Clinical trials: Out-of Hospital Cardiac Arrest
Heart Arrest, Out-Of-Hospital, Physical Activity
Physical Activity After Cardiac Arrest; a Sub-study in the Target Temperature Management Trial 2
The Target Temperature Management trial 2 (TTM2) is an international multi-center study, that randomize patients with OHCA of a presumed cardiac or unknown cause to target temperature management at 33°C or normothermia but…
- Trial name
- NCT03543332
- Testing
- Measures of physical activity and kinesiophobia
- Where
- 8 sites in Denmark, Sweden and 1 more
- Volunteers
- 109 people
- Sponsor
- Region Skane
Out-Of-Hospital Cardiac Arrest
AED-delivery Using Drones in Out-of-hospital Cardiac Arrest
Time to defibrillation is the most important predictor of survival in cardiac arrest. Traditional emergency medical system response is often to slow.
- Trial name
- NCT04415398
- Testing
- Automated flying Drone carrying an Automated external defibrillator (AED)
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Karolinska Institutet
Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Arrest
Relevance of Reversible Causes During OHCA (Rebecca Study)
Management of the reversible causes in cardiac arrest is fundamental for successful treatment of out-of-hospital cardiac arrests.
- Trial name
- REBECCA (NCT05784480)
- Testing
- Checklist for evaluation of reversible causes
- Where
- 2 sites in Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Cardiac Arrest, Resuscitation
Out-of-hospital Cardiopulmonary Resuscitation and AED Feedback
The purpose of this study is to determine whether an online automatic feedback improved CPR quality (No-flow time, compression depth, short-term survival and one year follow up) in this prospective randomised study of…
- Trial name
- NCT00449969
- Testing
- Zoll AED pro
- Where
- Germany
- Volunteers
- 312 people
- Sponsor
- University Hospital Muenster
Basic Life Support
Pedagogical Aspects on Training in Basic Life Support
Cardio vascular disease (CVD) including out-of-hospital cardiac arrest (OHCA) is still the leading cause of death in a global perspective.
- Trial name
- NCT03618888
- Testing
- Instructor-led training, Self-learning training
- Where
- Sweden
- Volunteers
- 2,623 people, healthy volunteers welcome
- Sponsor
- University of Boras
Cardiac Arrest (CA)
Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation?
To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest…
- Trial name
- LUCASVP (NCT06824961)
- Testing
- 5-second ventilation pause duration during mechanical CPR, 3-second ventilation pause duration during mechanical CPR
- Where
- 2 sites in Netherlands
- Volunteers
- 692 people
- Sponsor
- Amsterdam UMC, location VUmc
Out-of-hospital Cardiac Arrest (OHCA)
Cerebral Near Infrared Spectroscopy in Out-of-Hospital Cardiac Arrest and Neurological Prognosis
Out-of-hospital cardiac arrest (OHCA) prognosis remains poor : 7% of patients surviving without neurological impairment. 65% of patients dying after hospital admission were neurologically impaired.
- Trial name
- NISOHCA (NCT06972329)
- Testing
- Cerebral Near infrared spectroscopy (NIRSc).
- Where
- 6 sites in France
- Volunteers
- 542 people
- Sponsor
- Central Hospital, Nancy, France
Out-of-Hospital Cardiac Arrest
EMERGEncy Versus Delayed Coronary Angiogram in Survivors of Out-of-hospital Cardiac Arrest
Sudden cardiac death (SCD) remains a major public health issue with a low survival rate. The most common cause of SCD is acute coronary artery occlusion.
- Trial name
- EMERGE (NCT02876458)
- Testing
- Immediate coronary angiogram, Delayed coronary angiogram
- Where
- France
- Volunteers
- 336 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pediatric Out-of-Hospital Cardiac Arrest
POHCA Resuscitation: Evaluation of IM Epinephrine
This is a pragmatic, two-arm, open-label, prospective stepped-wedge cluster quasi randomized control trial (SW-CRCT) looking to evaluate early intramuscular (IM) epinephrine in the management of pediatric out-of-hospital cardiac…
- Trial name
- PRIME (NCT05166343)
- Testing
- Epinephrine Injection
- Where
- Canada
- Volunteers
- 284 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cardiac Arrest, Neurological Injury
Lactate in Cardiac Arrest
Blood lactate levels will be measured using a simple handheld device at time of return of spontaneous circulation (ROSC) following out of hospital cardiac arrest (OHCA).
- Trial name
- NCT02352350
- Testing
- Blood Lactate Levels, Neurological Outcomes
- Sponsor
- University of Florida
Cardiac Arrest
CT Perfusion (CTP) for Assessment of Poor Neurological Outcome in Comatose Cardiac Arrest Patients
ABSTRACT Brief Overview: Neurological assessment of comatose cardiac arrest patients (CCAP) is challenging because most of these patients are treated with sedatives and therapeutic hypothermia that prevent complete…
- Trial name
- CANCCAP (NCT04323020)
- Testing
- CT Perfusion
- Where
- Canada
- Volunteers
- 91 people
- Sponsor
- University of Manitoba
Out of Hospital Cardiac Arrest
Out of Hospital Cardiac Arrest: Trial Assessing the Survival Impact of Phone Advice
Medical call center have no phone advice protocol within out of hospital cardiac arrest in France. The purpose of the present study is to compare a group of patients with protocol phone advice delivered by the dispatchers…
- Trial name
- CONTAC (NCT02934867)
- Testing
- Protocol phone advice, Usual phone advice
- Where
- 19 sites in France
- Volunteers
- 729 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cardiac Arrest
Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-OH [Out of Hospital] Trial
Cardiac arrest is a sudden, unexpected loss of heart function. Therapeutic hypothermia, in which the body's temperature is lowered and maintained several degrees below normal for a period of time, has been used to successfully…
- Trial name
- THAPCA-OH (NCT00878644)
- Testing
- Therapeutic Hypothermia, Therapeutic Normothermia
- Where
- 34 sites in United States, Canada
- Volunteers
- 295 people
- Sponsor
- University of Michigan
Heart Arrest, Out-Of-Hospital, Biomarkers
Impact of Vitamin C on Biomarkers of Neurologic Injury in Survivors of Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) is one of the leading cause of death in the world. In Slovenia approximately 25% of resuscitated patients survives to discharge from hospitals, usually with poorer functional status.
- Conditions
- Heart Arrest, Out-Of-Hospital, Biomarkers, Oxidative Stress, Neurological Injury
- Trial name
- NCT04563000
- Testing
- Vitamin C
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Maribor
Cardiac Arrest, Cardiopulmonary Resuscitation
Mechanical Versus Manual Chest Compression
In this study, the investigators compared mechanical and manual chest compressions in out-of-hospital cardiac arrest cases.
- Trial name
- NCT04069377
- Testing
- LUCAS™ 2 Chest Compression System, Manuel chest compressions by human efforts
- Where
- Turkey (Türkiye)
- Volunteers
- 214 people
- Sponsor
- Ankara City Hospital Bilkent
Out-of-hospital Cardiac Arrest
Rapid Infusion of Cold Normal Saline During CPR for Patients With Out-of-hospital Cardiac Arrest
That paramedic core cooling during CPR using a rapid infusion of ice-cold (4 degrees C) large-volume (30mL/kg) normal saline improves outcome at hospital discharge compared with standard care in patients with out-of-hospital…
- Trial name
- RINSE (NCT01173393)
- Testing
- PARAMEDIC COOLING
- Where
- Australia
- Volunteers
- 1,220 people
- Sponsor
- Ambulance Victoria
Out-Of-Hospital Cardiac Arrest
A Randomised Trial of Expedited Transfer to a Cardiac Arrest Centre for Non-ST Elevation Out-of-hospital Cardiac Arrest
The aim of ARREST is to determine the best post-resuscitation care pathway for out of hospital cardiac arrest patients without ST-segment elevation.
- Trial name
- ARREST (NCT03872960)
- Testing
- Transfer to cardiac arrest centre
- Where
- 22 sites in United Kingdom
- Volunteers
- 862 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Out-of-hospital Cardiac Arrest (OHCA)
Trial of Mobile External Defibrillator for Out-of-hospital Cardiac Arrest in Singapore.
The goal of this clinical trial is to learn the feasibility of equipping the volunteer community responders (VCR) with the mobile external automated defibrillators (mAEDs) for the management of adults experiencing out-of-hospital…
- Trial name
- NCT07042061
- Testing
- Mobile external automated defibrillator
- Volunteers
- 1,000 people
- Sponsor
- Singapore General Hospital
Out-of-hospital Cardiac Arrest (OHCA)
Out-of-hospital Cardiac Arrest Epidemiology and Outcomes in Western Lithuania 2022-2028
Out-of-hospital cardiac arrest rate is common problem, because of high mortality rate. It is not clear incidence rate, epidemiology and outcomes in Lithuania
- Trial name
- NCT07622082
- Testing
- Protocol based
- Volunteers
- 4,000 people
- Sponsor
- Lithuanian University of Health Sciences
Out-of-hospital Cardiac Arrest
Continuous NMB in PCAS
The main purpose of this study is to test the hypothesis that continuous NMB could improve outcome in cardiac arrest patients treated with therapeutic hypothermia.
- Trial name
- NCT02790164
- Testing
- Esmeron, Saline
- Where
- South Korea
- Volunteers
- 81 people
- Sponsor
- Chun Song Youn