Clinical trials: Oropharynx Cancer
Head and Neck Cancer, Oropharyngeal Squamous Cell Carcinoma
Radiotherapy vs. Trans-Oral Surgery for HPV-Negative Oropharyngeal Squamous Cell Carcinoma
The goal of this randomized phase II study is a formal comparison of radiotherapy versus trans-oral surgery as the primary treatment of HPV-negative patients with early-stage oropharyngeal carcinoma.
- Trial name
- NCT04220749
- Testing
- Radiation, Trans-Oral Surgery (TOS) + Neck Dissection
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cancer Head Neck
Single and Combined Modality Trans-Oral Robotic Surgery in Early Oropharyngeal Cancer
Multi-centre retrospective observational cohort study with optional exploratory radiomic study (international) and prospective molecular analysis studies (UK only).
- Trial name
- SCORE (NCT05933889)
- Testing
- Molecular Analysis, Radiomic/ Morphological analysis
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Head and Neck Cancer, Precancerous Condition
Cetuximab in Treating Patients With Precancerous Lesions of the Upper Aerodigestive Tract
RATIONALE: Monoclonal antibodies, such as cetuximab, can block abnormal cell growth in different ways. Some block the ability of abnormal cells to grow and spread.
- Trial name
- NCT00524017
- Testing
- cetuximab
- Where
- 10 sites in United States, Canada
- Volunteers
- 35 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Squamous Cell Carcinoma of the Oral Cavity, Squamous Cell Carcinoma of the Larynx
De-Intensification of Postoperative Radiotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck
This randomized, prospective, multicenter phase II/III trial will study the reduction of radiation volume by eliminating radiotherapy (RT) to the elective neck using strictly defined surgical and radio-oncological standards to…
- Conditions
- Squamous Cell Carcinoma of the Oral Cavity, Squamous Cell Carcinoma of the Larynx, Squamous Cell Carcinoma of the Hypopharynx, Squamous Cell Carcinoma of the Oropharynx
- Trial name
- DIREKHT2 (NCT06030440)
- Testing
- Eliminating RT to the elective neck, RT standard of care
- Where
- Germany
- Volunteers
- 508 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Head and Neck Cancer, Thromboembolism
Flavopiridol in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of flavopiridol in treating patients who have…
- Trial name
- NCT00020189
- Testing
- acetylsalicylic acid, alvocidib, clopidogrel bisulfate
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer, Colorectal Cancer
Positron Emission Tomography/Computed Tomography Scanning Before Surgery in Patients With Non-Small Cell Lung Cancer, Colorectal Cancer, Breast Cancer, Esophageal Cancer, or Head and Neck Cancer
RATIONALE: Diagnostic procedures, such as positron emission tomography/computed tomography (PET/CT) scanning before surgery, may help measure the extent of disease.
- Conditions
- Breast Cancer, Colorectal Cancer, Esophageal Cancer, Head and Neck Cancer
- Trial name
- NCT01254591
- Testing
- 18F-fluoromisonidazole, fluorescence angiography, laboratory biomarker analysis
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University College London (UCL) Cancer Institute
Breast Cancer, Colorectal Cancer
Growth Factor Levels in the Blood of Patients Undergoing Radiation Therapy for Epithelial Cancer
RATIONALE: Measuring levels of transforming growth factor-beta (TGF-beta) in the blood of patients with epithelial cancers (head and neck, lung, breast, colorectal, and prostate) may help doctors predict how patients will respond…
- Conditions
- Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00897793
- Testing
- venipuncture, radiation therapy
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Oropharyngeal Carcinoma, Human Papilloma Virus
Multidimensional and Multimodal Profiling of Oropharyngeal Carcinoma
The purpose of this study is to better understand the natural history of oropharyngeal carcinoma (OPC), with or without an association with the human papilloma virus (HPV).
- Trial name
- NCT05880797
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Stanford University
Head Neck Cancer, Oropharyngeal Neoplasms
Human Papillomavirus Association and Genomic Exploration in Head-Neck Squamous Cell Carcinomas
Head and neck squamous cell carcinoma (HNSCC) represents a significant public health burden in Bangladesh with a high incidence and mortality rate.
- Trial name
- HPV & HNSCC (NCT06642324)
- Testing
- Histopathology, Immunohistochemistry, Real-Time PCR, Sequencing
- Where
- Bangladesh
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Head and Neck Cancer
Isotretinoin, Interferon Alfa, and Vitamin E in Treating Patients With Stage III or Stage IV Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy such as isotretinoin use different ways to stop tumor cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of tumor cells.
- Trial name
- NCT00054561
- Testing
- recombinant interferon alfa, vitamin E, isotretinoin
- Where
- 89 sites in United States, Australia and 3 more
- Sponsor
- Eastern Cooperative Oncology Group
Chemotherapeutic Agent Toxicity, Head and Neck Cancer
Randomized Amifostine For SCCHN
This research study is studying a drug called Amifostine as a treatment for squamous cell carcinoma in the head and/or neck area.
- Conditions
- Chemotherapeutic Agent Toxicity, Head and Neck Cancer, Mucositis, Radiation Toxicity
- Trial name
- NCT00095927
- Testing
- Amifostine, Carboplatin, Paclitaxel
- Where
- 9 sites in United States
- Volunteers
- 58 people
- Sponsor
- Dana-Farber Cancer Institute
Head and Neck Cancer
Cisplatin and Gemcitabine in Treating Patients With Advanced Squamous Cell Cancer of the Head and Neck
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003182
- Testing
- cisplatin, gemcitabine hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Hope Cancer Institute, Inc.
Head and Neck Cancer, Acute Pain
Perioperative Gabapentin Use In Head And Neck Mucosal Surgery Patients
Patient satisfaction with healthcare is increasingly being utilized as a metric to reflect provider and hospital quality of care.
- Conditions
- Head and Neck Cancer, Acute Pain, Postoperative Pain
- Trial name
- GABA (NCT02926573)
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Washington University School of Medicine
Oropharynx Cancer, Frailty
Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly
Previous studies of this type of head and necl cancer have shown high rates of cancer control but result in many short and long term side effects when treated with high dose radiation and chemotherapy.
- Trial name
- (DACHOC-E) (NCT06309225)
- Testing
- Modified dose and fields intensity modulated radiotherapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Omar Mahmoud
Oropharyngeal Cancer
18F-FDG-PET Guided Dose-Painting With Intensity Modulated Radiotherapy in Oropharyngeal Tumours
Treatment of cancers of the head and neck, including oropharyngeal tumours, usually consist of a combination of radiotherapy and chemotherapy, although surgery may also play a part.
- Trial name
- FiGaRO (NCT02953197)
- Testing
- FDG-PET guided radiation dose escalation
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Head and Neck Cancer
Erlotinib and Surgery in Treating Patients With Head and Neck Cancer That Can Be Removed by Surgery
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00601913
- Testing
- erlotinib hydrochloride, protein analysis, western blotting
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wake Forest University Health Sciences
Lymphedema, Oropharyngeal Cancer
Complete Decongestive Therapy (CDT) for Treatment of Head and Neck Lymphedema
Objectives: Specific Aim 1: Estimate the prevalence of head and neck lymphedema in patients who have been treated with surgery and/or radiation therapy (± chemotherapy) for oral cavity and oropharyngeal cancer.
- Conditions
- Lymphedema, Oropharyngeal Cancer, Head and Neck Cancer, Oral Cancer
- Trial name
- NCT00951470
- Testing
- Follow -Up Visits, Full CDT, Modified CDT Program
- Sponsor
- M.D. Anderson Cancer Center
Oropharyngeal Cancer
Improving Trans-oral Surgical Outcomes Through Intra-operative Image Guidance
The objective of this research is to perform a pilot study on patients undergoing laryngoscopy for diagnostic and tumor staging purposes (for pharyngeal or laryngeal cancer) in which intraoperative CT imaging will be performed…
- Trial name
- NCT02405000
- Testing
- Intraoperative CT imaging
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Dysplasia, Carcinoma of the Oral Cavity
A Trial of Photodynamic Therapy With HPPH for Treatment of Dysplasia, Carcinoma in Situ and T1 Carcinoma of the Oral Cavity and/or Oropharynx
Recent literature suggests that certain patients with squamous cell cancers of the head and neck region may benefit from photodynamic therapy whether or not they may have received prior therapy, e.g. radiation therapy
- Conditions
- Dysplasia, Carcinoma of the Oral Cavity, Carcinoma of the Oropharynx
- Trial name
- NCT01140178
- Testing
- HPPH
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Roswell Park Cancer Institute
Mucositis, Oropharyngeal Cancer
Acupuncture in Reducing the Severity of Chemoradiation-induced Mucositis in Patients With Oropharyngeal Cancer
Patients are asked to be in this study if have oropharyngeal cancer and will be treated with chemotherapy and radiation. This research is being done to find out if acupuncture can reduce the mouth inflammation and pain caused by…
- Trial name
- GCC1229 (NCT01883908)
- Testing
- Acupuncture with Seirin® needles, Usual medical care
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Maryland, Baltimore