Clinical trials: Off Pump Coronary Artery Bypass Surgery
Acute Kidney Injury
Effect of Sodium Bicarbonate on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass (OPCAB)
In this single-site, randomized, controlled and double-blind clinical trial, the investigators evaluate the effect of sodium bicarbonate on prevention of acute kidney injury in high risk patients undergoing off pump coronary…
- Trial name
- NCT01840241
- Testing
- sodium bicarbonate, normal saline
- Where
- South Korea
- Volunteers
- 162 people
- Sponsor
- Yonsei University
Coronary Artery Disease
A Prospective Randomized Study for Comparison of Y-Composite Grafts
The purpose of this study is to compare early and 1-year graft patency rates of saphenous vein composite grafts with those of right internal thoracic artery composite graft and mid-term clinical outcomes in patients who undergo…
- Trial name
- SAVERITA (NCT01051986)
- Testing
- saphenous vein composite grafting, right internal thoracic artery composite grafting
- Where
- South Korea
- Volunteers
- 224 people
- Sponsor
- Seoul National University Hospital
Neurological Injury, Stroke
Carbon Dioxide Surgical Field Flooding and Aortic No-touch Off-pump Coronary Artery Bypass Grafting to Reduce Neurological Injuries After Surgical Coronary Revascularization (CANON): a Randomised, Controlled, Investigator and Patient Blinded Single Center Superiority Trial With Three Parallel Arms.
The objective of this study is to investigate the value of employing the aortic no-touch off-pump coronary artery bypass technique and the practice of carbon dioxide surgical field flooding for the prevention of type 1 and 2…
- Conditions
- Neurological Injury, Stroke, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- CANON (NCT03074604)
- Testing
- aortic no-touch OPCABG, OPCABG with partial clamp applying carbon dioxide, OPCABG with partial clamp
- Where
- Poland
- Volunteers
- 192 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Coronary Artery Occlusive Disease
The Effect of Carotid IMT (Intima Media Thickness) on Postoperative Cognitive Dysfunction in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery
The patients who have undergone cardiac surgery have higher likelihood of postoperative cognitive dysfunction (POCD). The carotid intima-media thickness (IMT) is associated with cognitive dysfunction in the old.
- Trial name
- NCT02456493
- Where
- South Korea
- Volunteers
- 224 people
- Sponsor
- Yonsei University
Acute Coronary Syndrome (ACS)
Effect of Perioperative Clopidogrel Responsiveness on Ischemic Outcome in Patients With Acute Coronary Syndrome Undergoing Off-pump Coronary Artery Bypass Surgery
The whole blood Thrombelastograph (TEG®) Platelet Mapping™ assay measures clot strength, maximal amplitude (MA), reflecting maximal platelet function, and detects the reduction in platelet function, presented as percentage…
- Trial name
- NCT02184884
- Testing
- MACE after OPCAB, without MACE after OPCAB
- Where
- South Korea
- Volunteers
- 195 people
- Sponsor
- Yonsei University
Three Vessel Coronary Artery Disease
Association of Carotid Arterial Circumferential Strain With Left Ventricular Function and Hemodynamic Compromise During Off-pump Coronary Artery Bypass Surgery
This study is aimed to evaluate the association of common carotid artery circumferential strain with the echocardiographic parameters of left ventricular function and the degree of actual hemodynamic deterioration in patients…
- Trial name
- NCT01840969
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Yonsei University
the Efficacy and Safety of Off-pump CABG
Coronary Artery Bypass Surgery (CABG) Off or On Pump Revascularization Study
I. Main Research Question: To compare the risks and benefits of Off-pump Coronary artery bypass surgery (CABG) to On-pump CABG and to determine if one is better than the other.
- Trial name
- CORONARY (NCT00463294)
- Testing
- Coronary Artery Bypass Graft with the use of CPB, Coronary Artery Bypass Graft without the use of CPB
- Where
- 52 sites in Argentina, Brazil and 11 more
- Volunteers
- 4,752 people
- Sponsor
- Population Health Research Institute
Coronary Artery Disease
FiO2 and Outcomes After OPCAB (the CARROT Trial)
Conventionally, a relatively high level of fraction of inspired oxygen (FiO2) has been used for secure a margin of safety in patients undergoing cardiac surgery including off-pump coronary artery bypass grafting (OPCAB).
- Trial name
- NCT03945565
- Testing
- Fraction of inspired oxygen level
- Where
- South Korea
- Volunteers
- 414 people
- Sponsor
- Seoul National University Hospital
Pain, Postoperative
Clinical Study of Depodur Efficacy in Decreasing Post Operative Pain After Off Pump Coronary Artery Bypass Grafting (OP-CABG)
The purpose of this study is to determine whether epidural Depodur alleviates the pain of OP-CABG surgery. This includes pain associated with sternotomy, retraction, dissection and other tissue insults, as well as the induced…
- Trial name
- NCT00456638
- Testing
- Depodur
- Sponsor
- Drexel University College of Medicine
Coronary Artery Disease, Aspirin
Effect of Preoperative Aspirin in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
Effect of Preoperative Aspirin in patients undergoing Off-pump Coronary Artery Bypass Grafting. A double-blind, placebo-controlled, randomized trial.
- Trial name
- NCT03049085
- Testing
- Aspirin, vitamin C
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Medinet Heart Centre
Coronary Artery Occlusive Disease
Effect of Intraoperative Iloprost Inhalant on Hemodynamic Stability in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery
Considering that the cause of hemodynamic instability during OPCAB is closely related to right ventricular dysfunction with pulmonary artery hypertension, the use of inhaled iloprost (a selective pulmonary vasodilator) in…
- Trial name
- NCT04598191
- Testing
- Iloprost, Control (Normal saline)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Microcirculation, Anesthetic Complication Spinal
Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery
Volatile anesthetics, such as sevoflurane and desflurane, are commonly used in patients undergoing cardiac surgeries including off-pump coronary artery bypass.
- Trial name
- NCT03209193
- Testing
- Sevoflurane, Desflurane
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Bypass, Off-Pump
Prospective Cohort Study on Minimal Invasive Coronary Surgery
CABG technology is recognized as the preferred treatment, and its major adverse cardiac and cerebral event(MACCE) incidence and mortality are lower than percutaneous coronary intervention(PCI).
- Trial name
- PCSMICS (NCT04267835)
- Testing
- MIDCAB, thoracotomy OPCABG
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Coronary Artery Bypass, Off-Pump
Cell Savers and Blood Quality
Cell savers are routinely used in our hospital during off-pump coronary artery bypass grafting to retrieve and wash blood that is lost during the operation.
- Trial name
- NCT02046824
- Testing
- Xtra®, Sorin cellsaver, C.A.T.S.®, Fresenius cellsaver, CardioPAT®, Haemonetics, cellsaver
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- University Medical Center Groningen
Complications Due to Coronary Artery Bypass Graft, Graft Failure
Patency-Coronary Trial
Heart bypass surgery is used to increase blood flow to the heart. This surgery is usually done using a heart-lung machine (on-pump surgery) allowing the surgeon to perform the procedure on a still heart.
- Trial name
- PATENCY (NCT01414049)
- Testing
- On-pump CABG, Off-pump CABG
- Where
- 3 sites in Canada
- Volunteers
- 1,200 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Coronary Heart Disease, Stroke
Surgical Manipulation of the Aorta and Cerebral Infarction
The purpose of the study is to compare two surgical strategies for coronary artery bypass grafting with respect to the occurrence of cerebral infarctions made visible by magnetic resonance imaging
- Conditions
- Coronary Heart Disease, Stroke, Cerebral Infarction
- Trial name
- NCT00558779
- Testing
- OBCAB (Off Pump Coronary Artery Bypass Grafting), CABG (coronary artery bypass grafting)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Wuerzburg
Coronary Artery Disease
Association Between Vitamin D and Perioperative Hemoglobin Levels in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery: Role of Hepcidin
Preoperative anemia is present in more than 50% of patients undergoing cardiac surgery, which is associated with increased risk of transfusion, increased length of stay in the intensive care unit, and increased incidence of renal…
- Trial name
- NCT04986033
- Where
- South Korea
- Volunteers
- 135 people
- Sponsor
- Yonsei University
Analgesic Effects, Systemic Stress Response
Bilateral Ultrasound Guided Pectoralis Nerve Block Induces Hemodynamic Stability With Reducing Systemic Stress Response for Off-pump Coronary Artery Bypass Graft
Opioids used in attenuation of the neuroendocrine stress response in patients undergoing off-pump coronary artery bypass graft (OPCAB) it produces predictable satisfactory analgesia and sedation but with side effects such as…
- Conditions
- Analgesic Effects, Systemic Stress Response, Hemodynamic Stability
- Trial name
- NCT03734848
- Testing
- Bilateral Ultrasound Guided Pectoralis Nerve Block.
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tanta University
Hypoxemia, Recruitment
Comparison of Four Different Recruitment Maneuvers in Patients After Coronary Surgery
The risk of respiratory failure after cardiac surgery is high, and it may result in many complications. The maneuver of alveolar recruitment may improve the oxygen transport in the human organism.
- Trial name
- RECR-CABG (NCT01457651)
- Testing
- Alveolar recruitment
- Where
- Russia
- Volunteers
- 76 people
- Sponsor
- Northern State Medical University
Coronary Artery Disease With Need for Bypass Surgery, Coronary Artery Disease(CAD)
Postural Mobilization Compared to Noradrenaline Only in Off-Pump CABG Surgery
This interventional prospective randomized study is designed to compare hemodynamic management using postural mobilization (+/- noradrenaline) versus noradrenaline only in patients undergoing open-heart coronary artery bypass…
- Conditions
- Coronary Artery Disease With Need for Bypass Surgery, Coronary Artery Disease(CAD), Coronary Artery Bypass, Off Pump Coronary Artery Bypass Graft
- Trial name
- OPTICAB (NCT07163858)
- Testing
- passive leg raising for hemodynamic management during open-heart coronary bypass grafting, Use of Noradrenaline only in control group
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Infirmerie Protestante de Lyon