Clinical trials: Out-of Hospital Cardiac Arrest
Cardiac Arrest, Out-Of-Hospital Cardiac Arrest
Early Initiation of Extracorporeal Life Support in Refractory OHCA
Despite adequate conventional cardiopulmonary resuscitation (CCPR) and attempted defibrillation, a considerable number of patients in cardiac arrest fail to achieve sustained return of spontaneous circulation.
- Conditions
- Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Sudden Cardiac Death
- Trial name
- INCEPTION (NCT03101787)
- Testing
- Extracorporeal cardiopulmonary resuscitation (ECPR)
- Where
- 10 sites in Netherlands
- Volunteers
- 134 people
- Sponsor
- Maastricht University Medical Center
Non Shockable Out of Hospital Cardiac Arrest
Cyclosporine A in Cardiac Arrest
The investigators hypothesised that cyclosporine A administration at the onset of cardiopulmonary resuscitation, by inhibiting the mitochondrial permeability transition pore, could prevent the post cardiac arrest syndrome and…
- Trial name
- CYRUS (NCT01595958)
- Testing
- Cyclosporine A, cardio-pulmonary resuscitation
- Where
- France
- Volunteers
- 796 people
- Sponsor
- Hospices Civils de Lyon
Cardiac Arrest, Cardiopulmonary Arrest With Successful Resuscitation
Impact of NIRS-guided Cardiopulmonary Resuscitation After Cardiac Arrest on Resuscitation Rate
Sudden cardiac death is one of the main causes of morbidity and mortality worldwide. Cardiac arrest requires prompt intervention by cardiopulmonary resuscitation (CPR).
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest With Successful Resuscitation, Cerebral Oxygenation
- Trial name
- NICA (NCT03911908)
- Testing
- Cerebral oximetry (near infrared) based CPR-Algorithm
- Where
- Germany
- Volunteers
- 360 people
- Sponsor
- Dr. Serge Thal
Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA)
Measurement of Airway Opening Index During Out-of-hospital Cardiac Arrest: The Lazarus AOI Trial.
Out-of-hospital cardiac arrest (OHCA) is a leading cause of death worldwide. Despite constantly improving resuscitation techniques, the chances of survival remain limited.
- Conditions
- Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA), Resuscitated Sudden Cardiac Death
- Trial name
- Lazarus-AOI (NCT07438938)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Ghent
Cardiac Arrest
Effect of Vasopressin, Steroid, and Epinephrine Treatment in Patients With Out-of-hospital Cardiac Arrest
Steroid use could be considered for patients with weaker adrenal function among those with post-cardiac arrest (CA) return of spontaneous circulation (ROSC), according to the former study.
- Trial name
- NCT03317197
- Testing
- Control Group, Experimental Group 1, Experimental Group 2
- Where
- South Korea
- Volunteers
- 834 people
- Sponsor
- Korea University Guro Hospital
Cardiac Arrest With Successful Resuscitation
Gasping Improves Long-term Survival After Out-of-hospital Cardiac Arrest
The aim of our retrospective clinical study was to examine the association between agonal breathing, return of spontaneous circulation (ROSC), and long-term survival.
- Trial name
- NCT02998749
- Volunteers
- 584 people
- Sponsor
- Charles University, Czech Republic
Emergency Medical Service, Out-of-Hospital Cardiac Arrest
Venous Injection Compared To intraOsseous Injection During Resuscitation of Patients With Out-of-hospital Cardiac Arrest
Overall survival of patients after out-of-hospital cardiac arrest (*OHCA*) is less than 10% worldwide and in Taiwan. Interventions provided by the emergency medical system (*EMS*) before arrival at the hospital are of paramount…
- Conditions
- Emergency Medical Service, Out-of-Hospital Cardiac Arrest, Vascular Access, Intraosseous Access
- Trial name
- VICTOR (NCT04135547)
- Testing
- intra-osseous access vs. intra-venous access
- Where
- Taiwan
- Volunteers
- 1,732 people
- Sponsor
- National Taiwan University Hospital
Cardiogenic Shock, Microbial Colonization
Influence of Enteral Microbiome on Mortality of Patients With Cardiogenic Shock
Cardiogenic shock is associated with a high mortality. The microbiome is a double-edged sword which can convey protective and detrimental cardiovascular effects.
- Conditions
- Cardiogenic Shock, Microbial Colonization, Out-Of-Hospital Cardiac Arrest, Acute Heart Failure
- Trial name
- NCT06006754
- Testing
- Observational study
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital, Essen
Resuscitation, Cardiopulmonary
Effect of Early High-dose Epoetin Alfa During Cardiac Arrest (Pilot Study)
The purpose of this study is to test the possible neuroprotective effect of early high dose erythropoietin alpha after out of hospital cardiac arrest (OHCA).
- Conditions
- Resuscitation, Cardiopulmonary, Cardiac Arrest
- Trial name
- NCT00719498
- Testing
- Epo-alpha
- Volunteers
- 20 people
- Sponsor
- Janssen Cilag S.A.S.
Cardiac Arrest
Tele-Support for Emergency Medical Technicians
In this manikin-based simulation study the impact of tele-support during a simulated pediatric out-of-hospital cardiac arrest scenario on emergency medical technicians' guideline adherence, on gaze behavior as well as on…
- Trial name
- POHCA (NCT06362850)
- Testing
- Tele-support
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Out-of-hospital Cardiac Arrest
German Cardiac Arrest Registry
In Germany, 70.000 to 100.000 patients suffer from out-of-hospital cardiac arrest (OHCA) every year. More than half of these are due to cardiac causes.
- Trial name
- G-CAR (NCT05142124)
- Where
- 25 sites in Germany
- Volunteers
- 400 people
- Sponsor
- Leipzig Heart Science gGmbH
Out-of-Hospital Cardiac Arrest
Intraosseous Versus Intravenous Vascular Access During Resuscitation Following Out-of-Hospital Cardiac Arrest
1. Background: Intraosseous (IO) access is a new, fast, safe and efficient route of rescue of critically ill patients. Studies found drug pharmacokinetics and pharmacodynamics of IO are similar to IV route.
- Trial name
- NCT04130984
- Testing
- EZ-IO
- Where
- China
- Volunteers
- 2,356 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cardiac Arrest, Heart Arrest
Rehabilitation for Survivors of Out-of-hospital Cardiac Arrest
This study is a parallel group multicentre investigator-initiated clinical randomised controlled superiority trial that will include a total of 214 survivors of OHCA.
- Conditions
- Cardiac Arrest, Heart Arrest, Cardiopulmonary Resuscitation, Return to Work
- Trial name
- NCT05173740
- Testing
- Individually tailored rehabilitation intervention, Usual care
- Where
- Denmark
- Volunteers
- 214 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiopulmonary Resuscitation, Education
Efficacy of Online Real-time CPR Training
The purpose of this study is to evaluate the effectiveness of a new online real-time quality measurement and feedback video-based CPR training program.
- Trial name
- NCT04656405
- Testing
- Online real-time quality measurement and feedback video-based CPR training, Online real-time feedback video-based CPR training without quality measurement, Conventional CPR training
- Where
- South Korea
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Out of Hospital Cardiac Arrest, Ventricular Fibrillation
Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest
Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)/ventricular tachycardia (VT) do not respond to initial defibrillation.
- Conditions
- Out of Hospital Cardiac Arrest, Ventricular Fibrillation, Defibrillation, CPR
- Trial name
- DOUBLE D (NCT07174986)
- Testing
- Double sequential defibirllation, Standard defibrillation
- Where
- 14 sites in Netherlands, Spain and 1 more
- Volunteers
- 916 people
- Sponsor
- Gabriel Riva
Out-of-hospital Cardiac Arrest (OHCA), Agonal Breathing
CPR and Agonal Breathing Recognition Training for Police Officers
This study will evaluate an educational training program for police officers in New Taipei City, Taiwan. Police officers may arrive at out-of-hospital cardiac arrest events before emergency medical services and may be able to…
- Conditions
- Out-of-hospital Cardiac Arrest (OHCA), Agonal Breathing, Cardiopulmonary Resuscitation Training
- Trial name
- CPR-AB Police (NCT07695766)
- Testing
- CPR Refresher and Agonal Breathing Recognition Training
- Where
- Taiwan
- Volunteers
- 3,439 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Out of Hospital Cardiac Arrest
Time-differentiated Therapeutic Hypothermia
The purpose of this study is to determine if 48 hours of mild therapeutic hypothermia following out of hospital cardiac arrest gives a better cerebral outcome compared to 24 hours therapeutic hypothermia.
- Trial name
- TTH48 (NCT01689077)
- Testing
- Therapeutic hypothermia
- Where
- 10 sites in Belgium, Denmark and 4 more
- Volunteers
- 355 people
- Sponsor
- University of Aarhus
Cardiac Arrest, Out-Of-Hospital
Cardiac Arrest Pursuit Trial With Unique Registration and Epidemiologic Surveillance
Identification of Causes and Risk Factors for Out-of-Hospital Cardiac Arrest through Development of Prediction Model and Novel Biomarkers Study Objectives: 1.
- Trial name
- CAPTURES (NCT03700203)
- Where
- South Korea
- Volunteers
- 5,340 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Out-of-Hospital Cardiac Arrest
A Prospective, Multicenter Registry With Targeted Temperature Management After Out-of-hospital Cardiac Arrest in Korea
Therapeutic hypothermia after out-of-hospital cardiac arrest is considered as a standard care. However, optimal candidates, optimal dose, duration, timing of initiation and rate of rewarming is still unknown.
- Trial name
- NCT02827422
- Testing
- not provided
- Where
- South Korea
- Volunteers
- 1,800 people
- Sponsor
- Kyu Nam Park
Cardiac Arrest (CA), Heart Arrest
The Effect of SPecialty cAre on Recovery From Cardiac Arrest Trial (the SPARC Trial)
This randomized clinical trial will determine if adult participants who are in the emergency department after being resuscitated from a cardiac arrest outside of the hospital benefit from care delivered at specialized centers.
- Conditions
- Cardiac Arrest (CA), Heart Arrest, Heart Arrest, Out-Of-Hospital
- Trial name
- SPARC (NCT07002294)
- Testing
- Transfer to specialty care, Usual care
- Where
- United States
- Volunteers
- 1,618 people
- Sponsor
- University of Pittsburgh