histology or cytology.
- Trial name
- NCT07796113
- Testing
- Adebrelimab + Famitinib + Chemotherapy
- Where
- China
- Volunteers
- 24 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Gastroesophageal Reflux Disease, Endoscopy
Anti-Reflux Mucosal Ablation(ARMA) and Anti-Reflux Mucosectomy(ARMS) in Gastroesophageal Reflux Disease
According to the current published data and treatment mechanism, ARMS may led to more stenosis while ARMA may be less effective in long term follow-up.
- Trial name
- NCT05422404
- Testing
- Anti-Reflux Mucosectomy, Anti-reflux mucosal ablation
- Volunteers
- 150 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Gastroesophageal Reflux Disease
Safety and Efficacy of Dexlansoprazole Modified Release Formulation to Treat Gastroesophageal Reflux Disease
The purpose of this study is to assess the efficacy and safety of Dexlansoprazole modified release (MR) (30 mg once daily [QD] or 60 mg QD) compared to placebo in relief of daytime and nighttime heartburn over 4 weeks in subjects…
- Trial name
- NCT00321984
- Testing
- Dexlansoprazole MR
- Where
- 153 sites in United States
- Volunteers
- 947 people
- Sponsor
- Takeda
Gastroesophageal Reflux Disease
Effect of Nortriptyline in Cortical Representation of Heartburn in Nonerosive Reflux Disease (NERD) Patients
Patients with nonerosive reflux disease (NERD) are less responsive to standard treatment with proton pump inhibitors. The hypothesis of this study was that nortriptyline in analgesic doses may decrease heartburn perception and…
- Trial name
- NORGERD (NCT01065649)
- Testing
- Nortriptyline
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade de Passo Fundo
Squamous Cell Carcinoma of Esophagus
Neoadjuvant Chemotherapy of Nanoparticle Albumin-bound Paclitaxel in Squamous Cell Carcinoma of Esophagus
Albumin-bound paclitaxel regimen in advanced NSCLC has a better tumor response rate and safety than solvent-based paclitaxel. However, the safety and efficacy is uncertain in neoadjuvant therapy in esophageal cancer.
- Trial name
- NCT02033538
- Testing
- nanoparticle albumin-bound paclitaxel
- Where
- China
- Sponsor
- Zhejiang University
Esophageal and Gastric Varices
Comparison of Endoscopic Band Ligation Plus 24-hour Versus 72-hour Terlipressin Therapy
In the Western world, liver cirrhosis is a significant issue. Acute variceal bleeding (AVB) is a considerable complication of cirrhosis associated with high mortality.
- Trial name
- NCT05331768
- Testing
- banding ligation plus terlipressin infusion
- Where
- Mexico
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Esophageal Cancer
Combination Chemotherapy Combined With Radiation Therapy in Treating Patients Who Have Stage II or Stage III Cancer of the Esophagus
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00008047
- Testing
- fluorouracil, hydroxyurea, paclitaxel
- Where
- 14 sites in France
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Gastroesophageal Reflux Disease, Reflux Esophagitis
The Efficacy of i-Scan for Detecting Reflux Esophagitis
Endoscopy is a widely used modality for the diagnosis and classification of Gastroesophageal reflux disease (GERD), and the extent of esophageal mucosal breaks on endoscopy can be assessed.
- Trial name
- NCT01381991
- Testing
- i-scan
- Where
- South Korea
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Konkuk University Hospital
Gastric Cancer, Esophageal Cancer
CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer
This is a phase I trial of CA-4948 in combination with FOLFOX/PD-1 inhibitor with or without trastuzumab for unresectable gastric, GEJ, and esophageal cancer.
- Conditions
- Gastric Cancer, Esophageal Cancer, Stomach Cancer, Esophagus Cancer
- Trial name
- NCT05187182
- Testing
- CA-4948, Nivolumab, Pembrolizumab
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Viral Hepatitis B, Viral Hepatitis D
Replicor Compassionate Access Program
The goal of this compassionate access program is to provide early access to REP 2139-Mg for patients with HBV mono-infection or HBV / HDV co-infection who either have advanced (decompensated) cirrhosis or who have failed to…
- Conditions
- Viral Hepatitis B, Viral Hepatitis D, Cirrhosis, Liver, Decompensated Cirrhosis
- Trial name
- RCAP (NCT05683548)
- Testing
- REP 2139-Mg, Tenofovir Disoproxil Fumarate, Pegylated interferon alpha2a
- Where
- 13 sites in Austria, France and 3 more
- Sponsor
- Replicor Inc.
Reflux Disease, Microbiome
Development of a Preparation for Supportive Supplementation of Probiotics in Patients With Reflux
A two-arm, double-blind, randomized, placebo-controlled study investigating the efficacy of a probiotic preparation developed as supportive supplementation of probiotics in patients with reflux.
- Conditions
- Reflux Disease, Microbiome, Probiotics Supplement
- Trial name
- NCT07600008
- Testing
- A probiotic dietary supplement
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Olomouc
Barrett Esophagus, Esophageal Adenocarcinoma
Trans-Oral Sampling as an Alternative Surveillance of Barrett's Esophagus Pilot
The study aims to address the increasing incidence of esophageal cancer and Barrett's esophagus (BE) in the Western world by exploring a more efficient surveillance method.
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Diagnosis
- Trial name
- TOSS pilot (NCT07490340)
- Testing
- trans oral sampling: endosign
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Deglutition Disorders, Parkinson Disease
Outcomes to the Nutritional Need of Patients With Parkinson's Disease
The intervention involves the identification of 140 patients (70 per group), fed throughout the duration of the study with the two different solutions indicated.
- Conditions
- Deglutition Disorders, Parkinson Disease, Nursing, Quality of Life
- Trial name
- W-Domus (NCT04983290)
- Testing
- weancare-domus
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Milko Zanini
Acute Respiratory Distress Syndrome (ARDS)
COMPARISON OF LUNG RECRUITABILITY ASSESSMENT BY HYSTERESIS RATIO AND RECRUITMENT-TO-INFLATION RATIO, AND PEEP TITRATION IN ARDS.
This multicenter, single-blind physiological study aims to compare two bedside methods for assessing lung recruitability in mechanically ventilated patients with acute respiratory distress syndrome (ARDS): the…
- Trial name
- PV-TOOL (NCT07713420)
- Testing
- Physiological lung recruitability assessment and PEEP titration protocol
- Volunteers
- 30 people
- Sponsor
- Oriol Roca
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