Clinical trials: Ovarian Hyperstimulation Syndrome
Ovarian Hyperstimulation Syndrome
Cabergoline Reduces OHSS
The present study was designed to provide clinical confirmation of Cb2's value as a new approach in the prevention of increased vascular permeability and hemoconcentration, both signs of OHSS in humans, and in order to explore…
- Trial name
- NCT00440258
- Testing
- Cabergoline, MR, Ultrasound
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Polycystic Ovary Syndrome
Use of Myo-inositol as Adjuvant Therapy in Patients With Polycystic Ovary Syndrome (PCOS) in Vitro Fertilization (IVF)
The original mechanism of action of myo-inositol and preliminary results available in the literature on its use in IVF suggest its value as adjuvant gonadotropin therapy to reduce the risk of OHSS in PCOS patients.
- Trial name
- FIV-INOPK (NCT02221154)
- Testing
- Inofolic®, Gonadotropins; Folic Acid
- Where
- 4 sites in France
- Volunteers
- 49 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Pregnancy, Ovarian Hyperstimulation Syndrome
The Effect of a Dual Trigger on Intracytoplasmic Sperm Injection (ICSI) Reproductive Outcomes
The use of antagonist controlled ovarian stimulation protocols has allowed the use of GnRH agonist to be used for final oocyte maturation.
- Trial name
- NCT01979341
- Testing
- final oocyte maturation trigger
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Antalya IVF
Polycystic Ovary Syndrome
Response of VEGF and AT-II to HCG in PCOS
This research is to investigate the response of vascular active factors, vascular endothelial growth factor (VEGF) and angiotensin-Ⅱ (AT-Ⅱ) to ovary stimulation during 24h in patients with polycystic ovary syndrome…
- Trial name
- NCT02265861
- Testing
- HCG
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nanjing University School of Medicine
Ovarian Hyperstimulation Syndrome, Infertility Drugs
Transfer of Fresh Versus Frozen/Thawed Embryos in IVF Cycles Where GnRH Agonist is Utilized for Oocyte Maturation.
It has been suggested that in IVF cycles where GNRH agonist is utilized for final oocyte maturation in patients at risk of ovarian hyperstimulation, pregnancy rates are reduced.
- Conditions
- Ovarian Hyperstimulation Syndrome, Infertility Drugs, Female
- Trial name
- NCT00365027
- Testing
- Delayed embryo transfer
- Sponsor
- HaEmek Medical Center, Israel
Multifollicular Stimulation
An Observational Study to Compare the Dose of Gonal-fTM FbM Prescribed by the Doctor With the Recommendation of the Dose Calculator Consort and to Evaluate the Ease of Use of Pre-filled Pen of Gonal-fTM FbM Pen
This is a prospective, observational and multicentric study to compare the Gonal-f FbM (filled by mass) dose prescribed by the doctor with the Gonal-f FbM dose determined by the CONSORT (Consistency in r-FSH Starting doses for…
- Trial name
- NCT01080729
- Testing
- Recombinant-follicle stimulating hormone (r-FSH)
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Ovarian Hyperstimulation Syndrome
Efficacy and Safety of Dexamethasone Prevention for Patients of Ovarian Hyperstimulation Syndrome
This prospective, randomized, controlled clinical trial will evaluate the effect and security of dexamethasone prevention for Patients of Ovarian Hyperstimulation Syndrome.
- Trial name
- NCT02846493
- Testing
- bromocriptine, dexamethasone
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-sen University
OHSS (Ovarian Hyperstimulation)
Triggering of Final Oocyte Maturation With GnRHa (Buserelin) in GnRH Antagonist Cycles
The purpose of this study is to possibly further improve the clinical outcome and explore the incidence of OHSS in patients, who have final oocyte maturation with GnRHa (Buserelin) in GnRH antagonist IVF/ICSI cycles
- Trial name
- NCT00627406
- Testing
- Buserelin and Pregnyl, Pregnyl
- Where
- Denmark
- Volunteers
- 384 people
- Sponsor
- Regionshospitalet Viborg, Skive
Infertility
Comapring Luteal Phase Support in IVF Patients Who Are at High Risk for Developing OHSS
The purpose of this study is to compare two luteal support protocols in In vitro fertilization patients (IVF) and are at risk of developing ovarian hyperstimulation syndrome (OHSS).
- Trial name
- NCT02827656
- Testing
- Decapeptyl, hCG luteal support
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Ovarian Hyperstimulation Syndrome
Tolerability of Quinagolide in a Dose-titration Regimen in Oocyte Donors at Risk of Developing Ovarian Hyperstimulation Syndrome
Assess the tolerability of quinagolide 200 μg/day in a dose-titration regimen in oocyte donors undergoing controlled ovarian hyperstimulation and at risk of developing OHSS Secondary Objectives Estimate the effects of a…
- Trial name
- NCT00665041
- Testing
- Quinagolide
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Pregnancy Early, Miscarriage
Gonadotropin Releasing Hormone Agonist (GnRHa) Versus Estrogen and Progesterone for Luteal Support in High Responders
Gonadotropin Releasing Hormone agonist (GnRHa) triggering is used as an alternative to human chorionic gonadotropin (hCG) in GnRH antagonist protocol to eliminate the risk of ovarian hyperstimulation syndrome (OHSS).
- Conditions
- Pregnancy Early, Miscarriage, Ovarian Hyperstimulation Syndrome
- Trial name
- NCT04797338
- Testing
- Synarel, 0.2 Mg/Inh Nasal Spray, Estrofem, Utrogestan
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Polycystic Ovary Syndrome
Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS)
PolysCsytic Ovaries Syndrome (PCOS) is the most frequent endocrinopathy. The first stage of infertility treatment is Clomiphene Citrate which leads to 50 % pregnancies.
- Trial name
- PERCING (NCT00378729)
- Testing
- Metformin and FSHr, Ovarian drilling by FERTILOSCOPY
- Where
- France
- Volunteers
- 252 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ovarian Hyperstimulation Syndrome
Montelukast for Prevention & Treatment of OHSS
montelukast \& dydrgesteron will be given to cases with suspected or proven ovarian hyperstimulation in one group in comparison with dydrogesteron alone in the other group.
- Trial name
- NCT03794037
- Testing
- dydrgesterone 10 mg( tab)/12hs/14 days, montelukast 10 mg(tab) oral/24hs/ 7 days dydrgesterone 10 mg( tab) oral/12hs/14 days
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Benha University
Infertility
Outcome of Cetrotide Therapy for Management of Women at High-risk of Ovarian Hyperstimulation Syndrome
To evaluate safety and efficacy of 3-day cetrotide therapy started on day of oocyte retrieval (Day-0) in women at high-risk for development of ovarian hyperstimulation syndrome (OHSS) after gonadotropin- releasing hormon agonist…
- Trial name
- NCT02823080
- Testing
- Cetrorelix
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Benha University
Infertility, Hyperstimulation Syndrome, Ovaian
Vascular Cell Activation, Cell-Derived Microparticles and In Vitro Fertilisation, and In Vitro Fertilisation
Introduction: Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic phenomenon, poorly understood and difficult to predict, complicating intense ovarian stimulation cycle.
- Conditions
- Infertility, Hyperstimulation Syndrome, Ovaian, Thrombosis
- Trial name
- PREDHSO (NCT03051230)
- Volunteers
- 50 people
- Sponsor
- Poissy-Saint Germain Hospital
Polycystic Ovarian Syndrome, Ovarian Hyperstimulation Syndrome
Ovarian Hyperstimulation Syndrome and Cabergoline
Cabergoline prevents ovarian hyperstimulation syndrome in high risk patients by disrupting follicular fluid hormone microenvironmentally altering the follicular fluid levels of insulin like growth hormone -I (IGF-I)…
- Trial name
- NCT01569256
- Testing
- Cabergoline
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanim Womens' Health and Teaching Hospital
Ovarian Hyperstimulation Syndrome
The Influence of Timing of Cabergoline Initiation on Prevention of OHSS
Study the effect of early cabergoline administration in prevention of occurrence or decreasing the severity of OHSS in patients undergoing intra cytoplasmic sperm injection.And its effect on oocyte maturation,fertilization and…
- Trial name
- OHSS (NCT02620605)
- Testing
- Late Cabergoline 0.5mg, Early Cabergoline 0.5mg
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Mona M Shaban
Ovarian Hyperstimulation Syndrome
Co-administration of Low Dose hCG at the Time of GnRH Agonist Trigger or 35 Hours Later for the Prevention of OHSS
This a prospective randomized double blind study involving patients at high risk of OHSS development with peak serum E2 levels < 4,000 pg/ml comparing the ongoing pregnancy rates in patients who receive adjuvant hCG 1,000 IU at…
- Trial name
- NCT01815138
- Testing
- hCG
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- UConn Health
Polycystic Ovary Syndrome
Metformin Treatment Before in Vitro Fertilization (IVF) in Women With Ultrasound Evidence of Polycystic Ovaries
The aim of study was to investigate whether pre-treatment with metformin before and during IVF increases the live birth rate compared to placebo in women with sonographic evidence of polycystic ovaries (PCO), but without any…
- Trial name
- NCT01046032
- Testing
- Metformin
- Where
- 3 sites in United Kingdom
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Infertility
Diosmin Versus Cabergoline for Prevention of Ovarian Hyperstimulation Syndrome
The purpose of this study is to compare the effect of oral Diosmin to oral Cabergoline in the prevention of ovarian hyperstimulation syndrome (OHSS) in high-risk women underwent intracytoplasmic sperm injection (ICSI).
- Trial name
- infertility (NCT02134249)
- Testing
- Diosmin, Cabergoline
- Where
- 2 sites in Egypt
- Volunteers
- 200 people
- Sponsor
- Benha University