Clinical trials: Oxygen
High Flow Oxygen Therapy, Non Invasive Ventilation (NIV)
Predicting the Need for Invasive Mechanical Ventilation Using Different Risk Scores
This prospective, single-center observational study aims to evaluate the predictive performance of the ROX index, modified ROX index, and HACOR score for the need for invasive mechanical ventilation in adult intensive care unit…
- Trial name
- HFNC-NIV (NCT07896616)
- Volunteers
- 84 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Atelectases, Postoperative Pulmonary, Prone Position
ORI-Guided FiO₂ Titration in Prone Spine Surgery: Impact on Postoperative Atelectasis Assessed by Lung Ultrasound
Atelectasis is a frequent pulmonary complication after general anesthesia, often triggered by preoxygenation and intraoperative hyperoxia.
- Conditions
- Atelectases, Postoperative Pulmonary, Prone Position, Spine Surgery, Lung Ultrasound
- Trial name
- NCT07375173
- Testing
- Titrated Oxygen, Fixed oxygen
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Ankara Etlik City Hospital
Sarcoma, Hyperbaric Oxygen Therapy
Hyperbaric Oxygen Therapy for Soft Tissue Sarcoma Pilot Study
A parallel-group randomized pilot trial at a single institution (Duke University) on the effect of postoperative hyperbaric oxygen therapy on wound healing in patients with soft tissue sarcoma undergoing surgical resection with…
- Trial name
- NCT03144206
- Testing
- Hyperbaric oxygen
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Oxygen Toxicity, Hypercapnia
Oxygen Toxicity: Mechanisms in Humans
The goal of this clinical trial is to learn about the mechanisms of oxygen toxicity in scuba divers. The main questions it aims to answer are: How does the training of respiratory muscles affect oxygen toxicity? How do…
- Conditions
- Oxygen Toxicity, Hypercapnia, Seizures
- Trial name
- NCT05761756
- Testing
- Sleep Deprivation, Caffeine, Methylphenidate
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Duke University
Respiratory Muscle Training, Inspiratory Muscle Strength
The Effects of Interval Respiratory Muscle Training on Athletic Performance
This study evaluated the effects of a 4-week respiratory muscle training (RMT) program using constant versus incremental threshold resistance on respiratory muscle strength, pulmonary function, extremity strength, and…
- Conditions
- Respiratory Muscle Training, Inspiratory Muscle Strength, Maximal Oxygen Consumption
- Trial name
- NCT07887282
- Testing
- IMT %40 MIP, IMT %50-60-70-80
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Oxygen Saturation
Nellcor™ Investigational Device Sitting-Walking Study
To examine pulse rate and blood oxygen saturation accuracy of the Nellcor™ Investigational Device during non-motion and walking motion conditions in a diverse patient population through non-invasive means
- Trial name
- NCT07234279
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Prematurity, Respiratory Distress Neonatal
Effect of Automated Oxygen Control on Early-childhood Lung Mechanics
Preterm infants are at higher risk of long-term respiratory problems and abnormal lung function in childhood. Respiratory support including mechanical ventilation, that is the use of a machine to move air into and out of the…
- Conditions
- Prematurity, Respiratory Distress Neonatal, Oxygen Delivery
- Trial name
- NCT07866820
- Testing
- Forced oscillometry technique
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College Hospital NHS Trust
Oxygen Saturation, Percutaneous Coronary Intervention
Effects of Pilates Breathing Versus Diaphragmatic Breathing on Oxygen Saturation and Heart-Rate Variability in Post-Percutaneous Coronary Intervention Patients
Percutaneous Coronary Intervention (PCI) is a common procedure used to restore coronary blood flow in patients with coronary artery disease.
- Trial name
- NCT07872098
- Testing
- Pilates Breathing, Diaphragmatic breathing
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Foundation University Islamabad
Oxygen Saturation, Heart Rate
Effects of Alternate Nostril Breathing Versus Diaphragmatic Breathing on Oxygen Saturation and Heart-rate Variability in Post Percutaneous Coronary Intervention Patients
This study is a two-arm randomized parallel group trial designed to compare the effects of alternate nostril breathing vs diaphragmatic breathing on oxygen saturation and Heart-rate variability in hemodynamically stable post-PCI…
- Trial name
- NCT07867457
- Testing
- Alternate Nostril Breathing, Diaphragmatic breathing
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Foundation University Islamabad
Maximal Oxygen Consumption, Physical Performance
Adaptive Training Recommendations for Improved Physical Performance
In this study two different training strategies are compared; one is adaptive where the training is adjusted up or down on a daily basis to better match the recovery status (readiness) of the subject.
- Trial name
- ELLIDA (NCT06145152)
- Testing
- Adaptive exercise training, Static exercise training
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Swedish School of Sport and Health Sciences
Acute Respiratory Failure, Electrical Impedance Tomography (EIT)
Predicting High-Flow Nasal Oxygen Failure Within 72 Hours Using a Physiology-Informed Dual-Domain Model at 30 Minutes
This is a single-center, ambispective observational cohort study of adults with acute hypoxemic respiratory failure (AHRF) receiving high-flow nasal oxygen (HFNO) as initial respiratory support. The study includes three stages.
