Clinical trials: Oxygen Utilization
Liver Transplantation
co2 Gap and co2/o2 Ratio in Liver Transplant Patients
finding surrogate to co to trace the effect of preload challenge would make the test more applicable without the need of advanced hemodynamic monitors,suggested that co2 gap can be used to detect FR after mini fluid challenge and…
- Trial name
- co2gap (NCT03374579)
- Testing
- Fluid challenge
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Kasr El Aini Hospital
Left Heart Hypoplasia
Maternal Hyperoxygenation in Fetal Left Heart Hypoplasia
Heart disease is the leading cause of infant death related to birth defects. Congenital heart disease in which the left sided structures of the heart (left heart hypoplasia or LHH) are too small are among the most severe, and…
- Trial name
- MHO (NCT05334966)
- Testing
- Maternal Hyperoxygenation
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
COVID-19
Interest in the Use of Nasal High-Flow Oxygen Therapy (OptiFlow™) in Secondary Transport of COVID-19 Positive Patients
Since the beginning of COVID-19 pandemic situation, several modes of ventilation have been tried to correct the hypoxaemia induced by SARS-CoV-2 virus.
- Trial name
- SAMU83 (NCT05289141)
- Testing
- Use of high flow nasal oxygen therapy, Use of other non-invasive ventilation or high concentration oxygen masks
- Where
- France
- Volunteers
- 229 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Lung Disease, Acute Respiratory Distress Syndrome
Palliative Use of High-flow Oxygen Nasal Cannula in End-of-life Lung Disease Patients
The prevalence of severe dyspnoea among terminally ill patients has been reported as 70% and 90% for lung cancer and chronic obstructive pulmonary disease (COPD) patients, respectively.
- Trial name
- NCT02253667
- Testing
- HFONC, Conventional oxygen therapy
- Where
- Portugal
- Sponsor
- Hospital Sao Joao
Breast Cancer, Upper Extremity
Arm Exercise Capacity and Maximal Oxygen Consumption With Breast Cancer
Breast cancer is the most common type of cancer among women worldwide. The incidence rate has reached approximately 16%. According to 2016 data from the Ministry of Health, the incidence of breast cancer in Turkey is 46.8 per…
- Conditions
- Breast Cancer, Upper Extremity, Oxygen Consumption, Healthy
- Trial name
- NCT06018038
- Testing
- Arm Exercise Capacity, Peak Oxygen Consumption (VO2peak), Muscle oxygenation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Incentive Spirometry, Oxygen Saturation
The Effects Incentive Spirometry Use in Coronary Artery Bypass Surgery
Background: Incentive spirometry is used in addition to care, especially in reducing pulmonary complications after surgery. Complications in the cardiovascular and pulmonary systems can basically be determined by blood values and…
- Trial name
- NCT05192785
- Testing
- Incentive Spirometry Group
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Hyperoxia, Complication
The Effectiveness of the Use of Oxygen Reserve Index in Preventing Hyperoxia in the Intensive Care Unit.
Oxygen therapy is the most common treatment modality for patients with hypoxemia in intensive care units, but target values for normoxemia are not clearly defined. Therefore, iatrogenic hyperoxemia is a very common situation.
- Conditions
- Hyperoxia, Complication, Mechanical Ventilation Complication
- Trial name
- NCT05807815
- Testing
- Titration of fraction of inspired oxygen (FiO2) guided by ORI and oxygen saturation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Tepecik Training and Research Hospital
Pain, Postoperative
Use of Oxygen Nebulizer for Preventing Post-operative Sore Throat
Rationale: Delivery dry gas during anesthesia is associated with post-operative sore throat (POST). Oxygen nebulizer therapy increases humidity to the airway, especially post-extubation.
- Trial name
- POST (NCT01763177)
- Testing
- Oxygen
- Where
- Thailand
- Volunteers
- 1,036 people
- Sponsor
- Prince of Songkla University
Prematurity; Extreme
Use of NIRS in Preterm Population Born at Altitude
Near-infrared spectroscopy (NIRS), is a technology that can provide continuous, non-invasive monitoring of oxygenation in tissue.
- Trial name
- NCT04639583
- Testing
- Near-infrared spectroscopy (NIRS) utilization
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of New Mexico
Chest Trauma, High Flow Oxygenation
Management of Moderately Hypoxemic Thoracic Trauma
In France, the average incidence of thoracic trauma is 10,000 to 15,000 each year. These patients are at risk of early and late post traumatic respiratory complications as follows: pneumonia, Acute Respiratory Distress Syndrome…
- Trial name
- TrOMaTho (NCT03997630)
- Testing
- High flow Oxygenation, Standard oxygen
- Where
- 18 sites in France
- Volunteers
- 770 people
- Sponsor
- University Hospital, Brest
Congestive Heart Failure
Peripheral Venous Oxygen Saturation and Biomarkers to Estimate Cardiac Output and Filling Pressures in Heart Failure
The relationship between peripheral venous saturation and central hemodynamics (including right and left heart filling pressures and cardiac output), mixed venous oxygen saturation, and contemporary biomarkers of heart failure is…
- Trial name
- NCT00595738
- Testing
- Standard of care therapy for severe decompensated heart failure
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Smoking ( Cigarette)
Effect of Buteyko Breathing Exercise Combined With Postural Stability Exercises on Maximal Oxygen Consumption in Young Adult Smokers
Background: Smoking is one of the most significant risk factors for respiratory diseases, affecting both lung function and overall respiratory health.
- Trial name
- BBE PSE VO2max (NCT07257783)
- Testing
- Buteyko breathing exercise combined with postural stability exercises
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Yasmeen Alaa Abd El-Hamied Ahmeed
COVID-19, Lung Infection
Treatment of COVID-19 With Opaganib in Patients With Pneumonia Requiring Oxygen
Patients diagnosed with COVID-19 infection will be offered treatment with Opaganib, 500 mg Q12 hours. Opaganib will be continuously administered for up to 2 weeks, until discharged on room air (if earlier than 2 weeks).
- Trial name
- Opaganib-RHB (NCT04502069)
- Testing
- Opaganib
- Where
- Israel
- Sponsor
- RedHill Biopharma Limited
Cephalalgia
Protocol to Ease Acute Cephalalgia in Emergency-department
The purpose of this study is to determine if the use of a therapeutic and global protocol to relieve cephalalgia is helpful in the emergency department of Grenoble University Hospital.
- Trial name
- PEACE (NCT02236442)
- Testing
- Recommendation to use global headache treatment protocol
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Grenoble
Bronchiolitis, Hypoxia
Heated High Flow Oxygen Use in Infants With Bronchiolitis and Hypoxia
Bronchiolitis is a common cold weather seasonal respiratory illness affecting infants and children. Multiple supportive therapies have been tried in infants with bronchiolitis including albuterol, racemic epinephrine, hypertonic…
- Trial name
- HHFNC (NCT01662544)
- Testing
- Oxygen delivery
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Cardiac; Arteriosclerosis, Aortic Valve Disease
The Association Between Delivered Oxygen and Cerebral Impact During the Use of Cardiopulmonary Bypass.
Investigating the connection between delivered oxygen index and cerebral impact with COx (cerebral oximetry index) och cerebral injury markers during the routine use of cardiopulmonary bypass.
- Trial name
- NCT05620875
- Testing
- Cerebral injury markers, Cerebral oximetry index
- Where
- Sweden
- Volunteers
- 106 people
- Sponsor
- Uppsala University
ACL Injury, Hip Injuries
Muscle O2 Saturation and Hemoglobin Levels During Rehabilitation From Arthroscopic Surgery
This study will utilize the Moxy wearable sensor to measure muscle oxygen saturation levels in athletes following lower extremity surgery (ACL or Hip arthroscopy) to evaluate their Return-to-Play.
- Trial name
- NCT05488054
- Testing
- Physical Therapy, Monitored Work-out, Moxy Oxygen Sensor Device
- Where
- 2 sites in United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Performance Enhancing Product Use, Change, Body Weight
Effects of Acute Glycerol Ingestion on Performance, Metabolic and Biochemical Markers in International Athletes
This clinical study evaluates the acute effect of glycerol ingestion on performance (power output), weight, urine specific gravity, biochemical (antioxidants and lactate) and metabolic (indirect calorimetry) markers in…
- Conditions
- Performance Enhancing Product Use, Change, Body Weight, Change, Body Temperature, Antioxidative Stress
- Trial name
- NCT05295836
- Testing
- GLYCEROL
- Where
- Spain
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Tachycardia, Hypertension
To Observe Haemodynamic Parameters Including, Heart Rate, Blood Pressure, Respiratory Rate , and Oxygen Saturation, With or Without Giving Reversal Agent on Extubation, in Patients Receiving Single Shot of Atracurium , and to Observe Post Operative Residual Paralysis and Airway Reflexes in PACU.
The goal of this clinical trial is to to observe the haemodynamic parameters including Heart Rate Blood pressure Respiratory rate and Oxygen Saturation with or without giving reversal agent on extubation in patients receiving…
- Conditions
- Tachycardia, Hypertension, Hypoxia, Hyperventilation
- Trial name
- NCT07097441
- Testing
- neostigmine (reversal agent)
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ziauddin University
Obesity & Overweight, Energy Expenditure
Metabolic and Nutritional Responses to Acute High-intensity Interval Exercise Performed Under Hypoxic vs. Normoxic Conditions at Matched External Workload in Adults With Overweight and Obesity.
Obesity management involves lifestyle and dietary measures that include appropriate nutrition and increased physical activity (PA).
- Conditions
- Obesity & Overweight, Energy Expenditure, Substrate Oxidation
- Trial name
- HYPOXHIIT (NCT07814599)
- Testing
- HIIE - Normoxia, HIIE - Hypoxia
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques