Clinical trials: Orthopedics
Ankle Fracture
Liposomal Bupivacaine With Bupivacaine in Ankle Fracture Open Reduction Internal Fixation (ORIF)
This study is a randomized controlled trial assessing pain control in ankle fractures repaired with open reduction and internal fixation.
- Trial name
- NCT02480621
- Testing
- Liposomal Bupivacaine with Bupivacaine
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Jamaica Hospital Medical Center
Hip Fracture
Does Tranexamic Acid Reduce the Need for Blood Transfusions in Patients Undergoing Hip Fracture Surgery?
Does tranexamic acid improve the perioperative care of those patients treated surgically for hip fracture by decreasing the proportion of patients requiring transfusion and decreasing total perioperative bleeding.
- Trial name
- NCT01714336
- Testing
- tranexamic acid
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Mayo Clinic
Acute Pain
Oral Treatment for Orthopaedic Post-operative Pain With Dexketoprofen Trometamol and Tramadol Hydrochloride
This study aims to evaluate the analgesic efficacy of single and repeated doses of fixed combination of dexketoprofen trometamol (DKP) and tramadol hydrochloride (TRAM) in comparison to the single agents (and placebo for the…
- Trial name
- DAVID-art (NCT01902134)
- Testing
- Tramadol-single dose, Dexketoprofen-single dose, Dexketoprofen/Tramadol-single dose
- Where
- 37 sites in Czechia, Germany and 8 more
- Volunteers
- 641 people
- Sponsor
- Menarini Group
Musculoskeletal Injury Trauma
An Integrated-Delivery-of-Care Approach to Improve Patient Outcomes, Safety, Well-Being After Orthopaedic Trauma
Orthopedic trauma is an unforeseen life-changing event. Nearly 2.8 million Americans sustain traumatic orthopedic injuries such as major fractures or amputation each year.
- Trial name
- NCT02591472
- Testing
- Integrated care (ICare), Usual Care (UsCare), Patient-Reported Outcomes Measurement Information System
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Florida
Orthopedic Disorder
Parental Perceptions on Prescription Opioid Use
This study involves an anonymous survey given to parents regarding their perceptions on prescription opioid use for pain control in children undergoing orthopedic surgery.
- Trial name
- NCT05344118
- Testing
- Survey
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Nationwide Children's Hospital
Tourniquets, Knee Arthroplasty, Total
Tourniquet Pressure in Primary Total Knee Arthroplasty
This proposed novel randomized control trial (RCT) seeks to address this gap in TKA protocol by gaining a better understanding of the relationship between tourniquet pressure and time, and intraoperative performance and…
- Conditions
- Tourniquets, Knee Arthroplasty, Total, Knee Replacement, Total
- Trial name
- NCT02830087
- Testing
- Tourniquet Cuff Pressure
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Post-operative Time Saving Techniques
Application Time of Plaster-of-Paris Splint Packs Compared to Bulk Supplies Following Standard Orthopaedic Procedure
The investigators wish to perform a randomized controlled study to determine how much time and money is saved by orthopedic foot and ankle surgeons through the use of prepared splint packs compared to bulk supplies.
- Trial name
- NCT01602484
- Testing
- Pre-prepared Splint Pack composed by Medline, Bulk splint supplies
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Pain, Nausea
A Controlled Study to Determine the Efficacy and Safety of CL-108 5 mg for Acute Pain and the Prevention of OINV
To determine the analgesic efficacy of CL-108 5 mg by comparison with placebo and the anti-emetic efficacy of CL-108 5 mg by comparison with hydrocodone 5 mg/acetaminophen 325 mg.
- Conditions
- Pain, Nausea, Vomiting
- Trial name
- NCT03657810
- Testing
- CL-108 5 mg, Norco
- Where
- 5 sites in United States
- Volunteers
- 349 people
- Sponsor
- Charleston Laboratories, Inc
Bone Metastases, Musculoskeletal Cancer
Aspirin and Compression Devices for VTE Prophylaxis in Orthopaedic Oncology
This is a research study to compare the efficacy of aspirin (acetylsalicylic acid) and pneumatic compression devices versus enoxaparin (also known as Lovenox) and pneumatic compression devices in preventing deep vein thrombosis…
- Conditions
- Bone Metastases, Musculoskeletal Cancer, Soft Tissue Sarcoma, Thromboembolism
- Trial name
- NCT01696760
- Testing
- acetylsalicylic acid, enoxaparin, PCD
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Anterior Pelvic Ring Fractures
Comparison of Subcutaneous INFIX and EXFIX for Anterior Pelvic Ring Fractures Requiring Stabilization
The purpose of this research is to compare patient outcomes of two treatment methods that are currently used as standard of care to treat anterior pelvic ring injuries that require stabilization.
- Trial name
- NCT02403154
- Testing
- Internal Fixator, External fixator
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Indiana University
Arthropathy of Hip, Arthropathy of Knee
Evaluation of the Duration of Bupivacaine Spinal Block in Orthopedic Procedures With and Without Epinephrine Wash
Bupivacaine spinal is commonly performed as the primary anesthetic for orthopedic procedures. In some cases the duration of the block is inadequate. An epinephrine wash is sometimes performed to prolong the duration of the block.
- Trial name
- NCT02619409
- Testing
- Bupivacaine Only, EPI25, EPI50 group
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Incision, Surgical
Orthopaedic Surgical Wound Closure Comparison Study
This study is trying to find out if there is one method of surgical incision closure is better than another. The three different wound closure methods in this study are currently used in standard of care.
- Trial name
- NCT05251064
- Testing
- Suture, Clozex, Zipline
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Virginia
Bone Fractures, Radius Fractures
Management of Distal Radius Fractures in Children Younger Than 11 Years Old.
This fractures have been managed with anatomical reduction performed under anesthesia or using sedatives. In our institution this means prolonged hospital stay, involvement of an anesthesiologist and the use of an special room in…
- Conditions
- Bone Fractures, Radius Fractures, Closed Fractures
- Trial name
- NCT02670629
- Testing
- Partial reduction with overriding position, Closed anatomic reduction
- Volunteers
- 58 people
- Sponsor
- Carlos A Acosta-Olivo
Proximal Humeral Fracture
Orthopaedic Treatment Proximal Humeral Fractures
Prospective non-randomized, open, unicentric observational study to compare two different treatments for Three-four parts fractures of proximal humerus (Neer's Classification) in elderly patients (over 75 years old).
- Trial name
- NCT03339570
- Testing
- Orthopedic treatment for a proximal humeral fracture
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Mikel Aburto
Orthopedic Disorder
Comparative Evaluation of Lumbar Plexus and Suprainguinal Fascia Iliaca Compartment Blocks
The investigators aim to compare the use of a suprainguinal fascia iliaca compartment block vs lumbar plexus block as an adjunct to general anesthesia in pediatric patients undergoing orthopedic procedures involving the hip or…
- Trial name
- NCT03746951
- Testing
- Ropivacaine Hcl 0.5% Inj Vil 20Ml
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Nationwide Children's Hospital
Delirium, Delirium, Dementia, Amnestic, Cognitive Disorders
Ramelteon in the Prevention of Post-operative Delirium
This trial focuses on a Phase II randomized masked clinical trial testing the effectiveness and safety of peri-operative administration of ramelteon, a melatonin agonist in the prevention of postoperative delirium.
- Conditions
- Delirium, Delirium, Dementia, Amnestic, Cognitive Disorders, Delayed Emergence From Anesthesia, Cognitive Disorders
- Trial name
- RECOVER (NCT02324153)
- Testing
- Ramelteon, Microcrystalline Cellulose, Riboflavin 100 mg
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Pediatric Extremity Fracture, Pediatric Extremity Soft Tissue Injury
Peripheral Nerve Blocks in Pediatric Orthopedic Patients
Context: Single shot peripheral nerve blocks have limited duration of action depending on the local anesthetic agent used in the block. But it rarely lasts longer than 12 hrs.
- Trial name
- NCT02236130
- Testing
- Regional block, General Anesthesia, Local Anesthetic Ropivacaine
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
Arthroplasty, Knee Replacement, Wound Healing
Zip® Surgical Skin Closure Device vs. Staples for Skin Closure in Subjects Having Undergone Bilateral Knee Arthroplasty
Study designed to compare the Zip Surgical Skin Closure device vs. conventional staples for wound closure following bi lateral knee replacement surgery.
- Trial name
- NCT02460172
- Testing
- Zip Surgical Skin Closure, Steel Staples
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- ZipLine Medical Inc.
Anxiety, Pain
Virtual Reality Decreases Child Anxiety and Pain as Well as Caregiver Anxiety and Pain Perception During Orthopaedic Clinic Office Procedures
The purpose of this study is to demonstrate that the use of a virtual reality experience can decrease child and caregiver anxiety and pain for simple orthopaedic office procedures.
- Trial name
- NCT05708586
- Testing
- Control, Virtual Reality (VR)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Michigan
Procedural Sedation, Regional Anesthesia Block
Lusedra (Fospropofol Disodium) for Minimal to Moderate Sedation for Regional Anesthesia Block Prior to Orthopedic Surgery
How does Lusedra compare with current standard of care (midazolam) for minimal to moderate sedation for regional anesthesia blocks prior to orthopedic surgery?
- Conditions
- Procedural Sedation, Regional Anesthesia Block, Orthopedic Surgery
- Trial name
- NCT01195103
- Testing
- Fospropofol disodium, Fentanyl
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mayo Clinic