- Conditions
- Acute Respiratory Failure, Electrical Impedance Tomography (EIT), High-Flow Nasal Oxygen Therapy
- Trial name
- EFI-HFNO (NCT07366541)
- Testing
- High-Flow Nasal Oxygen Therapy, Electrical Impedance Tomography Monitoring
- Where
- China
- Volunteers
- 115 people
- Sponsor
- Ruijin Hospital
Mechanical Ventilation Weaning, Spontaneous Breathing Trial
High-Flow Tracheal Oxygen During Spontaneous Breathing Trial
The purpose of this study is to find out whether high-flow tracheal oxygen (HFTO) delivered at flows greater than 60 L/min can increase end-expiratory lung volume (EELV) in intubated patients during a spontaneous breathing trial…
- Conditions
- Mechanical Ventilation Weaning, Spontaneous Breathing Trial, High Flow Oxygen Therapy
- Trial name
- HFTO-SBT (NCT07864415)
- Testing
- T-piece, HFTO 50, washout, HFTO 70, washout, PSV., T-piece, HFTO 70, washout, HFTO 50, washout, PSV.
- Volunteers
- 30 people
- Sponsor
- Argentinian Intensive Care Society
Running, Athletic Performance
A Multiphase Analysis of Next-generation Trail Footwear
This study will investigate how different advanced-foam trail-running footwear configurations affect running economy, performance, comfort, and fatigue in competitive trail runners.
- Conditions
- Running, Athletic Performance, Oxygen Consumption, Muscle Fatigue
- Trial name
- NEXTGENTRAIL (NCT07855042)
- Testing
- Running footwear
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fernando González-Mohíno Mayoralas
Vital Pulp Therapies, pH
Prognostic Value of Pulpal Blood pH and Oxygen Saturation in Vital Pulp Therapy: Determination of Clinically Relevant Thresholds in a Prospective Clinical Study
The increasing emphasis on biological tissue preservation in contemporary endodontics has positioned vital pulp therapy (VPT) as an important treatment strategy for maintaining pulp vitality and preserving the functional…
- Conditions
- Vital Pulp Therapies, pH, pH Changes, Oxygen Saturation
- Trial name
- NCT07848698
- Testing
- vital pulp therapy
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- ertuğrul karataş
Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of COPD
Controlled Versus Standard Oxygen Therapy in ICU Patients With Acute Exacerbation of COPD
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Acute exacerbations frequently require intensive care unit (ICU) admission.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of COPD, Intensive Care Unit (ICU), Controlled Oxygen Therapy
- Trial name
- OXYCOPD-ICU (NCT07842510)
- Testing
- Controlled oxygen therapy, Standard oxygen therapy
- Where
- 2 sites in Tunisia
- Volunteers
- 240 people
- Sponsor
- Hôpital Universitaire Taher Sfar
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO
This multicenter randomized controlled trial compare two transfusion strategies of red blood cells transfusion in patients supported by veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Transfusion Related Complication, Anemia
- Trial name
- ICONE (NCT05699005)
- Testing
- Packed Red Blood Cells (PRBCs)
- Where
- 4 sites in France
- Volunteers
- 236 people
- Sponsor
- University Hospital, Lille
Nasal Dryness Associated With Low-Flow Oxygen Therapy
Topical Nasal Moisturization for Oxygen-Related Nasal Dryness During Low-Flow Oxygen Therapy
Conventional low-flow oxygen therapy delivered through a nasal cannula can cause nasal dryness and discomfort. This study evaluated whether topical nasal moisturization with 0.9% isotonic saline nasal drops or a hyaluronic…
- Trial name
- NCT07822451
- Testing
- Conventional Low-Flow Oxygen Therapy, 0.9% Isotonic Saline Nasal Drops, Hyaluronic Acid-Based Nasal Spray
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
ACL Injury, Hemodynamics
A Paradigm Shift in Musculoskeletal Rehabilitation Assessment After ACL Reconstruction Using Near-Infrared Spectroscopy
This study aims to establish and compare muscle haemodynamic response patterns in physically active subjects with anterior cruciate ligament (ACL) reconstruction, at different time points after surgery, against healthy controls…
- Conditions
- ACL Injury, Hemodynamics, Oxygen Consumption Based Assessment of Hemodynamics, Exercise
- Trial name
- HemoNIRS-LCA (NCT06621355)
- Testing
- Incremental Interval Test on a Cycle Ergometer
- Where
- Spain
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Universitat de Lleida
Patient Transport, Respiratory Failure
HERMES: International Survey and Portable External Power Evaluation During Respiratory Support Transport
The HERMES Phase I-II study was a two-phase observational investigation designed to characterize contemporary practices and safety-related challenges associated with the transport of patients requiring advanced respiratory…
- Conditions
- Patient Transport, Respiratory Failure, Noninvasive Ventilation, High-Flow Nasal Oxygen
- Trial name
- HERMES (NCT07807189)
- Testing
- Portable External Power Supply
- Where
- 20 sites in United States, Chile and 12 more
- Volunteers
- 246 people
- Sponsor
- Medipol University
Acute Respiratory Failure, Respiratory Insufficiency
HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport
The HERMES Phase III study is an international, multicenter, prospective observational investigation designed to characterize the quality and safety of patient transport during advanced respiratory support.
- Conditions
- Acute Respiratory Failure, Respiratory Insufficiency, Respiratory Distress, Critical Illness
- Trial name
- HERMES (NCT07805603)
- Testing
- Advanced Respiratory Support During Patient Transport
- Where
- 4 sites in Colombia, Egypt and 2 more
- Volunteers
- 565 people
- Sponsor
- Medipol University