Clinical trials: Opioid Use
Schizophrenia, Cannabis Dependence
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
The aim of the present study is to assess the availability of cannabinoid receptors (CB1R) in the human brain. CB1R are present in everyone's brain, regardless of whether or not someone has used cannabis.
- Conditions
- Schizophrenia, Cannabis Dependence, Prodromal for Psychotic Illness, Family History of Alcoholism
- Trial name
- NCT01730781
- Testing
- [11-C]OMAR
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid Use
Two Approaches of Transversus Abdominis Block (TAP ) in Laparoscopic Cholecystectomy
the investigators will compare the effect of pre-operative oblique subcostal TAP and lateral TAP blocks on the total perioperative opioids consumption for patients undergoing elective laparoscopic cholecystectomy
- Trial name
- TAP (NCT05946733)
- Testing
- Group A, Group B, Group C
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Pain, Postoperative, Nausea, Postoperative
Perioperative Dexamethasone Reduces Postoperative Pain and Nausea After Hip Arthroscopy
The purpose of this study is to assess the effect of Dexamethasone on postoperative pain and nausea after hip arthroscopy.
- Conditions
- Pain, Postoperative, Nausea, Postoperative, Opioid Use
- Trial name
- NCT04610398
- Testing
- Dexamethasone 4mg, NaCl 0.9%
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Post-Operative Analgesia, Opioid Use, Unspecified
Comparing Post-Operative Analgesic Effects of PCAM With Dexmedetomidine 1 mcg/ml vs PCAM With Dexmedetomidine 2 mcg/ml
PCA morphine have been a common method in providing excellent analgesia for post-operative period. However, the usage of morphine is not without any side effects such as nausea, vomiting, respiratory depression, and over…
- Conditions
- Post-Operative Analgesia, Opioid Use, Unspecified, Laparotomy Surgery
- Trial name
- NCT05288738
- Testing
- Dexmedetomidine 1 mcg/ml, Dexmedetomidine 2 mcg/ml
- Where
- Malaysia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Postoperative Pain, Opioid Use
Preoperative Gabapentin for Cosmetic Breast Surgery
The goal of this clinical trial is to compare postoperative pain and opioid consumption in patients who undergo cosmetic breast surgery and are treated preoperatively with gabapentin.
- Trial name
- NCT05997355
- Testing
- Gabapentin 600Mg Tab
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Puerto Rico
Breast Cancer, Mastectomy
Preoperative Regional Nerve Block for Acute and Chronic Post-Operative Pain Following Mastectomy
The purpose of this study is to see if pre-operative regional nerve blocks compared to a placebo nerve block can decrease chronic post mastectomy pain, immediate postoperative pain and postoperative narcotic consumption.
- Conditions
- Breast Cancer, Mastectomy, Anesthesia, Local, Narcotic Use
- Trial name
- RELIEF (NCT04019834)
- Testing
- regional nerve block with local anesthesia of bupivacaine with steroid
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Opiate Dependence
ALK21-004: Single-dose Opiate Challenge of Medisorb® Naltrexone (VIVITROL®) in Adults Who Use Opioids
This was a Phase 2, multicenter, randomized, double-blind pilot study in opioid-using adults to assess the presence, duration, and degree of opiate blockade as well as the safety and tolerability of Medisorb® naltrexone…
- Trial name
- NCT01218984
- Testing
- Medisorb naltrexone 75 mg, Medisorb naltrexone 150 mg, Medisorb naltrexone 300 mg
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Alkermes, Inc.
Opioid-use Disorder, Substance Use Disorders
Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)
The purpose of this clinical trial is to investigate Low Intensity Focused Ultrasound (LIFU) using the Exablate® Model 4000 Type 2.0/2.1 as an adjunctive neuromodulatory treatment for OUD (Opioid Use Disorder) and/or other…
- Trial name
- NCT04197921
- Testing
- Exablate Model 4000 Type 2.0/2.1
- Where
- 4 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- InSightec
Opioid Use, Opioid Dependence
Efficiency And Quality In Post-Surgical Pain Therapy After Discharge
Following inpatient surgery, more than 80% of patients are prescribed opioids for use after discharge, yet up to 90% of patients report leftover opioids, and only 16% maximize non-opioid therapy.
- Conditions
- Opioid Use, Opioid Dependence, Opioid Misuse, Post-Surgical Complication
- Trial name
- EQUIPPED (NCT05221866)
- Testing
- Empowering Patient to Steer Their Pain Management After Surgery, Provider-facing Prescription Aid
- Where
- United States
- Volunteers
- 711 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
HIV Prevention, HCV
Integrated HIV Prevention and HCV Care for PWID
The objective of this study is to compare and evaluate two strategies of delivering PrEP and Hepatitis C Virus (HCV) treatment to people who inject drugs to determine the best method of providing care.
- Conditions
- HIV Prevention, HCV, Opioid Use, Intravenous Drug Usage
- Trial name
- M2HepPrEP (NCT03981445)
- Testing
- ARTAS Adapted Patient Navigation, Adherence Counseling
- Where
- 3 sites in United States, Canada
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- Columbia University
Anxiety, Chronic Pain
Controlled Substance Treatment Agreements in an Internal Medicine Residents' Clinic
The purpose of this study is to characterize and improve controlled substance, carisoprodol and tramadol use in an internal medicine residents' clinic.
- Conditions
- Anxiety, Chronic Pain, Opioid Use, Unspecified
- Trial name
- NCT02244099
- Testing
- Controlled Substance
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Opioid-use Disorder
Effects of Remote Motivational Enhancement & MySafeRx on Post-Detox Engagement in B/N Treatment -RCT
Opioid overdoses are a significant problem nationwide and novel interventions that can prevent overdose by improving Buprenorphine/ Naloxone (B/N) treatment for opioid use disorder are a public health priority.
- Trial name
- MySafeRx (NCT04822168)
- Testing
- MySafeRx™, Standard Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of South Florida
Adherence, Medication, Opioid Use Disorder
Assessing Dose Taken in Opioid Use Disordered Patients With an Electrochemical Sensor
CARI Health aims to develop a methadone dose taken sensor that provides real-time data on interstitial fluid (ISF) levels that could be used as a methadone adherence monitor for daily doses.
- Trial name
- NCT05998876
- Testing
- Remote Medication Monitor (RMM) - Prototype, Daily Methadone Dose
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cari Health Inc.
Chronic Pain, Chronic Insomnia
Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain
The goal of this study is to test two behavioral interventions for chronic insomnia in individuals with chronic pain and use prescribed opioid medication to treat their chronic pain.
- Conditions
- Chronic Pain, Chronic Insomnia, Opioid Use
- Trial name
- NCT06345872
- Testing
- CBT-I, Treatment as usual, Tapered Withdrawal
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Post-operative Pain, Colon Cancer
The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery
The purpose of the study is to evaluate the effect of Exparel on pain control and patient outcome after colon resection. The investigators will evaluate the clinical course of the patients who receive exparel as compared to the…
- Conditions
- Post-operative Pain, Colon Cancer, Diverticulitis
- Trial name
- NCT02052557
- Testing
- Bupivacaine, Bupivacaine liposome suspension
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Des Moines University
Opioid-use Disorder
Pilot Research on Opioid Use Disorder
This study evaluates the effects of peripheral nerve stimulation on opioid withdrawal, craving, and use in participants with opioid use disorder (OUD) who are initiating treatment with buprenorphine/naloxone.
- Trial name
- PROUD (NCT04244227)
- Testing
- Empower Neuromodulation System
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Theranova, L.L.C.
Substance Use Disorder, Opioid Use Disorder
Testing the CrOss Systems Technical Assistance for Retaining Staff (COSTARS) Model for Improving Staff Retention Among Child Welfare Workers and Peer Supporters, and Implementation of Evidence Based Interventions.
The goal of this study is to test whether the CrOss System Technical Assistance for Retaining Staff (COSTARS) supervision leadership institute can promote workforce stability and improved implementation outcomes within the Ohio…
- Conditions
- Substance Use Disorder, Opioid Use Disorder, Child Maltreatment, Implementation
- Trial name
- COSTARS (NCT07439783)
- Testing
- COSTARS, Implementation As Usual
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Alicia Bunger
Pain, Postoperative, Opioid Use
Therapeutic Efficacy of Intravenous Lidocaine Infusion Compared With Epidural Analgesia for Postoperative Pain Control in Adult Patients Undergoing Major Abdominal Surgery: Non-Inferiority Clinical Trial
Major abdominal surgery continues is one of the most performed surgical procedures in the world, both electively and urgently. One of the main problems of this type of intervention is postoperative pain.
- Trial name
- NCT04017013
- Testing
- Epidural Analgesia, Lidocaine Infusion
- Where
- Colombia
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Substance Use Disorders
Efficacy of Drug and Risk Behavior Counseling Intervention Among Injecting Drug Users at Opioid Substitution Treatment
Behavior drug and risk reduction counseling (BDRC), a structured, non-intense, cognitive-behavioral approach intervention designed to increase methadone maintenance treatment retention and reduce drug use and related risk…
- Trial name
- NCT03721380
- Testing
- Treatment as usual
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- National Taiwan University
Pain, Postoperative
Effect of Gabapentin on Postoperative Opioid Analgesic Use and Pain in Adolescents Undergoing Tonsillectomy
This study aims to determine if administration of gabapentin preoperatively followed by a standing postoperative course is effective in reducing and possibly eliminating the use of opioid analgesics following this procedure.
- Trial name
- NCT05024825
- Testing
- Gabapentin, hydrocodone, acetaminophen and ibuprofen
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Albany Medical College