Clinical trials: Older Adults With Mild Neurocognitive Disorders
Mild Cognitive Impairment
Effectiveness of an ACT-Based Cognitive Intervention on Quality of Life and Cognitive Function in Elderly Residents With MCI
This study investigates the effects of an Acceptance and Commitment Therapy (ACT)-based cognitive intervention on Quality of Life (QOL) and cognitive function among elderly residents with Mild Cognitive Impairment (MCI) in…
- Trial name
- EACT (NCT06753578)
- Testing
- Acceptance and Commitment Therapy (ACT), standard care
- Where
- Spain
- Volunteers
- 215 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Mild Cognitive Impairment, Older Adults
Effectiveness of Alternative Therapy for Improving Cognition, Balance, and Physical Activity
The composite effect of reduced balance, cognition, gait abnormalities/gait disturbances, and physical activity in older adults with mild cognitive impairments (MCI) leads to fear of falling and reduced participation in daily…
- Conditions
- Mild Cognitive Impairment, Older Adults, Neurological Injury
- Trial name
- NCT04160299
- Testing
- Dance-based exergaming
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Mild Cognitive Impairment
Efficacy of Computerized Cognitive Training in the Elderly With Mild Cognitive Impairment
Mild cognitive impairment (MCI) is the prodrome of the cognitive function declining before Alzheimer's disease or other dementia showed up, the impairments of language, visuospatial relationship, attention, and memory included…
- Trial name
- NCT03577717
- Testing
- computerized cognitive training, occupational therapy
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- Taipei Hospital, Taiwan
Mild Cognitive Impairment
Effect of Action Observation Training on Gait Variables and Global Cognitive Functions
This study will investigate the effect of Action Observation Teaining (AOT) on gait variables and global cognitive functions in older adults with mild cognitive impairment (MCI).
- Trial name
- NCT03522389
- Testing
- AOT with gait training, Gait training, Education
- Where
- Thailand
- Volunteers
- 39 people
- Sponsor
- Mahidol University
Cognitive Dysfunction, Cognitive Disorder, Cognitive Training
Effects of Adaptive Difficulty Computerized Cognitive Training on Cognitive Function Improvement in Older Adults With Mild Cognitive Impairment
This study aims to evaluate the effectiveness of adaptive computerized cognitive training (CCT) in improving cognitive function among community-dwelling older adults with mild cognitive impairment (MCI) and to compare the…
- Trial name
- NCT07753382
- Testing
- Adaptive Computerized Cognitive Training
- Where
- China
- Volunteers
- 36 people
- Sponsor
- China Medical University, China
Mild Cognitive Impairment (MCI)
AI-Supported Cognitive Rehabilitation for Older Adults With Mild Cognitive Impairment
Mild cognitive impairment (MCI) is associated with increased risk of progression to dementia, highlighting the need for accessible interventions to support cognitive health.
- Trial name
- ReMind-AI (NCT07474038)
- Testing
- AI-Supported Cognitive Rehabilitation
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Kaiser Permanente
Healthy Older Adults, Memory Complaints
A Computer-based Memory Strategy Training Program for Older Adults
A computer-based cognitive rehabilitation program based on daily tasks utilising the semantic or perceptual encoding strategies called Enhancing Memory in Daily Life (E-MinD Life) has been developed for Chinese people.
- Conditions
- Healthy Older Adults, Memory Complaints, Mild Cognitive Impairment (MCI)
- Trial name
- NCT07039708
- Testing
- E-MinD Life Semantic, Cognitive stimulation
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Dementia, Neurocognitive Disorders
Prefrontal Cortex Dynamics of the Elderly During a Cognitive Stimulation Programme
This research aims to evaluate the effect of cognitive stimulation (CS) on the functioning of the prefrontal cortex (PFC), seeking an analysis of both cerebral hemodynamics in neuroplasticity and aspects related to the initiation…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT04693611
- Testing
- Individual cognitive stimulation therapy (iCST), Functional near-infrared spectroscopy (fNIRS)
- Where
- Portugal
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas
Mild Cognitive Impairment (MCI)
The Effects of Methylphenidate on the Cognitive Function of Older People With Mild Cognitive Impairment
Background: The increase in life expectancy and the rise in the ratio of older to younger people in the population has resulted in an increase in the number of those suffering from a decrease in cognitive ability, such as Mild…
- Trial name
- NCT02180529
- Testing
- Methylphenidate
- Where
- Israel
- Volunteers
- 16 people
- Sponsor
- Meir Medical Center
Age-associated Memory Impairment
Supplemental Hydrogen Plus PQQ for Mitochondrial Biomarkers and Brain Function in Elderly With Mild Cognitive Impairment
The goal of this randomized controlled double-blind parallel-group interventional trial is to evaluate the effects of dietary supplementation with molecular hydrogen and pyrroloquinoline quinone in elderly.
- Trial name
- CALERIE (NCT05910047)
- Testing
- Supplement
- Where
- Serbia
- Volunteers
- 34 people
- Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
Mild Cognitive Impairment
Correlation Between Prognosis of Mild Cognitive Impairment and Hearing Function in Community Elderly
Cognitive dysfunction is a high incidence disease in the elderly. To date, there is no effective treatment. At the same time, early cognitive impairment is easy to be ignored, delayed intervention.
- Trial name
- NCT05336942
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Tongji University
Alzheimer Disease, Mild Cognitive Impairment
Evaluation of the Effectiveness and Safety of Transcranial Direct Current Stimulation in Combination With Nasal Near Infrared Stimulation to Improve Cognitive Functions and Quality of Life in Elderly People With Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD).
Alzheimer's disease (AD) and mild cognitive impairment (MCI) are progressive neurodegenerative conditions with limited therapeutic options. Today, around 30 million people worldwide suffer from Alzheimer's dementia.
- Trial name
- NCT07290686
- Testing
- tDCS stimulation, tDCS, iNIRS stimulation
- Where
- Poland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Physical Function, Executive Function (Cognition)
Effects of Resistance and Dual-Task Training on Physical, Oculomotor, and Executive Functions in Older Adults With MCI
The goal of this clinical trial is to determine the effect of a combined therapeutic intervention program with anaerobic exercises (resistance exercises) and dual tasks on the physical, oculomotor, and executive functions of…
- Conditions
- Physical Function, Executive Function (Cognition), Saccadic Eye Movements
- Trial name
- NCT07278141
- Testing
- Anaerobic therapeutic exercises (resistance exercise), Anaerobic therapeutic exercises (resistance exercise) plus Dual Task
- Where
- 2 sites in Chile, Spain
- Volunteers
- 66 people
- Sponsor
- Universidad Santo Tomas, Chile
Cancer, Cognitive Impairment
Cancer and Mild Cognitive Impairment Dyadic Intervention
The purpose of this study is to see whether programs that include both a patient and their spouse or a patient and family caregiver (known as a dyad) are helpful for families in which one member of the dyad has cancer and mild…
- Trial name
- NCT05144516
- Testing
- Behavioral: COPE +
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Duke University
Healthy, Mild Cognitive Impairment
tES Effects on Associative Memory Performance
Previous studies showed that transcranial electric stimulation (tES) applied over the prefrontal cortex improves cognitive performance in healthy elderly adults as well as in patients suffering from mild cognitive impairment or…
- Conditions
- Healthy, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT03351452
- Testing
- real anodal transcranial direct current stimulation, real transcranial alternating current stimulation
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Bern
Amnestic Mild Cognitive Impairment, Aging
Recollection Training in Healthy Older Adults and Older Adults With Amnestic Mild Cognitive Impairment
We have developed a training intervention that successfully improves older adults' memory. We have also shown that older adults whose memory is as good as younger adults' memory (Hi-Old) use an altered pattern of memory-related…
- Trial name
- NCT00643266
- Testing
- Recollection Training, Control
- Where
- Canada
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Baycrest
Creatine, Exercise
Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment
The goal of this 26-week trial is to learn if creatine supplementation and resistance training (i.e., weightlifting; exercise that increases muscle mass), alone and together, impact cognition, brain health, and physical function…
- Conditions
- Creatine, Exercise, Mild Cognitive Impairment (MCI)
- Trial name
- NCT06948149
- Testing
- Creatine monohydrate, Resistance training
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Western University, Canada
Mild Cognitive Impairment (MCI)
Sensory Integration Training for Older Adults With Mild Cognitive Impairment
This study aims to investigate the effects of sensory integration training on cognitive functions, quality of life, and social participation in older adults with Mild Cognitive Impairment (MCI)
- Trial name
- NCT07466615
- Testing
- Aerobic Exercise, Sensory Integration Training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Akdeniz University
Chronic Pain, Physical Activity
Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline
The investigators aim to conduct a randomized controlled trial to compare two symptom-management programs for Black older adults with early cognitive decline (self-reported confirmed by testing) and chronic pain.
- Conditions
- Chronic Pain, Physical Activity, Older Adults, Mild Cognitive Impairment
- Trial name
- HABIT (NCT06246929)
- Testing
- MBCT+w, ALED
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Massachusetts General Hospital
Mild Cognitive Impairment
The Impact of Physical Exercise on Working Memory in Elderly People With Mild Cognitive Impairment
Age-related cognitive decline has evolved into a global public health concern, with deteriorated executive function serving as its predominant manifestation.
- Trial name
- NCT07644156
- Testing
- Resistance band exercise intervention, Brisk walking intervention, Eight-Section brocade exercise intervention
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai University of Sport