Clinical trials: Opioid Use After Surgery
Knee Replacement, Total Knee Arthroplasty
Trial of Liposomal Bupivacaine for TKA
Total knee arthroplasty (TKA), also known as a knee replacement, is a procedure performed to reduce severe pain and improve function of the joint.
- Conditions
- Knee Replacement, Total Knee Arthroplasty, Post-Operative Pain
- Trial name
- NCT05635916
- Testing
- Liposomal bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Northern Light Mercy Hospital
Narcotic Use, Renal Transplant Donor of Left Kidney
Postoperative Pain Protocol Limiting Narcotics for Laparoscopic Hand-assisted Donor Nephrectomy
Kidney donors represent healthy patients and their anticipated postoperative course should be uncomplicated and brief. This study looks to optimize the perioperative pain regimen of laparoscopic donor nephrectomy patients by…
- Trial name
- NCT06458842
- Testing
- Ketamine
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Opioid Use
Rectal Acetaminophen Use During Oocyte Retrievals to Reduce Post-Operative Opioid Utilization
The primary aim of this study is to evaluate the administration of rectal acetaminophen to current and standard anesthesia and analgesia protocol in oocyte retrievals would reduce postoperative utilization of opioids (Tylenol…
- Trial name
- NCT03732469
- Testing
- Acetaminophen, Fentanyl, Propofol
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Pain, Postoperative, Post-Mastectomy Chronic Pain Syndrome
Paravertebral Versus Pectoralis Block for Post Mastectomy Pain
Post-mastectomy pain affects more than half of patients undergoing the procedure and can last for years. It has been well established that development of chronic pain is related to experienced pain in the perioperative period.
- Conditions
- Pain, Postoperative, Post-Mastectomy Chronic Pain Syndrome, Opioid Use
- Trial name
- NCT03656679
- Testing
- Pectoralis Blockade (PECs), Paravertebral Blockade
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Opioid Use, Surgical Recovery
Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse
The goal of the study to see if giving a numbing medicine around the cervix (called a paracervical block) during vaginal hysterectomy with prolapse repair helps people feel less pain and need fewer strong pain medicines…
- Conditions
- Opioid Use, Surgical Recovery, Vaginal Hysterectomy, Prolapse Pelvic
- Trial name
- NCT07213635
- Testing
- Bupivacaine-epinephrine, Normal saline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Pain, Postoperative Nausea
Perioperative Dexamethasone Reduces Postoperative Pain and Nausea After Periacetabular Osteotomy
The purpose of this study is to assess the effect of Dexamethasone on postoperative pain and nausea after periacetabular osteotomy.
- Conditions
- Pain, Postoperative Nausea, Amount of Postoperative Opioid Use in Milligrams
- Trial name
- NCT05120076
- Testing
- Dexamethasone 4 Mg/mL Injectable Solution, NaCl 0.9%
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Pain, Postoperative
Reducing Opioid Use and Misuse After Wisdom Molar Extractions
Reducing opioid prescription related use and misuse is a major focus for countering the national epidemic of opioid overdose and death.
- Trial name
- NCT04414917
- Testing
- Twin block, iPill dispenser
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Thyroid, Parathyroid Adenoma
Exparel Injection Effect on Postoperative Opioid Usage
The question proposed by this study, is one of patient outcomes. Does intraoperative injection of Exparel decrease postoperative use of opioid pain medications in patients undergoing thyroid and parathyroid surgery? The trial…
- Trial name
- NCT04085913
- Testing
- Lidocaine Epinephrine, Bupivacaine Hydrochloride-EPINEPHrine, Lidocaine Epinephrine, Bupivacaine Hydrochloride-EPINEPHrine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Pain
Lidocaine For Treatment of Post-operative Pain From Donor Sites Following Burn Injury.
Burn pain is known to be one the most severe forms of acute pain often requiring large amounts of narcotics in addition to other adjuvants.
- Trial name
- LidocaineBurn (NCT02229578)
- Testing
- Lidocaine
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Anesthesia, Pain, Postoperative
Effects Of Additional MgSO4 30 Mg/KgBW Intravenous and Ketorolac
This study aims to compare two groups of post-orthopedic patients who received a standard regimen, namely ketorolac 30mg, to the second group, which was given the standard regimen and adjuvant magnesium sulfate 30mg/kgBW 1 hour…
- Conditions
- Anesthesia, Pain, Postoperative, Surgery, Opioid Use
- Trial name
- NCT05609955
- Testing
- MgSO4
- Where
- Indonesia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Bariatric Surgery Candidate, Pain, Postoperative
Efficacy of External Oblique Intercostal Block in Laparoscopic Bariatric Surgery
Laparoscopic bariatric procedures nowadays are employed under ERAS protocol as an ambulatory surgery. Pain after laparoscopic procedures arises significantly from port site incisions in the anterior abdominal wall, and shoulder…
- Conditions
- Bariatric Surgery Candidate, Pain, Postoperative, Narcotic Use, Analgesia
- Trial name
- NCT05592522
- Testing
- External oblique intercostal block, Oblique subcostal TAP block, Posterior Rectus sheath block
- Where
- Saudi Arabia
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Al Mashfa Medical Center
ACL, Opioid Use
VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)
The goal of this project is to test the effects of the VibraCool mechanical stimulation neuromodulatory therapeutic device on post-operative pain and opioid use following anterior crucitate ligament reconstruction (ACLR), and…
- Conditions
- ACL, Opioid Use, Cryotherapy Effect, Vibration; Exposure
- Trial name
- NCT06456268
- Testing
- VibraCool mechanical stimulation and neuromodulatory therapeutic device, Cryocompression (Game Ready, Bregs) device, Standard ice packs
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Columbia University
Postoperative Pain, Narcotic Use
Novel Multimodal Pain Control Protocol for Minimally Invasive Gynecologic Surgery
The study is a randomized controlled trial investigating a multimodal postoperative pain management protocol which will include use of ice therapy and scheduled opioid-sparing medications for pain control after minimally invasive…
- Conditions
- Postoperative Pain, Narcotic Use, Cryotherapy Effect
- Trial name
- NCT04710277
- Testing
- Opioid-sparing multimodal pain management, Usual care
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Postoperative Pain, Obstetric Pain
Lidocaine Patches After Cesarean Section
The aim of this study is to investigate the impact of using lidocaine patches after cesarean section on pain control and opioid use in the immediate post-operative period.
- Conditions
- Postoperative Pain, Obstetric Pain, Opioid Use
- Trial name
- LPACS (NCT04443569)
- Testing
- Lidocaine patch
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Yale University
Post Operative Pain, Spinal Surgery
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and…
- Trial name
- MEND (NCT07222072)
- Testing
- Methadone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Post-operative Pain, Post-partum Pain
Increased Ketorolac Administration After Cesarean Section and Its Effect on Opioid Use: a Randomized Control Trial
To evaluate the efficacy of increased ketorolac in reducing opioid use after cesarean section.
- Conditions
- Post-operative Pain, Post-partum Pain, Cesarean Section Complications
- Trial name
- NCT03678675
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Opioid Use, Pain Postoperative
Comparison of Pain Relief After Arthroscopic Knee Surgery: Adductor Canal Block and Genicular Nerve Block
This prospective randomized study aims to compare the analgesic efficacy of Adductor Canal Block (ACB) and Genicular Nerve Block (GNB) groups to relieve postoperative pain in participants between ages of 18-72 undergoing…
- Conditions
- Opioid Use, Pain Postoperative, Arthroscopic Knee Surgeries
- Trial name
- NCT06909851
- Testing
- Adductor Canal Block (ACB), Genicular Nerve Block (GNB)
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Post-operative Pain, Acute, Opioid Use, Unspecified
Patient Centered Post-Op Pain Management Software Tool Interventional Study Verses Standard of Care
The goal of this clinical trial is to learn if the Pain Coach App will result in less opioids being prescribed to and used by patients undergoing Shoulder/Hip/Knee Arthroplasty surgery while maintaining the same or better pain…
- Conditions
- Post-operative Pain, Acute, Opioid Use, Unspecified, Arthroplasty Complications, Knee Osteoarthritis
- Trial name
- NCT06469177
- Testing
- Pain Coach App
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Opioid Use, Postoperative Pain
Opioid Prescribing Practices in Laparoscopic Gynecologic Surgery
The purpose of this study is to compare opioid prescribing practices by either routine provider prescribing practices, or with the use of a calculator, i.e., the Opioid Calculator, published by the University of Michigan…
- Trial name
- NCT06532708
- Testing
- 5x Oxycodone Oral Tablets, 16x Oxycodone Oral Tablets
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Postoperative Pain, Opioid Use
Trial of Pregabalin for Post-operative Pain in Women Undergoing Abdominal Hysterectomy
We hypothesize that pregabalin will decrease post-operative pain scores and opioid use following abdominal hysterectomy compared to placebo.
- Trial name
- NCT00781131
- Testing
- Pregabalin
- Where
- Canada
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre