Clinical trials: Older Adults With Mild Neurocognitive Disorders
Mild Cognitive Impairment
Effectiveness of Tongue Resistance Exercises on Tongue and Swallowing Function in Frail Older Adults With MCI
The purpose of this study is to explore the effects of tongue resistance exercises on tongue muscle strength and swallowing function in frail older adults with mild cognitive impairment living in the community.
- Trial name
- NCT06766487
- Testing
- Tongue resistance exercises, cheek bulging exercises
- Where
- Taiwan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Chang Gung Medical Foundation
Cognitive Dysfunction
Guilingji Capsule for Mild-to-moderate Cognitive Impairment
This study is aiming to evaluate the efficacy and safety of Guilingji capsule in older adults with mild-to-moderate cognitive impairment who diagnosed as the kidney and marrow deficiency pattern in TCM.
- Trial name
- NCT03647384
- Testing
- Gulingji capsules, Ginko Biloba Extract tablet
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Mild Cognitive Impairment
Comparison of High-Intensity Interval Training and Moderate-Intensity Continuous Training in Mild Cognitive Impairment
This study aims to determine the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) on cognitive and physical fitness in community-dwelling adults diagnosed with Mild Cognitive…
- Trial name
- NCT07248709
- Testing
- High-Intensity Interval Training (HIIT), Moderate-Intensity Continuous Training
- Where
- 2 sites in Pakistan
- Volunteers
- 68 people
- Sponsor
- Riphah International University
Gingivitis, Periodontal Diseases
Results From Objective Brushing Data Saved From a Powered Toothbrush Related to Values for Oral Health
For this study, 213 individuals were recruited. During the Baseline examination, each participant received a powered toothbrush and was carefully instructed on how to use the toothbrush and recommended using it for at least 2…
- Trial name
- NCT05941611
- Testing
- Powered toothbrush
- Where
- Sweden
- Volunteers
- 213 people
- Sponsor
- Blekinge Institute of Technology
Mild Cognitive Impairment, Aging
Effect of Digital Cognitive Training on the Functionality of Older Adults With Mild Cognitive Impairment (MCI)
The purpose of this study is to investigate the effect of digital cognitive training in the functionality of older adults with Mild Cognitive Impairment.
- Trial name
- NCT03911765
- Testing
- digital cognitive training
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Mild Cognitive Impairment
Memory Aid - Working Memory Training in Patients With Mild Cognitive Impairment.
Background: Mild Cognitive Impairment (MCI) is a condition characterized by memory problems more severe than normal cognitive changes due to old age, and less severe than dementia.
- Trial name
- MCI (NCT01991405)
- Testing
- Computerized Working Memory Training.
- Where
- Norway
- Volunteers
- 90 people
- Sponsor
- Sorlandet Hospital HF
Mild Cognitive Impairment
Cognitive Integrated Motor Training (CM) to Improve Gait and Balance and Reduce Falls in Older Adults With Mild Cognitive Impairment
Problems with walking and balance are common in older adults with mild cognitive impairment. Walking and balance problems limit independence and increase risk for injuries due to falls.
- Trial name
- CM (NCT06719297)
- Testing
- Personalized cognitive-sensorimotor VR/MR training, Standard of Care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Kessler Foundation
Mild Cognitive Impairment, Stroke
Evolving Methods of Hybrid Exercise-cognition Approach to Promote Health-related Conditions for the Elderly With MCI
The aim of the study is to determine: (1) the effects of combined physical exercise and cognitive training versus exercise or cognitive training alone on cognition, physical function, daily function, quality of life and social…
- Trial name
- NCT03927586
- Testing
- cognitive training, physical exercise training
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Chang Gung Memorial Hospital
Alzheimer's Disease
Efficacy and Safety of Plasma Exchange With 5% Albumin in Beta-amyloid Peptide Clearance in Cerebral Spinal Fluid
The purpose of this study was to evaluate the efficacy and safety of plasma exchange with 5% albumin in beta-amyloid peptide clearance in cerebrospinal fluid, and its effects in patients with mild-moderate Alzheimer's disease.
- Trial name
- NCT00742417
- Testing
- Albutein 5%, Control
- Where
- 4 sites in United States, Spain
- Volunteers
- 42 people
- Sponsor
- Instituto Grifols, S.A.
Memory Disorders, Alzheimer Disease
Impact of Covid-19 on Frequent Social Interaction Through Communication Technologies in the Cognitive Status of Socially-isolated Older Adults
The current study will examine the impact of frequent social interaction through communication technologies during COVID-19 pandemic in the cognitive status of socially-isolated older adults with and without cognitive impairment.
- Conditions
- Memory Disorders, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- NCT04480112
- Testing
- Technology based social interactions, No research related technology based social interactions
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Boston University
Alzheimer Disease, Mild Dementia
Acute Effect of Low-intensity Gamma rTMS on Cognitive and EEG Parameters in Adults With Mild Dementia by Alzheimer's Disease
Neurocognitive disorders have a growing prevalence and impact on public health; their main etiology corresponds to Alzheimer's disease. To date, there is no treatment that can reverse neuronal damage in these pathologies.
- Trial name
- NCT05784298
- Testing
- low-intensity rTMS
- Where
- Mexico
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Mild Cognitive Impairment
Effectiveness of Walking Exercise in Improving Cognitive Function in Older Adults With Mild Cognitive Impairment
The increasing prevalence of mild cognitive impairment (MCI) in our rapidly aging population prompts the need for devising effective interventions to prevent the onset of cognitive impairment and delay its progression to…
- Trial name
- NCT04515563
- Testing
- Stretching exercise, Low-frequency, moderate-intensity walking group, High-frequency, moderate-intensity walking group
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Mild Cognitive Impairment, Healthy
The Aerobic & Cognitive Exercise Study
The purpose of this study is to clarify the benefits to brain health and thinking processes that result from different forms of exercise.
- Trial name
- ACES (NCT02237560)
- Testing
- Cybercycle-Game, Cybercyle-Tour, Game Only
- Where
- 12 sites in United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Union College, New York
Dementia
Increasing Engagement and Positive Emotional Behavior of Older Adults With Mild-Moderate Dementia With the Use of Motion-Based Technology and Meaningful Activities
The purpose of this study is to investigate if engagement in self-selected motion-based games such as Wii and the "Magic Table" is correlated to higher levels of engagement and more positive emotional behaviors.
- Trial name
- NCT07209124
- Testing
- Experimental: Intervention 1 (AB): Engagement in Motion-Based Activities (Wii & Magic Table), Experimental: Intervention 2 (BA): Engagement in Motion-Based Activities (Magic Table BA)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Midwestern University
Mild Cognitive Impairment
Neurobic Exercise Program on Cognitive Abilities
This research aims to investigate the significance of a neurobic exercise program on cognitive abilities, memory retention, activities of daily living (ADL), and quality of life (QOL) among older adults with mild cognitive…
- Trial name
- NCT06601751
- Testing
- Neurobic Exercise Program, Traditional Brain Exercise
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Mild Cognitive Impairment, Sleep
Home Sleep Therapy for Older Adults With MCI
The goal of this clinical trial is to learn about the ability of non-invasive brain stimulation during sleep to enhance people's deep sleep and its potential benefit on memory in people with mild cognitive impairment via home use…
- Conditions
- Mild Cognitive Impairment, Sleep, Transcranial Electrical Stimulation, Machine Learning
- Trial name
- NCT05771844
- Testing
- Transcranial Electrical Stimulation
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brain Electrophysiology Laboratory Company
Alcohol Use Disorder, Mild Cognitive Impairment
rTMS in Older Adults With MCI and AUD
Alcohol misuse is a risk factor for early onset cognitive impairment, contributing to 10% of early onset dementia, with risk corresponding to consumption.
- Conditions
- Alcohol Use Disorder, Mild Cognitive Impairment, Transcranial Magnetic Stimulation
- Trial name
- NCT05896332
- Testing
- Active, Open Label iTBS-rTMS
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Medical University of South Carolina
Mild Cognitive Impairment (MCI), Depression
Brain Aging and Treatment Response in Geriatric Depression
The proposed project will evaluate the role of neuroimaging biomarkers of brain aging (i.e., neurodegenerative and vascular brain changes) and mild cognitive impairment in the patterns of treatment response to memantine combined…
- Trial name
- NCT01902004
- Testing
- Escitalopram, Memantine
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of California, Los Angeles
Mild Cognitive Impairment
Effects of Brain Training Games on Cognitive Function and Quality of Life in MCI
The study aims to determine the effects of brain training games on cognitive function and Quality of life among older adults with MCI.
- Trial name
- NCT06437704
- Testing
- Brain training game Lumosity, Simulation game simcity buildit
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Cognitive Dysfunctions, Cognitive Disorder
Additional Effects of Immersive vr 360 Degree Videos With Aerobic Exercises on Cognitive Functions in Elderly With Mild Cognitive Impairment
One of the key challenges faced by individuals with Mild Cognitive Impairment (MCI) is the decline in cognitive abilities, particularly global cognition, attention, and executive function, which are essential for maintaining…
- Conditions
- Cognitive Dysfunctions, Cognitive Disorder, Cognitive Decline
- Trial name
- NCT07242495
- Testing
- VR 360 degree Videos and Aerobic Chair Exercises intervention, Chair Aerobic Exercises
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad